Abstract The papers gathered in this Special Issue cover different phases of ancient, medieval, and modern Greek and Latin and explore an array of issues and trends dealing with historical aspects of Greek and Latin lexicography. The articles have been organized into three thematic units following chronological order: (i) ancient Greek and Latin lexicography; (ii) Greco-Latin lexicography in late antiquity, the Middle Ages, and the modern world; and (iii) uses, perspectives, and ongoing projects in Greco-Latin lexicography. Some papers address more formal issues (linguistic, morphological, semantic, and syntactic) relevant to the study of Greek and Latin lexicography, while other contributions deal with ongoing lexicographical projects, offering fresh perspectives on the future of lexicography.