You have accessJournal of UrologyProstate Cancer: Detection & Screening VIII (MP81)1 Apr 2020MP81-15 TWO-MINUTE PROSTATE MAGNETIC RESONANCE IMAGING PREDICTS GLEASON SCORE: AN ADVANCED MACHINE LEANING OF RAPID T2-WEIGHTED IMAGING Ileana Montoya Perez*, Jussi Toivonen, Harri Merisaari, Pekka Taimen, Otto Ettala, Tapio Pahikkala, Peter Boström, Hannu Aronen, and Ivan Jambor Ileana Montoya Perez*Ileana Montoya Perez* More articles by this author , Jussi ToivonenJussi Toivonen More articles by this author , Harri MerisaariHarri Merisaari More articles by this author , Pekka TaimenPekka Taimen More articles by this author , Otto EttalaOtto Ettala More articles by this author , Tapio PahikkalaTapio Pahikkala More articles by this author , Peter BoströmPeter Boström More articles by this author , Hannu AronenHannu Aronen More articles by this author , and Ivan JamborIvan Jambor More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000000973.015AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: To develop and validate Gleason score classifier using texture features and advance machine learning algorithms of rapid prostate T2-weighted magnetic resonance imaging (T2w) with acquisition time less than 2 minutes. METHODS: Eighty-two prospectively enrolled patients with histologically confirmed prostate cancer (PCa) underwent 3 Tesla magnetic resonance imaging before prostatectomy. T2-weighted magnetic resonance imaging (T2w) was performed using single shot turbo spin echo sequence with repetition time/echo time 4668/130 ms, field of view 250x250 mm2, acquisition matrix size 250x320, and acquisition time 1 minute 10 seconds. A histogram alignment method was used to correct a non-standardness of T2w (“intensity drift”). Prostate cancer lesions were delineated using whole mount prostatectomy sections as the ground true. In total, 1631 unique texture features were extracted including Gabor function, Haar transform, image moments, Sobel operator, local binary patterns (LBP), gray-level co-occurrence matrix (GLCM). Classifier was built using logistic regression with either L1 or L2 regularization to compensate the high dimensionality of the data by penalizing large coefficient values of the inferred linear models. The classification performance (Gleason score 3+3 vs >3+3), was evaluated by area under a receiver operating characteristic curve (AUC) values. The classification performance of the model built by the regularized logistic regression algorithms was estimated by a nested cross validation strategy with an outer leave-pair-out cross-validation and an inner 10-fold cross validation for hyperparameter selection (Figure 1). RESULTS: The final data set was composed of 126 PCa lesions, 36 and 90 lesions had Gleason score 3+3 and >3+3, respectively. The best performing texture features belonged to GLCM and Gabor function groups. The classifier achieved AUC (95% confidence interval) of 0.85 (0.74 - 0.92). CONCLUSIONS: Machine learning classifier using radiomic and texture features of 2-minute prostate MRI demonstrated a good performance in the classification of prostate cancer Gleason score. Rapid T2-weighted imaging with acquisition time less than 2 minutes and advanced machine learning are promising tools for non-invasive Gleason score prediction. Source of Funding: This study was financially supported by grants from Sigrid Jusélius Foundation, Finnish Cultural Foundation, Orion Pharma Research Foundation, TYKS-SAPA Research funds, Finnish Cancer Society, and Instrumentarium Research Foundation. © 2020 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 203Issue Supplement 4April 2020Page: e1242-e1242 Advertisement Copyright & Permissions© 2020 by American Urological Association Education and Research, Inc.MetricsAuthor Information Ileana Montoya Perez* More articles by this author Jussi Toivonen More articles by this author Harri Merisaari More articles by this author Pekka Taimen More articles by this author Otto Ettala More articles by this author Tapio Pahikkala More articles by this author Peter Boström More articles by this author Hannu Aronen More articles by this author Ivan Jambor More articles by this author Expand All Advertisement PDF downloadLoading ...
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