Adult Laryngeal Papillomatosis Research Articles

Epidemiological features of laryngeal papillomatosis in adults in Moscow

To evaluate the incidence of laryngeal papillomatosis (LP) and LP recurrence in adults and to determine the risk factors for the development of LP recurrence in adults in Moscow. To solve the tasks set, a survey of patients carried out, including the collection of complaints and anamnesis, a standard examination of the ENT organs, an assessment of the condition of the larynx, and a histological examination. We conducted a retrospective analysis of the case histories of 299 patients with LP observed and treated at the Sverzhevsky Research and Clinical Institute of Otorhinolaryngology in the period 2010-2020. On average, over the entire study period, the prevalence of PG was 17.80%. It was found that out of 299 patients, 69.6% (n=208) had a relapse of LP. Papilloma of the larynx were more often localized in the glottis. 275 (92%) patients had a widespread form of LP. LP recurrences were significantly more common in women and in patients with an existing cicatricle process in the larynx. The relapse rate was higher in non-smokers (73.5% vs 47.8%; p<0.001). Although the recurrence rate was higher in patients with non-voice occupations (70.6% vs. 52.9%), there was no statistically significant association between relapses and the vocal professions (p=0.125). As a result of the study, a number of risk factors for laryngeal papillomatosis recurrent have been identified, and their study should be continued.

Epidemiological features papillomatosis of the larynx in adults: a literature review

The literature review presents current data on the epidemiology, drug, and surgical treatment of laryngeal papillomatosis in adults. Possible prospects for further study of the prevalence and incidence of the disease and provoking factors of recurrence of the disease for the development of possible preventive measures are considered.

Laryngeal Papillomatosis in Adults: Assessment for Ten Years at the ENT Department of the National University Hospital of Fann (Dakar, Senegal).

Objectives The aim of this study was to describe the epidemiological, diagnostic, and therapeutic aspects of adult laryngeal papillomatosis in Senegal. Patients and Methods. This is a retrospective descriptive study of patients aged above 18 years with laryngeal papillomatosis and followed at the ENT department of the NUH of Fann between 01 January 2009 and 31 December 2018. Results The mean age at diagnosis was 37.74 years and a sex ratio of 0.93. The 20–29 age group was the most represented (45.2%). The average consultation delay was 8.34 years. All patients had dysphonia at the moment of the diagnostic and in 35.5% of cases, and it was associated with laryngeal dyspnea. Glottis localization was present in all our patients, i.e., 100% of the cases. A tracheotomy was performed in 9.67% of cases. All of our patients have had their papilloma peeled per endoscopic with tweezers. No cases of malignant degeneration were found in our study. Conclusion Laryngeal papillomatosis is the most common benign tumor of the larynx in both children and adults. Despite the progress of endoscopy and antiviral treatments, its treatment poses many problems in our undermedicalized countries.

Surgery for adult laryngeal papillomatosis

Recurrent laryngeal papillomatosis is a viral (human papillomavirus) disease that causes the growth of epithelial verrucous lesions. Patients with laryngeal papillomatosis undergo multiple surgeries due to the tendency of the lesions to reoccur and cause recurrent voice and breathing problems. The goal of the surgical treatment is to remove the lesions while protecting the delicate layered structure of the vocal folds in order to prevent scarring and permanent damage to the mucosa. This is a review of the currently performed operative procedures for treating recurrent adult laryngeal papillomatosis. They involve the use of cold instruments, lasers, and microdebriders. There is a trend towards preferential use of microdebriders and office-based laser procedures in compliant patients. There is no consensus on any surgical method of choice, and further investigations and long-term results of the ones in current use are warranted to provide more clear-cut guidelines for optimal management.

EPIDEMIOLOGICAL DATA ON LARYNGEAL PAPILLOMATOSIS IN THE MOSCOW REGION

Im - to evaluate the prevalence of laryngeal papillomatosis in adults and children, to analyze the structure of the disease and to generalize the dynamics of the disease in the Moscow region. Materials and methods. The authors have carried out an epidemiological analysis of laryngeal papillomatosis in the Moscow region in the period from 2008 to 2014. Results. According to the received data, the prevalence of laryngeal papillomatosis in the Moscow region is 2.3 per 100000 children and 1.95 per 100000 adults. Discussion. Based on the epidemiological data, the significance of laryngeal papillomatosis in adults and children has been proved, and increased morbidity has been revealed. Laryngeal papillomatosis is one of the most important social and health problems. Taking into account the significant increase in the incidence of laryngeal papillomatosis in adults and children, it is necessary to focus on the organization of preventive measures aimed not only at preventing relapses, but also against the spread of HPV infection among healthy population in the Moscow region. To conclude, it is necessary to carry out annual analysis of the structure and course of the disease in the Moscow region.

Anatomic Derkay Score Is Associated with Voice Handicap in Laryngeal Papillomatosis in Adults.

The Derkay staging system quantifies recurrent respiratory papillomatosis (RRP) severity based on involvement of laryngeal structures. Despite its broad use in the laryngology literature, the association between Derkay score and voice-related quality of life has not previously been studied. It is hypothesized that Derkay score positively correlates with the Voice Handicap Index-10 (VHI-10). Case series with chart review. Tertiary medical center. Forty-six adult RRP patients treated from 2007 to 2013 at a tertiary medical center were included. Anatomic Derkay scores at the time of each RRP procedure were calculated. VHI-10 scores obtained within 30 days preceding the procedures were used to assess for correlation between Derkay staging system and VHI-10. Ninety-three procedures performed on 46 patients met inclusion criteria. Mean Derkay score was 11.9 (range, 2-28), and mean VHI-10 was 18.0 (range, 0-40). There was a significant positive correlation between Derkay score and VHI-10 (Spearman coefficient r = 0.42, P < .0001). The anatomic burden of RRP as assessed by Derkay staging system is positively correlated with voice-related quality of life as quantified by the VHI-10.

Роль циклооксигеназы-2 в развитии папилломатоза гортани у взрослых

Роль циклооксигеназы-2 в развитии папилломатоза гортани у взрослых

HPV infection in ENT - certainties and assumptions

Case report We present the possibilities of diagnosis of HPV infection in ENT, and the therapeutic, prophylactic and curative modalities, as well as the assumptions and prevention goals through vaccination within this specialty. We communicate the management of three clinical cases of laryngeal papillomatosis in adults. The first case, a 75-year-old woman, 4 times under surgical intervention with “cold surgery”, vaccinated with Silgard. The second case, a 55-year-old woman, also 4 times under surgical intervention receives Gardasil after the last intervention. The third case, a 35-year-old man, 2 times surgically operated after diagnosed with papiloma scuamosis and vaccined with Silgard. All the above mentioned cases don’t present any regression of the disease during the last three years.

Natural History of Adult-Onset Laryngeal Papillomatosis following Multiple Cidofovir Injections

A prospective study was performed to assess the intermediate and long-term efficacy of intralesional cidofovir therapy associated with surgical excision in laryngeal papillomatosis in adults. Endoscopy with intralesional injection of cidofovir 5 mg/mL was performed 3 times at 4-week intervals. The concentration was later increased to 7.5 mg/mL and the interval between injections shortened to 2 weeks. Further treatment was performed at 3 or 6 months, depending on the evolution of the papillomas. After complete remission, the treatment was stopped and the patients were reviewed every 6 months. Nineteen patients completed the protocol, with a mean of 4.5 injections each. Complete remission was obtained in 17 cases (89%) after a mean of 3.8 procedures. Remission was stable after a mean follow-up of 24 months (range, 8 to 57 months). With higher cidofovir concentrations at shorter intervals, patients needed fewer injections to achieve remission (mean, 2.1 versus 4.7 injections). The effectiveness of intralesional cidofovir therapy in adult-onset recurrent respiratory papillomatosis was impressive. Once obtained, complete remission was stable on intermediate or long-term follow-up. The concentration and the interval between injections seemed to influence the number of injections necessary to achieve remission.

P53 protein expression in benign lesions of the upper respiratory tract.

p53 is a tumor suppressor gene that is lost or mutated in most forms of human malignancy. There are, however, very few studies evaluating p53 expression in normal epithelium or benign lesions. We screened for p53 protein expression in a variety of benign epithelial lesions of upper respiratory tract using monoclonal antibody DO-1 on paraffin-embedded material. We studied a total of 109 cases: 16 cases of juvenile and 36 cases of adult laryngeal papillomatosis, 10 cases each of laryngeal nodules and laryngeal polyps, 17 cases of inverted papilloma, and 20 cases of nasal polyps. Nuclear immunoreactivity for p53 protein was demonstrated in 14 (88%) of 16 cases of juvenile laryngeal papillomatosis, 33 (92%) of 36 cases of adult laryngeal papillomatosis, 4 (40%) of 10 cases of laryngeal nodules, 8 (80%) of 10 cases of laryngeal polyps, 7 (41%) of 17 cases of inverted papilloma, and 2 (10%) of 20 cases of nasal polyps. These results pertained only to the basal epithelial layer in all cases of laryngeal nodules, laryngeal polyps, and nasal polyps. Intermediate layer cells were also positive for p53 in the majority of the cases of both juvenile (69%) and adult (75%) laryngeal papillomatosis and in a minority of the cases of inverted papilloma (18%). Overexpression of p53 protein is commonly demonstrable in benign epithelial lesions of the upper respiratory tract. This observation suggests that p53 protein accumulation may occur in the absence of mutation of the p53 gene and may correlate with epithelial proliferative activity.

成人喉頭乳頭腫に対するCO&lt;SUB&gt;2&lt;/SUB&gt;レーザーとインターフェロン併用療法治療経験

成人喉頭乳頭腫に対するCO&lt;SUB&gt;2&lt;/SUB&gt;レーザーとインターフェロン併用療法治療経験