Latest Scientific Results Research Articles

Evolutionary Constructor of Connectivity in Systems Formation

The hypothesis about the possibility of different types of being has always served as a fruitful source for constructing various models. The latest scientific results on combining the results of information theory with the achievements of physics provide a reasoned justification for the hypothesis under consideration. In this article, being and other being are considered as the basis for constructing the Universe on the basis of the identity of opposites of such categories as “essence – phenomenon”, “form – content” and “continuity – discreteness”. Research on the scale of the quantum and nano ranges allows us to come to the construction of rational designs for the possible basis of objective reality. It is the general principle that gives all things and phenomena of such reality an interconnected, including synchronous, character.

Proposed new definition for hospital-acquired SARS-CoV-2 infections: results of a confirmatory factor analysis.

The present study aims to develop and discuss an extension of hospital-acquired severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections (HA-SIs) definition which goes beyond the use of time parameters alone. A confirmatory factor analysis was carried out to test a suitable definition for HA-SI. A two-center cohort study was carried out at two tertiary public hospitals in the German state of lower Saxony. The study involved a population of 366 laboratory-confirmed SARS-CoV-2-infected inpatients enrolled between March 2020 and August 2023. The proposed model shows adequate fit indices (CFI.scaled = 0.959, RMSEA = 0.049). A descriptive comparison with existing classifications revealed strong features of our model, particularly its adaptability to specific regional outbreaks. The use of the regional incidence as a proxy variable to better define HA-SI cases represents a pragmatic and novel approach. The model aligns well with the latest scientific results in the literature. This work successfully unifies, within a single model, variables which the recent literature described as significant for the onset of HA-SI. Further potential improvements and adaptations of the model and its applications, such as automating the categorization process (in terms of hospital acquisition) or employing a comparable model for hospital-acquired influenza classification, are subjects open for discussion.

Photobiomodulation in Alzheimer's Disease-A Complementary Method to State-of-the-Art Pharmaceutical Formulations and Nanomedicine?

Alzheimer's disease (AD), as a neurodegenerative disorder, usually develops slowly but gradually worsens. It accounts for approximately 70% of dementia cases worldwide, and is recognized by WHO as a public health priority. Being a multifactorial disease, the origins of AD are not satisfactorily understood. Despite huge medical expenditures and attempts to discover new pharmaceuticals or nanomedicines in recent years, there is no cure for AD and not many successful treatments are available. The current review supports introspection on the latest scientific results from the specialized literature regarding the molecular and cellular mechanisms of brain photobiomodulation, as a complementary method with implications in AD. State-of-the-art pharmaceutical formulations, development of new nanoscale materials, bionanoformulations in current applications and perspectives in AD are highlighted. Another goal of this review was to discover and to speed transition to completely new paradigms for the multi-target management of AD, to facilitate brain remodeling through new therapeutic models and high-tech medical applications with light or lasers in the integrative nanomedicine of the future. In conclusion, new insights from this interdisciplinary approach, including the latest results from photobiomodulation (PBM) applied in human clinical trials, combined with the latest nanoscale drug delivery systems to easily overcome protective brain barriers, could open new avenues to rejuvenate our central nervous system, the most fascinating and complex organ. Picosecond transcranial laser stimulation could be successfully used to cross the blood-brain barrier together with the latest nanotechnologies, nanomedicines and drug delivery systems in AD therapy. Original, smart and targeted multifunctional solutions and new nanodrugs may soon be developed to treat AD.

Ozone-high-doses ACC. to Dr. Lahodny and the latest scientific results.

Self-funding his own work on the so-called therapeutic effects of medical ozone with respect to its alleged potential impacts on mitochondria and stem cells, he has been focusing since 2010 on an innovative form of ozone therapy called OHT—“Ozonhochdosistherapie”— commonly known as “10 pass” in the USA. Through a specific process involving 10 repeated interactive transits incurred via autohemotherapy, the blood is “fused” with 200 ml of ozone gas respectively brought to a concentration of 70 mcg/ml, thus providing a cumulative ozone intake of 140,000 mcg.
 The evolution of the ozonotherapeutic treatment promoted by Lahodny would then consist, in a way, in breaking the restrictive rules relating to pragmatic dosage which tended to prevail until now with regard to a usual protocol which still remains well anchored in traditional customs and habits. Indeed, any former procedure usually involved a single injection of ozonated autologous blood therapy containing 200 ml of ozone at a concentration of 40 mcg, after which the session would end. This conceptual limit was based on an arbitrary credo that exceeding
 this dose boundary—in terms of both quantity and concentration administered—would be likely to result in cell bursting by blood dissolution, a supputive risk whose consequences had previously been considered hypothetically lethal.
 In 2014, he discovered and refined a new dosage—L1—that he believes would activate the growth of stem cells and the production of adenosine triphosphate (ATP). Its application can be summed up as a major autologous blood therapy combined with massive doses of ozone injections both in terms of concentration — up to 70 mcg/ml in ozon IV or even 80 mcg/ml in rectal insufflation - and quantity: which generally implied 140,000 mcg, but sometimes up to 280,000 mcg in the treatment of more complex conditions. Thanks to this innovative approach, Lahodny claimed to obtain therapeutic results that he described as “exceptional” in the treatment of a number of chronic pathologies as well as several other morbid conditions which are generally considered difficult to treat.

Мифогенез и антропогенез

In the period of the 19th – beginning of the 21th century in the study of mythol­ogy three paradigms of the study of mythogenesis have consistently dominated – historical, non-historical and historical-cognitive. The historical-cognitive para­digm is based on the latest scientific results in the field of archeology, anthro­pology and cognitive science. The modern model of anthropogenesis assumes the existence of general regularities of development of three types of Homo – Homo sapiens, Neanderthals and Denisovans. There are reasons that are not only Homo sapiens, but also the Neanderthals and Denisovans had high cognitive ca­pabilities and signs of modern human behavior. The most important foundations of mythogenesis are the functioning of language and the activity of the imagina­tion. All three populations of ancient mankind reached a cognitive minimum, which opened the way to mythogenesis. Signs of mythogenesis are clearly recorded no later than the time of the transition from the Middle to Upper Pale­olithic, during the Early Aurignacian, but the beginning of this process goes back to an earlier period.

Interpretation of the Traditional Chinese Medicine portion of the diagnosis and treatment protocol for corona virus disease 2019 (Trial Version 7).

The TCM protocol in the Diagnosis and Treatment Protocol for corona virus disease 2019 (COVID-19) (Trial Version 7) has been updated from previous versions. The protocol was formulated under the direct leadership of the National Administration of Traditional Chinese Medicine, based on the experience of a panel of experts, supported by evidence from fever clinics and from the outcomes of emergency (EM) observation rooms and inpatients throughout China (especially in Wuhan, Hubei Province) in combination with the latest scientific research results and data. The present interpretation of the TCM protocol is based on an overall understanding of the revised content, and aims to guide and standardize its clinical application to provide a reference for clinicians.

Chemistry & chemical technology. Lithuanian chemists conference, May 16, 2019

The aim of the conference is to bring together young scientists, engineers, researchers and students of Lithuanian universities, institutes, centers of science and business to carry out research in the field of chemistry and chemical technology, to provide the opportunity to expand knowledge and present the latest scientific results and ideas.

The Alert Collector: Sources to Ponder: Developing a Meditation Collection

Meditation practices date back thousands of years to the forest-dwelling rishis of Asia who viewed it as a way to achieve spiritual growth leading to enlightenment. Meditation has today become an increasingly popular practice in mainstream western culture. News media continually churn out stories about the latest scientific results showing the physical, mental, and social benefits of meditating. Celebrities and athletes from the Beatles to David Lynch to LeBron James talk about how meditation has influenced their life and work. Meditation is practiced in corporations and boardrooms and is used in military training programs. Meditation has become commodified and commercialized, with meditation studios springing up in major cities, books about meditation hitting bestseller lists, and Silicon Valley engineers producing meditation apps by the dozens.

The Philosophicum – Model Project of <i>Philosophy of Medicine</i> in Medical Education and Practice in Germany <i>Perspective Article</i>

Medical and philosophical thinking belong together, cannot be separated neither in scientific theory nor in practice, and only the symbiosis of both can face the challange to reflect the basic phenomenon of both of these desiciplines: human life itself. No patient expects to be treated exclusively on the basis of the latest scientific results, but also wants to be perceived by his doctor as an unique individual. It is the doctor’s specific task to embed the scientifically developed diagnoses therapeutically into each individual patient’s biography. Furthermore such a perspecitve increases patient safety and it enables a future of trust in the doctor-patient relationship. The „Philosophicum“ is a model project in Germany that brings together philosophers, physicians and students to do research and education in the broad and enriching intersection of medicine and philosophy. Based on many years of experience, we are convinced that a structured philosophical education can substantially improve medical studies and subsequently doctors‘ work. Medical anthropology and hermeneutics are necessary and also teachable. The preparation should start early in the medical education and should be strengthened by bedside training while interacting with the patient. This requires philosophically interested and trained doctors and students. Exactely for that reason we favor integrating a philosophicum into the medical eduacation and practice.

Conference Report on TEDD & 3R Workshop at ZHAW Waedenswil.

On April 7, 2017, TEDD (Tissue Engineering for Drug Development and Substance Testing) and the Animal Research Foundation joined forces at ZHAW Waedenswil to present their latest scientific results in the domain of the 3Rs of biomedical research: how to Refine, Reduce and Replace animal testing with alternative approaches.

Report on the fifth meeting of INRA's national network of ecotoxicologists, ECOTOX.

The fifth meeting of INRA's national network of ecotoxicologists took place on 25 to 27 November 2014 in Biarritz, France. The main aim of the meeting was to bring together ecotoxicologists from INRA and associated partners, providing them ample opportunity to share and discuss their latest scientific results as well as the national policy of research in ecotoxicology and to precise perspectives for the network.

Assurer la sécurité alimentaire dans un contexte de changement climatique : un défi collectif

There is an urgent need to renew our agricultural model: 1 billion people still suffer from starvation nowadays, we are running short with fossile resources and climate change is already transforming agriculture throughout the World. Food security is at stake for the decades to come and most of the international decision makers are becoming aware of it, as illustrated by a series of conferences and summits which include: the G20 summit on agriculture in Paris (June 2011) and the Earth Summit which took place in Rio on last June.However, while preparing for those important meetings decision-makers were in need for an accurate and comprehensive information on the latest scientific results. This is the reason why the international commission on sustainable agriculture and climate change was set up in 2011.Made of 13 eminent scientists, this international commission was in charge of identifying which policy changes and actions are needed to help the world achieve food security in the face of climate change. After 15 months of working, the commission issued its final report in March 2012 and this article is aimed at introducing the main conclusions of this report.

Scientific Journeys of the BIOVEG network, September 27-29, 2010, UASVM Cluj-Napoca

Conference Information: 12th International BIOVEG Symposium Plant Biodiversity and Food Diversification Place: University of Agricultural Sciences and Veterinary Medicine, September 27-29, 2010 Cluj-Napoca, Romania The aim of the BIOVEG Symposium is to present the latest scientific results on all aspects of research in plant biotechnology. Various tools are now available to describe the biological diversity of plant species useful for food diversification. They allow fine analysis of basic components, but also their interactions, using different and complementary disciplines such as genetics, microbiology, biochemistry and physiology. The involvement of Plant biodiversity and Food diversification in one symposium is not a common process. However, the FAO data (2008) relevant to the state of the food worldwide are clear on at least two main points: I) there is a well defined relationship between quality of diet and dietary diversification; II) the most affected countries are India, countries in sub-Saharan Africa, the Pacific area of Asia and China as they have a high potential of biodiversity. If food is a vital necessity, the overall diet is different between rich and poor countries. In poor countries, cereals, roots and tubers cover 66% of eaten plants. In rich countries, fruits and vegetables play a much larger role (19% vs. 11%). In rich countries, attention is increasingly paid to the nutritional quality and food intakes for a better life. In poor countries, it is foremost eat to survive. Nearly 900 million peoples suffering from hunger in the world but 90% of them live in developing countries. India (231 MH) is at the head, followed by sub-Saharan Africa (212 MH), Asia - Pacific (189 MH) and China (123 MH). The rest of the world has barely 100 MH malnourished peoples. However, the Pacific area of Asia provided the world in many domesticated plant species (Citrus, numerous fruits and vegetables). Tools to describe biodiversity of plant species for food diversification have made many advances in recent years. New technologies allow deep and detailed analysis of the biodiversity and quality of the food supply. Several different and complementary disciplines such as genetics, microbiology, biochemistry and physiology are involved. Beyond the simple description step, it is to improve products or value-added varieties and also to maintain traditional pools of genetic diversity for tomorrow. We must also appeal to disciplines such as plant breeding or the wide range of plant biotechnologies to generate new diversity aspects and to preserve existing genetic resources. This requires of course a broad collaboration of local people, the best able to defend their specificities. In this context, 2010 Conference of Scientific Journeys of the BIOVEG network was organized around five main sessions: 1. Genetic resources, local domestication, plant breeding, cytogenetics. 2. Plants - micro-organisms interaction which include phytopathology, symbiotic relationship, toxins impacts. 3. Final biochemical composition, antioxidants analysis, lipid contents and composition, metabolic pathways regulations. 4. Non-conventional diversity creation methods such as induced mutations. 5. Ex situ and in situ genetic resources conservation.

Leading in agroindustry, research institute for vegetable breeding and seed production marked by 90 year since date of establishment

In 2010, All-Russian Research Institute of Vegetable Breeding and Seed Production is celebrating 90 years of existence. This article covers the latest scientific results and current explorations at the Institute.

Serendipity

Serendipity

Zero-Mode Waveguides for Real-Time Observation of Single Nucleotide Incorporation

Single-molecule fluorescence studies on the incorporation of fluorescently labeled nucleotides by DNA polymerizing enzymes typically operate at nucleotide concentrations well below their Km values. While this is inevitable given the femtoliter observation volumes accessed via conventional fluorescence microscopy, the biological relevance of the insights gained into enzymatic kinetics may be compromised. Zero-mode waveguides (ZMWs), sub-wavelength holes in a thin metal film, provide an excellent solution to this problem by greatly reducing the observation volume [M. J. Levene, et al., 2003, Science 299, 682-686].We have successfully designed and fabricated ZMWs of about 100 nm in width. In addition we have developed a surface treatment protocol based on PEG functionalization to make the ZMWs biocompatible, and to facilitate the controlled tethering of biomolecules [A. Crut, et al., Nanotechnology, in press (2008)]. In these structures, we have observed the real-time observation of single nucleotide incorporation at biologically-relevant concentrations in ZMWs, The latest scientific results will be presented.

The Second International Meeting on Yeast Apoptosis (IMYA 2), Smolenice, Slovak Republic, 17-20 September 2003.

We know it is only dying yeast but we all like it more and more… Two years ago a group of researchers sharing the same scientific interest decided that an IMYA meeting should be organized every year. That initiative aimed at regularly joining researchers working on the very new and growing field of programmed cell death (PCD) and aging in yeast. The first IMYA meeting was held in 2002 in Braga, Portugal. The 2003 annual meeting was held in Smolenice, Slovak Republic, and it was organised by Jordan Kolarov (Comenius University, Bratislava), Ludmila Sabova (Slovak Academy of Sciences), Zdena Palkova (Charles University, Prague), Alena Pichova (Czech Academy of Sciences, Prague) and Martin Kucej (Comenius University, Bratislava). The beautiful castle of Smolenice and its wonderful surrounding landscape offered 60 participants (from 10 European countries, USA, Australia, India, Iran, South Korea and Japan) a unique stay during the three-days meeting. They could share and discuss, in a very quiet and relaxed atmosphere, their latest scientific results and enjoy a visit to natural caves and a castle in the vicinity, as well as the taste of Slovak wines and food and the sound of folk music and songs. The scientific programme started with an opening lecture on Cellular responses to reactive oxygen species by Ian Dawes (University of New South Wales, Sydney, Australia) and included 23 oral presentations and fifteen posters, mostly covered by the five topic sessions on: (1) Evolutionary aspects of apoptosis; (2) The yeast cell death pathway; (3) Aging and apoptosis relationship; (4) Bcl-2 proteins and mitochondria; and (5) Exogenously triggered yeast cell death. Ian Dawes presented a picture of …