Abstract: An earthquake can cause significant harm to various aspects, including buildings, general life, and particularly multistory structures. In India, structures constructed in earthquake-prone regions, as defined by IS 1893: 2002, must be designed to withstand the loads, stresses, and consequences of earthquakes. Several techniques are available for assessing multi-story structures in this context, such as the Response Spectrum Method, Equivalent Lateral Force Method, Time History Method, and adhering to specific code provisions. Numerous researchers have undertaken studies to analyze multi-story buildings using one or more of these methods. However, there exists still a confusion about an effective and efficient method preferred for seismic design of multi-story buildings. Among the various approaches, the seismic coefficient method and response spectrum method are the most widely used. This comparative investigation aims to review research reports that have employed the Equivalent Lateral Force Method and Response Spectrum Method to analyze multi-story buildings in earthquake-prone areas. The design response spectrum serves as the initial reference point for most established seismic design and assessment procedures. It primarily dictates the inertia forces that buildings and structures must withstand during an earthquake. This paper aims to introduce and discuss contemporary concepts regarding the creation and utilization of earthquake design response spectra. Additionally, the paper highlights the various methods of seismic analysis being investigated in the past literature. It also gives an overview of various investigations being carried out using linear and non-linear static analysis of RCC structures. Many of the ideas presented are specifically aimed at aiding engineers who work in regions with low to moderate seismic activity. The main objective is to inform engineers about modern approaches to developing response spectra. This knowledge can then be applied effectively in both analytical and design contexts when dealing with earthquake-related challenges