Abstract The pressure loss due to the hydraulic transport of large solid particles should be predicted for the design of subsea mining systems. The mixture flow in a flexible jumper is expected to be unsteady during lifting operations in an actual mining system. The authors develop a one-dimensional mathematical model that predicts such pressure loss under pulsating mixture flows in a static inclined pipe assuming that the flow in the jumper is fully developed. An experiment is performed on the hydraulic transport of solid particles to obtain data for model validation. In this experiment, several kinds of solid particles are used: alumina beads, glass beads, and gravel. The experimental parameters are mixture velocity, solid concentration, pulsation period and amplitude of water velocity, and pipe inclination angle. The proposed model is validated through a comparison with experimental data. The validation confirms that the model is applicable for the prediction of the pressure loss in inclined pipes under pulsating flow conditions. Furthermore, we calculate the pressure loss due to the hydraulic transport of polymetallic sulfide ores using the proposed model. The calculation results show that the time-averaged pressure loss drastically varies with the pipe inclination angle, reaching its maximum value between the pipe inclination angles of 30 deg and 60 deg, at which the flow is inclined upward. The results also show that the amplitude of pressure loss pulsation differs little between pipe inclination angles and that the pulsation component of pressure loss should be considered in designing lifting systems.