Southeast Asia is an essential region for companies carrying out large-scale land acquisitions (LSLAs). Exploring the distribution patterns and influencing factors of LSLA projects in this region is of great practical significance for summarizing the characteristics of LSLA projects in Southeast Asia, for gaining a thorough understanding of LSLA project development rules, and for formulating reasonable policies to guide local LSLA projects. This study explores the spatial distribution and influencing factors of LSLA projects in Southeast Asia using the mean center method, the kernel density estimation method, and the grey correlation method. The findings indicate the following: Firstly, the majority of LSLA projects in Southeast Asia are located in the Indo-China Peninsula, Cambodia, Myanmar, Laos, and other countries, which represent significant regions of interest for LSLA projects in this region. Secondly, the spatial distribution of LSLA intention projects and LSLA contract projects in Southeast Asia is similar, whereas LSLA production projects differ from the former two. Thirdly, the scale of LSLA projects in Southeast Asia is closely related to the host country’s natural resources, socio-economic conditions, governance, and market environment. The total GDP, per capita arable land area, net foreign direct investment inflow, and political stability have been identified as exerting a significant influence on investment corporations’ selection of LSLA host countries.