Large Particles Research Articles

Preparation of cementing material and recovery of iron resources using converter slag

This study aims to optimize the modification of blast furnace slag and converter slag using dust removal ash as a reducing agent, with the dual goals of enriching cementitious materials and recovering iron resources. The results show that the pulverization effect of the modified slag is optimized when the dust removal ash addition ratio is 14 wt%, the reduction temperature is 1450 °C, and the reduction time is 30 min. Under these conditions, the pulverization and iron recovery rates reached 65.23 % and 60.85 %, respectively. The composition of the reduction-modified product is influenced by the particle size of the reduction product, which in turn affects its phase composition. The main phases of small particles (particle size < 0.150 mm) identified were magnesium rose pyroxene (Ca3Mg(SiO4)2, C3MS2) and dicalcium silicate (γ-Ca2SiO4, γ-C2S). The main phases of large particles (particle size > 0.150 mm) identified were dicalcium silicate (β-Ca2SiO4, β-C2S) and Ca2Fe2O5. Iron primarily exists in the form of an alloy and cementite, while P is dispersed in the iron beads in the form of Fe3P, Fe2P, and Mn2P in a striped configuration.

Pt/Nb2O5-Al2O3 Catalysts for the Hydrogenation and Reductive Amination of Furfural

Furfural is a well-recognized biomass platform. Hydrogenation and reductive amination of furfural are two principal routes in the valorization of this compound. In both reactions, the presence of reducible species (SMSI effect) and acid sites could favor the selectivity toward some interesting products. Both conditions could be obtained using metal particles supported on reducible mixed oxides. In this work, we investigate the use of Pt/Nb2O5-Al2O3 catalysts for the hydrogenation and reductive amination of furfural at distinct Nb2O5 contents. A decaniobate salt was used as a precursor of Nb2O5. The solids were reduced at 500 °C to assure the migration of reducible NbOx species. The solids were characterized by XRD, Raman spectroscopy, HR-TEM, N2-physisorption, NH3-TPD and Pyr-DRIFTS. The results showed that higher Nb2O5 loadings led to a lower distribution of Al2O3 and Pt, favoring the catalysts’ acidity. This fact implies that large particle size and the presence of Nb2O5 islands favor the formation of furfuryl alcohol but have a detrimental effect on the amine formation in the reductive amination of furfural.

The secret is quartz: technology of production of an eleventh-twelfth century western Mediterranean polychrome glazed ware

A group of a well-known polychrome glazed ceramic, widespread in the western Mediterranean in the eleventh and first half of the twelfth centuries, has been analysed for the first time using Optical Microscopy (OM) and a Field Emission Scanning Electron Microscopy (FE-SEM) with Energy-Dispersive X-ray Spectroscopy (EDS), in order to shed some light on the materials, production technology and provenance, about which there are various hypotheses. This ware is characterised by a perfectly drawn and varied iconography, with often stylised zoomorphic and anthropomorphic and nautical motifs. It was produced in an as yet unidentified workshop in North Africa or the Iberian Peninsula. The pottery analysed was found in an archaeological excavation in the Barrio Andalusi of Almería (south-east of Spain). Technologically, the ceramics are fairly homogeneous, with copper-green and manganese-brown pigments applied over the raw tin glaze filled with large undissolved quartz particles. The use of quartz is consistent with a Fatimid-Zirid contribution from Ifriqiya, the use of tin is consistent with an Andalusi Umayyad-Taifas contribution, and the green and brown colours on a white ground to either Ifriqiya or Andalusi. Our study has shown that the use of quartz on the decorated glazed surface is not related to the need for an opacifier, but rather to the need for a highly viscous melt that limits the spread of the pigments during the firing allowing a finer and more detailed drawing. This fusion of different techniques has been identified for the first time. It is intriguing from the historical point of view of medieval technology, and provides the first insights into understanding the technological transfers and technical solutions that took place in the Mediterranean basin during this period.

Enhancing drilling efficiency: An experimental study on additives for mud loss mitigation in fractured media

Drilling in fractured formations poses a substantial challenge due to mud loss, which not only impedes operations but also leads to substantial costs and delays. Effectively controlling mud loss is crucial for efficient drilling. However, determining the appropriate mud additive to minimize mud loss in fractured formations requires further investigation. This is because proper mud additives can assist in sealing fractures, preventing wellbore instability issues and minimizing formation fluid influx. This study aims to investigate mud loss in fractured porous media by evaluating three additives' performance using an experimental setup that provides different fracture apertures. This setup provides an accurate simulation of down-hole static filtration at high pressure/temperature by flowing pressurized mud through fractured porous media and measuring effluent under different scenarios. The particular focus is on preformed particle gel (PPG), walnut shell, and shell additives. The study examines the effects of these additives, their particle sizes, and their mixture effect on mud loss. An optimal concentration of 8000 ppm of PPG, as well as larger particle sizes (mesh No.200) of walnut shell and shell, are found to be more effective in controlling mud loss, reducing mud loss by 34.4%, 110%, and 20.85%, respectively, compared to the base mud. The results reveal that when mud contains only one additive, the walnut shell is the most effective, reducing the volume of mud loss from 394.2 cc to 150.2 cc, while a mixture of PPG-shell-base mud at elevated temperatures represents the highest performance of additive combinations. The PPG-shell-base mud significantly reduces mud loss from 394.2 cc to 115 cc and 27.8 cc at 50 °C and 80 °C. In conclusion, this research not only contributes valuable insights to the field but also offers practical recommendations for the use of additives to effectively control mud loss during drilling operations in fractured formations, ultimately improving drilling efficiency and cost-effectiveness.

Modeling the settling and resuspension of microplastics in rivers: Effect of particle properties and flow conditions

Microplastics have numerous different shapes, affecting the fate and transport of these particles in the environment. However, theoretical models generally assume microplastics to be spherical. This study aims to develop a modeling approach that incorporates the shapes of microplastics to investigate the vertical transport of microplastics in rivers and simulate the effect of particle and flow characteristics on settling and resuspension. To achieve these aims, a mechanistic model was developed utilizing the mass-balance and hydrodynamic equations. Scenario analysis was implemented assigning different values to model parameters, such as bed shear stress, shape factor and particle size to simulate the effect of flow patterns and particle properties. The model outcomes revealed that the residence time of microplastics in the water column was longest in medium bed shear stress, whilst it was shortest in low bed shear stress. This suggests that the influence of turbulence is not unidirectional; it can both increase and decrease microplastic concentrations and residence time in the water column. According to the scenario analysis, the settling flux of microplastics was the highest for near-spherical particles and increased with the size of the particles, as well as with increasing bed shear stress. However, the resuspension of particles was primarily influenced by increasing bed shear stress, but the ranking of resuspension flux values for different shaped and sized microplastics exhibited alterations with changing flow patterns. Turbulent conditions predominantly influenced the resuspension of near-spheres and large microplastics. On the contrary, the settling of fibers and small microplastics were significantly influenced by changing flow patterns, whereas near-spheres and largest particles were least affected. The model results were sensitive to changes in shape factor developed for this model, therefore this parameter should be improved in future studies.

Control mechanism of short-term fertilization with cattle manure on the release characteristics of soil colloids in farmland: grain size and physicochemical properties

BackgroundUnderstanding the release characteristics of soil colloids is a prerequisite for studying the co-transport of colloids and pollutants in subsurface environment. As a crucial agricultural management measure, fertilization not only alters the material composition of farmland soil, but also significantly regulates the properties and release patterns of soil colloids. This study systematically investigated the regulatory mechanism of short-term cattle manure fertilization on the macroscopic release and microscopic properties of soil colloids with different particle sizes, providing a theoretical foundation for subsequent research on the fate and transport of agricultural non-point source pollutants.ResultsThe colloids in natural agricultural soil primarily consist of inorganic components. Graded extraction of the colloids has revealed that the combined proportion of colloids with particle sizes of 1–2 μm and 0.45–1 μm accounts for approximately 80.5%. Applying cattle manure inhibits the release of soil colloids, and the content of large particle size (1–2 μm) components increases. The content of organic colloids is increased due to the high total organic carbon (TOC) in cattle manure, particularly those with a particle size less than 1 μm. The characterization of organic colloid components revealed a significant increase in aromatic carbon and oxygen-containing functional groups, while the aliphatic content decreased. The response sequence regarding changes in functional groups within organic colloids induced by fertilization was as follows: –CH3, –CH2 > C–O > –OH > C=C. Fertilization promotes the release of 1:1-type inorganic mineral colloids, increasing the content of poorly crystalline minerals. The retention of aromatic carbon and oxygen-containing functional groups by poorly crystalline mineral colloids served as the primary mechanism leading to their increased content levels. Changes in environmental factors significantly impacted the release and properties of soil colloids. Conditions such as low cationic valence, high ionic strength, and high pH promoted the release of soil colloids.ConclusionsThe short-term fertilization resulted in a reduction in the release of soil colloids and brought about significant alterations in their particle size composition and properties. The findings of this study provide valuable insights into understanding the impact of fertilization-induced colloid release on the environmental behavior of agricultural non-point source pollutants.

Effects of neat and silver coated fly ash cenospheres on the properties of styrene-butadiene-styrene block copolymer composites obtained by a solution mixing method

Utilization of industrial by-products to develop novel value-added materials while mitigating their environmental impact is a crucial issue. Fly ash (FA) microparticles are a common component of power plant waste. This work aims to investigate the impact of varying concentrations of neat/silver-coated FA on the morphology and thermal properties of styrene-butadiene-styrene/FA composites. Composite materials based on styrene-butadiene styrene triblock copolymer (SBS) with various volume fractions of as-received and silver-coated FA were prepared using a solution mixing method. Silver-coated cenosphere particles were prepared using an electroless plating method. Scanning electron microscopy and optical microscopy showed that the solution mixing method obtains composite materials characterized by uniform dispersion of filler without large particle aggregates and predominantly unbroken cenospheres. The tensile strength of the composite with 10% of both as-received and silver-coated fly ash remains at the level of the unfilled SBS sample. However, at higher filler concentrations (20% and 30%), a decrease in strength by 27% and 42% respectively is observed, possibly due to the agglomeration of FA, which leads to a poorer interface and dispersion at higher filler weights. Additionally, thermal analysis in an oxygen atmosphere showed that the introduction of both as-received and metallized cenospheres in the same quantity increased the thermal stability of the tested composition. The temperatures at 5% mass loss of SBS/FA composites were on average 70°C higher than those of the original SBS.

Numerical simulation of dust deposition characteristics of photovoltaic arrays taking into account the effect of the row spacing of photovoltaic modules

Dust deposition on the surfaces of Photovoltaic (PV) arrays during their operation markedly affects their power generation efficiency. Previous research has overlooked the impact of the row spacing of PV modules on the actual dust deposition on PV arrays. This study investigates the dust deposition process and its behavior on PV arrays considering variations in row spacings, inlet wind speeds, dust particle sizes, and dust particle counts. By employing commercial Computational Fluid Dynamics (CFD) software, incorporating the SST k-ω turbulence model and discrete particle model, numerical simulations were performed to analyze the airflow field, dust particle trajectories, dust deposition patterns, and deposition rates on the PV array through grid-independent verification and numerical validation. At the same time, we performed a comparative analysis of the deposition rate considering the rebound of dust particles on the PV module surface versus the case where rebound is not considered. Results revealed that the maximum dust deposition rates at different inlet wind speeds were 6.84 %, 8.84 %, 11.0 %, and 14.6 %, corresponding to dust sizes of 50 μm, 100 μm, 120 μm, and 300 μm, respectively. Smaller dust particles exhibited lower deposition rates, while larger particles were influenced more by mass inertia and gravity, leading to predominant deposition on the front row of PV modules. Larger dust particles are more likely to deposit primarily on the front row of PV modules in a PV array. The tilt angles of 30°, 45°, and 60° were chosen to study the effects of different tilt angles on the dust deposition of PV arrays, and the results show that the dust deposition rate decreases as the tilt angle increases, and it is worth noting that the larger the tilt angle, the larger the dust deposition rate is when the dust particles are especially small as 5 μm. When wind speeds are low and dust particles are small, the dust deposition rate gradually rises as the row spacing increases. However, at higher wind speeds with small dust particles, the row spacing has minimal impact on the dust deposition rate. Conversely, with larger dust particles, increasing the row spacing results in a lower dust deposition rate. These findings underscore the significance of optimizing PV array design for enhanced power generation efficiency.

Synergistic effects of aggregate-void distribution on low-temperature fracture performance and crack propagation of asphalt concrete under mode I and mode II fracturing

Mesoscopic structures of asphalt concrete play an important role in low-temperature cracking behavior. Existing studies mainly focus on a single feature of the mesoscopic structure, neglecting the spatial distribution and synergistic effects of aggregates and voids, especially in Mode II fracturing. The results show that: in the case of −5 °C and Mode I fracturing, the fracture trend is less affected by the spatial distribution of mesoscopic structure, and tending to spread through aggregate and asphalt mastic along the shortest path. In the case of −5 °C and Mode II fracturing, the crack is easily affected by the distribution of large particle size aggregates in the initial zone, but not by the uneven distribution of voids. In the case of 10 °C and Mode I fracturing, the dominant large aggregate particle size influence on the path is weakened, and the effect of void distribution on the cracking path is perceptibly increased. In the case of 10 °C and Mode II fracturing, the location of large-particle aggregate determines the main streak of fractures, and the uneven distribution of void space determines the occurrence of fracture bending.

Examining the Correlation between the Inorganic Nano-Fertilizer Physical Properties and Their Impact on Crop Performance and Nutrient Uptake Efficiency.

The physical properties of nano-fertilizers (NFs) are important in determining their performance, efficacy, and environmental interactions. Nano-fertilizers, due to their small size and high surface area-to-volume ratio, enhance plant metabolic reactions, resulting in higher crop yields. The properties of nano-fertilizers depend on the synthesis methods used. The nanoparticle's nutrient use efficiency (NUE) varies among plant species. This review aims to analyze the relationship between the physical properties of NF and their influence on crop performance and nutrient uptake efficiency. The review focuses on the physical properties of NFs, specifically their size, shape, crystallinity, and agglomeration. This review found that smaller particle-sized nanoparticles exhibit higher nutrient use efficiency than larger particles. Nano-fertilizer-coated additives gradually release nutrients, reducing the need for frequent application and addressing limitations associated with chemical fertilizer utilization. The shapes of nano-fertilizers have varying effects on the overall performance of plants. The crystalline structure of nanoparticles promotes a slow release of nutrients. Amorphous nano-fertilizers improve the NUE and, ultimately, crop yield. Agglomeration results in nanoparticles losing their nanoscale size, accumulating on the outer surface, and becoming unavailable to plants. Understanding the physical properties of nano-fertilizers is crucial for optimizing their performance in agricultural applications.

A supramolecular method to control protein assembly using a biogenic polyamine

ABSTRACT We report a method to modulate the formation and stability of nano- and micro-assemblies of bovine serum albumin (BSA) formed with CB[7] using the treatment of a biogenic polyamine such as spermine (SPM). Our findings show that SPM impacts the size and surface charge of BSA-CB[7] assemblies, effectively reducing the size of nanoscale particles and making their surface charges more positive. Conversely, for larger particles spanning more than a few micrometres in diameter, SPM treatment is less effective in reducing their size. This ineffectiveness is attributed to the interaction between the external surface of CB[7] and BSA, which remains relatively unaffected by SPM. Over time, with an excess of CB[7], this interaction becomes more pronounced, resulting in aggregation of large particles and subsequent sedimentation. Since SPM is a biogenic polyamine found at elevated levels in cancerous tissues, this result may offer a strategic direction for designing supramolecular systems to control protein assemblies in oncological environments, highlighting the significant potential of supramolecular chemistry in biomedical applications.

Aloe vera Cuticle: A Promising Organic Water-Retaining Agent for Agricultural Use

Water is an important resource for both human and environmental survival. However, due to current human practices, we are facing a serious crisis in accessing water. Thus, solutions must be explored to optimize the use of this resource. In the search for an organic water-retaining agent for agricultural use, the techno-functional properties of Aloe vera (Aloe barbadensis Miller) cuticle, an agro-industrial residue generated after gel extraction, were evaluated. The residue was dried and ground. The effects of particle size (180 µm and 250 µm), temperature (10 °C, 20 °C, 30 °C, and 40 °C), and pH (4.5, 6.0, and 7.0) on the solubility and water-holding capacity (WHC) of the obtained product (i.e., hydrogel) were then evaluated. The treatment with the highest WHC was selected and compared with the WHC of a commercial synthetic polyacrylamide gel widely used in agriculture. The effects of KNO3 and Ca(NO3)2 at different concentrations (10 g L−1, 20 g L−1, 30 g L−1, and 40 g L−1) on the WHC of the gels were assessed. Particle size, temperature, and pH interactions had statistically significant effects on solubility, while the WHC was affected by particle size × temperature and pH × temperature interactions. The highest product solubility (75%) was obtained at the smallest particle size (i.e., 180 µm), pH 4.5, and 20 °C. Meanwhile, the highest WHC (18 g g−1) was obtained at the largest particle size (i.e., 250 µm), pH 6.0, and 20 °C. This optimized gel kept its WHC across both salts and their concentrations. In contrast, the commercial gel significantly decreased its WHC with salt concentration. The product elaborated with A. vera cuticle could have bioeconomic potential as a water-retention agent for agricultural use, with the advantage that it is not affected by the addition of salts used for plant fertilization.

HPC software for modelling field electron emission

The aim of this work is modeling processes of field electron emission in strong electromagnetic fields. This problem is relevant for many technical and medical applications. At present time, electrical devices that combine a large value of field, a powerful relativistic effect and an ultra-short time interval of action are in demand. They find their application in the treatment of the surfaces with inorganic, organic and mixed structures. Modeling of such devices encounters certain difficulties due to the complexity of the mathematical description of the emission processes. In this paper, an approach using the method of large smoothed particles in combination with grid calculation of fields based on Maxwell's equations is proposed. The study was carried out within the framework of the problem of calculating the field emission of electrons from the surface of axisymmetric metal cathodes on Cartesian and unstructured curved meshes. To implement the approach, a complex mathematical model, a parallel numerical algorithm and its software realization have been developed. The elaborated software is focused on the use of multiprocessor computing systems with a central architecture. Test calculations confirmed the correctness of the proposed approach and the high efficiency of its software implementation.

Na+ orientates Jahn-Teller effect to tune Li+ diffusion pathway and kinetics for Single-Crystal Ni-rich LiNixCoyMn1-x-yO2 cathode materials

Single-crystallization is an effective strategy for enhancing both capacity and stability of Ni-rich LiNi1-x-yCoxMnyO2 (NCM) cathode materials, especially at high cut-off voltages. However, the kinetics limitation of solid-phase Li+ diffusion is a major concern because of the long diffusion path in large single-crystal particles. To address this issue, we synthesize a Na-doped single-crystal LiNi0.82Co0.125Mn0.055O2 (NCM-Na) cathode material by a facile mixed-molten-salt sintering process. Na+ is revealed to be uniformly doped at the Li+ lattice sites within the entire single-crystal particles. This Na+ doping effectively enhances the dynamics of Li+ transport in the layered oxide phases. The NCM-Na material with 2 at.% Na doping shows a Li+ diffusion coefficient up to more than 8 times higher than pristine NCM. In-situ X-ray diffraction and finite element analysis demonstrate significantly facilitated H1-H2-H3 phase transition in NCM-Na materials, compared with the severe phase separation phenomenon in NCM counterpart, hoisting their rate capacity and structure stability. Thus, the NCM-Na material achieves a superior reversible capacity of 177.7 mAh/g at 5C, and a capacity retention of 94.4 % after 100 cycles at 0.5C at a high cut-off voltage of 4.5 V. By density function theory calculations, we reveal that Na+ doping can selectively stabilize the surrounding Li+ at the second farthest hexagonal vertexes by tuning the orientation of the Jahn-Teller effect of Ni3+. These Li+ ions frame a high-speed pathway for preferential Li+ diffusion, which promotes the Li+ diffusion kinetics even in highly delithiated states. Our findings provide insights into the Na+ doping mechanism and present a low-cost, highly efficient, and scalable method to enhance the performance of single-crystal Ni-rich NCM materials.

Coated and un-coated urea incorporated with organic fertilizer improves rice nitrogen uptake and mitigates gaseous active nitrogen loss and microplastic pollution

Coated urea can improve nitrogen use efficiency (NUE) for crops, while it is also identified as a potential source of microplastics (MPs). Organic fertilizer (OF) shows potential to promote MPs degradation. However, little is known about the influence of OF incorporated with coated urea on MPs accumulation, NUE, and gaseous N loss (NH3 and N2O) in paddies. Therefore, a field experiment was conducted to address this gap, with five fertilization treatments, viz., urea (un-coated) with full rates (U), coated urea with full rates (CU), coated urea with reduced rates (RCU), 70 % coated urea blending 30 % urea with reduced rates (RBU), and RBU blending OF (ORBU). The results showed that, compared with U, the CU increased the number of MPs by 62.2–117.4 %. The ORBU significantly reduced the weight of MPs by 53.2 % through decreasing large-particle size. Additionally, the ORBU enhanced the effect of CU on increasing grain yield and NUE, mainly due to the improvement in the yield components and N uptake. The distribution of NH4+ in water and soil was a major factor driving NH3 and N2O emissions. The ORBU elevated activities of N-assimilation enzymes, decreased water NH4+ and NH3 emissions, and increased soil NH4+ and ammonium-oxidation bacteria and (nirK+nirS)/nosZ, ultimately increased soil N2O emissions compared with RBU. However, the reduction in NH3 much outweighed the increase in N2O emissions. In conclusion, this study highlighted coated urea as a source of MPs pollution, emphasized OF amendment as a strategy to diminish MPs accumulation, and found that OF incorporated with coated urea could increase grain yield and N uptake of rice while mitigating gaseous N loss in paddies.

Study of adhesive wear mechanisms in asperity junctions based on phase field fracture method

Adhesive wear that is mostly induced by adhesion between asperities of rough surfaces in contact is one of the most common forms of wear of materials. However, the adhesive wear mechanisms are still not fully understood. In this work, the phase field fracture method that does not require any assumption on the crack path is used to explore the debris formation mechanism during asperity separation in adhesive wear. It is found that for ideal materials without defects the size of wear particles depends on the contact length. A small contact length leads to fracture at the junction and the formation of small wear particles. On the contrary, a large contact length will cause fracture in the bulk, resulting in large wear particles. Moreover, the angle of crack propagation decreases with increasing base angle of asperity and the ratio of the asperity height to the base edge width. The variation of fracture angle is mainly related to the ratio of asperity height to the base edge width that will influence the angle of the interaction force between asperities in the wear process. For materials with initial hole defect, the formation mechanism of wear particles will be little affected when the hole is rather small or far away from the junction. However, as the hole diameter further increases, the wear particles will change from large particles to small ones. And for materials with initial crack defect, the crack propagation always starts from the initial crack during adhesive wear. Moreover, for adhesive wear of materials with an initial crack at the bottom of asperity, fracture angle in the bulk is significantly positively correlated with the contact length and large wear particles are easy to form. However, during adhesive wear of asperity with the initial crack inside the bulk of asperity, small particles are more likely to form. This work contributes to further understanding of adhesive wear process.

Numerical study of perturbed shock driven instability in a dilute gas-particle mixture

The effects of particles on the Richtmyer–Meshkov (RM) instability of a flat interface driven by perturbed and reflected shock waves are numerically investigated. By utilizing three different sizes of particles (d=5μm, 20μm and 50μm) and two types of heavy gases (SF6 and CO2), the effect of the presence of particles with different sizes on the RM instability and the dynamic process of particle diffusion have been explored, respectively. The evolution of interface morphology under smaller particle (d=5μm and 20μm) conditions bears a striking resemblance to that of the condition without particles while the large particles (d=50μm) contribute to the formation of many “wrinkles” on the interface due to the large particle size and particle inertia. The addition of particles with smaller size (d=5μm and 20μm) can either slightly inhibit or promote the growth of the mixing width at the late stage of the interface evolution, depending on the extent of interface evolution. Both the particle size and the type of heavy fluid are able to influence the particle motion.

Role of Food Texture, Oral Processing Responses, Bolus Properties, and Digestive Conditions on the Nutrient Bioaccessibility of Al Dente and Soft-Cooked Red Lentil Pasta.

The purpose of this study was to assess the impact of food texture, oral processing, bolus characteristics, and in vitro digestive conditions on the starch and protein digestibility of al dente and soft-cooked commercial red lentil pasta. For that, samples were cooked as suggested by the provider and their texture properties were promptly analysed. Then, normal and deficient masticated pasta boluses were produced by four healthy subjects, characterised in terms of their oral processing, bolus granulometry, texture and viscoelastic properties, and finally subjected to static in vitro digestion, according to the INFOGEST consensus for both adults and the older adult population. Normal masticated boluses exhibited greater saliva impregnation and lower proportions of large particles, hardness, and stiffness than deficient masticated boluses. Likewise, insufficiently masticated al dente-cooked pasta boluses caused a delay in oral starch digestion owing to the larger particles attained during food oral processing, while reduced intestinal conditions in the elderly only interfere with the release of total soluble proteins in all samples. This work evidences the importance of considering the initial texture of products, oral capabilities, processing behaviour, and physical and mechanical properties of food boluses in digestion studies, opening new prospects in designing pulse-based foods that meet the nutritional requirements of the world's population.

Digital Twin for Continuous Production of Virus-like Particles toward Autonomous Operation.

Lentiviral vector and virus-like particle (VLP) manufacturing have been published in fed-batch upstream and batch downstream modes before. Batch downstream and continuous upstream in perfusion mode were reported as well. This study exemplifies development and validation steps for a digital twin combining a physical-chemical-based mechanistic model for all unit operations with a process analytical technology strategy in order to show the efforts and benefits of autonomous operation approaches for manufacturing scale. As the general models are available from various other biologic manufacturing studies, the main step is model calibration for the human embryo kidney cell-based VLPs with experimental quantitative validation within the Quality-by-Design (QbD) approach, including risk assessment to define design and control space. For continuous operation in perfusion mode, the main challenge is the efficient separation of large particle manifolds for VLPs and cells, including cell debris, which is of similar size. Here, innovative tangential flow filtration operations are needed to avoid fast blocking with low mechanical stress pumps. A twofold increase of productivity was achieved using simulation case studies. This increase is similar to improvements previously described for other entities like plasmid DNAs, monoclonal antibodies (mAbs), and single-chain fragments of variability (scFv) fragments. The advantages of applying a digital twin for an advanced process control strategy have proven additional productivity gains of 20% at 99.9% reliability.

Study of ignition and combustion of aluminum/ethanol nanofluid based on reactive molecular dynamics simulation

Aluminum/ethanol nanofluid fuel offers high energy density, high combustion efficiency, and low pollutant emissions, making it highly promising for aerospace applications. In recent years, the fundamental combustion characteristics for aluminum/ethanol nanofluid fuel have been extensively studied. However, current experimental techniques are still difficult to reveal the micro-mechanisms ignition and combustion of aluminum/ethanol nanofluid fuel. Hence, the ignition and combustion mechanisms of aluminum/ethanol nanofluid fuel were investigated from a microscopic point of view through reactive molecular dynamics simulation. The simulation results show that the mechanisms of enhanced ethanol combustion by aluminum nanoparticles mainly consists of micro-explosion at high temperature and small particle size, chain reaction at low temperature and large particle size, melt-dispersion in the mild oxidation state and diffusive oxidation in the moderate and heavy oxidation states. In addition, the initial stage of the combustion of aluminum nanoparticles with core-shell structure in ethanol is mainly a non-homogeneous surface reaction. This work reveals the combustion characteristics and mechanisms of aluminum/ethanol nanofluid fuel from an atomic perspective, which is expected to provide insights for the exploration and application of ethanol-based nanofluid fuel in the future.