The manoeuvrability of submarines is one of the important factors from mission and safety points of view. In particular, manoeuvring motions with a large drift angle and/or angle of attack in both the horizontal and the vertical planes have different motion parameters compared to the normal manoeuvring motions. To evaluate the manoeuvrability during these types of particular motions of submarines, especially at the initial design stage, the manoeuvring hydrodynamic derivatives that are related to various manoeuvring motions must be identified.Karasuno model, which is termed a physical based model, has the advantages that it needs only model experiments for drift motion and it can provide greater accuracy under motion with large angles. Despite these advantages, this model has not been applied to other vessels excluding fishing vessels. The applicability of this method to submarines therefore should be examined. The applicability of Karasuno model for submarines is validated through a computational fluid dynamics (CFD) analysis and comparisons with experimental data in this work. The findings contribute to identifying the manoeuvring hydrodynamic forces for submarines and evaluating their manoeuvring performance. Through rigorous validation, the potential of the proposed model as a reliable tool for predicting and analyzing submarine maneuvering motions is demonstrated.