Context. Studies of gravitational microlensing effects require the estimation of their detection efficiency as soon as one wants to quantify the massive compact objects along the line of sight of source targets. This is particularly important for setting limits on the contribution of massive compact objects to the Galactic halo. These estimates of detection efficiency must not only account for the blending effects of accidentally superimposed sources in crowded fields, but also for possible mixing of light from stars belonging to multiple gravitationally bound stellar systems. Aims. Until now, only blending due to accidental alignment of stars had been studied, in particular as a result of high-resolution space images. In this paper, we address the impact of unresolved binary sources that are physically gravitationally bound and not accidentally aligned, in the case of microlensing detection efficiencies toward the Large Magellanic Cloud (LMC). Methods. We used the Gaia catalog of nearby stars to constrain the local binarity rate, which we extrapolated to the distance of the LMC. Then we estimated an upper limit to the impact of this binarity on the detection efficiency of microlensing effects, as a function of lens mass. Results. We find that a maximum of 6.2% of microlensing events on LMC sources due to halo lenses heavier than 30 M⊙ could be affected as a result of the sources belonging to unresolved binary systems. This number is the maximum fraction of events for which the source is a binary system separated by about one angular Einstein radius or more in a configuration where light-curve distortion could affect the efficiency of some detection algorithms. For events caused by lighter lenses on LMC sources, our study shows that the chances of blending effects by binary systems is likely to be higher and should be studied in more detail to improve the accuracy of efficiency calculations.