Large Ethnic Population Research Articles

Ethnobiological study of Tumpeng, traditional food in Surakarta City, Central Java, Indonesia

Abstract. Septhia ND, Izdihar NS, Destiani NFL, Rindiani N, Izdihar RS, Setyawan AD. 2024. Ethnobiological study of tumpeng, traditional food in Surakarta City, Central Java, Indonesia. Asian J Ethnobiol 7: 61-67. The Javanese ethnic group, which is the largest ethnic population in Indonesia, shows its cultural richness through a variety of traditional foods, one of which is tumpeng. This research aims to find out information about each ingredient in tumpeng, the meaning of tumpeng in various Javanese traditions or ceremonies, and the knowledge of the people in Surakarta City, Central Java, Indonesia regarding this tradition through ethnobotanical studies. The research method used was observation and interviews with the people of Surakarta City regarding the Tumpengan tradition. Of the 60 respondents from Baluwarti, Kauman, and Mojosongo Villages in Surakarta City, the majority, especially 42 people, showed a "somewhat understand" level of understanding of tumpeng. The locals mention at least 19 plants and 3 animals often used as ingredients in tumpeng, such as coconut, water spinach, spinach, yarlong beans, mung bean sprouts, carrots, cucumber, cabbage, as well as chicken meats and eggs, milkfish, and anchovies. Tumpeng and each food element on it has a deep symbolic meaning for the community which is related to the relationship between humans and God, humans and nature, and humans and humans. For example, side dish such as chicken symbolizes gratitude and peace given by God, and cone-shaped rice shows the hope that there must always be progress and improvement in every life.

The NICHD Fetal 3D Study: A Pregnancy Cohort Study of Fetal Body Composition and Volumes.

There's a paucity of robust normal fractional limb and organ volume standards from a large and diverse ethnic population. The Fetal 3D Study was designed to develop research and clinical applications for fetal soft tissue and organ volume assessment. The NICHD Fetal Growth Studies (2009-2013) collected 2D and 3D fetal volumes. In the Fetal 3D Study (2015-2019), sonographers performed longitudinal 2D and 3D measurements for specific fetal anatomical structures in research ultrasounds of singletons and dichorionic twins. The primary aim was to establish standards for fetal body composition and organ volumes, overall and by maternal race/ethnicity, and determine whether these standards vary for twins versus singletons. We describe the study design, methods, and details about reviewer training. Basic characteristics of this cohort, with their corresponding distributions of fetal 3D measurements by anatomical structure, are summarized. This investigation is responsive to critical data gaps in understanding serial changes in fetal subcutaneous fat, lean body mass, and organ volume in association with pregnancy complications. In the future, this cohort can answer critical questions regarding the potential influence of maternal characteristics, lifestyle factors, nutrition, and biomarker and chemical data on longitudinal measures of fetal subcutaneous fat, lean body mass, and organ volumes.

Ethnonationalism and the changing pattern of ethnic Kazakhs’ emigration from China to Kazakhstan

Amid the post-Cold War global revival of ethnonationalism, Kazakhstan – a newly independent state born out of the collapse of the Soviet Union – launched its ‘ethnic repatriation programme’, encouraging ethnic Kazakhs from outside Kazakhstan to ‘return home’. China has a large ethnic Kazakh population and shares a border of more than 1500 km with Kazakhstan in Xinjiang. Since the 1990s, over 150,000 ethnic Kazakhs originally from China have chosen to emigrate to Kazakhstan. Sketching China’s and Kazakhstan’s state policies toward ethnic Kazakh migration since the 1990s, this article addresses how different factors and rationales have shaped individuals’ decisions to emigrate to Kazakhstan or to stay in China. The article relies upon available, multilingual data and over 30 in-depth interviews with respondents in both Kazakhstan and China. We argue that, for ethnic Kazakhs emigrating from China to Kazakhstan, socio-economically and environmentally based rationales, including perceptions of developmental prospects, social welfare benefits and social ties were most salient during the 2000s. However, since the late 2000s, politico-culturally based rationales, such as ethno-nationalism, Kazakh linguistic and cultural concerns, educational opportunities, and other factors have become increasingly salient especially during the 2010s.

Testimonios of Latino Male Preservice Teachers as Models for Caring and Bilingualism


 
 
 This qualitative study of three Latino male preservice teachers in a bilingual education preparation program centers on the use of testimonio as a methodology to give voice to the complex experiences of young Latinos as they navigate their way through career choices and college. While work on male teachers has historically focused on white men and more recently black men, Latinos represent a very large ethnic population in the United States with varied histories, cultural practices, and linguistic practices. While caring has been conflated as a practice of female teachers, the young men in this study illustrate an ethic of care that is more complex than that of affect. Their care is directly tied to their willingness to pay forward their learning and experiences to other Latino children by way of teaching in bilingual programs. The findings of this research illustrate the complex terrain that these young men navigate as they decide on a career in a historically white and female profession. This study offers implications for in-service teachers and their role in cultivating the next generation of male teachers. For universities and colleges of education, this study offers insight into the institutional challenges and support systems these Latino men must circumnavigate.
 
 

CFTR mutational screening by next-generation sequencing reveals novel variants and a high carrier rate in a Middle Eastern population.

Cystic fibrosis is the most common life-limiting autosomal recessive disease in western countries with an incidence of 1:2500 in United States and 1:1000 in some European countries. Similar incidences were noted for the Middle East with variations from 1 in 2560 to 1 in 15,876 according to the degree of consanguinity. This is a preliminary systematic study that aims to assess the incidence and carrier rate of cystic fibrosis in the Middle Eastern Lebanese population; known for a high frequency of consanguinity. One hundred thirteen DNA samples were collected from neonatal blood cards obtained from newborns to healthy unrelated families with no previous history of Cystic fibrosis. Screening for Cystic Fibrosis-causing pathogenic variants was performed using next generation sequencing, and 17 different single nucleotide variants were detected, including six pathogenic and likely pathogenic. 5.5%-7% newborns were found to be carriers of a variant strongly suggestive of pathogenicity and comparable to published literature worldwide. This pilot analysis highlights the challenging interpretation of CFTR variants in a country underrepresented by large ethnic population analyses, and stresses the importance of premarital screening programs for Cystic fibrosis.

Russia–Kazakhstan Relations in the Early Post-Soviet Era: Explaining the Roots of Cooperation

After the collapse of the Soviet Union, Kazakhstan was faced with domestic conditions that made cooperation with Russia rational. Kazakhstan inherited a large ethnic Russian population and a severe economic depression. These conditions affected other countries emerging from the Soviet Union, but only Belarus matched Kazakhstan’s level of strategic cooperation with Russia. President Nursultan Nazarbaev’s dominance of Kazakhstan’s national security agenda offers a partial explanation for the cooperation, but we still need to ask what makes him different from the leaders of other post-Soviet countries that faced the same conditions. Kazakhstan’s pattern of historical development provides the key to understanding the cooperation. The timing of the country’s contact and experiences with the Russian-led empires led to a ‘dominant ally’ image of Russia that continues to decide the two countries’ relationship to the present day.

Why Isn’t Latvia the “Next” Crimea? Reconsidering Ethnic Integration

In the aftermath of Russia's military incursion in Ukraine and the annexation of Crimea in 2014, a flurry of articles predicted the next territorial conquest of President Vladimir Putin's Russian revanchism. High on the list were the Baltic countries, which sit precariously on the edge of Europe and historically have been the “bloodlands” between East and West in author Timothy Snyder's phrasing. More specifically, journalists and analysts pointed to the “Russian enclaves” in northeastern Estonia and southeastern Latvia, where, by many accounts, large ethnic Russian populations were prepared to rise up against Baltic governments with a bit of provocation from across the eastern border. However, six years on, there is little indication that Russian speakers in the Baltic countries are on the brink of causing an internal uprising. While there are multiple factors that can help explain the Baltic “dog that didn’t bark,” this essay considers an often overlooked variable in the equation: the depth of civic and cultural integration among Russian speakers in Latvia.

PILOT OUTCOMES OF A COMMUNITY-BASED FALLS PREVENTION PROGRAM TARGETING OLDER ARAB AMERICANS

Arab American (AA) is the 3rd largest ethnic population in the state of Michigan. Previous studies found that Michigan Arabs were less healthy than the general population in Michigan. Older AAs have higher mortality risk than non-Arab and non-Hispanic Whites, particularly due to chronic diseases. Community-based programs are an effective approach to prevent disease and injury, improve health, and enhance quality of life. While evidence for functional gains resulting from Tai Chi exercise is accumulating, there is little research and support for its feasibility and effectiveness that target older AAs, who are not culturally related to Tai Chi. Participants in this report were 8 older female AAs (mean age 62.4±3.2, range 58-66) who sought services at a not-for-profit Arab Community Center, which aims to enable and empower residents and communities to lead informed, productive and culturally sensitive lives. A certified Tai Chi instructor led the classes using Yang-style Tai Chi moves. The participants completed a 12-week twice-weekly 1-hour Tai Chi classes and post-program focus group discussion, held in a classroom of the Community Center. Post-intervention improvement in timed up & go test (p>.05), comfortable & fast gait speed (p>.05), unipedal stance time (p>.05) were observed. Themes identified from focus group supported Tai Chi’s benefits in balance and salient mental health benefits. The pilot data provides preliminary evidence for therapeutic gains resulting from Tai Chi practices. Agencies serving older AAs play important roles by creating and promoting evidence-based health promotion practices to address the growing needs among older adults.

On the origins of the Sakhas' paternal lineages: Reconciliation of population genetic / ancient DNA data, archaeological findings and historical narratives

Sakhas are Turkic-speaking people from Northeastern Siberia, constituting the largest ethnic population in Yakutia. According to popular legends, two heroes who arrived from the Asian Steppe during the late medieval ages, namely Elley Bootur and Omogoy Baay, are the progenitors of all Sakhas. While there is ample historical evidence towards the existence of such legendary characters, archaeological findings and ancient DNA studies provide further insights on actual Sakha ethnogenesis. This study aims to establish the genetic basis of the legendary characters Elley and Omogoy, at least through their paternal lineages, and then to reveal the prevalence of these Y-chromosomes among the contemporary Yakut population. To this end, an attempt was made to delineate fact from fiction with respect to the Sakhas’ paternal lineages through a reconciliation of population genetics data on contemporary and ancient Sakhas, along with archaeological evidence and well-recorded historical narratives. To achieve this, 17-loci Y-chromosomal STR and haplogroup analyses were conducted on a contemporary Sakha who was presumably a direct descendant of Elley’s paternal line. Furthermore, 367 Sakha Y-chromosomal STR haplotypes were compiled from the literature and elsewhere, and searched against the Y-chromosome STR Haplotype Reference Database to find potential matches with non-Sakha populations. Sakhas’ paternal lineages were found to comprise 6 major descent clusters, each corresponding to an ancient clan. The most prevalent haplotype indeed corresponded to that of the contemporary Elley descendant. Furthermore, data presented in the current work suggests a Khitan origin for this paternal line. As shown before, Sakhas’ paternal lineages were found to be very homogenous and exhibit signs of a strong population bottleneck. Reconciled genetic and archaeological data agree well with Sakhas’ historical narratives, whereby, at least from a paternal lineage perspective, only a few individuals may have arrived from Central Asia and had reproductive success that led to the Sakha Y-chromosomal diversity today.

Analysis of genetic polymorphism of methylenetetrahydrofolate reductase in a large ethnic Hakka population in southern China.

Methylenetetrahydrofolate reductase (MTHFR) catalyzes conversion of methylene tetrahydrofolate to methylte trahydrofolate. MTHFR C677T polymorphism has been regarded as a risk factor for various vascular diseases. Our study aimed to investigate the distribution frequencies of this polymorphism among Hakka population living in southern China. We retrospectively recruited 5102 unrelated Chinese Hakka subjects. MTHFR C677T polymorphism was tested using the polymerase chain reaction (PCR) and DNA sequencing. A total of 2358 males and 2744 females (aged from 10 years to 101 years) were included in this study. In total, 2835 (55.63%) subjects were homozygous for the C allele (CC), 1939 (38.00%) subjects were heterozygous (CT), and 325 (6.37%) subjects were homozygous for the T allele (TT). The allelic frequency of mutant T was 25.37% with 325 individual homozygous for this defective allele resulting in a frequency of about 6.37% for the TT genotype. According to the study results, the overall frequency of MTHFR C677T genotypes did not differ significantly among the gender and age groups. Our study showed the prevalence of MTHFR C677T polymorphism in a large ethnic Hakka population living in southern China. It would be important implications for the primary prevention of various vascular diseases.

Molecular analysis of hemoglobinopathies in a large ethnic Hakka population in southern China.

Thalassemia is an inherited autosomal recessive disorder with microcytic hypochromic anemia resulting from reduced or absent synthesis of 1 or more of the globin chains of hemoglobin. This study provided the insight into prevalence and molecular characterization of thalassemia in Hakka population. 14,524 unrelated subjects were included in our study from January 2015 to November 2017. All the subjects were detected by hematological analysis, hemoglobin electrophoresis analysis, and molecular diagnosis (gap-polymerase chain reaction and flow-through hybridization technology). Data analysis was used to compare allele frequencies between the Hakka populations. Seven thousand four hundred twenty-two cases of microcytosis were found. The percentage of microcytosis in Meizhou, Ganzhou, and Heyuan was 50.91% (6738/13,236), 51.27% (445/868), and 56.90% (239/420), respectively. A total of 5516 mutant chromosomes were identified, including 3775 α-thalassemia and 1741 β-thalassemia. --SEA/αα was the most common α-thalassemia genotype, followed by -α3.7/αα and -α4.2/αα, accounted for 84.92% of α-thalassemia genotypes. Twelve kinds of mutations and 26 genotypes in β-thalassemia were found. IVS-II-654(C→T), CD41-42(-TCTT), −28(A→G), and CD17(A→T) alleles accounted for 92.65% of these mutations. IVS-II-654/N, CD41-42/N, -28/N, CD17/N genotypes accounted for 91.53% of β-thalassemia genotypes. 27 fetuses with at-risk pregnancies were subjected to prenatal diagnosis. Five fetuses were Bart's hydrops syndrome and 2 fetuses with β-thalassemia major. There were some differences in molecular characterization of thalassemia among Hakka people in different areas of southern China. Our results enriched the related information of thalassemia in the region, which provided valuable references for the prevention and control of thalassemia.

IN VITRO ANTIOXIDANT POTENTIAL AND HEPATOPROTECTIVE ACTIVITY OF TAXUS WALLICHIANA

Objectives: Taxus wallichiana, the member of family Taxaceae is used for the cure of various ailments by a large ethnic population native to the forests in Kashmir valley. The aim of this study is to evaluate antioxidant potential and hepatoprotective action of T. wallichiana as claimed by the ethnic population segment. Methods: Antioxidant potential of different T. wallichiana extracts was evaluated by estimating the total phenolics, 1,1-diphenyl -2-picrylhydrazyl (DPPH), reducing power, microsomal lipid peroxidation (LPO), and hydroxyl radical scavenging activity through standard protocols. Hepatoprotective activity of T. wallichiana was determined by evaluation of liver marker enzyme (aspartate transaminase, alanine transaminase, and alkaline phosphatase) levels using standard protocols and by histological analysis of rat liver tissues of different animal groups against CCl4 induced liver damage. Results: Phenolic content expressed as gallic acid equivalents (GAE/g) was found maximum in case of ethanolic extract (153.34 mg GAE/g), followed by extracts of methanol (149.24 mg GAE/g), hexane (134 mg GAE/g), ethyl acetate (128.9 mg GAE/g), chloroform (121.37 mg GAE/g), and aqueous (113.00 mg GAE/g). At concentration of 700 μg/ml, DPPH radical scavenging activity of methanol extract was 88.29% with IC50 (212.00 μg/ml), aqueous (82.47%) with IC50 (258.29 μg/ml), and ethyl acetate (79.57%) with IC50 (301.80%μg/ml). The reducing power of the extracts increased in a concentration dependent manner. At concentration of 700 μg/ml, 79%, 68%, and 56% inhibition was observed with extracts of methanol, aqueous, and ethyl acetate on microsomal LPO with IC50 values of 126.09, 168.83, and151.96 μg/ml, respectively. Superoxide radical scavenging activity of T. wallichiana extracts increased in a dose-dependent manner with IC50 values 170.30 μg/ml (methanol), 257.00 μg/ml (aqueous), and 297.55 μg/ml ethyl acetate extract. T. wallichiana extracts exhibited antioxidant effects on calf thymus DNA damage. The results further depict the hepatoprotective action of T. wallichiana extract at doses of 100 and 300 mg/kg and were comparable with that of standard treatment comprising 50 mg/kg-day of Vitamin C, a known hepatoprotective agent. The data were substantiated with histopathological studies of rat liver sections. Conclusion: These results comprehensively depict that T. wallichiana extracts are endowed with the free radical sequestering potential and be employed as potential antioxidant and hepatoprotective arsenal against many oxidative stress linked diseases.

Analysis of SLCO1B1 and APOE genetic polymorphisms in a large ethnic Hakka population in southern China.

Statins are the most widely used lipid-lowering drugs, which have a significant effect on the inhibition of cardiovascular disease. The efficacy and side effects of statins are associated with the polymorphisms of SLCO1B1 and APOE genes. The purpose of this study was to analyze the SLCO1B1 and APOE gene polymorphisms in the Hakka population of southern China. A total of 3249 subjects including 2019 males and 1230 females participated in this study. Polymerase chain reaction (PCR)-fluorescence probe technique for polymorphisms analysis and analyzed the genotypes frequencies of SLCO1B1 and APOE genes. The frequencies of SLCO1B1 521T>C between men and women were statistically significant (SLCO1B1 521TT, χ2 =8.431, P=.004; SLCO1B1 521TC, χ2 =7.436, P=.007). The frequencies of haplotypes *1b/*1b (40.07%) and *1a/*1b (32.56%) of SLCO1B1 gene accounted for 72.63%, followed by *1b/*15(14.40%), *1a/*1a (5.82%), *1a/*15 (5.57%), *15/*15 (1.45%), and *1a/*5 (0.12%). The frequencies of haplotypes *1a/*15 and *1b/*1b of SLCO1B1 gene between men and women were statistically significant (*1a/*15, χ2 =6.789, P=.009; *1b/*1b, χ2 =3.998, P=.004). In this study, genotype ɛ3/ɛ3 accounted for 69.04%, followed by ɛ3/ɛ4 (16.19%), ɛ2/ɛ3 (11.60%), ɛ2/ɛ4 (1.35%), ɛ4/ɛ4 (1.08%), and ɛ2/ɛ2 (0.74%) in all subjects, in which ɛ3 had the greatest allele frequency (82.93%), followed by ɛ4 (9.85%) and ɛ2 (7.22%). We found that 47 subjects carrying the SLCO1B1 521 (CC) polymorphism who had not any myopathy caused by statins. We analyzed the SLCO1B1 and APOE gene polymorphisms in the Hakka population of southern China. This study provides a reference for the individualized meditation for Hakka population in this area.

Analysis of apolipoprotein E genetic polymorphism in a large ethnic Hakka population in southern China.

There is currently no data about the genetic variations of APOE in Hakka population in China. The aim of this study was to analyze the allelic and genotypic frequencies of APOE gene polymorphisms in a large ethnic Hakka population in southern China. The APOE genes of 6,907 subjects were genotyped by the gene chip platform. The allele and genotype frequencies were analyzed. Results showed that the ∊3 allele had the greatest frequency (0.804) followed by ∊2 (0.102), and ∊4 (0.094), while genotype ∊3/∊3 accounted for 65.43% followed by ∊2/∊3 (15.85%), ∊3/∊4 (14.13%), ∊2/∊4 (3.01%), ∊4/∊4 (0.84%), and ∊2/∊2 (0.74%) in all subjects. The frequencies of the ∊4 allele in Chinese populations were lower than Mongolian and Javanese, while the frequencies of the ∊2 allele were higher and ∊4 allele lower than Japanese, Koreans, and Iranian compared with the geographically neighboring countries. The frequencies of ∊2 and ∊4 alleles in Hakka population were similar to the Vietnamese, Chinese-Shanghai, Chinese-Kunming Han and Chinese-Northeast, and French. The frequency of ∊2 in Hakka population was higher than Chinese-Dehong Dai and Chinese-Jinangsu Han. The low frequency of the APOE ∊4 allele may suggest a low genetic risk of Hakka population for cardiovascular disease, Alzheimer’s disease, and other diseases.

Estimation of stature from hand and handprint measurements in Iban population in Sarawak, Malaysia and its applications in forensic investigation

Handprints and dismembered hands are commonly found during crime scene investigations and disaster victim identifications, respectively. It has been indicated that the accuracy of handprint and hand measurements for estimating stature maybe population specific. Since Iban is the largest ethnic population in Sarawak, Malaysia and because the application of anthropometry of hand and handprint within this population as well as other populations within the Southeast Asian countries remain unreported, this present study that investigated the reliability and accuracy of these two anthropometric aspects acquires forensic significance. Upon measuring the height, 21 measurements were recorded on each hand and the corresponding handprint of 50 male and 52 female consented adult Iban subjects. Using univariate statistics as well as simple and multiple regression analyses, interpretation of the measurements examined here was attempted. Results revealed that lengths of hand and handprint are the more reliable traits for estimating stature in both the male and female Iban subjects (p < 0.05) with correlation strength ranging from 0.60 to 0.76. Comparable to the established skeletal standards for hand, the stature prediction accuracy using hand and handprint measurements investigated in this research ranged between 4.29 and 5.78 cm. Hence, this research provided the first forensic standard for estimation of stature among the Iban population in Sarawak that may prove useful for crime scene investigations and disaster victim identifications in Malaysia.

Association between nonsteroidal anti-inflammatory drugs use and risk of central nervous system tumors: a dose-response meta analysis.

Although studies have examined the association between nonsteroidal anti-inflammatory drugs (NSAIDs) use and central nervous system (CNS) tumors risk, the results are inconclusive. Here, we conducted a dose-response meta-analysis in order to investigate the correlation between NSAIDs use and CNS tumors risk. Up to July 2017, 12 studies were included in current meta-analysis. NSAIDs use was significantly associated with a lower risk of CNS tumors. Furthermore, non-aspirin NSAIDs or aspirin use are significantly associated with a lower risk of CNS tumors. Additionally, NSAIDs use was associated with significantly a lower risk of glioma, glioblastoma but not meningioma. Subgroup analysis showed consistent findings. Furthermore, a significant dose-response relationship was observed between NSAIDs use and CNS tumors risk. Increasing cumulative 100 defined daily dose of NSAIDs use was associated with a 5% decrement of CNS tumors risk, increasing NSAIDs or non-aspirin NSAIDs or aspirin use (per 3 prescriptions increment) was associated with a 7%, 7%, 10% decrement of CNS tumors risk, increasing per 2 year of duration of NSAIDs or non-aspirin NSAIDs or aspirin use was associated with a 6%, 8%, 6% decrement of CNS tumors risk. Considering these promising results, NSAIDs use might provide helpful for reducing CNS tumors risk. Large sample size and different ethnic population are warranted to validate this association.

Tumor necrosis factor-alpha gene -308G > A polymorphism alters the risk of hepatocellular carcinoma in a Han Chinese population.

BackgroundThe aim of the present study was to evaluate the influence of tumor necrosis factor-alpha (TNF-α) −308 G > A polymorphism on hepatocellular carcinoma (HCC) risk.MethodsThe present case–control study was conducted in a Han Chinese population consisting of 753 HCC patients and 760 controls from May 2010 to March 2013. The −308 TNF-a promoter polymorphisms were detected. Conditional logistic regression was performed to analyze the association between TNF-α −308 G > A polymorphism and the risk of HCC, which were estimated by odds ratios (ORs) and their 95% confidence intervals (95% CIs).ResultsThe genotypic frequencies in the cases were not similar to that of the controls, differences being statistically significant (P = 0.002). Using the GG genotype as the reference genotype, AA was significantly associated with increased risk of HCC (adjusted OR = 5.12, 95% CI = 2.31–7.82). Similarly, AG + AA genotype showed 5.59-fold increased HCC risk in a dominant model. Furthermore, we found A allele was significantly associated with increased risk of HCC, compared with G allele (OR = 4.18, 95% CI = 1.76–6.97).ConclusionThe present study showed that TNF-α −308 G > A polymorphism was associated with increased HCC risk in a Han Chinese population. Further prospective studies on large and different ethnic populations will be necessary to confirm our findings and elucidate the underlying molecular mechanism for the development of HCC.Virtual SlidesThe virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/13000_2014_199

Left ventricular hypertrophy and risk reclassification for coronary events in multi-ethnic adults

Left ventricular hypertrophy (LVH) has not been evaluated for reclassification improvement in the intermediate Framingham risk category for incident hard coronary events in a large multi ethnic population free of cardiovascular disease at baseline. A post-hoc analysis on the Multi Ethnic Study of Atherosclerosis (MESA) dataset (n = 4921) was performed. LVH was defined as the upper 95 th percentile of cardiac magnetic resonance imaging derived left ventricular mass (LVM) indexed based on body surface area (BSA) and height. Multivariate Cox proportional hazards models were used to assess the independent association between LVH and composite outcomes like all cardiovascular disease (CVDa) and hard coronary heart disease (CHDh) events over a mean follow-up period of 4.5 years. To assess the incremental value of LVH over traditional CV risk factors for CHDh prediction, we compared the discrimination, calibration and net reclassification index (NRI) of models comprising of traditional CV risk factors with and without LVH. LVH derived from LVM indexed by BSA (LVH-BSA) and height(1.7)(LVH-height) showed an independent association with CVDa (LVH-BSA: hazard ratio (HR) 1.52, 95% confidence interval (CI) 1.05-2.20, p = 0.03; LVH-height(1.7): HR 1.58, 95% CI 1.14-2.18, p = 0.012) and CHDh (LVH-BSA: HR 2.36, 95% CI 1.37-4.04, p = 0.002; LVH-height(1.7): HR: 1.95, 95% CI: 1.17-3.26, p = 0.01). Addition of LVH to the model based on traditional CV risk factors demonstrated no significant improvement in NRI for CHDh in either the entire cohort (LVH-BSA: NRI 1.7%, 95% CI: -8.3% to 11.7%, p = 0.74; LVH-height(1.7): NRI 2.7%, 95% CI: -5.8% to 11.3%, p = 0.62) or the intermediate risk group (LVH-BSA: NRI 12.0%, 95% CI: -5.7% to 29.8%, p = 0.19; LVH-height(1.7): NRI 14.5%, 0.1% to 28.8%, p = 0.05). Although an independent predictor of cardiovascular events, LVH does not lead to clinically meaningful reclassification of the overall and intermediate risk population for CHDh.

Destination Attributes and Chinese Outbound Tourism to Europe目的地特性和中国对欧洲的对外旅游

China is one of the fastest growing outbound tourism markets. Europe is an attractive destination for Chinese tourists. However, Europe still accounts for a small percentage of Chinese outbound tourism. If European countries want to benefit from this market, they should pay attention to Chinese tourists’ preferences. This article contributes to the understanding of Chinese outbound tourism by analyzing those destination attributes that can influence the number of Chinese tourists received. From a sample of 47 European countries, our findings suggest that a greater cultural distance from China, a large number of World Heritage Sites, a large ethnic Chinese population, and a large number of flight connections to China are associated with the amount of Chinese tourists visiting each country.

Clinico-epidemiological profile of orofacial clefts among children of coastal district of Southern India: A 5 year hospital based study

Background: In India with a large multi ethnic population, most of the epidemiological studies on cleft lip/palate (CL/P) have been sporadic. Inequalities exist, both in access to and quality of cleft care with distinct differences in urban versus rural access and over the years the accumulation of unrepaired clefts of the lip and palate make this a signifi cant health care problem in India. Aims and Objectives: The primary aims of this study was to assess the predominant pattern of cleft lip and palate (CLP) cases in Mangalore and secondary aim is to evaluate the role of possible risk factors like previous familial history, maternal diet and nutritional supplementation, consanguinity. Materials and Methods: This was a 5-year hospital based, retrospective study of the birth records, in which all the cases of CL/P up to the age group of 5 years were studied. The data was retrieved from the Medical Records Department of two main hospitals in Mangalore. The data was collected using a semistructured, pre-tested proforma that was designed based on the review of literature. Results: The cleft occurrence in Mangalore was found to be 2.42/1000 births/year. Cleft lip (CL) along with cleft palate (CP) was found to be the highest in both Hospitals about (64.6%), followed by isolated CL (28.5%), followed by isolated CP (5.1%) and the least being isolated CL with cleft alveolus (1.9%). Conclusions: From the study, it can be concluded that recording of adequate ante-natal history in the birth records hasn’t been given critical Importance. Furthermore, there is a lack of parental counseling provided in the government hospital.