In this perspective, laser interaction with materials and its applications in precision engineering are mainly introduced for the manufacturing, as well as maintenance, repair, and overhaul (MRO) of aeroengines. In precision engineering, the laser ablation tool has also been more applicable considering its great advantages in microprocessing and nanofabrication. It is interesting to explore the specific process and characteristics of laser ablation, which play an important role in advanced manufacturing. Due to the complicated production procedures of an aeroengine, it is important to explore the physics behind laser interaction with aerospace and aeronautical metallic materials in order to properly utilize the unique characteristics of lasers, such as high monochromaticity, high brightness, high directivity, and high coherence. Meanwhile, it is beneficial to study the dynamic process of interactions and its mechanisms in laser applications, such as laser cleaning, texturing, and shock peening. There exist both photo-chemical and photo-thermal processes when lasers and materials interact. Several typical cases are introduced, which have great potential and high impact applications in the manufacturing and MRO industry of aeroengines. Based on laser ablation in specific industries, the building-up of MRO support system for aeroengines could be provided by a dynamic mechanism between the pioneering research results and industrial demand, leading to the fast development of advanced high-end manufacturing equipment.