Over the last few years, community empowerment has become a central focus when discussing the sustainability of large-scale urban regeneration processes, especially those related to the implementation of nature-based solutions. In this article, the authors describe the experience of the CLEVER Cities project in the city of London, by looking at the dynamics of the early stages of co-creation and the implications on co-governance, motivation and policy. Particular attention is given to the importance of carefully evaluating the project context to guide where emphasis is given on the use of specific co-creation strategies such as building trust, raising awareness or networking. In this case, a set of strategies emerge that are a response to several factors but are strongly influenced by the backdrop of limited social structuring encountered in South Thamesmead, South London. The methods are derived based on a qualitative and looped observation approach over three phases applied to three urban living labs in the project area. Finally, to structure the results, an iterative co-production of knowledge approach is used to cluster the strategies into ten more synthetic recommendations based on collaborative governance, communication and capacity building, as well as incentives and motivation. Further, guidance is given by highlighting priorities to inform policy and place-based planning actions.