Sindh province of Pakistan has a long history of severe droughts. Several large scale climate drivers (LSCD) are known for their effect on precipitation worldwide but studies in the Sindh region are missing; wide variety of LSCDs and lagged associative information. This study aimed to identify the significant LSCDs in Sindh province of Pakistan and improve the forecast skill of monthly precipitation by employing the principal component analysis (PCA), artificial neural network (ANN), Bayesian regularization neural network (BRNN), and multiple regression analysis (MRA), while considering the 12 months lagged LSCDs such as Nino-1+2, Nino-3, Nino-3.4, Nino-4, Quasi-Biennial Oscillation (QBO) at 30 and 50hPa (QBOI and QBOII), sea surface temperature (SST), 2m air temperature (T2M), 500 hPa and 850 hPa geopotential heights (H500 and H850), surface and 500 hPa zonal velocity (SU and U500), latent and sensible heat fluxes over land (LHFOL and SHFOL), and surface specific humidity (SSH). Global Land Data Assimilation System (GLDAS), Tropical Rainfall Measuring Mission (TRMM), ModernEra Retrospective Analysis for Research and Application (MERRA-2), NOAA, Freie University Berlin, and Hadley Centre Sea Ice and Sea Surface Temperature (HadISST) datasets were used. Results manifested that significant LSCDs with 99% confidence level were SU, U500, T2M, SST, SHFOL, LHFOL, SSH, and H850. During test period, compared with MR models of 0.39 to 0.64 and principal components of 0.31 to 0.57, the ANN and BRNN models had better predictive skills with correlation coefficients of 0.57 to 0.83 and 0.52 to 0.76, respectively. It can be concluded that the ANN and BRNN models enable us to predict monthly precipitation in Sindh region with lagged LSCDs.
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