Large Segments Research Articles

Employment in the performance of pre-paid educational and scientific works: social and economic aspects

Relevance. Currently, the market for custom-made educational and scientific work is a large segment of the shadow economy characterized by significant volumes. In the structure of this market, we may observe the formation of special types of social and economic agents and their interaction practices. However nowadays both the essential social and economic characteristics of such employment and its cultural value aspects, which form the social subjectivity of the performers of the work, have not fully become the object of scientific reflection.The purpose is to study the social and economic aspects of employment in the field of contract work.Objectives: to reveal the theoretical and methodological foundations of actualization of employment for the performance of commissioned educational and scientific works in the general structure of freelancing; to specify the content of the main social and economic characteristics of the performance of commissioned works; to implement a typology of motivation of authors of commissioned works; to determine the current directions of further scientific research on the stated problem.Methodology. The article uses sociological concepts of post-industrial society and sociological theories of postmodernity. Special attention is paid to the provision of a number of basic general scientific methods, as well as modeling and generalization methods. The empirical basis of the study was the results of the author's sociological study conducted by the method of an expert online survey (N=50).Results. The employment volume in the sphere of contract work in the general structure of freelancing was considered in the article. The content of socio-economic characteristics of employment in the performance of commissioned works (at the personal and subjective levels) is revealed as well as the typology of value and motivational orientations of the authors of commissioned works was carried out.Conclusions. Pre-paid educational and scientific works tends to professionalize, though this sphere is hindered by the low average income from this customers. It is financial motivation that is predominant in the structure of work factors for the authors of commissioned works.

Challenges Associated With Re-Emergence of Lassa Fever in Nigeria: An Exploratory Study of Epidemiology, Phylogenomics, and Recommendations Toward Its Eradication.

Lassa fever (LF) is a viral hemorrhagic illness endemic in Nigeria and other West African countries. In recent years, the number of reported cases of LF in Nigeria has increased. In this study, we discussed the epidemiology of LF, the phylogenomics of the LF virus, issues associated with the increased cases of LF, and recommendations for tackling the future occurrence of LF in Nigeria. Epidemiology data on LF were obtained from the Nigeria Centre for Disease Control database and analyzed using Microsoft Excel software. About 59 partial and complete sequences consisting of both small and large segments of the LF virus were retrieved from the National Center for Biotechnology Information from 1969 to 2013 to study the evolutionary relationship of the LF virus in Nigeria. Nigeria has been shown to have the highest prevalence of Lassa fever among African countries, with seasonal occurrence in both wet and dry seasons. Furthermore, the phylogenetic analysis of the LF virus showed a great relationship with several outbreaks of LF in Nigeria and other African countries. To combat the increasing cases of LF in Nigeria, there is a need to increase the molecular diagnosis capacity in Nigeria, improve public health awareness about the disease in rural and urban settlements, integrate a surveillance system through the One Health lens, and support LF vaccine research in Africa.

USD-SLAM: A Universal Visual SLAM Based on Large Segmentation Model in Dynamic Environments

USD-SLAM: A Universal Visual SLAM Based on Large Segmentation Model in Dynamic Environments

Dalit Muslims of Barak Valley: A Socio-Historical Study

This article is an attempt to examine the historical background of Dalit Muslim communities in the Barak Valley of southern Assam in the context of Dalit Muslims in India. The Marathi word ‘Dalit’ (broken) has been widely used in the intellectual discourses to mean the oppressed class of people among the Hindus—the untouchables and low castes. It was the outcome of age-old social inequality and discrimination prevalent in the Indian subcontinent that a large segment of the population was being pushed to the outer edge of human society. They were destined to live a life of semi-human beings. Following from this, the word ‘Dalit Muslim’ is quite new in the academic and political discourses and strongly resented by the orthodox Muslims. Theoretically, Islam does not recognize any social distinctions based on race, ethnicity, occupation and, of course, caste. However, empirical studies including censuses since the British period confirm the presence of severe social inequality and discrimination among Indian Muslims similar to the Hindu caste system. The origin of Dalit Muslims was associated with the historical expansion of Islam in India following the conversion of millions of low castes and Dalits to Islam in order to escape social discrimination. But their conversion to Islam did not mitigate caste; rather, they were simply added to the new social organization with similar class and status. They continued to pursue their hereditary occupation, being considered demeaning by their ashraf co-religionists, and branded them with derogatory terms such as ajlaf, razil, kamin, itr, arzal, or lowborn. They were treated the most contumely without having the slightest regard for the Islamic principle of social equality by the upper caste Muslims due to their association with the demeaning occupations. Therefore, they were destined to live apart from the mainstream social life and reduced to the extent of outcastes or Dalit as compared to the Hindu caste organization. This article examines the socio-historical background of different Dalit Muslim communities in the Barak Valley of southern Assam.

Relationship of Caries between Primary Molars and the Permanent First Molar.

Dental caries is a multifactorial disease that affects large segment of population worldwide. To evaluate the detailed relationship between carious status of primary molars and permanent first molars among 8.5-10 years old children. Two-hundred and seven children were included in this cross-sectional study. The permanent incisors were fully erupted, the primary canines had no caries experience, and premolars were not erupted. The dentition status of the primary molars and permanent first molars was examined according to the World Health Organization criteria. Pearson correlation, independent sample t-test, and linear and logistic regression analysis were used. The significance level was set at 0.05. The mean (standard deviation) of decay, missing and filled teeth/surface for primary molars and permanent first molar (dmfs&dmft/DMFS&DMFT) were 4.12 (2.53), 8.40 (7.43), 0.77 (1.16) and 1.01 (1.81), respectively. Weak and medium correlations were found between d-component and D-component (r < 0.5), though statistically significant (P value < 0.001). Moreover, there was a relationship between the number of primary molars caries and the presence of caries on the permanent first molar located in the same side and jaw of these primary molars and those located in the opposite side and jaw of the primary molars. Nearly one-fifth of the caries on the permanent molars might be attributed to caries on the primary molars among 8.5-10 years-old children. The odds ratio of developing caries on the permanent first molars was 1.5 for children with primary molars caries in comparison to children with no primary caries.

Portal Project as a Study of Digital Sculpture in the Public Space in the 21st Century

This article examines the effects of digital technologies on art in the 21st century and the transformation of art in the public sphere. After the Internet revolution, significant progress has been made in areas such as artificial intelligence, big data, the Internet of Things (IoT), blockchain, and biotechnology. These technologies have also created significant transformations in art disciplines, offering artists new forms of expression such as virtual reality, augmented reality, and interactive installations. Today, one of the main goals of public art practices, which also use these new forms of expression, is to convey social, cultural, and political messages by reaching large segments of society. Digital art, on the other hand, transforms these practices, offering viewers more interactive, participatory, and innovative experiences. The article discusses how digitalization transforms the social context of art through the discussions of Jürgen Habermas, Hannah Arendt, Henri Lefebvre, and Michel Foucault on the concept of public space. What these theorists have in common is that they emphasize that the public sphere is a central concept for understanding and transforming society's political, social, and cultural structure. While Habermas sees the public sphere as the ground for democratic debates, Arendt considers this space an arena based on the visible actions of individuals. While Lefebvre argues that the public sphere is constantly reproduced by social relations and power dynamics, Foucault, on the other hand, draws attention to how the relations of power and surveillance shape this field. With the approaches of these theorists, it has been tried to associate the redefinition of the public sphere through digitalization and the transformative role of art in this process. In addition, Benediktas Gylys' Portal Project, a public artwork discussed in the axis of all these discussions, aims to strengthen cultural and social ties by combining digital sculpture and relational aesthetics. While the project aims to increase the interaction of different cultures through live video connections between cities, it also raises important ethical questions about surveillance and privacy. In addition, it has been examined that the new forms of expression and interaction methods offered by digital technologies make public spaces more dynamic and democratic and strengthen the role of art in social interactions.

The Last Point in the Evolution of Human-animal Perception and Its Reflection on the News in Turkey

The human-animal relationship has changed from time to time with the evolution of cultural history. In the theoretical part of the study, a journey from being one or brother and sister to seeing the animal as an object and from there to be reduced to a means of healing traumas is described to the extent permitted by the dimensions of the article. The main stops in this evolution are emphasized, and the structural constructions of this relationship are analyzed. Following this analysis, the discourse analysis of the news articles was carried out. Through this analysis method, it was show what the real purpose of the news articles was and where this purposes tood in the evolution described in the theoretical part. After constructing the background of the article&amp;apos;s narrative with qualitative-historical descriptions and interpretations in the theoretical part, discourse analysis was chosen as the method. Since the November 25th incident at the Konya Animal Shelter created a debate in a large segment of social institutions, four news articles from four newspapers covering the incident on the same day on the internet were selected and analyzed. The newspapers where the news items were published were identified based on their closeness to and opposition to the government. Findings on how the same news item was constructed were shown and interpreted. The attitude of the newspapers while reporting the event and the point in the evolution of the animal-human relationship were discussed. Thus, in the light of anthropological interpretations, this study has also revealed how animals are objectified in newspapers.

“The World Isn't Black and White”: Adolescent Youth of Color Reflect on School Ethnic‐Racial Climate, Context, and Identity in Middle School

ABSTRACTContemporary scholars of race contend that the long‐heralded “American Dream” rhetoric continues to thrive within the ideology of colorblindness, whereby race is deemed insignificant. Public schools are not insulated from this, and recent political assaults the teaching of “divisive” concepts have already had a chilling effect on classroom content, posing a threat to the affirmation of racially marginalized students. Using qualitative interviews, we examined the salience of ethnicity‐race and ethnic‐racial identity for students of varied ethnic‐racial groups (n = 22) in a middle school community that was ethno‐racially diverse, but where White students constituted a large segment of the population. Guided by critical race theory (CRT) and phenomenological variant of ecological systems theory (PVEST), our analyses generated five thematic categories upon which ethnicity‐race were relevant to students: learning and appreciation for diversity, ethnic‐racial identity, teacher behaviors, student treatment, and same‐race peer connections and support. Findings are discussed in terms of implications for teachers and counselors to stand in solidarity with youth in challenging hegemonic whiteness in schools.

Classification of lumbar spine disorders using large language models and MRI segmentation

BackgroundMRI is critical for diagnosing lumbar spine disorders but its complexity challenges diagnostic accuracy. This study proposes a BERT-based large language model (LLM) to enhance precision in classifying lumbar spine disorders through the integration of MRI data, textual reports, and numerical measurements.MethodsThe segmentation quality of MRI data is evaluated using dice coefficients (cut-off: 0.92) and intersection over union (IoU) metrics (cut-off: 0.88) to ensure precise anatomical feature extraction. The CNN extracts key lumbar spine features, such as lumbar lordotic angle (LLA) and disc heights, which are tokenized as direct scalar values representing positional relationships. A data source of 28,065 patients with various disorders, including degenerative disc disease, spinal stenosis, and spondylolisthesis, is used to establish diagnostic standards. These standards are refined through post-CNN processing of MRI texture features. The BERT-based spinal LLM model integrates these CNN-extracted MRI features and numerical values through early fusion layers.ResultsSegmentation analysis illustrate various lumbar spine disorders and their anatomical changes. The model achieved high performance, with all key metrics nearing 0.9, demonstrating its effectiveness in classifying conditions like spondylolisthesis, herniated disc, and spinal stenosis. External validation further confirmed the model’s generalizability across different populations. External validation on 514 expert-validated MRI cases further confirms the model’s clinical relevance and generalizability. The BERT-based model classifies 61 combinations of lumbar spine disorders.ConclusionsThe BERT-based spinal LLM significantly improves the precision of lumbar spine disorder classification, supporting accurate diagnosis and treatment planning.

A Lassa virus live attenuated vaccine candidate that is safe and efficacious in guinea pigs

Lassa virus (LASV) is a rodent-borne mammarenavirus that causes tens to hundreds of thousands of human infections annually in Western Africa. Approximately 20% of these infections progress to Lassa fever (LF), an acute disease with case–fatality rates from ≈20–70%. Currently, there are no approved vaccines or specific therapeutics to prevent or treat LF. The LASV genome consists of a small (S) segment that has two genes, GP and NP, and a large (L) segment that has two genes, L and Z. In both segments, the two genes are separated by non-coding intergenic regions (IGRs). Recombinant LASVs (rLASVs), in which the L segment IGR was replaced with the S segment IGR or in which the GP gene was codon-deoptimized, lost fitness in vitro, were highly attenuated in vivo, and, when used as vaccines, protected domesticated guinea pigs from otherwise lethal LASV exposure. Here, we report the generation of rLASV/IGR-CD, which includes both determinants of attenuation and further enhances the safety of the vaccine compared with its predecessors. rLASV/IGR-CD grew to high titers in Vero cells, which are approved for human vaccine production, but did not cause signs of disease or pathology in guinea pigs. Importantly, guinea pigs vaccinated with rLASV/IGR-CD were completely protected from disease and death after a typically lethal exposure to wild-type LASV. Our data support the development of rLASV/IGR-CD as a live-attenuated LF vaccine with stringent safety features.

A case series on caesarean myomectomy

Uterine leiomyoma is the frequently identified benign tumor and its incidence is about 10%-20% in pregnant women. Treatment of myoma during caesarean section remains a debated subject in spite of advancement in medical treatment. A patient who undergoes myomectomy during cesarean section will not require a second operation, anesthetic complications and increased expenditure. Here, we report a series of 8 cases where myomectomy was performed during caesarean section for large anterior lower segment fibroids ranging in size from 4 to 12 cms.

Extensive binding of uncharacterized human transcription factors to genomic dark matter.

Most of the human genome is thought to be non-functional, and includes large segments often referred to as "dark matter" DNA. The genome also encodes hundreds of putative and poorly characterized transcription factors (TFs). We determined genomic binding locations of 166 uncharacterized human TFs in living cells. Nearly half of them associated strongly with known regulatory regions such as promoters and enhancers, often at conserved motif matches and co-localizing with each other. Surprisingly, the other half often associated with genomic dark matter, at largely unique sites, via intrinsic sequence recognition. Dozens of these, which we term "Dark TFs", mainly bind within regions of closed chromatin. Dark TF binding sites are enriched for transposable elements, and are rarely under purifying selection. Some Dark TFs are KZNFs, which contain the repressive KRAB domain, but many are not: the Dark TFs also include known or potential pioneer TFs. Compiled literature information supports that the Dark TFs exert diverse functions ranging from early development to tumor suppression. Thus, our results sheds light on a large fraction of previously uncharacterized human TFs and their unappreciated activities within the dark matter genome.

Are We on the Same Page? Chinese General Visitors’ Perception of the Role of Museums in Sustainable Development

The issue of sustainability has emerged as a focal point within the museum sector. This article aims to investigate the perceptions and attitudes of Chinese general visitors towards museums and sustainability. To achieve this, we employed a visitor evaluation approach, with inhabitants of the Chinese mainland serving as the target population. We conducted a survey using an online questionnaire, yielding a total of 1260 valid samples. The study finds that most museum visitors in mainland China see a strong link between museums and sustainable development, with factors like age, gender, education, familiarity with sustainable development, and museum interaction shaping these perceptions. The results indicate that large segments of the Chinese visitors hold a favourable perception of the significance of museums in terms of environmental, social, economic, and cultural sustainability. However, the visitor generally does not wish to sacrifice their own visiting experience to enhance museums’ sustainable development capacities. The article examines the relationship between museums and sustainability and offers recommendations for museum practice and policymaking in China and beyond.

Mosaic chromosomal alterations (mCAs) in individuals with monoclonal B-cell lymphocytosis (MBL)

MBL is a precursor condition to chronic lymphocytic leukemia (CLL), characterized by monoclonal B-cells in blood. Mosaic chromosomal alterations (mCAs) are a form of clonal hematopoiesis that include gains, losses, and copy-neutral loss-of-heterozygosity of large DNA segments. Both MBL and mCAs have been found to increase the risk of CLL and lymphoid malignancies, and the aim of our study was to investigate how mCAs relate to MBL, which is currently unknown. We analyzed genetic, flow cytometric, and hematologic data from 4632 individuals from the Mayo Clinic Biobank and CLL Database. MBL was detected using flow cytometry and classified as high-count (HC) or low-count (LC) MBL based on clone size. mCAs were detected primarily from whole blood DNA using sensitive SNP-array-based analyses. mCAs commonly altered in CLL (deletion of 6q, 11q, 13q, 17p, and trisomy 12) were specific (>99%) to individuals with MBL and CLL. HC-MBL and LC-MBL individuals were 881-fold and 8-fold, respectively, more likely to harbor CLL-associated mCAs than those without MBL. The cell fraction bearing these mCAs typically exceeded the B-cell fraction, suggesting their origin prior to the B-cell lineage. Integrating genetic and blood count data enabled detecting HC-MBL with high specificity in a biobank sample. These results quantify the contribution of mCAs to MBL and could enable large studies of HC-MBL without the need for flow cytometric screening.

CTCF-dependent insulation of Hoxb13 and the heterochronic control of tail length

Mammalian tail length is controlled by several genetic determinants, among which are Hox13 genes, whose function is to terminate the body axis. Accordingly, the precise timing in the transcriptional activation of these genes may impact upon body length. Unlike other Hox clusters, HoxB lacks posterior genes between Hoxb9 and Hoxb13, two genes separated by a ca. 70 kb large DNA segment containing a high number of CTCF sites, potentially isolating Hoxb13 from the rest of the cluster and thereby delaying its negative impact on trunk extension. We deleted the spacer DNA to induce a potential heterochronic gain of function of Hoxb13 at physiological concentration and observed a shortening of the tail as well as other abnormal phenotypes. These defects were all rescued by inactivating Hoxb13 in-cis with the deletion. A comparable gain of function was observed in mutant Embryonic Stem (ES) cells grown as pseudoembryos in vitro, which allowed us to examine in detail the importance of both the number and the orientation of CTCF sites in the insulating activity of the DNA spacer. A short cassette containing all the CTCF sites was sufficient to insulate Hoxb13 from the rest of HoxB, and additional modifications of this CTCF cassette showed that two CTCF sites in convergent orientations were already capable of importantly delaying Hoxb13 activation in these conditions. We discuss the relative importance of genomic distance versus number and orientation of CTCF sites in preventing Hoxb13 to be activated too early during trunk extension and hence to modulate tail length.

Morphometric analysis and tortuosity typing of the large intestine segments on computed tomography colonography with artificial intelligence.

Morphological properties such as length and tortuosity of the large intestine segments play important roles, especially in interventional procedures like colonoscopy. Using computed tomography (CT) colonoscopy images, this study aimed to examine the morphological features of the colon's anatomical sections and investigate the relationship of these sections with each other or with age groups. The shapes of the transverse colon were analyzed using artificial intelligence. The study was conducted as a two- and three-dimensional examination of CT colonography images of people between 40 and 80 years old, which were obtained retrospectively. An artificial intelligence algorithm (YOLOv8) was used for shape detection on 3D colon images. 160 people with a mean age of 89 men and 71 women included in the study were 57.79±8.55 and 56.55±6.60, respectively, and there was no statistically significant difference (p= 0.24). The total colon length was 166.11±25.07 cm for men and 158.73±21.92 cm for women, with no significant difference between groups (p=0.12). As a result of the training of the model Precision, Recall, and Mean Average Precision (mAP) were found to be 0.8578, 0.7940, and 0.9142, respectively. The study highlights the importance of understanding the type and morphology of the large intestine for accurate interpretation of CT colonography results and effective clinical management of patients with suspected large intestine abnormalities. Furthermore, this study showed that 88.57% of the images in the test data set were detected correctly and that AI can play an important role in colon typing.

Quantitating SARS-CoV-2 neutralizing antibodies from human dried blood spots.

In the earliest days of the COVID-19 pandemic, the collection of dried blood spots (DBS) enabled public health laboratories to undertake population-scale seroprevalence studies used to estimate rates of SARS-CoV-2 exposure. With SARS-CoV-2 seropositivity levels now estimated to exceed 94% in the United States, attention has turned to using DBS to assess neutralizing antibodies within cohorts of interest. With this goal in mind, we generated contrived DBS (cDBS) and whole blood-derived DBS from convalescent and vaccinated individuals and subjected DBS eluates to a battery of assays, including a SARS-CoV-2 multiplexed microsphere immunoassay (MIA), a receptor binding domain (RBD)-human ACE2 inhibition assay (iACE2), a cell-based pseudovirus neutralization assay, and real-time PCR-based surrogate neutralization assay (NAB-Sure). The DBS results were benchmarked against paired serum samples tested in a clinically validated SARS-CoV-2 plaque reduction neutralization titer (PRNT) assay. The results of an 8-plex MIA and NAB-Sure assays demonstrated highly significant correlations with PRNT values when evaluated with a panel of 86 paired serum-DBS samples. Both the MIA and NAB-Sure are adaptable to automated liquid handlers for high-throughput capacity. While neutralizing assays were limited to the ancestral SARS-CoV-2 WA1, this study nonetheless represents an important proof of concept demonstrating the potential utility of DBS as a biospecimen type for use in assessing immunity to SARS-CoV-2 at the community and population levels.IMPORTANCESARS-CoV-2 variants of concern continue to circulate globally and remain a serious health threat to large segments of the population. From a public health standpoint, identifying vulnerable communities based on immune status is critical in terms of vaccine booster recommendations. In this report, we investigated the utility of dried blood spots (DBS) as a biospecimen type from which to estimate SARS-CoV-2 neutralizing antibody titers. Using contrived and whole blood-derived DBS, we demonstrate that SARS-CoV-2 neutralizing antibodies are readily measurable in DBS eluates and correlate with plaque reduction neutralization titer (PRNT) values from paired serum samples. Moreover, several of the methods used to estimate SARS-CoV-2 neutralizing antibodies in DBS eluates are adaptable to high-throughput platforms.

Girlcore: the Right Way to be Female? Examining the Effect of Choice Feminism on What it Means to be a 'Woman' through the Language and Trends of Tiktok

Since the beginning of the 2010s and the advent of what many call the fourth wave of feminism, “choice feminism” has accounted for an increasingly large segment of people who call themselves “feminists”. This movement can widely be observed through commentary on femininity on social media such as TikTok and women choose to use the platform. Since the rise of TikTok in 2020 many different trends and debates have appeared in relation to what it means to be a “girl” or “woman”, and these instances can be observed and analysed to ask a larger question of what being female and identifying as such means in the modern era and years to come. In a world more and more defined by our online presence and the use of social media, there is a landscape in which there is increasing desire to market oneself. In using micro-labels, micro-labels here referring to the hyper-specific aesthetic or identity related categories that have risen in popularity over the last couple years on social media (Sojit Pejcha, 2023), we transform ourselves from human beings to concepts. This process seems to be specifically taken up by women who exercise their “choice” to objectify themselves in a radical new way; something that I argue is much more comfortable than having to deal with the true acceptance of the human experience and what it means to be a woman.

Multi-targets cleavage of BmNPV genome through genome-wide repeat sequence using CRISPR/Cas9 antiviral system.

The escalating severity of Bombyx mori nuclear polyhedrosis virus (BmNPV) infections poses significant challenges to the silkworm industry, especially when massive production shifts occur from the eastern regions to western regions with lower labor costs. Education and experience levels are different and disease control is badly needed. To solve the problems, we have developed an innovative CRISPR/Cas9 system specifically targeting BmNPV to enhance viral resistance. For the system, we selected BmNPV genes linked to virus replication and proliferation as targets, designing 2 sites for each gene. Mutating the target sequence renders the system incapable of efficiently cleaving the virus genome, hence decreasing cleavage efficiency. We conducted a search for "NGG" or "CCN" target sequences in the BmNPV genome, excluding non-recurring and potential targets in the B.mori genome. We successfully identified 2 distinct target sequences in the BmNPV genome-one being repeated 12 times and the other three times. These sequences lead to fragmentation of virus genome into multiple large segments that are difficult to repair. Transgenic silkworms demonstrate robust resistance to viruses, significantly boosting their survival rates compared with wild-type silkworms under various virus infection concentrations. Our system efficiently targets dozens of viral genomes with just 2 sequences, minimizing transposable elements while ensuring cutting effectiveness. This marks a pioneering advancement by using repetitive elements within the virus genome for targeted CRISPR cleavage, aiming for antiviral effects through genome fragmentation rather than disrupting essential viral genes. Our research introduces innovative concepts to CRISPR antiviral investigations and shows promise for the practical application of gene editing in industrial silkworm strains.

Study on the influence of the sY1192 gene locus in the AZFb/c region on sperm quality and pregnancy outcome.

Y chromosome microdeletions are an important cause of male infertility. At present, research on the Y chromosome is mainly focused on analyzing the loss of large segments of the azoospermia factor a/b/c (AZFa/b/c) gene, and few studies have reported the impact of unit point deletion in the AZF band on fertility. This study analyzed the effect of sperm quality after sY1192 loss in 116 patients. The sY1192-independent deletion accounted for 41.4% (48/116). Eight patterns were found in the deletions associated with sY1192. The rate of sperm detection was similar in the semen of patients with the independent sY1192 deletion and the combined sY1192 deletions (52.1% vs 50.0%). The patients with only sY1192 gene loss had a higher probability of sperm detection than the patients whose sY1192 gene locus existed, but other gene loci were lost (52.1% vs 32.0%). The hormone levels were similar in patients with sY1192 deletion alone and in those with sY1192 deletion and other types of microdeletions in the presence of the sY1192 locus. After multiple intracytoplasmic sperm injection (ICSI) attempts, the pregnancy rate of spouses of men with sY1192-independent deletions was similar to that of other types of microdeletions, but the fertilization and cleavage rates were higher. We observed that eight deletion patterns were observed for sY1192 microdeletions of AZFb/c, dominated by the independent deletion of sY1192. After ICSI, the fertilization rate and cleavage rate of the sY1192-independent microdeletion were higher than those of other Y chromosome microdeletion types, but there was no significant difference in pregnancy outcomes.