Purpose: This research examines the integration of drone technology into last-mile delivery operations, focusing on its impact on supply chain efficiency, cost reduction, and sustainability. The study explores operational challenges, such as air traffic management, payload limitations, regulatory compliance, and public perception, providing a comprehensive understanding of how drones can reshape last-mile logistics. Methodology: The study employs a multi-faceted approach, combining historical analysis, in-depth case studies, and scenario planning to assess the impact of drone technology on last-mile delivery efficiency, cost optimization, and accessibility. Data is gathered from industry reports, interviews with logistics professionals, and regulatory documents. Thematic analysis is conducted to identify critical patterns, while scenario-based modeling offers insight into the potential outcomes of various integration strategies. A comparative evaluation of existing last-mile delivery methods against drone-based delivery models is also provided. Findings: The research reveals that drone technology offers significant potential for enhancing last-mile delivery efficiency, particularly in urban areas and remote locations, aligning with findings from studies like those by Murray & Chu (2015). However, the study identifies considerable obstacles, including regulatory challenges, limited payload capacities, and public acceptance issues. Solutions such as airspace regulation frameworks, collaborative logistics networks, and advanced battery technologies are highlighted as critical enablers for successful drone integration. Contribution to Theory, Policy and Practice: This study contributes to the growing body of knowledge on drone technology's role in logistics by providing a comprehensive framework for businesses and policymakers to navigate the complexities of drone integration. It recommends actionable steps for integrating drones into last-mile delivery, bridging the gap between theoretical innovation and practical application. It provides policy recommendations for regulatory bodies to develop airspace management systems that support drone operations. For practitioners, the research offers a strategic guide to overcoming operational challenges, facilitating the adoption of drones as a sustainable solution for last-mile delivery.