Laser Therapy In Management Research Articles

Efficacy of low energy fractional carbon dioxide laser therapy in management of post-surgical hypertrophic scars

Background: aberrant & accelerated wound-healing process that results in hypertrophic scarring causes extracellular matrix & collagen to deposit abnormally in the dermis. After tissue damage occurs, a defensive reaction called tissue repair occurs. Aim; in this review; we aimed to present the effectiveness of low-energy fractional carbon dioxide laser therapy in treating hypertrophic scars following surgery. Summary: A safe & effective approach for treating hypertrophic burn scars is fractional ablative CO2 laser therapy. Even though more treatment sessions have been necessary for satisfying outcomes, a big improvement can be seen after just one round of therapy. Combination therapy with other modalities can decrease the need for repetition of therapy as efficacy increases. Though, in some studies, combination therapy may shorten the duration of studied case downtime & in others, combination therapy may increase side effects. essential for laser energy setting needs to be adjusted for each hypertrophic scar condition. larger research population & longer follow-up period are recommended.

The Efficacy of Low Energy Fractional Carbon Dioxide Laser Therapy in Management of Post-Surgical Hypertrophic Scars

The Efficacy of Low Energy Fractional Carbon Dioxide Laser Therapy in Management of Post-Surgical Hypertrophic Scars

The Efficacy of Low Energy Fractional Carbon Dioxide Laser Therapy in Management of Post Surgical Hypertrophic Scars

The Efficacy of Low Energy Fractional Carbon Dioxide Laser Therapy in Management of Post Surgical Hypertrophic Scars

Results of Infantile Hemangioma Laser Therapy in Children with Persistent Residual Signs after Systemic Propranolol Therapy: Clinical Cases

Background. Infantile hemangiomas are revealed in 1-3% of newborns and 10-12% of infants. There are only anecdotal reports on the laser therapy efficacy in this pathology management. However, there is no common approach to the use of this method in the complex treatment of infantile hemangioma in infants. Clinical Cases Description. Two clinical cases of infantile hemangioma are presented. Patients underwent complex treatment: systemic propranolol and laser therapy via pulsed dye laser. Laser exposure modes ware selected individually: laser spot sizes were 10 and 12 mm, energy levels were 5-10 J/cm2, burst duration was short (0.45 ms) or long (10-20 ms), procedure duration was from 15 to 40 minutes, number of procedures varied from 1 to 8. Laser therapy has shown its efficacy in treatment of superficial infantile hemangioma. Conclusion. The indication for using laser therapy in management of infants with hemangiomas is especially persistent residual signs such as telangiectasias and erythema after spontaneous or drug involution phase. Laser therapy allows us to avoid aggressive methods and improves the quality of life of our patients according to this article.

Efficacy of Low-Level Laser Therapy in Management of Temporomandibular Joint Pain: A Double Blind and Placebo Controlled Trial.

Stomatognathic system is an interaction of the muscles of mastication, dentition, neural component, and temporomandibular joint. Any dysfunction in this system may lead to temporomandibular disorders (TMDs). Various non-surgical modalities have been employed for treating TMDs. The aim of the study was to objectively evaluate the effects of low-level laser therapy (LLLT) in treatment of patients with TMDs. Sixty individuals diagnosed with TMDs were divided randomly into two groups (Group I-placebo and Group II -LLLT). A series of 20 sessions of LLLT applied both in closed mouth and maximum mouth opening position were given over a period of 08weeks. Assessment was done in terms of improvement in mouth opening, pain, clicking, and deviation of mandible. The data collected were analyzed statistically. The results showed improvement in the pain reduction, improvement in the maximum mouth opening, reduction in deviation, and clicking in both groups but better treatment outcome in the low-level laser group. Though conservative measures improved the symptoms in TMD but LLLT has shown better results in comparison with the placebo group. Being non-surgical can be employed in combination with other modes for effectively treating such disorders. Keywords: Pain, Dysfunction, Temporomandibular joint disorders (TMDs), Low-level laser therapy (LLLT).

Low level laser Therapy in Management of Oral Lichen Planus (OLP)

Oral lichen planus (OLP) is a chronic state of inflammatory condition with immunological behavior ofunknown etiology, Laser application on different lesions has been suggested as new treatment modalitieswithout significant adverse effects. Eighteen females subjected from OLP with mean age (37.9) years;without signs and symptoms for any medical diseases, these patients treated with low level laser (Epic X10 diode laser for soft tissues). The symptoms of oral lichen planus can be treated by 630-980 nm low levellasers to reducing both the pain and mouth soreness with no adverse effects. The action of laser in this fieldby; convert the pro-inflammatory state to anti-inflammatory condition and progression in collage repair, cellproliferation and finally tissue regeneration.

Low-intensive Laser Therapy for Management of Cerebral Dysfunction in Patients with Obstructive Jaundice of Non-tumor Origin

BACKGROUND The liver’s function is impaired above all others in the mechanical jaundice, which leads to the progression of endogenous intoxication and the damage of different organs and systems, including the brain. The development of hepatic encephalopathy undoubtedly aggravates the course of the disease, which requires its timely management.AIM OF STuDy: to evaluate the effcacy of the low-intensity laser therapy when managing the cerebral dysfunction in mechanical jaundice of non-tumor origin.MATERIAL AND METHODS A comprehensive study of 60 patients with obstructive jaundice of non-tumor origin was performed. The patients were divided into 2 groups: I (comparison) — the standard therapy (n=30); II (studied) group — inclusion of low-intensity laser irradiation of blood (n=30). On check dates (day 1 and 7), the severity of cerebral dysfunction was assessed in all patients using the psychometric tests (“Point in Circle, “Labyrinth”). The microcirculation was assessed with LACC 02 device (Russia). The coagulation/lysis system of blood was studied with TEG 5000 thrombelastograph (USA).RESULTS In patients with obstructive jaundice, disorders of the functional state of the liver were noted, which resulted in the growth of total bilirubin, alanine and aspartic aminotransferases, and toxic products. All this was accompanied by cerebral dysfunction, which was shown by results of the psychometric study and extended performance of tests, in particular (“Point in Circle”, “Labyrinth”). Signifcant changes and disorders of the hemostatic system were revealed in patients. The complex treatment of obstructive jaundice, which included laser therapy, allowed a relatively rapid recovery of the functional state of the brain to be observed, as evidenced by the shortening of the test time for the tests being studied. The positive effect of this kind of therapy was accompanied by a decrease in the severity of the syndrome of endogenous intoxication, improved microcirculation and hemostasis.CONCLUSION The presence of pancreatic obstructive jaundice lead to the development of florid syndrome of endogenous intoxication, which was reflected in the growth of ALT, AST, amylase, and total bilirubin. During the entire period of the study, a decrease in studied blood parameters was observed in patients who had underwent low-intensity laser therapy sessions. Conducting a psychometric study in the initial periods revealed some violations, such as extended performance of tests (“Point in Circle”, “Labyrinth”).

Clinical Outcomes of Low-level Laser Therapy in Management of Advanced Implant Surgery Complications: A Comparative Clinical Study

Nowadays, implant insertion is accompanied by undesired consequences. As surgery techniques become more and more complex, an increase of intra- and post-op complications can be expected. Application of low-level laser (LLL) is one of the conservative approaches to control the complications with any side effects and low treatment costs. The present study aimed to evaluate the effect of 650 nm LLL irradiation on the reduction of complications after advanced implant surgeries. In this triple-blinded clinical trial, 30 patients aged between 25 to 65 years were in need of bone graft or sinus lift procedure for simultaneously implant insertion. In the LLL treatment group, the surgical site of each implant was treated with 650 nm laser. The same method and duration were applied in the placebo group. The pain levels, facial swelling, and wound healing were evaluated. This study indicated that pain levels were reduced in the laser group (p <0.05). Also, facial swelling in the 3rd and 7th day after the surgery relieved more in laser group. Furthermore, investigation of the surgical site showed a higher level of wound healing in the laser group (p <0.05). Regarding the biological effects of advanced implant surgeries and accompanying complications, adjuvant treatment with a laser could significantly improve wound healing and reduce the severity and duration of pain and swelling. This clinical trial demonstrates reductions of the level of pain, facial swelling and improvements of wound healing are followed by the use of low-level laser therapy.

Low level laser Therapy in Management of Oral Lichen Planus (OLP)

Oral lichen planus (OLP) is a chronic state of inflammatory condition with immunological behavior of unknown etiology, Laser application on different lesions has been suggested as new treatment modalities without significant adverse effects. Eighteen females subjected from OLP with mean age (37.9) years; without signs and symptoms for any medical diseases, these patients treated with low level laser (Epic X 10 diode laser for soft tissues). The symptoms of oral lichen planus can be treated by 630–980 nm low level lasers to reducing both the pain and mouth soreness with no adverse effects. The action of laser in this field by; convert the pro-inflammatory state to anti-inflammatory condition and progression in collage repair, cell proliferation and finally tissue regeneration.

Efficacy of low-level laser therapy in management of recurrent herpes labialis: a systematic review.

Recurrent herpes labialis (RHL) is a highly prevalent viral infection that affects the oro-facial region. Current treatment options have limited efficacy in reducing healing time and recurrence rate of the disease. Recently, low-level laser therapy has been proposed as a potential treatment alternative for the management of RHL with no side effects. This systematic review aims to evaluate the effectiveness of laser therapy in the management and prevention of RHL. A comprehensive search of Medline/PubMed, Scopus, and Web of Science was carried out to identify published clinical trials comparing laser intervention to active and/or non-active controls for the treatment of RHL. Due to marked heterogeneity of available data, studies were assessed qualitatively, and no statistical analysis was performed. Of the retrieved 227 articles, six clinical trials met the eligibility criteria. The wavelengths, the power output, and energy density ranged between 632.5-870nm, 5-80W, and 2.04-48J/cm2, respectively. All included studies found laser to be effective in the management and prevention of RHL, without any side effects. The findings of this review suggest that laser is potentially a safe and effective treatment alternative for the management of RHL. However, due to high variability in study designs and inconsistency in laser parameters among the included studies, more well-designed randomized clinical trials with standardized laser parameters are highly warranted.

Efficacy of low-level laser therapy in management of symptomatic oral lichen planus: a systematic review.

Oral lichen planus (OLP) is a chronic inflammatory disease of unknown etiology and indefinite cure. This systematic review assessed the efficacy of low-level laser therapy in the treatment of symptomatic OLP. Electronic databases (PubMed, Scopus, and Web of Science) were searched from date of inception till and including December 2016, using various combinations of the following keywords: oral lichen planus, laser therapy, low-level laser therapy, and phototherapy. Owing to heterogeneity of data, no statistical analyses were conducted. Initially, 227 publications were identified. After selection, only six studies were included in this systematic review. In these studies, the laser wavelengths, power output, and duration of irradiation ranged between 630-980nm, 20-300mW, and 10s-15min, respectively. All of the included studies found laser to be effective in management of OLP, without any reported adverse effects. The results of the included studies confirm that low-level laser therapy is effective in management of symptomatic OLP and can be used as an alternative to corticosteroids. However, due to variety of methods and substantial variations in laser parameters among these studies, more randomized clinical trials with large sample sizes are highly warranted.

Low-level laser therapy for management of TMJ osteoarthritis

Aims:This study investigated the efficacy of low-level laser therapy (LLLT) for the management of temporomandibular joint (TMJ) osteoarthritis.Methodology:In a double-blind clinical trial, 20 patients with TMJ osteoarthritis were randomly divided into laser and placebo groups. The patients in the laser group received irradiation from an 810 nm low-level laser (Peak power 80 W, average power 50 mW, 1500 Hz, 1 μs pulse width, 120 seconds, 6 J, 3·4 J/cm2 per point), which was applied on four points around the TMJs and on painful muscles three times a week for 4 weeks. In the placebo group, the treatment was the same as that in the laser group, but with laser simulation. The patients were evaluated before laser therapy (T1), after 6 (T2) and 12 (T3) laser applications and 1 month after the last application (T4), and the amount of mouth opening and the pain intensity were recorded.Results:No significant differences were found in mouth opening either between the study groups or between the different evaluation times in each group (P>0·05). There was no significant difference in pain symptoms of the masticatory muscles and TMJ between the laser and the placebo groups (P>0·05), but some significant within-group improvements were present for Visual Analogue Scale (VAS) scores of the body of the masseter and TMJ in both groups.Conclusions:LLLT using the present laser parameters was no more effective than the placebo treatment for reducing pain and improving mouth opening in patients with TMJ osteoarthritis.

Low Level Laser Therapy in Management of Complications after Intra Oral Surgeries

One of the basic purposes in dental treatment is providing a painless treatment for patients. This purpose may be achieved by the application of laser in dentistry. Low-level laser therapy (LLLT) is an internationally accepted title for biomodulation with low-level lasers which we use to achieve ideal therapeutic effects. Low-level laser therapy is a painless, reproducible, non-invasive, and without need of anesthesia treatment which is used to treat a variety of pain syndromes, injuries, wounds, fractures, neurological conditions and pathologies. Laser therapy works on the principle of inducing a biological response through energy transfer. The parameters that used in laser therapy determine the effective depth of penetration. We can mention anti-inflammatory effects, stimulation of wound healing, stimulation of immune system, increase of blood flow and activation of vasodilatation, increase of cellular metabolism and analgesic effects as advantages of the application of this type of laser. The aim of this review study was to evaluate the effect of low-level laser

Low Level Laser Therapy in Management of Chemotherapy-Induced Oral Mucositis: Prophylaxis or Treatment?

Introduction: Chemotherapy-induced oral mucositis (COM) is a common, debilitating complication of cancer therapy. The aims of this study were to evaluate the effect of low level laser therapy (LLLT) on prevention of COM in patients with hematologic malignancies. Methods: Fifty-five patients hospitalized to undergo chemotherapy in Imam Hospital were included into the study. These patients were divided into two groups. The oral cavity of the patients were illuminated by continues laser beam using a GaAlAs laser device with wavelength of 630 nm, power output 30 mW, and dose of 5 J/cm 2 for six days (LLLT group). The patients in the second group underwent placebo irradiation (power output equal to zero) with the similar protocol. The severity of the COM was clinically evaluated based on WHO grading scale. The patientys’ quality of life was assessed before and after the intervention according to EORTC QLQ-C30 questionnaire. Results: The incidence of COM in LLLT group (31%) was less than the placebo group (41%). Mean duration of COM healing was 4.8 and 12 days in LLLT and placebo groups, respectively (p=0.03). Xereostomia was significantly less severe in LLLT group in comparison with the placebo group (p=0.007). Conclusion: Our findings showed that LLLT significantly reduced the incidence of oral mucositis of WHO grade 3 and 4 as the most debilitating form of oral mucositis, in which oral alimentation is impossible. Also, LLLT could reduce duration of oral mucositis, decreased the risk of secondary infection, and accelerated return to normal nutrition. Lasers; Laser Therapy, Low Level; Mucositis, Oral; Chemotherapy; Quality of life; Disease Management; therapy; Prophylaxis

Intravitreal Triamcinolone Injection as an Adjuvant to Standard Laser Therapy in Management of Proliferative Diabetic Retinopathy

Purpose: To evaluate efficacy and safety of combined intravitreal triamcinolone acetonide (IVTA) injection plus panretinal photocoagulation (PRP) in comparison with PRP in proliferative diabetic retinopathy (PDR). Methods: 38 eyes of nineteen patients with PDR were enrolled. One eye of each patient was randomly selected to undergo IVTA injection one week prior to PRP session (IVTA eye), and contralateral eye treated with PRP alone (control eye). Patients were followed at 1, 4 and 6 months after treatment. Main outcome measures included change in logarithm of the minimum angle of resolution best-corrected visual acuity (logMAR BCVA), central macular thickness (CMT) and complications. Results: Mean baseline logMAR BCVA was 0.41±0.36 (IVTA eyes) and 0.36±0.30 (control eyes). At 6 months, Mean change of visual acuity to logMAR BCVA was - 0.054±0.114 (IVTA eyes) and 0.053±0.145 (control eyes) (p=0.02). Mean baseline CMT was 274.5±61.7 µm (IVTA eyes) and 246.7±74.7 µm (control eyes). Injected eyes showed significant reduction in mean CMT at all visits. However, there was no significant difference for CMT between IVTA and control eyes at all visits. Significant reduction of CMT in IVTA eyes was observed at 1 month from 319.2±79.1 to 260.5±78.5 (p=0.024). At 6 months, CMT reduction was still significant in IVTA eyes as compared with baseline values (p=0.048). In control eyes, CMT was not significantly reduced at 1 and 6 months of treatment. Conclusions: IVTA injection is a relatively safe method which might have prophylactic role against visual acuity exacerbation and macular edema secondary to PRP in PDR eyes.

Therapeutic Efficacy of Exercise and Laser Therapy in the Symptomatic Management of Osteoarthritis of the knee joint

Laser therapy is considered as one of the therapeutic modalities used in the management of osteoarthritis. However, its effectiveness is stillcontroversial and ambiguous. The main purpose of this study was to determine the therapeutic efficacy of Laser therapy in the management of knee osteoarthritis. Sixteen patients with chronic osteoarthritisof the knee were grouped into Low Level Laser Therapy ([LLLT], n=10) and control (n=6) groups. Both groups received standard care of exercise (mode: low intensity, time: 15 minutes) per session for 6 weeks. In addition to the exercise, the LLLT group received 18 LLLT (Laser class 3b, frequency of 5KHz, wave length of 810nm) treatments for 10 minutes. The control group received exercise therapy only. Pain (visual analogue scale [VAS]) and range of motion (ROM) for pain and stiffness respectively were assessed. Collected data was processed and analyzed using students't-test to determine if significant differences exist between theLLLTand control groups. Findings of the study revealed no significant effect of LLLT over exercise in VAS and ROM. The study affirms and concluded that exercise therapy should form the basis and bulk adjunct physical therapy in the management of osteoarthritis over Laser therapy.

Low-level laser therapy in management of postmastectomy lymphedema

The aim of this paper was to study the effects of low-level laser therapy (LLLT) in the treatment of postmastectomy lymphedema. Eleven women with unilateral postmastectomy lymphedema were enrolled in a double-blind controlled trial. Patients were randomly assigned to laser and sham groups and received laser or placebo irradiation (Ga-As laser device with a wavelength of 890 nm and fluence of 1.5 J/cm2) over the arm and axillary areas. Changes in patients' limb circumference, pain score, range of motion, heaviness of the affected limb, and desire to continue the treatment were measured before the treatment and at follow-up sessions (weeks 3, 9, 12, 18, and 22) and were compared to pretreatment values. Results showed that of the 11 enrolled patients, eight completed the treatment sessions. Reduction in limb circumference was detected in both groups, although it was more pronounced in the laser group up to the end of 22nd week. Desire to continue treatment at each session and baseline score in the laser group was greater than in the sham group in all sessions. Pain reduction in the laser group was more than in the sham group except for the weeks 3 and 9. No substantial differences were seen in other two parameters between the two treatment groups. In conclusion, despite our encouraging results, further studies of the effects of LLLT in management of postmastectomy lymphedema should be undertaken to determine the optimal physiological and physical parameters to obtain the most effective clinical response.