You have accessJournal of UrologySexual Function/Dysfunction: Medical, Hormonal & Non-surgical Therapy II (MP36)1 Sep 2021MP36-17 EXPLORING THE ASSOCIATION OF ANDROGEN MODULATION THERAPY AMONG MEN HOSPITALIZED WITH COVID19: A RETROSPECTIVE OBSERVATIONAL STUDY Albert Ha, Nahid Punjani, Vinson Wang, Joseph Caputo, Brendan K Wallace, Luis Pina, Valary Raup, Philip Li, James McKiernan, and Joseph Alukal Albert HaAlbert Ha More articles by this author , Nahid PunjaniNahid Punjani More articles by this author , Vinson WangVinson Wang More articles by this author , Joseph CaputoJoseph Caputo More articles by this author , Brendan K WallaceBrendan K Wallace More articles by this author , Luis PinaLuis Pina More articles by this author , Valary RaupValary Raup More articles by this author , Philip LiPhilip Li More articles by this author , James McKiernanJames McKiernan More articles by this author , and Joseph AlukalJoseph Alukal More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000002045.17AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: While primarily associated with prostate cancer pathogenesis, TMPRSS2 has recently been identified as a co-receptor for ACE2, the target protein used by SARS-CoV2 for viral entry. This protein is primarily regulated by the androgen receptor, and this mechanism may partly explain the disproportionate burden of disease among males. We hypothesized that the use of androgen modulation therapies (AMT) such as 5-a-reductase inhibitors (5-ARI) and androgen deprivation therapy (ADT) may affect inpatient outcomes among hospitalized men with COVID-19. METHODS: In a single-center retrospective analysis in a large urban hospital system, hospitalized males with laboratory-confirmed diagnosis of COVID-19 and a history of benign prostatic hyperplasia (BPH) and/or prostate cancer was identified from February to June 2020. Men were then stratified by use of specific AMT (ADT or 5-ARI). Baseline patient and hospital characteristics were analyzed using descriptive statistics, and multivariable regression models were used to explore the association of AMT with inpatient mortality, length of hospital stay (LOS), and other ICU outcomes (ICU admission, ICU Length of Stay, Non-Invasive Mechanical Ventilation, Intubation, and ARDS). RESULTS: A total of 396 inpatients were identified, with 130 (32.8%) having prior use of AMT. Of these, a large majority used 5-ARI (n=122, 93.8%). Mean (SD) age of patients was higher for those using AMT (76.5 (10.7) vs. 71.1 (11.8) years; p<0.001). No significant differences were identified in AMT use by race, body mass index, smoking status, or Charlson Comorbidity Index. Despite adjustment for these factors, AMT use was not associated with ICU admission, ventilation status, length of ICU stay, or length of hospital stay. However, a non-significant trend of decreased mortality was identified with the use of AMT (adjusted OR: 0.56; 95% CI: 0.29–1.02; p=0.06) (Table 1). CONCLUSIONS: Preliminary analysis suggests that AMT does not appear to improve inpatient outcomes among hospitalized males with COVID-19. The non-significant trend of decreased inpatient mortality, however, may be attributed to insufficient power. Future research with large sample sizes may uncover potential benefits of androgen modulation on COVID19 pathogenesis and outcomes. Source of Funding: None © 2021 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 206Issue Supplement 3September 2021Page: e642-e642 Advertisement Copyright & Permissions© 2021 by American Urological Association Education and Research, Inc.MetricsAuthor Information Albert Ha More articles by this author Nahid Punjani More articles by this author Vinson Wang More articles by this author Joseph Caputo More articles by this author Brendan K Wallace More articles by this author Luis Pina More articles by this author Valary Raup More articles by this author Philip Li More articles by this author James McKiernan More articles by this author Joseph Alukal More articles by this author Expand All Advertisement PDF downloadLoading ...