In this paper, a novel approach was proposed to achieve the joining of AlN and Cu by nanosecond laser pre-irradiation of AlN. The effects of the speed of laser scanning on the morphology, chemical compositions, and properties of the surface of AlN ceramic and the mechanism of laser-assisted joining of AlN and Cu were investigated. With the increase of the speed of laser scanning, the surface roughness of AlN decreased. After nanosecond laser irradiation, element Al was detected on the surface of AlN. When nanosecond laser irradiation was applied, the hydrophilicity and the surface energy of the ceramic surface were improved. The modified AlN was successfully joined to Cu at the temperature of 620 °C with a speed of laser scanning of 500 or 1000 mm/s. The results of TEM confirmed the presence of Al4Cu9, indicating the metallurgical combination of Cu and AlN. Also, the method presented in this paper was supposed to be of great reference significance for the joining of ceramics and metals.