Groundwater behaviors in lake-floodplain systems are dynamic and complex; in particular, the role of groundwater flux in regulating lake water storage subject to strong seasonal variation is not well understood. This study addresses the contribution of groundwater flux in a large floodplain system (Poyang Lake, China), with focus on quantifying the groundwater-lake interactions at multiple time scales in high rainfall (2010) and low rainfall (2011) years using a groundwater flow model (MODFLOW). Simulated results revealed that the unconfined aquifer received approximately 8 % of the annual rainfall as groundwater recharge. Fluctuations in shallow groundwater and lake water level reflected hydraulic synchronization and hysteresis. Additionally, the diurnal variability in the groundwater-lake exchange fluxes was subject to dynamic and bidirectional patterns, and a time lag between the water exchange and rainfall was also found. For 2010 and 2011, the monthly net flux of lake infiltration into groundwater was 1.5-10.0 mm and 0.1-6.0 mm and groundwater exfiltration into lake was 1.3-9.5 mm and 0.4-2.2 mm, respectively, demonstrating a significant variation of the exchange magnitude and direction. In particular, we found that groundwater exfiltration contributed up to 55 % of lake storage change in February of 2011. The outcomes from this study indicate that groundwater can be a major component of the Poyang Lake's water balance, which suggests an important role of groundwater in regulating the lake water storage and perhaps other flood pulse systems.