With recent prioritization of equity in pediatric health outcomes, a shift to examine neighborhood-level health care disparities within pediatric populations has occurred, specifically in the context of critical illness. Does an association exist between individual indicators of neighborhood-level disadvantage and incidence of PICU admission? Pediatric patients younger than 18 years admitted to a PICU in a large urban tertiary pediatric hospital from January 1, 2016, through December 31, 2019, with a residential address in the city of Baltimore or Baltimore County on the day of admission were included in this ecological study. Demographic and clinical characteristics of children admitted to the PICU were summarized, with the primary outcome being PICU admission. Unadjusted negative binomial regression was used to examine the association between census tract-level PICU admissions and the previously described census tract-level indicators of neighborhood socioeconomic position. Regression models included an offset term for the population younger than 18 years for each census tract; results of models are reported as incidence rate ratios (IRRs) with corresponding 95%CIs. We identified 2,476 PICU admissions: 1,351 patients from the city of Baltimore (10.25 per 1,000 children) and 1,125 patients from Baltimore County (6.31 per 1,000 children). Most PICU admissions (n= 906 [68%]) for the city of Baltimore represented an area deprivation index (ADI) of > 60, whereas most Baltimore County PICU admissions (n= 919 [82.3%]) represented an ADI of< 60. At the neighborhood level, the percentage of families living below the poverty line was associated with greater incidence of PICU admission in the city of Baltimore (IRR, 1.09; 95%CI, 1.00-1.18) and Baltimore County (IRR, 1.19; 95%CI, 1.05-1.36). For every $10,000 increase in median household income, PICU admission rates dropped by 9%for the city of Baltimore (IRR, 0.91; 95%CI, 0.86-0.95) and Baltimore County (IRR, 0.91; 95%CI, 0.88-0.94). Neighborhoods with vacant housing units also were associated with a higher incidence of PICU admission in the city of Baltimore (IRR, 1.10; 95%CI, 1.01-1.21) and Baltimore County (IRR, 1.46; 95%CI, 1.21-1.77), as was a 10%increase in occupied homes without vehicles (city of Baltimore: IRR, 1.14; 95%CI, 1.07-1.21; Baltimore County: IRR, 1.23; 95%CI, 1.11-1.37). Health outcomes of pediatric critical illness should be examined in the context of structural determinants of health, including neighborhood-level and environmental characteristics.