Large Tertiary-level Hospital Research Articles

Initial Experiences in Starting a Renal Transplant Center: Ab-initio profile of donors we encountered

Introduction: Kidney transplantation is the ultimate treatment for people with ESRD. The Donors for such kidney can be either from living or from cadaver donors. The living donors are healthy people who are thoroughly worked up and screened. For the benefit of another person we subject a healthy subject to surgery. For this reason a study on how a donor’s health is affected as a result of kidney donation needs evaluation. Methods: This study is a combined retrospective and prospective study. The retrospective data were taken from the case sheet of patients maintained at the urology department of a large tertiary level hospital doing renal transplants. Prospective study of the cases were carried out by following up detail donor workup including history, clinical examination and investigations relevant to donor work up as per the protocol followed in the transplant center. Each prospective case were studied for complications of donor nephrectomy and followed up for a period of up to one year after donor nephrectomy. Results: A total of 36 donors underwent donor nephrectomy during the study period. There were only two laparoscopic nephrectomies and 34 by standard retroperitoneal open surgical method. 13 donors had postoperative complications (36.11%). The duration of stay varied from 5-35 days. Majority of the donors (44%) had a stay within the range of 10-15 days, followed by a stay of 5-10 days (30-56 percent of the donors). The remaining stay ranged from 2.78% to 8.33 %. The average stay in the hospital was found to be 14.17 days with SD of 6.45 days. Conclusion: Living kidney donation with all its advantages still holds the best solution for end stage renal disease. The inconvenience of haemodialysis along with the cost and loss of labour of a patient on haemodialysis makes renal transplant the ultimate replacement of a non-functioning kidney. The advantage of timing of transplantion according to the condition of the recipient makes it far superior than cadaver grafts.

Point of Care Lung Ultrasound Injury Score-A simple and reliable assessment tool in COVID-19 patients (PLIS I): A retrospective study.

In COVID-19 patients, lung ultrasound is superior to chest radiograph and has good agreement with computerized tomography to diagnose lung pathologies. Most lung ultrasound protocols published to date are complex and time-consuming. We describe a new illustrative Point-of-care ultrasound Lung Injury Score (PLIS) to help guide the care of patients with COVID-19 and assess if the PLIS would be able to predict COVID-19 patients' clinical course. This retrospective study describing the novel PLIS was conducted in a large tertiary-level hospital. COVID-19 patients were included if they required any form of respiratory support and had at least one PLIS study during hospitalization. Data collected included PLIS on admission, demographics, Sequential Organ Failure Assessment (SOFA) scores, and patient outcomes. The primary outcome was the need for intensive care unit (ICU) admission. A total of 109 patients and 293 PLIS studies were included in our analysis. The mean age was 60.9, and overall mortality was 18.3%. Median PLIS score was 5.0 (3.0-6.0) vs. 2.0 (1.0-3.0) in ICU and non-ICU patients respectively (p<0.001). Total PLIS scores were directly associated with SOFA scores (inter-class correlation 0.63, p<0.001), and multivariate analysis showed that every increase in one PLIS point was associated with a higher risk for ICU admission (O.R 2.09, 95% C.I 1.59-2.75) and in-hospital mortality (O.R 1.54, 95% C.I 1.10-2.16). The PLIS for COVID-19 patients is simple and associated with SOFA score, ICU admission, and in-hospital mortality. Further studies are needed to demonstrate whether the PLIS can improve outcomes and become an integral part of the management of COVID-19 patients.

Prevalence and Factors Associated with Microalbuminuria in Pediatric Patients with Type 1 Diabetes Mellitus at a Large Tertiary-Level Hospital in Botswana.

IntroductionMicroalbuminuria is considered the earliest sign of diabetic nephropathy among patients with type 1 diabetes mellitus (T1DM). The prevalence of microalbuminuria among African children with T1DM is reported to be high, yet its prevalence and population-specific risk factors in Botswana are not known.AimThis study aimed to determine the prevalence of microalbuminuria among children and young adults with T1DM in Botswana and identify factors associated with microalbuminuria in this population.MethodsA retrospective cross-sectional study was conducted on 127 T1DM patients aged <24 years followed at a pediatric endocrinology clinic in Botswana from 2010 to 2017. Clinical, laboratory, and demographic data were collected using chart review and patient surveys. Descriptive statistics were reported as mean and standard deviation for continuous variables, and frequency and percentage for categorical variables. Prevalence of microalbuminuria was calculated as a simple proportion. Group comparison was done using two-sample independent t-test, X2-test, or Fisher’s exact test and logistic regression to assess for associations. Level of significance was set at p<0.05.ResultsThere were a total of 71 (55.9%) females. The mean age was 18.7 (±5) years and mean duration of T1DM was 6.6 (±4.6) years. Most study participants were of African descent. The prevalence of microalbuminuria was 28.3%. Group comparison revealed gender (p= 0.040), duration of diabetes (p= 0.002), systolic blood pressure (p=0.003), baseline glycated hemoglobin (HbA1c) (p=0.009) and Tanner’s stage (p=008) to be significantly associated with microalbuminuria. On binary logistic regression, only gender (p=0.039) and baseline HbA1c (p=0.039) were independently associated with the presences of microalbuminuria.ConclusionThis study identified a high prevalence of microalbuminuria among children and young adults with T1DM in Botswana and reaffirms the importance of early detection, glycemic control, and regular screening to prevent diabetic nephropathy.

450 Low Dose CT Protocols - The Future for Paediatric Foreign Body Aspiration?

Abstract Aim Suspected foreign body aspiration is a common attendance at the paediatric emergency department. Low dose Computer tomography (CT) protocols (0.06-2mSv) have been developed to be able to diagnose these patients more effectively. Method All paediatric low dose CT protocols for foreign body aspiration from a large tertiary level hospital were identified retrospectively over a year. Data was collected on prior imaging, result, further intervention and subsequent follow up of patients. Results Eight patients were identified. Three (37.5%) identified a foreign body on CT. All three had subsequent microlaryngoscopy and all found a foreign body present. Of the five negative scans, none re-presented or had any associated symptoms of a foreign body at follow up. Five had previous Chest X-ray, all of which were inconclusive. Conclusions Although need for ongoing research into the area, low dose CT thorax protocols for suspected foreign body aspiration is a promising and effective tool. Its use across the country will likely lead to reduced negative microlaryngoscopy rates with huge associated benefits for both the patient and the ENT department.

The CRIB II (Clinical Risk Index for Babies II) Score in Prediction of Neonatal Mortality.

Predicting the outcome of neonatal critical patients remains elusive. The multiple factors of maternal state of health (infections, diabetes, gestosis), the placental situation (premature rupture of membranes) as well as multiple factors from the baby (small for gestational age, low Apgar score, low birth infections, mechanical ventilation, hypoglycaemia hyperglycamiea) render the approach to treatment of each patient individual and the outcome uncertain. Several approaches and scales are developed in order to assess the mortality risk in those rather complicated situations.We used the CRIB-II scale to assess the mortality risk in 80 patients delivered in a large tertiary level hospital with more than 4,000 deliveries yearly. The patients were stratified according to all the neonatal risk factors and comorbidities. The CRIB-II scale identified well the mortality rates, but not the outcomes. A large and well-balanced cohort of patients followed for a longer period is required to discern in detail the importance of CRIB-II scale in predicting outcomes in high-risk new-borns. This could serve as an assistance to personalized approach to severely sick children. In addition, it is a valuable method in comparing outcomes in different NICUs and outcomes in different times in the same NICU, thus rendering possible improvements in the same unit and among several NICU departments.

Burnout, compassion fatigue and psychological capital: Findings from a survey of nurses delivering palliative care

BackgroundAgeing populations worldwide and a concomitant increase in chronic conditions translates into an increased demand for the delivery of palliative and end of life care by nurses. This increasing demand for palliative care provision may produce stressors resulting in negative outcomes such as burnout and compassion fatigue. AimThe purpose of this study was to explore burnout and compassion fatigue, as well as potential protective factors, among nurses in New Zealand. MethodsAn online survey was conducted with 256 registered nurses (between January 2016 and February 2017) recruited through nursing organisations and a large tertiary level hospital. Data analysis consisted of descriptive statistics, multivariate analysis of variance, Pearson correlations, and hierarchical multiple regression. ResultsPsychological empowerment and the commitment and challenge components of psychological hardiness significantly predicted lower scores for the burnout while previous palliative care education and challenge predicted lower scores for the secondary traumatic stress component of compassion fatigue. Significant predictors of compassion satisfaction included previous palliative care education, psychological empowerment and both the commitment and challenge components of psychological hardiness. ConclusionNurses draw upon unique combinations of “psychological capital” to deal with caring for patients with life-limiting illnesses. Any interventions to increase nurse palliative care education uptake must be tailored to develop and support these internal resources.

Lived experiences of Rwandan ICU nurses caring for patients with a do-not-resuscitate order

Background. Do not resuscitate (DNR) is the policy and practice of deliberately not attempting to resuscitate a person whose heart has stopped beating. Research on nursing care for patients designated with DNR orders has been conducted since the late 1980s; however, no study appears to have been carried out in the Rwandan setting. Purpose . The purpose of this study was to explore the lived experiences of nurses caring for a patient with a DNR order in an intensive care unit (ICU) in Kigali, Rwanda, in order to suggest nursing recommendations. Methods. Using a phenomenological approach, two semi-structured interviews were conducted with each participant to explore their lived experiences of caring for patients with DNR orders. The sample comprised six nurses from an ICU in a large tertiary-level hospital in Kigali, Rwanda. Results . The data were organised into categories based on a review of the data from the interviews of the six participants. The categories were: feeling emotional distress; barrier to optimal care; and not part of decision-making. Conclusion . DNR orders are a fairly new concept in Rwanda and the practice of DNR orders in ICU is very demanding for the staff, especially the ICU nurses. Additional education about DNR orders as well as policies to guide its implementation could assist ICU nurses in their difficult work.

Profile of geriatric patients presenting to the emergency department

Background: In both developed and developing countries, the proportion of people over 60 years of age is growing faster than any other age group as a result of longer life expectancy due to improved health care. As a result, emergency department (ED) visits are on the rise. Materials and Methods: This retrospective observational study was conducted in the ED of a large tertiary level hospital between September 2014 and December 2014. All patients >65 years presenting to the ED were included in the analysis. Results: During the study period, 1090 geriatric patients comprised 13.9% of the ED admissions. The mean age of the patients was 74.2 ± 20.32 years. There was a male predominance (65.4%). The most common presenting complaints were breathing difficulty (28%), fever (21.6%), vomiting (14%), chest pain (11.5%), abdominal pain (11.5%), trauma (11%), giddiness (10.4%), and altered sensorium (10%). The distribution of the most common organ systems involved are as follows: Cardiovascular system (18.7%), respiratory system (15.8%), trauma (13.9%), genitourinary system (13.8%), neurological system (12.3%), skin and soft tissue infections (6%), and others (25.1%). Among the respiratory conditions, acute exacerbation of asthma/chronic obstructive pulmonary disease was the most common (61.2%), followed by pneumonia (28.9). More than half (51.5%) were discharged from ED, 47.5% (518 patients) were admitted to the hospital, and 0.91% (10 patients) expired in the ED. A further 64 patients expired during the hospital stay. The overall inhospital mortality among the geriatric emergencies was 6.8% (79/1090). The mean length of hospital stay was 8.06 days. Conclusion: The admission profile among this geriatric population showed that cardiorespiratory conditions are the most common emergencies, followed by trauma. ED of India should be aware of this demographic profile and be prepared to handle these emergencies efficiently.

Two routes of administration for misoprostol in the treatment of incomplete abortion: a randomized clinical trial

Background This study was conducted to compare the safety, effectiveness and acceptability of 400 mcg sublingual misoprostol and 600 mcg oral misoprostol for treatment of incomplete abortion. Study Design We used an open-label randomized controlled trial conducted from July 2005 to August 2006 in a large tertiary level maternity hospital in Antananarivo, Madagascar, and a large tertiary level hospital in Chisinau, Moldova. Three hundred consenting women seeking treatment for clinically diagnosed incomplete abortion with uterine size ≤12 weeks since last menstrual period were randomized to misoprostol either 600 mcg orally or 400 mcg sublingually. The primary outcome measure was the complete resolution of clinical signs and symptoms of incomplete abortion without need for surgical intervention. Women were seen for follow-up on Day 7 and, if necessary, on Day 14 to assess abortion status. The study was powered to detect a 7% difference in efficacy with a total of 142 women required in each arm. Results Efficacy rates were 94.6% and 94.5%, for the oral and sublingual routes, respectively (RR: 1.00, 95% CI=0.95–1.06, p=.98). At 1 week follow-up, more than 80% of women had completed abortions (77.8% oral and 84.8% sublingual, p=.12). Mean pain scores were 2.95 and 3.04, respectively, for the oral and sublingual groups. Side effects included abdominal pain, bleeding, headaches and dizziness/weakness with no differences reported between the two groups. Acceptability and satisfaction were high for both routes and women indicated a preference for medical versus surgical treatment if ever needed in the future. Conclusions Both treatment regimens were very effective. Four hundred micrograms of sublingual misoprostol and 600 mcg oral misoprostol appear to have similar safety and effectiveness profiles when used for the treatment of incomplete abortion. A lower 400-mcg misoprostol dose may provide an alternative treatment option as well as have potential benefits in terms of cost.

Raspberry leaf in pregnancy: Its safety and efficacy in labor

Objective: Many women consume the raspberry leaf herb during their pregnancies in the belief that it shortens labor and makes labor “easier.” Methodology: Because of the paucity of research regarding this herb, particularly in relation to pregnancy and birth, the authors undertook a double-blind, randomized, placebo-controlled trial. The sample consisted of 192 low-risk, nulliparous women who birthed their babies between May 1999 and February 2000 at a large tertiary-level hospital in Sydney, Australia. The aim of the study was to identify the effect and safety of raspberry leaf tablets (2 × 1.2 g per day), consumed from 32 weeks’ gestation until labor, on labor and birth outcomes. Results: Raspberry leaf, consumed in tablet form, was found to cause no adverse effects for mother or baby, but contrary to popular belief, did not shorten the first stage of labor. The only clinically significant findings were a shortening of the second stage of labor (mean difference = 9.59 minutes) and a lower rate of forceps deliveries between the treatment group and the control group (19.3% vs. 30.4%). No significant relationship was found between tablet consumption and birth outcomes. Conclusion: The lack of significant differences between the groups on measures expected to demonstrate the effect of raspberry leaf ingestion during pregnancy on labor prompted consideration of the issue of effectiveness of dosage level. Suggestions for further research are offered.

A controlled assessment of the in vitro fertilization performance of British women of Indian origin compared with white women

To compare the reproductive performance of Indian versus white women in IVF. Controlled comparative clinical study. In vitro fertilization center based in university department in large tertiary level hospital. Results from first IVF treatment cycles in 44 Indian patients were compared with results from 88 white patients, matched by age and body mass index, over the same treatment year. The patients were selected from a prospectively collected IVF databank. Standard luteal-phase start long GnRH analogue regime. Ovarian stimulation with FSH and hMG. Transvaginal ultrasound-guided oocyte recovery. In vitro fertilization and ET following established protocols. Rates of abandoned cycles, egg retrievals, ETs, clinical pregnancies, miscarriages, and live births were compared in the first IVF treatment cycle. Cumulative pregnancy rates (PRs) over three cycles in the two groups of patients were also compared. More cycles were abandoned in the Indian than in the white group: 22.7% versus 9.1%. The Indian live birth rate per cycle was worse: 9.1% versus 22.7%. The performance of the two groups was otherwise similar: ovarian stimulation with hMG and FSH required 26.0 required 26.0 ampules in the Indian group versus 24.6 ampules in the white group, mean number of follicles on the day of egg retrieval 8.7 versus 8.7, mean number of eggs 5.9 versus 5.8, fertilization rate 82.4% versus 82.5%; ET rate 73.5% versus 82.5, mean number of embryos transferred 2.1 versus 1.8, and clinical PR per cycle started 18.2% versus 27.3%. Under the same IVF regime, Indians performed worse than whites at the stage of ovarian stimulation (higher rate of abandoned cycles for poor response) and in live birth rate. Cumulative conception and live birth rates also tended to be worse in Indians than in whites.