Large Family Research Articles

GBF1 deficiency causes cataracts in human and mouse.

Any opacification of the lens can be defined as cataracts, and lens epithelium cells play a crucial role in guaranteeing lens transparency by maintaining its homeostasis. Although several causative genes of congenital cataracts have been reported, the mechanisms underlying lens opacity remain unclear. In this study, a large family with congenital cataracts was collected and genetic analysis revealed a pathological mutation (c.3857C > T, p.T1287I) in the GBF1 gene; all affected individuals in the family carried this heterozygous mutation, while unaffected family members did not. Functional studies in human lens epithelium cell line revealed that this mutation led to a reduction in GBF1 protein levels. Knockdown of endogenous GBF1 activated XBP1s in the unfolded protein response signal pathway, and enhances autophagy in an mTOR-independent manner. Heterozygous Gbf1 knockout mice also displayed typic cataract phenotype. Together, our study identified GBF1 as a novel causative gene for congenital cataracts. Additionally, we found that GBF1 deficiency activates the unfolded protein response and leads to enhanced autophagy, which may contribute to lens opacity.

Calibrated representations of the double Dyck path algebra

AbstractThe double Dyck path algebra $$\mathbb {A}_{q,t}$$ A q , t and its polynomial representation first arose as a key figure in the proof of the celebrated Shuffle Theorem of Carlsson and Mellit. A geometric formulation for an equivalent algebra $$\mathbb {B}_{q,t}$$ B q , t was then given by the second author and Carlsson and Mellit using the K-theory of parabolic flag Hilbert schemes. In this article, we initiate the systematic study of the representation theory of the double Dyck path algebra $$\mathbb {B}_{q,t}$$ B q , t . We define a natural extension of this algebra and study its calibrated representations. We show that the polynomial representation is calibrated, and place it into a large family of calibrated representations constructed from posets satisfying certain conditions. We also define tensor products and duals of these representations, thus proving (under suitable conditions) the category of calibrated representations is generically monoidal. As an application, we prove that tensor powers of the polynomial representation can be constructed from the equivariant K-theory of parabolic Gieseker moduli spaces.

Family trajectories among immigrants and their descendants in three European countries: A multistate approach in comparative research

This study investigates partnership changes and childbearing among immigrants and their descendants in the UK, France, and Germany. Our analysis of longitudinal data shows, first, significant diversity in family trajectories among immigrants and their descendants in Europe. Immigrants from other European countries and their descendants tend to cohabit prior to marriage, and their fertility in unions is often similar to that of the native population. In contrast, South Asians and Turkish populations exhibit marriage-centred family behaviour with elevated third-birth rates. Individuals of sub-Saharan African or Caribbean origin display higher rates of non-marital family transitions. Second, we observe some changes in partnership and childbearing patterns across migrant generations; these are stronger for fertility than for partnership patterns. Third, migration background is particularly associated with partnership patterns, whereas the destination country context influences childbearing patterns. We expect some patterns to persist across future migrant generations (e.g. preference for marriage vs cohabitation), whereas others are likely to vanish (e.g. large families).

Assessment of mental well-being and its socio-economic determinants among older adults in the Rohingya refugee camp of Bangladesh

Older adults residing in refugee settlements with unhealthy living environments, inadequate access to health care services, and limited psychosocial support are vulnerable to experience mental health problems jeopardizing their mental well-being. The present study aims to explore the mental well-being status and its socio-economic determinants among the older adults living in the Rohingya refugee camp in Bangladesh. This cross-sectional study was conducted among adults aged ≥ 60 residing in five sub-camps within the Rohingya refugee camp of Cox’s Bazar, Bangladesh. Data were collected through face-to-face interviews conducted between November and December 2021. The 14-item Warwick-Edinburgh Mental Well-being Scale was used to assess mental well-being. A cumulated score was derived using the scale ranging from 14 to 70, with higher scores indicating greater levels of mental well-being. A generalized linear regression model was used to examine the socio-economic factors associated with the mental well-being of older adults. A total of 864 older adults participated in the study having a mean mental well-being score of 45.4. Regression analysis revealed that the difference in the logs of mental well-being score was expected to be significantly lower among participants aged 70–79 years (β: − 1.661; 95% CI: − 2.750 to − 0.572; p = 0.003), aged ≥ 80 years (β: − 3.198; 95% CI: − 5.114 to − 1.282; p = 0.001), and those with any non-communicable chronic conditions (β: − 2.903; 95% CI: − 3.833 to − 1.974; p < 0.001) when compared to their counterparts. Conversely, the difference in the logs of mental well-being score was expected to be significantly higher among individuals with formal schooling (β: 3.370, 95% CI: 1.855 to 4.886, p < 0.001) and those having additional income besides aid (β: 1.629; 95% CI: 0.642 to 2.615; p = 0.001), compared to their respective counterparts. Our findings highlight the need to provide psychosocial assistance to older individuals, particularly those who live in large families, suffer from chronic diseases, and live in socio-economic deprivation.

Gender Perceptions in Multi-child Families: The Structure of Family Affecting Gender Stereotypes among Chinese College Students

This paper focuses on gender stereotypes in Chinese multi-child and one-child families to examine whether siblings influence gender stereotypes in College students. In this work, 141 questionnaires (M = 67, F = 74) on gender stereotype representations were collected. The t-test was used to detect gender stereotypes between groups from different families. This study demonstrates that large families influence gender stereotypes among college students, with females from large families showing significantly different feedback on gender stereotypes than males with siblings. Due to son preference, more resources for survival and education in the family will be invested in boys, which implies injustice and oppression of girls. China has already enacted the three-child policy, and the impact of gender inequality ideology on children's gender stereotypes in multi-child families, as reflected in this study, has theoretical value for the future promotion of gender equality education in Chinese families.

Chemical Antiquity in Metabolism.

ConspectusLife is an exergonic chemical reaction. The same was true when the very first cells emerged at life's origin. In order to live, all cells need a source of carbon, energy, and electrons to drive their overall reaction network (metabolism). In most cells, these are separate pathways. There is only one biochemical pathway that serves all three needs simultaneously: the acetyl-CoA pathway of CO2 fixation. In the acetyl-CoA pathway, electrons from H2 reduce CO2 to pyruvate for carbon supply, while methane or acetate synthesis are coupled to energy conservation as ATP. This simplicity and thermodynamic favorability prompted Georg Fuchs and Erhard Stupperich to propose in 1985 that the acetyl-CoA pathway might mark the origin of metabolism, at the same time that Steve Ragsdale and Harland Wood were uncovering catalytic roles for Fe, Co, and Ni in the enzymes of the pathway. Subsequent work has provided strong support for those proposals.In the presence of Fe, Co, and Ni in their native metallic state as catalysts, aqueous H2 and CO2 react specifically to formate, acetate, methane, and pyruvate overnight at 100 °C. These metals (and their alloys) thus replace the function of over 120 enzymes required for the conversion of H2 and CO2 to pyruvate via the pathway and its cofactors, an unprecedented set of findings in the study of biochemical evolution. The reactions require alkaline conditions, which promote hydrogen oxidation by proton removal and are naturally generated in serpentinizing (H2-producing) hydrothermal vents. Serpentinizing hydrothermal vents furthermore produce natural deposits of native Fe, Co, Ni, and their alloys. These are precisely the metals that reduce CO2 with H2 in the laboratory; they are also the metals found at the active sites of enzymes in the acetyl-CoA pathway. Iron, cobalt and nickel are relicts of the environments in which metabolism arose, environments that still harbor ancient methane- and acetate-producing autotrophs today. This convergence indicates bedrock-level antiquity for the acetyl-CoA pathway. In acetogens and methanogens growing on H2 as reductant, the acetyl-CoA pathway requires flavin-based electron bifurcation as a source of reduced ferredoxin (a 4Fe4S cluster-containing protein) in order to function. Recent findings show that H2 can reduce the 4Fe4S clusters of ferredoxin in the presence of native iron, uncovering an evolutionary precursor of flavin-based electron bifurcation and suggesting an origin of FeS-dependent electron transfer in proteins. Traditionally discussed as catalysts in early evolution, the most common function of FeS clusters in metabolism is one-electron transfer, also in radical SAM enzymes, a large and ancient enzyme family. The cofactors and active sites in enzymes of the acetyl-CoA pathway uncover chemical antiquity in metabolism involving metals, methyl groups, methyl transfer reactions, cobamides, pterins, GTP, S-adenosylmethionine, radical SAM enzymes, and carbon-metal bonds. The reaction sequence from H2 and CO2 to pyruvate on naturally deposited native metals is maximally simple. It requires neither nitrogen, sulfur, phosphorus, RNA, ion gradients, nor light. Solid-state metal catalysts tether the origin of metabolism to a H2-producing, serpentinizing hydrothermal vent.

Kaitan Gender dan Struktur Keluarga dengan Pemberian Intervensi Gizi Spesifik pada Anak Usia 6-23 Bulan

This study aimed to explore the relationship between gender and family structure by providing specific nutritional interventions to children aged 6-23 months. The method used was analytical observational with a cross-sectional approach. The research results from chi-square analysis showed that there was a significant relationship between the child's gender and family type and the provision of specific nutrition (p value &lt;0.05). The majority of male children received positive specific nutrition, namely 52.2%, and girls received positive specific nutrition, namely 64.9%. The nuclear family type provided specific nutrition positively by 63.1% and the large family type provided specific nutrition negatively by 52.8%. In conclusion, the child's gender and family type have a significant influence on the provision of specific nutrition and nuclear families are more likely to provide better nutrition. Keyword: Child's Gender, Provision of Specific Nutrition, Stunting, Family Type

Connecting the Dots between GmPERK-1 and Enhanced Grain Weight in Glycine max

Large and distinct families of receptor-like kinases (RLKs) play elemental roles in many fundamental processes of plants. The proline-rich extensin-like receptor kinase (PERK) family is one of the most pivotal classes of RLKs. To date, there have been no comprehensive or published studies conducted on the PERK gene family in Glycine max. This research aimed to characterize the role of the PERK gene family in cultivated soybean using a systematic array of bioinformatic and experimental approaches. We identified 16 PERK members in G. max through local BLASTp, using PERK members from Arabidopsis thaliana as a query. Tissue expression of genes, predicted via tissue specific expression analysis from the soybean database “SoyBase”, revealed that these PERK genes exhibit differentiated expression patterns in various plant organs. The gene structure was predicted via Gene Structure Display Server (GSDS). Phylogeny was demonstrated through an evolutionary tree employing the neighbor-joining method. Subcellular localization of proteins was identified via “Softberry” and cis-acting elements were identified through PlantCARE. The KASP (Kompetitive Allele Specific PCR (KASP)) marker was developed for the GmPERK-1-C and GmPERK-1-T allele, targeting position 167 nt in the CDS region. Genotyping results indicated that GmPERK-1 exhibits promising potential for utilization in molecular breeding programs for soybean to increase crop yield. Collectively, our findings indicate that G. max accessions harboring the GmPERK-1-C allele exhibit significantly higher thousand grain weight compared to accessions carrying the GmPERK-1-T allele. This research enhances the understanding of the molecular roles of PERK genes in G. max, providing valuable insights for the utilization of favorable genetic variations in soybean molecular breeding programs.

A critical role of a plant-specific TFIIB-related protein, BRP1, in salicylic acid-mediated immune response

An integral part of plant immunity is transcription reprogramming by concerted action of specific transcription factors that activate or repress genes through recruitment or release of RNA polymerase II (Pol II). Pol II is assembled into Pol II holoenzyme at the promoters through association with a group of general transcription factors including transcription factor IIB (TFIIB) to activate transcription. Unlike other eukaryotic organisms, plants have a large family of TFIIB-related proteins with 15 members in Arabidopsis including several plant-specific TFIIB-related proteins (BRPs). Molecular genetic analysis has revealed important roles of some BRPs in plant reproductive processes. In this study, we report that Arabidopsis knockout mutants for BRP1, the founding member of the BRP protein family, were normal in growth and development, but were hypersusceptible to the bacterial pathogen Psuedomonas syringae. The enhanced susceptibility of the brp1 mutants was associated with reduced expression of salicylic acid (SA) biosynthetic gene ISOCHORISMATE SYNTHASE 1 (ICS1) and SA-responsive PATHOGENESIS-RELATED (PR) genes. Pathogen-induced SA accumulation was reduced in the brp1 mutants and exogenous SA rescued the brp1 mutants for resistance to the bacterial pathogen. In uninfected plants, BRP1 was primarily associated with the plastids but pathogen infection induced its accumulation in the nucleus. BRP1 acted as a transcription activator in plant cells and binded to the promoter of ICS1. These results collectively indicate that BRP1 is a functionally specialized transcription factor that increasingly accumulates in the nucleus in response to pathogen infection to promote defense gene expression.

A naturally appearing family of Cantorvals

The aim of this note is to show the existence of a large family of Cantorvals arising in the projection description of primitive two-letter substitutions. This provides a common and naturally occurring class of Cantorvals.

Related type 2C protein phosphatases Pic3 and Pic12 negatively regulate immunity in tomato to Pseudomonas syringae.

Type 2C protein phosphatases (PP2Cs) constitute a large family in most plant species but relatively few of them have been implicated in immunity. To identify and characterize PP2C phosphatases that affect tomato (Solanum lycopersicum) immunity, we used CRISPR/Cas9 to generate loss-of-function mutations in 11 PP2C-encoding genes whose expression is altered in response to immune elicitors or pathogens. We report that two closely related PP2C phosphatases, Pic3 (PP2C immunity-associated candidate 3) and Pic12, are involved in regulating resistance to the bacterial pathogen Pseudomonas syringae pv. tomato (Pst). Loss-of-function mutations in Pic3 led to enhanced resistance to Pst in older but not younger leaves, whereas such mutations in Pic12 resulted in enhanced resistance in both older and younger leaves. Overexpression of Pic3 and Pic12 proteins in leaves of Nicotiana benthamiana inhibited resistance to Pst, and this effect was dependent on Pic3/12 phosphatase activity and an N-terminal palmitoylation motif associated with localization to the cell periphery. Pic3, but not Pic12, had a slight negative effect on flagellin-associated reactive oxygen species generation, although their involvement in the response to Pst appeared independent of flagellin. RNA-sequencing analysis of Rio Grande (RG)-PtoR wild-type plants and two independent RG-pic3 mutants revealed that the enhanced disease resistance in RG-pic3 older leaves is associated with increased transcript abundance of multiple defense related genes. RG-pic3/RG-pic12 double mutant plants exhibited stronger disease resistance than RG-pic3 or RG-pic12 single mutants. Together, our results reveal that Pic3 and Pic12 negatively regulate tomato immunity in an additive manner through flagellin-independent pathways.

Phonon-mediated unconventional superconductivity in rhombohedral stacked multilayer graphene

Understanding the origin of superconductivity in correlated two-dimensional materials is a key step in leveraging material engineering techniques for next-generation nanoscale devices. While it is widely accepted that phonons fluctuations only mediate conventional (s-wave) superconductivity, the common phenomenology of superconductivity in Bernal bilayer and rhombohedral trilayer graphene, as well as in a large family of graphene-based moiré systems, suggests a common superconducting mechanism across these platforms. In particular, in all these platforms some superconducting regions violate the Pauli limit, indicating unconventional superconductivity, naively ruling out conventional phonon-mediated pairing as the underlying mechanism. Here we combine first principles simulations with effective low-energy theories to investigate the superconducting mechanism and pairing symmetry in rhombohedral stacked graphene multilayers. We find that phonon-mediated superconductivity explains the main experimental findings, namely the displacement field and doping level dependence of the critical temperature, and the presence of two superconducting regions with different pairing symmetries that depend on the parent normal state. In particular, we find that intra-valley phonon scattering favors a triplet f-wave pairing when combined with electronic correlations stabilizing a spin- and valley-polarized normal state. We also propose a so far unexplored superconducting region at higher hole doping densities nh ≈ 4 × 1012 cm−2, and demonstrate how this highly hole-doped regime can be reached in heterostructures consisting of monolayer α-RuCl3 and rhombohedral trilayer graphene. Our findings promote phonon-mediated pairing as a strong contender to explain superconductivity across a wide range of graphene platforms, and demonstrate that phonons can, in fact, stabilize unconventional superconducting orders.

Bioinformatic, Enzymatic, and Structural Characterization of Trichuris suis Hexosaminidase HEX-2.

Hexosaminidases are key enzymes in glycoconjugate metabolism and occur in all kingdoms of life. Here, we have investigated the phylogeny of the GH20 glycosyl hydrolase family in nematodes and identified a β-hexosaminidase subclade present only in the Dorylaimia. We have expressed one of these, HEX-2 from Trichuris suis, a porcine parasite, and shown that it prefers an aryl β-N-acetylgalactosaminide in vitro. HEX-2 has an almost neutral pH optimum and is best inhibited by GalNAc-isofagomine. Toward N-glycan substrates, it displays a preference for the removal of GalNAc residues from LacdiNAc motifs as well as the GlcNAc attached to the α1,3-linked core mannose. Therefore, it has a broader specificity than insect fused lobe (FDL) hexosaminidases but one narrower than distant homologues from plants. Its X-ray crystal structure, the first of any subfamily 1 GH20 hexosaminidase to be determined, is closest to Streptococcus pneumoniae GH20C and the active site is predicted to be compatible with accommodating both GalNAc and GlcNAc. The new structure extends our knowledge about this large enzyme family, particularly as T. suis HEX-2 also possesses the key glutamate residue found in human hexosaminidases of either GH20 subfamily, including HEXD whose biological function remains elusive.

Signaling by Neutrophil G Protein-Coupled Receptors that Regulate the Release of Superoxide Anions.

In human peripheral blood, the neutrophil granulocytes (neutrophils) are the most-abundant white blood cells. These professional phagocytes are rapidly recruited from the bloodstream to inflamed tissues by chemotactic factors that signal danger. Neutrophils, which express many receptors that are members of the large family of G protein-coupled receptors (GPCRs), are critical for the elimination of pathogens and inflammatory insults, as well as for the resolution of inflammation leading to tissue repair. Danger-signaling molecular patterns such as the N-formylated peptides that are formed during bacterial and mitochondrial protein synthesis and recognized by formyl peptide receptors (FPRs) and free fatty acids recognized by free fatty acid receptors (FFARs) regulate neutrophil functions. Short peptides and short chain fatty acids activate FPR1 and FFA2R, respectively, while longer peptides and fatty acids activate FPR2 and GPR84, respectively. The activation profiles of these receptors include the release of reactive oxygen species (ROS) generated by the NADPH oxidase. Activation of the oxidase and the production of ROS are processes that are regulated by proinflammatory mediators, including TNFα and GM-CSF. The receptors have signaling and functional similarities, although there are also important differences, not only between the two closely related neutrophil FPRs, but also between the FPRs and the FFARs. In neutrophils, these receptors never walk alone, and additional mechanistic insights into the regulation of the GPCRs and the novel regulatory mechanisms underlying the activation of NADPH oxidase advance our understanding of the role of receptor transactivation in the regulation of inflammatory reactions.

Phospholipase A2 expression in prostate cancer as a biomarker of good prognosis: A comprehensive study in patients with long follow-up.

Phospholipase A2 (PLA2) is a large family of enzymes involved in the inflammatory process that catalyzes the hydrolysis of membrane phospholipids, leading to the production of free fatty acids and lysophospholipids, starting the arachidonic acid cascade. Their expression has been related to the behavior of several cancers. Our objective is to search for PLA2 expression in prostate cancer (PCa) tissue that correlates with prognosis and survival. Using qRT-PCR, we analyzed the expression levels of PLA2G1B, PLA2G2A, PLA2G2D, PLA2G4A, PLA2G4B, PLA2G4C, PLA2G4D, PLA2G4E, PLA2G4F, PLA2G6, PLA2G7, PLA2G16, PNPLA1, and PNPLA2 in PCa tissue from 108 patients submitted to radical prostatectomy, followed by a mean time of 163 months. All PLA2 was overexpressed in PCa compared to normal tissue. Interestingly, higher expression of some PLA2 was related to favorable prognostic factors: lower levels of PSA (PLA2G2A, PLA2G4D), lower rates of lymph node metastasis (PLA2G16 and PLA2G1B), and organ-confined disease (PLA2G4A). Most importantly, PLAG4B was independently related to longer disease-free survival. This is the first study exploring comprehensively the expression levels of PLA2 in PCa, showing that the higher expression of some PLA2 should be used as biomarkers of good prognosis and longer disease-free survival.

Noncrossing Partition Lattices from Planar Configurations

AbstractThe lattice of noncrossing partitions is well-known for its wide variety of combinatorial appearances and properties. For example, the lattice is rank-symmetric and enumerated by the Catalan numbers. In this article, we introduce a large family of new noncrossing partition lattices with both of these properties, each parametrized by a configuration of n points in the plane.

Large and/or single‐parent families: Public attitudes towards pronatalist and anti‐poverty family policies in Hungary

AbstractIn the 2010s, new family benefits were introduced in Hungary, focusing on large families to halt population decline. However, poverty reduction became sidelined, as these schemes benefited higher‐income earners. Based on poverty statistics, the article investigates how two family types associated with a higher risk of poverty—large families and single‐parent families—fare under this new selective pronatalist system. Furthermore, based on new representative national survey data, the article explores public support for the reforms. Although the income poverty rate for large families significantly decreased during the 2010s, it remained persistently high for single‐parent families, especially large single‐parent families. The findings indicate strong public support for state assistance to large, single‐parent and poor families and state pronatalism. However, the public prioritises support for poor, single‐parent families. This underscores a partial mismatch between public attitudes and government policy. Nonetheless, this policy probably secured public legitimacy, chiefly due to the general support for state pronatalism and large families, which were vigorously implemented in family policies, albeit selectively.

Access to Secondary School Education among Girls from Pastoral Communities: A case of the Barbaig in Hanang District, Manyara Region of Tanzania

Access to education for girls in many societies faces significant challenges, often leading to girls being viewed as inferior to boys. However, little is known about the unique challenges facing girls from pastoral societies and their access to schooling. Therefore, this paper sheds light on girls' access to secondary school education in the Barbaig pastoral community in the Hanang District, Manyara Region of Tanzania. Specifically, it examines the challenges girls face in accessing secondary education in their area. The study uses a cross-sectional research design and involved 210 girls from Dirma, Chief Gejaru, and Mwahu secondary schools. Proportional sampling and simple random sampling techniques were used to obtain respondents for this study. Data were collected through interviews, focus group discussions, and documentary reviews. Qualitative and quantitative approaches were used in data analysis. The results revealed that a shortage of girls’ facilities and services in schools, families' low socio-economic status, and harmful gender norms, traditions, and practices were among the challenges. Other challenges include early pregnancies and early marriage, parents’ desire for wealth, nomadic lifestyle, large family size, and long distance from home to school. It is recommended that the Education Department in Hanang District implement educational policies that ensure students in every school have sufficient resources. Furthermore, community leaders should insist on the importance of girls’ education. This will only be possible if local authorities actively collaborate with relevant stakeholders to solve the educational challenges facing the girls from the Barbaig tribe.

Studi Deskriptif: Analisis Tematik pada Nilai-nilai Adat dan Budaya dalam Sosialisasi Orang Tua yang Berasal dari Suku Minangkabau kepada Anak

Value socialization is a process by which individuals learn the values, norms, and behaviors accepted in the society in which they live. The family as the child's first environment, plays an important role as a media channel in disseminating the values that exist in society to children this study uses a qualitative approach design conducted with the use of open ended questionnaire that is a questionnaire that can capture varied responses from various participants.Socialization of Indigenous values of Minangkabau culture is a very important process in maintaining and passing down cultural wealth from one generation to the next. Minangkabau people, which is a tribe that inhabits the territory of West Sumatra. As the largest matrilineal tribe in the world, the Minangkabau have a strong Indigenous value system that reflects their close relationship with nature, tradition, and local wisdom. The Minangkabau people pass on cultural heritage through the maternal line, and this socialization process generally occurs in families, communities, and indigenous institutions. Values such as adab, the value of mutual assistance, mutual respect, and active involvement in the lives of large families and communities become the main focus of the family has a central role in the socialization of the Indigenous values of Minangkabau culture. Researchers highlight the importance of the role of parents as value bearers and primary teachers in Minangkabau families, especially mothers. Mothers are not only responsible for educating children in terms of daily habits, but also for passing on cultural heritage through stories and practices that may be of a more traditional nature. Socialization of Indigenous values of Minangkabau culture is not limited to the family sphere, socialization of Indigenous values of Minangkabau culture is not only informational, but also involves direct experience that deepens understanding and appreciation of their cultural wealth.

Nickel phosphorous trisulfide: A ternary 2D material with an ultra-low coefficient of friction

AbstractUltra-low friction is crucial for the anti-friction, anti-wear, and long-life operation of nanodevices. However, very few two-dimensional materials can achieve ultra-low friction, and they have some limitations in their applications. Therefore, exploring novel materials with ultra-low friction properties is greatly significant. The emergence of ternary two-dimensional materials has opened new opportunities for nanoscale ultra-low friction. This study introduced nickel phosphorous trisulfide (NiPS3, referred to as NPS), a novel two-dimensional ternary material capable of achieving ultralow friction in a vacuum, into the large nanotribology family. Large-size and high-quality NPS crystals with up to 14 mm × 6 mm × 0.3 mm dimensions were grown using the chemical vapor transport method. The NPS nanosheets were obtained using mechanical exfoliation. The dependence of the NPS nanotribology on layer, velocity, and angle was systematically investigated using lateral force microscopy. Interestingly, the coefficient of friction (COF) of NPS with multilayers was decreased to about 0.0045 under 0.005 Pa vacuum condition (with load up to 767.8 nN), achieving the ultra-low friction state. The analysis of the frictional dissipation energy and adhesive forces showed that NPS with multilayers had minimum frictional dissipation energy and adhesive forces since the interlayer interactions were weak and the meniscus force was excluded under vacuum conditions. This study on the nanoscale friction of a ternary two-dimensional material lays a foundation for exploring the nanoscale friction and friction origin of other two-dimensional materials in the future.