Large Age Differences Research Articles

KESENJANGAN USIA DALAM PERNIKAHAN MENURUT FIQH MUNAKAHAT DI KECAMATAN WARUNGASEM

This research aims to explain the age gap that occurs in marriage. The subjects in this study were husband and wife couples whose ages were more than 8 years apart. Interviews and observations were conducted in October 2023. This research used descriptive qualitative research methods. The aspects discussed in this research are the meaning of marriage itself, the factors that cause the age gap in marriage, and also the impact of this large age difference. The results of this research are that marriages with a large age gap do not affect the household situation becoming strained, even if the husband is more mature, then he will be able to guide his wife and children. Couples who are ready to get married physically and mentally are also expected to have a prosperous and quality family.

Survival in Elderly Ovarian Cancer Remains Challenging in the Nordic Countries.

Despite treatment having improved through intensive surgical procedures and chemotherapy-and more recently, targeted therapies-ovarian cancer is the most fatal female cancer. As such, we wanted to analyze age-specific survival trends for ovarian cancer in Denmark, Finland, Norway and Sweden over the past 50 years, with a special aim of comparing survival development between the age groups. We modelled survival data from the NORDCAN database for 1-, 5- and conditional 5/1-year relative (between years 1 and 5) survival for ovarian cancer from 1972 to 2021. Young patients had a 70% 5-year survival while the survival was only 30% for the oldest patients. Conditional survival showed that survival between years 1 and 5 did not improve for patients older than 60 years throughout the 50-year period, during which time the gaps between the youngest and the oldest patients widened. Improvement in 1-year survival was so large that it masked the modest development between years 1 and 5, resulting in a widening age disparity in 5-year survival. The current treatment practices, which appear increasingly effective for younger patients, have not helped remedy the large age differences in ovarian cancer survival. Early detection methods and therapeutic innovations are urgently needed, and aged patients need a special focus.

META-ANALYSIS OF RAVITCH AND NUSS PROCEDURES FOR THE TREATMENT OF FUNNEL-SHAPED CHEST DEFORMITY IN CHILDREN AND ADOLESCENTS

Funnel-shaped chest deformity is the most common anomaly of the chest wall development, occurring in 8 out of every 1 000 children. The defect is noticeable at birth in approximately 86 % of patients with chest deformity. Objective. To conduct a systematic review comparing the treatment of funnel-shaped chest deformity in children and young people under 20 years of age by surgical methods according to Ravitch and Nuss by the number of complications that occur in the short (up to 30 days) and long-term periods (2–3 years). Methods. A search of scientometric databases revealed 1 734 sources, of which 8 papers were selected for further analysis. Results. We evaluated systematic reviews and meta-analyses comparing methods of treatment of lumbar deformity in children and adolescents. It was determined that there are currently no randomized trials comparing these procedures in children and adolescents. A comparative analysis of the risk of complications in the surgical treatment of the funnel-shaped sternum in children and young adults using the Ravitch and Nuss methods determined that there is no difference in the overall incidence of complications between the Nuss and Ravitch procedures when considering the pediatric population in terms of overall, early, and late complications. With the development of the Nuss technology, complications associated with plate mixing are practically non-existent, and the development of new methods of controlling operations, anesthesia and further patient management has reduced the development of both postoperative and long-term complications. Conclusions. According to the results of the meta-analysis of the risk of early and late complications, it is impossible to definitively determine the advantage of any surgical method for the correction of lumbar deformity of the chest. The number of Nuss surgeries has been increasing over the years, which means that the minimally invasive approach is the method of choice for patients and surgeons, although questions remain about achieving structural stability and the method of Nuss correction in severe deformities. The lack of definitive conclusions is more related to the methodological problems of the analyzed data, including a limited number of observations and a large age difference in the observation groups, the lack of a standard for presenting data to describe the patient's condition (magnitude and type of deformity, primary complications of the cardiac and respiratory systems, the presence of complicating factors).

Spatial and temporal analysis of bottleneck flow for the elderly and the young pedestrians under multiple modes

The aging of the population is becoming a global concern. With the increasing number of the elderly, the growing traffic demands are facing greater challenges. The elderly with lower movement ability is more vulnerable to be injured in accidents. Collaborative assistant is an effective way to prevent accidents of falling down for the elderly. In this study, we carried out a series of controlled experiments involving the elderly and the young pedestrians under different modes, including the separate, mixed and synergistic modes. The traffic efficiencies of crowds under different movement modes are compared and their movement characteristics are analyzed. Through the spatial and temporal analysis, it can be found that the primary factor hindering the traffic efficiency of the elderly crowd is the longer time headway. The mean headway distance among homogeneous pedestrians is smaller than that among heterogeneous pedestrians with larger age differences. In addition, the fundamental diagrams under different movement modes are obtained and compared. The findings contribute to a better understanding of the movement for the young assisting the old in the crowded environment. The results have practical applications in the modeling and evacuation management for the public places where the elderly gathered, such as the aged care institutions.

Hybrid Spatial-Channel Attention Mechanism for Cross-Age Face Recognition

Face recognition techniques have been widely employed in real-world biomimetics applications. However, traditional approaches have limitations in recognizing faces correctly with large age differences because of significant changes over age in the same person, leading to unsatisfactory recognition performance. To address this, previous studies propose to decompose and identify age and identity features independently in facial images across diverse age groups when optimizing the discriminative model so as to improve the age-invariant face recognition accuracy. Nevertheless, the interrelationships between these features make it difficult for the decomposition to disentangle them properly, thus compromising the recognition accuracy due to the interactive impacts on both features. To this end, this paper proposes a novel deep framework that incorporates a novel Hybrid Spatial-Channel Attention Module to facilitate the cross-age face recognition task. Particularly, the proposed module enables better decomposition of the facial features in both spatial and channel dimensions with attention mechanisms simultaneously while mitigating the impact of age variation on the recognition performance. Beyond this, diverse pooling strategies are also combined when applying those spatial and channel attention mechanisms, which allows the module to generate discriminative face representations while preserving complete information within the original features, further yielding sounder recognition accuracy. The proposed model is extensively validated through experiments on public face datasets such as CACD-VS, AgeDB-30, and FGNET, where the results show significant performance improvements compared to competitive baselines.

Comparison of Kidney Graft Function and Survival in an Emulated Trial With Living Donors and Brain-Dead Donors.

Living donation (LD) transplantation is the preferred treatment for kidney failure as compared to donation after brain death (DBD), but age may play a role. We compared the 1-year estimated glomerular filtration rate (eGFR) after kidney transplantation for recipients of LD and DBD stratified by recipient and donor age between 2015 and 2018 in a matched cohort. The strength of the association between donation type and 1-year eGFR differed by recipient age (P interaction < 0.0001). For LD recipients aged 40-54years versus same-aged DBD recipients, the adjusted odds ratio (aOR) for eGFR ≥60mL/min/1.73m2 was 1.48 (95% CI: 1.16-1.90). For DBD recipients aged ≥ 60years, the aOR was 0.18 (95% CI: 0.12-0.29) versus DBD recipients aged 40-54years but was 0.91 (95% CI: 0.67-1.24) versus LD recipients aged ≥60years. In the matched cohort, 4-year graft and patient survival differed by donor age and type. As compared with DBD grafts, LD grafts increased the proportion of recipients with 1-year eGFR ≥60mL/min/1.73m2. Recipients aged ≥60years benefited most from LD transplantation, even if the donor was aged ≥60years. For younger recipients, large age differences between donor and recipient could also be addressed with a paired exchange program.

Age Difference between Spouses and Women Empowerment in Nigeria

Women empowerment is the increased ability of women to make life choices, and it is a major challenge among couples in decision making process in sub-Saharan Africa. Women empowerment among couples in Nigeria is influenced by the variations in the age of husband and wife especially among women with older husbands. This study examined the influence of spousal age difference on women empowerment in Nigeria using NDHS 2018 dataset. Women empowerment was measured by decision on health, household purchase and visit to family. Women were considered empowered if they take at least two of the decision singlehandedly and shared one with her spouse. Data were analysed using descriptive and logistic regression at P≤0.05. Spousal age difference was found to influence women empowerment in Nigeria. Women who were same age with husband and 1-4years and 5-9 years younger than husband were 2times more likely to be empowered, while women 10 or more year were 1 time more likely to be empowered. Specifically, women were more empowered if 1-4years younger than husband, as large spousal age difference limits women autonomy. The study has shown the implication of women marrying men who are far older than them and has given stakeholders a diverse approach toward empowerment of women and achieving SDG5.

Pengaruh Mahasiswa Kampus Mengajar Angkatan Ke-6 Pada Pengembangan Keterampilan Pembelajaran Di SDN Kalangsemanding Jombang

This research aims to evaluate the impact of student participation in the campus teaching program 6th generation on the learning process carried out at SDN Kalangsemanding in the subjects of Mathematics, Science, Indonesian. The focus of this research is to identify the impact of the contribution of campus teaching program students 6 to the development of students' learning skills at the elementary school level. The research methods used in this study involve direct observation, interviews, and data analysis to measure improvements in learning skills in the classroom, social interactions with teachers and friends, as well as the positive or negative impacts of this program. The results of the research are expected to provide insight into the effectiveness of campus student participation in teaching 6 in improving the quality of learning in elementary schools. Students can feel inspired by seeing younger students who already have the knowledge and skills they want. The presence of campus students teaching at target schools can motivate students to pursue higher education and pursue their dreams. Students who may initially have difficulty connecting with teachers can still find a stronger connection or identification with younger campus teaching students and a less large age difference can create a better and more interesting learning environment. They were very happy with the presence of students at school, until the time for goodbye arrived, they were not willing to let campus students go to their respective campuses to teach.

Leader age and international conflict: A regression discontinuity analysis

Does leader age matter for the likelihood of interstate conflict? Many studies in biology, psychology, and physiology have found that aggression tends to decline with age throughout the adult lifespan, particularly in males. Moreover, a number of major international conflicts have been attributed to young leaders, including the conquests of Alexander the Great and the ambitious military campaigns of Napoleon. However, the exact nature of the relationship between leader age and international conflict has been difficult to study because of the endogeneity problem. Leaders do not come to power randomly. Rather, many domestic and international factors influence who becomes the leader of a country, and some of these factors could correlate with the chances of interstate conflict. For instance, wary democratic publics might favor older leaders when future international conflict seems likely, inducing a relationship between older leaders and interstate conflict. This article overcomes such confounding by using a regression discontinuity design. Specifically, it looks at close elections of national leaders who had large differences in age. It finds that when older candidates barely defeated younger ones, countries were much less likely to engage in military conflict. Its sample is also fairly representative of democracies more broadly, meaning that the findings likely hold true for cases outside the sample. The results demonstrate the important role that individuals play in shaping world politics. They also illustrate the value of design-based inference for learning about important questions in the study of international relations and peace science.

Theoretical aspects of the development of special endurance in ski racers of secondary school age

Relevance. The structure of the activity consisted in the theoretical justification of the shown methods, their use in practice and the rationality of performing these exercises. As a result of the key problem, solving the problem of endurance education in school years, it is necessary to take into account in detail the large age differences in the adaptive reactions of the body to high physical exertion.The purpose of the study is to study and demonstrate various methods and means of developing special endurance in ski racers of secondary school age.Organization and methods of research. In the early stages of the development of special endurance in children, it is necessary. have a level of general endurance. Hence, it is customary to use a number of such methods and means that make it possible to exert precisely dosed effects (running over various distances, skiing and other cyclic exercises, as well as regularly performed gymnastic and other general preparatory exercises organized in the form of "circular training".The results of the study and their discussion. The results obtained during the research make it possible to conclude that endurance and all its varieties are considered the most significant quality for ski racing. And for the development of special endurance in skiing, all training methods should be used, regardless of the age and level of training of the athlete, the main thing is to follow the sequence of these methods so that the skier gradually improves his own performance.Conclusions. Thus, we can say that endurance and all its types are the most important quality for ski racing. And for the development of special endurance in ski racing, it is necessary to apply all training methods, regardless of the age and level of training of the athlete, types.

Development of atrial fibrillation and changes in its course after an infection COVID-19 depending on age, gender and anthropometric characteristics

The aim – to analyze the probability of the development of atrial fibrillation (AF) «de novo», as well as to determine the course of an already existing rhythm disturbance after a transferred infection of COVID-19 in patients with different age, gender and anthropometric characteristics.Materials and methods. The study involved 116 patients with AF who were hospitalized in the department of clinical arrhythmology and electrophysiology from September 20.09.2020 to 21.12.2021 and had a history of coronavirus infection (CI). The 1st group – 36 people (31 %) in whom AF occurred after CI. The 2nd group – 25 patients in whom the form of AF has changed. The 3rd group – 55 patients in whom the form of AF did not change. In the 3rd group, two subgroups were formed: 3A – 35 patients in whom, although the form of AF did not change, the frequency or duration of arrhythmia paroxysms increased, and 3B – 20 patients without significant changes in the course of AF. As the first control group (C1), 49 patients with AF without a history of CI were examined. The second control group (C2) was formed by 22 patients after a CI in whom AF did not develop.Results and discussion. C1 patients were older than C2 patients by 10.4 years, p&lt;0.0001. Individuals of groups 2 and 3 were probably older by an average of 2.5 years than the patients of the first control group. Group 2 patients were statistically significantly older (by 3.6 years) than group 3 patients. A large difference in age (by 12.9 years, p&lt;0.001) of patients of the 1st group compared to the second control group was noted. That is, the older age of the patients was the cause of both «de novo» AF after a CI and the worsening of the course of this arrhythmia in those patients who had it before the infection of COVID-19. There were more women than men in the 2nd and 3rd compared to each other (where the ratio was 1.16:1.0) and compared to the control group (where the ratio was 0.44:1.0). Among the patients of the 3rd group, the frequency and duration of paroxysms increased in subgroup 3A, where there were statistically more women than in subgroup 3B and in the first control group. In addition, there were significantly more women than men in subgroup 3A (ratio 1.5:1.0, p&lt;0.0001), which is a significant difference in the ratio of female to male patients in patients of subgroup 3B, where their ratio was 1.0:1.0. Therefore, female gender is a risk factor for the deterioration of the course of AF after infection with COVID-19.Excess body weight was found in 60 % of cases in patients who underwent CI and had AF. Patients of the 1st group, in contrast to C2, more often had excess body weight (BMI from 25 kg/m2 to 29 kg/m2). In subgroup 3A, unlike subgroup 3B, the average value of BMI was higher by 9 %. Excess weight contributes to the appearance of AF after CI and worsens the course of this arrhythmia.Conclusions. Excess body weight or obesity was found in 60 % of cases – i.e. in the vast majority of OG patients who underwent CI and had AF. The older age of patients (mostly over 60 years old), excess body weight and female gender in patients after a COVID-19 infection were risk factors for the occurrence of «de novo» AF and worsened the course of this already existing rhythm disorder.

Dynamics of the distribution of marriages of churchgoers of the Grado-Tyumen Assumption Church in Tyumen in 1863–1867

The article is based on the materials of the church registers of the Grado-Tyumen Assumption Church in the city of Tyumen, the Tyumen district, the Tobolsk province, and analyzes the features of marital behavior and the dynamics of the distribution of marriages in the city of Tyumen in 1863–1867 in order to find out how and with what intensity the changes occurred in the traditional values of premarital and marital behavior in this territory. This fact substantiates the relevance of the research, since without a comprehensive analysis of the dynamics of the distribution of marriages and identification of the characteristics of marital behavior, it is impossible to fully imagine the social and economic evolution of the city of Tyumen as the largest and most important commercial and industrial center of Russia beyond the Urals. Various aspects of the marital behavior of the inhabitants of the city of Tyumen in the Tobolsk province in the second half of the 19th century have been considered on the basis of modern methodological principles of gender studies; situations with secondary and subsequent marriages, interclass marriages, and marriages with immigrants have been studied. The position of widows of soldiers and their attractiveness as brides in the territory of the Tyumen district has also studied, and the reasons for marriages with a large age difference in favor of the bride identified. A conclusion has been made about the features of marital behavior and the parameters of the distribution of weddings during the year, the age of marriage and the social origin of the spouses.

Performance Evaluation of Face Recognition Model in Deep Learning using Old Facial Photos: A Mathematical Modelling Using SVM Supervised Learning

Deep Learning has been a remarkable state-of-the-art method in any classification challenge, particularly in face recognition applications. In this paper, Feature Extraction in face recognition using Deep CNNs handpicked pre-trained CNN architectures such as InceptionV3, MobileNetV2, ResNet50, and VGG19 were experimentally explored. Initially, these architectures extracted important features from eight (8) classes of face photos with large age differences of ten (10) years from the present age of an individual. The features were processed with the application of a Support Vector Machine (SVM) classifier to enhance its performance. The evaluation of each model was based on average scores ofaccuracy, precision, recall, and f1-score. The results concluded an accuracy of 84.60%, a weighted precision of 85%, a weighted recall of 84.60%, and a weighted f1-score of 84.60% obtained by ResNet50.Further, ResNet50 has the highest obtained 98% generated ROC-AUC score. With the results presented, ResNet50 isrecommended for application development related to face recognition with the consideration of large age gaps of 10 years.

Factors Associated With Domestic Violence Against Women at Different Stages of Life: Findings From a 19-Year Longitudinal Dataset From the MINIMat Trial in Rural Bangladesh (2001-2020).

Despite the abundance of literature, longitudinal studies evaluating the factors associated with domestic violence (DV) at different stages and over longer periods of women's lives are rare. We evaluated factors associated with physical and sexual DV during pregnancy, at 10-year, and 18-year follow-ups after pregnancy and within a 19-year period of life using a cohort of women (n = 1,126) who participated in the Maternal and Infant Nutrition Interventions, Matlab trial in rural Bangladesh. Data on women's experience of DV, social and economic characteristics, empowerment, and family condition were recorded in a similar manner during pregnancy and at 10- and 18-year follow-ups, using standard questionnaires. Multivariate logistic regression models and generalized estimating equations were used to evaluate factors associated with women's experience of physical and sexual violence at each discrete time point and over a period of 19 years, respectively. During pregnancy, women were more likely to experience violence if they were members of microcredit programs/non-governmental organizations (NGOs), living in an extended family and had lower wealth status. At the 10- and 18-year follow-ups, higher levels of decision-making and higher wealth status were protective against the experience of violence. At the 18-year follow-up, women with larger age differences from their husbands were less likely to experience violence, while membership in microcredit programs/NGOs was associated with higher odds of experiencing violence among women. Within a period of 19 years, a higher level of education, living in an extended family, higher decision-making level and higher wealth index were protective against the experience of violence, while membership in microcredit programs/NGOs was a risk factor. In conclusion, this study showed that correlates of violence might change at different time points in women's life. Thus, policies and programs should consider the stage of women's lives while planning interventions for addressing violence against women.

Psychiatric disorders among adult deliberate self-harm patients and subsequent risk of dying by suicide, mental and behavioural disorders and other external causes

IntroductionDeliberate self-harm (DSH) treated in general hospital is a well-established risk factor for suicide and other cause mortality. However, few studies have used population data to investigate the differential impact of specific psychiatric disorders on the risk of subsequent suicide, by sex and age of the patient in the context of previous DSH episodes. MethodAll patients aged 18 and older treated for DSH in general hospitals during the period 2008–2018 were identified through national registers. Cox proportional hazards regression was used to ascertain the associated risk of death by suicide, mental and behavioural disorder and other external causes. ResultsThe cohort consisted of 39 479 patients of which 878 died by suicide, 461 by mental and behavioural disorders and 1037 by other external causes. Overall, schizophrenia spectrum disorders, affective disorders and personality disorders increased the risk of suicide. Large gender and age differences were identified in the risk of suicide associated with personality disorders and affective disorders. Alcohol use disorders and dementia increased the risk of dying by mental and behavioural disorders and alcohol use disorders and other substance use disorders increased the risk of death by external causes. ConclusionSchizophrenia spectrum disorders, affective disorders and personality disorders increased the risk of suicide among DSH patients, but the effect varied by gender, age and history of previous DSH. Psychiatric evaluation of all DSH patients and treatment tailored to the patient's specific needs is essential to reduce the risk of premature death.

Communication Behavior of Mandailing Culture Husband and Wife at Different Age Different Wedding in Sopoonggang Baru Village (Case Study of Wife Older Than Husband)

This study explores the phenomenon of couples who marry at different ages with the aim of knowing how the communication behavior of husband and wife in the Mandailing culture in marriages with a large age difference in the Mandailing culture. There are many differences in marriage with a large age difference between husband and wife which tends to make it difficult for couples to unite thoughts, ideas and opinions. This will be a challenge for the household so that it can make a household that is sakinah, mawaddah, warahmah. This research uses a qualitative approach with a descriptive qualitative research type. Source of data obtained from primary and secondary data. Data collection techniques were used through observation, in-depth interviews and documentation with three husband and wife couples with a much older age difference than their husbands with a distance of five years, seven years and ten years. The results of research conducted in Sopoonggang Baru Hamlet show that different age marriages are much older for wives than husbands, but there are problems that often occur in domestic life, including: difficult to control emotions, relationships decreased sexual relations between husband and wife, jealousy, differences in perspectives and economic problems. To solve problems that occur in marriages of different ages, the following methods are used by informants to solve problems in the household, namely: discussing and ignoring each other. There are several things that couples with different ages do in building household harmony including being honest, being open to each other, trusting each other and staying closer to Allah SWT.

Interventions to improve outcomes for caregivers of patients with advanced cancer: A systematic review and meta-analysis.

12026 Background: More than one in ten adults in the US are family caregivers, with cancer among the most common diagnoses of care recipients. Family caregivers of patients with advanced cancer often have poor quality of life (QOL) and mental health. We examined the effectiveness of interventions offering support for caregivers of patients with advanced cancer on caregiver QOL and mental health outcomes. Methods: We searched Ovid MEDLINE, EMBASE, Cochrane CENTRAL, and CINAHL databases from inception through 6/2021. Eligible studies reported on randomized controlled trials for adult caregivers of adult patients with advanced cancer. Meta-analysis was conducted for primary outcomes of QOL, physical well-being, mental well-being, anxiety, and depression, from baseline to follow-up of 1-3 months; secondary endpoints were these outcomes at 4-6 months and additional caregiver burden, self-efficacy, family functioning and bereavement outcomes. Random effects models were used to generate summary standardized mean differences (SMD). Meta-regression was conducted for primary outcomes that were significant for the intervention, assessing for mediation effect modification by caregiver sex and age of patient and caregiver. Type I error was 0.05. PROSPERO Registration: CRD42019136321. Results: Of 12,193 references identified, 56 articles reporting on 49 trials involving 8,554 caregivers were eligible for analysis; 16 (33%) targeted caregivers (mostly psychoeducational or problem-solving interventions), 19 (39%) patient-caregiver dyads (mostly counseling/therapy), and 14 (29%) patients and their families (mostly palliative care teams). At 1-3 month follow-up, interventions had a significant effect on overall QOL (SMD 0.24 (0.10 to 0.39), I2 = 52.0%), mental well-being (SMD 0.14 (0.02 to 0.25), I2 = 0.0%), anxiety (SMD 0.27 (0.06 to 0.49), I2 = 74.0%), and depression (SMD 0.34 (0.16 to 0.52), I2 = 64.4%), compared to standard care. At 1-3-month follow-up, a larger age difference (older patient and younger caregiver) was associated with a greater positive effect on QOL (p = 0.04) and depression (p = 0.02). In narrative synthesis, interventions demonstrated improvements in caregiver self-efficacy and grief. Conclusions: Interventions targeting caregivers, dyads, or patients and families led to improvements in caregiver QOL and mental health outcomes. These data support the routine provision of available interventions to support caregivers of patients with advanced cancer.

Gender Asymmetries in Cross‐National Couples

AbstractWe use census microdata for Spain and the United States to examine gender differences in cross‐national heterosexual couples (marriages and cohabitating unions involving natives and immigrant spouses). We examine whether native men and native women in cross‐national couples exhibit similar patterns regarding the country of birth, age, and educational attainment of their international partners. Countries are ranked by their level of the human development index (HDI). In both Spain and the United States, native men are slightly overrepresented in cross‐national couples. Native men are more likely to be married to individuals from low HDI countries than native women. On the contrary, native women are predominantly married to men born in countries with similar or higher levels of HDI. Unions of native men are characterized by large spousal age differences, which increase with the HDI gap; this pattern reverses among native women. These gender asymmetries do not extend to education level, with cross‐national couples, overall, involving highly educated individuals. These results point to the endurance of certain features of traditional marriage patterns in cross‐national couples, but the patterns differ starkly between native men and native women.

Polymorphism of the ApoE gene as a risk factor of obesity in workers exposed to occupational hazards at ferrous metallurgy enterprises

Obesity contributes to the development of severe concomitant diseases and substantially degrades the quality of life. This pathological condition is caused by multiple risk factors including hazardous workplace exposures and genetic predisposition. The ApoE gene participates in regulation of lipid metabolism. Its most significant polymorphisms are rs429358 and rs7412 with the resulting е2, е3 and е4 alleles. This study did not consider effects of electromagnetic fields generated by office electrical equipment or the lifestyle of the subjects. The sample included people with a large age difference due to the rarity of the apolipoprotein е2 and е4 alleles. The sample was not standardized by age and years of work experience. The aim of this study was to investigate associations between the ApoE gene polymorphisms and body mass index in workers employed at a metallurgic plant. We examined 328 male office workers and workers of a converter workshop. The body mass index (BMI) was calculated based on the results of instrumental measurements of weight and height using the conventional formula. DNA was isolated from peripheral blood using the LumiPure DNA gel extraction kit, and polymorphisms were determined using amplification by Calero et al with modifications and horizontal agarose gel electrophoresis. The data were analyzed using the Kruskal – Wallis test. Statistically significant differences were established in the blue-collar workers. The highest mean BMI value was established in the e2 allele carriers. We found that people with the e2 allele in their genotype were more prone to obesity. We also assume a potential association between the unsafe work environment and a more pronounced manifestation of the phenotype. These findings can be used for identifying individuals at risk and taking timely preventive measures.

Полиморфизм гена АРОЕ как фактор риска развития ожирения работников с вредными условиями труда на предприятиях черной металлургии

Obesity contributes to the development of severe concomitant diseases and substantially degrades the quality of life. This pathological condition is caused by multiple risk factors including hazardous workplace exposures and genetic predisposition. The ApoE gene participates in regulation of lipid metabolism. Its most significant polymorphisms are rs429358 and rs7412 with the resulting е2, е3 and е4 alleles. This study did not consider effects of electromagnetic fields generated by office electrical equipment or the lifestyle of the subjects. The sample included people with a large age difference due to the rarity of the apolipoprotein е2 and е4 alleles. The sample was not standardized by age and years of work experience. The aim of this study was to investigate associations between the ApoE gene polymorphisms and body mass index in workers employed at a metallurgic plant. We examined 328 male office workers and workers of a converter workshop. The body mass index (BMI) was calculated based on the results of instrumental measurements of weight and height using the conventional formula. DNA was isolated from peripheral blood using the LumiPure DNA gel extraction kit, and polymorphisms were determined using amplification by Calero et al with modifications and horizontal agarose gel electrophoresis. The data were analyzed using the Kruskal – Wallis test. Statistically significant differences were established in the blue-collar workers. The highest mean BMI value was established in the e2 allele carriers. We found that people with the e2 allele in their genotype were more prone to obesity. We also assume a potential association between the unsafe work environment and a more pronounced manifestation of the phenotype. These findings can be used for identifying individuals at risk and taking timely preventive measures.