Large Body Research Articles

RETRACTABLE UROLOGY THREE-PRONGED GRASPING FORCEPS FOR REMOVAL OF LARGE, NONMAGNETIC INTRAOCULAR FOREIGN BODIES.

To demonstrate the use of urology retractable three-pronged grasping forceps in the removal of a large, round, and nonmagnetic intraocular foreign body (IOFB) that was difficult to remove with other surgical instruments. Extraction of a 3.0 mm lead shot pellet embedded in vitreous hemorrhage was attempted with multiple surgical instruments including an intraocular magnet, IOFB forceps, and two tools designed for urology stone removal: a three-pronged grasping forceps and a nitinol basket extractor. Owing to the round and smooth surface, large size, and nonmagnetic nature of the IOFB, extraction was challenging and failed with multiple other surgical instruments. The wide and secure grasp of the grasping forceps allowed for swift IOFB extraction without iatrogenic injury to the retina. The grasping forceps offer an effective and safe method for removal of large, round, and nonmagnetic IOFBs.

Subcortico-Cortical Dysconnectivity in ADHD: A Voxel-Wise Mega-Analysis Across Multiple Cohorts.

A large body of functional MRI research has examined a potential role for subcortico-cortical loops in the pathogenesis of attention deficit hyperactivity disorder (ADHD), but has produced inconsistent findings. The authors performed a mega-analysis of six neuroimaging data sets to examine associations between ADHD diagnosis and traits and subcortico-cortical connectivity. Group differences were examined in the functional connectivity of four subcortical seeds in 1,696 youths with ADHD diagnoses (66.39% males; mean age, 10.83 years [SD=2.17]) and 6,737 unaffected control subjects (47.05% males; mean age, 10.33 years [SD=1.30]). The authors examined associations between functional connectivity and ADHD traits (total N=9,890; 50.3% males; mean age, 10.77 years [SD=1.96]). Sensitivity analyses were used to examine specificity relative to commonly comorbid internalizing and non-ADHD externalizing problems. The authors further examined results within motion-matched subsamples, and after adjusting for estimated intelligence. In the group comparison, youths with ADHD showed greater connectivity between striatal seeds and temporal, fronto-insular, and supplementary motor regions, as well as between the amygdala and dorsal anterior cingulate cortex, compared with control subjects. Similar findings emerged when ADHD traits were considered and when alternative seed definitions were adopted. Dominant associations centered on the connectivity of the caudate bilaterally. Findings were not driven by in-scanner motion and were not shared with commonly comorbid internalizing and externalizing problems. Effect sizes were small (largest peak d, 0.15). The findings from this large-scale mega-analysis support established links with subcortico-cortical circuits, which were robust to potential confounders. However, effect sizes were small, and it seems likely that resting-state subcortico-cortical connectivity can capture only a fraction of the complex pathophysiology of ADHD.

Psycho-neuroendocrine-immune Aspects of COVID-19 and its Relationship with Post-traumatic Stress Disorder

Abstract: A large body of literature indicates that the novel coronavirus disease (COVI D-19) was, and still is, a stressful and traumatic experience for different groups of people. Exposure to unexpected deaths or fear of death increases the risk of developing post-traumatic stress disorder (PTSD) anxiety disorder. Understanding the relationship between PTSD and SARS-CoV- 2 infection can help reduce the risk of developing psychiatric diseases, especially anxiety disorders. Here, we used the central mega databases of PubMed, Google Scholar, Scopus, Springer, and Science Direct. We explored the articles based on keywords and related articles. Social isolation stress during quarantine and hyperactivity of the hypothalamic-pituitary-adrenal (HPA) axis via increased cortisol synthesis and release seems to be key findings in current literature. Evidence shows that induced neuroendocrine changes in patients with COVID-19 can cause psychiatric diseases related to fear and anxiety. Studies suspect that angiotensinconverting enzyme 2 (ACE2) expressed in the hypothalamus and pituitary gland can be targeted by the infection and thereby could be a player in inducing psychiatric disorders. Here, we discuss the relationship between Covid-19 and post-traumatic stress disorder from psychoneuroendocrine- immune aspects and highlight the pro-inflammatory cytokines as mediators in the CNS-related processes, hoping to provide insights into the pathophysiology of PTSD.

Feature selection for sentiment analysis using hybrid multiobjective evolutionary algorithm

As the volume of data continues to grow, the significance of text classification is on the rise. This vast amount of data majorly exists in the form of texts. Effective data preparation is essential to extract sentiment data from this vast amount of text, as irrelevant and redundant information can impede valuable insights. Feature selection is an important step in the data preparation phase as it eliminates irrelevant and insignificant features from the huge features set. There exist a large body of work related to feature selection for image processing but limited research is done for text data. While some studies recognize the significance of feature selection in text classification, but there is still need for more efficient sentiment analysis models that optimize feature selection and reduce computational. This manuscript aims to bridge these gaps by introducing a hybrid multi-objective evolutionary algorithm as a feature selection mechanism, combining the power of multiple objectives and evolutionary processes. The approach combines two feature selection techniques within a binary classification model: a filter method, Information Gain (IG), and an evolutionary wrapper method, Binary Multi-Objective Grey Wolf Optimizer (BMOGWO). Experimental evaluations are conducted across six diverse datasets. It achieves a reduction of over 90 percent in feature size while improving accuracy by nearly nine percent. These results showcase the model’s efficiency in terms of computational time and its efficacy in terms of higher classification accuracy which improves sentiment analysis performance. This improvement can be beneficial for various applications, including recommendation systems, reviews analysis, and public opinion observation. However, it’s crucial to acknowledge certain limitations of this study. These encompass the need for broader classifier evaluation, and scalability considerations with larger datasets. These identified limitations serve as directions for future research and the enhancement of the proposed approach.

OptoProfilin: A Single Component Biosensor of Applied Cellular Stress.

The actin cytoskeleton is a biosensor of cellular stress and a potential prognosticator of human disease. In particular, aberrant cytoskeletal structures such as stress granules formed in response to energetic and oxidative stress are closely linked to ageing, cancer, cardiovascular disease, and viral infection. Whether these cytoskeletal phenomena can be harnessed for the development of biosensors for cytoskeletal dysfunction and, by extension, disease progression, remains an open question. In this work, we describe the design and development of an optogenetic iteration of profilin, an actin monomer binding protein with critical functions in cytoskeletal dynamics. We demonstrate that this optically activated profilin ('OptoProfilin') can act as an optically triggered biosensor of applied cellular stress in select immortalized cell lines. Notably, OptoProfilin is a single component biosensor, likely increasing its utility for experimentalists. While a large body of preexisting work closely links profilin activity with cellular stress and neurodegenerative disease, this, to our knowledge, is the first example of profilin as an optogenetic biosensor of stress-induced changes in the cytoskeleton.

Experimental results for RVK-500 recombiner tested in conditions typical for pressurized water NPP severe accidents

Severe accidents at NPPs with light water coolant can lead to situations when large quantities of hydrogen are released due to zirconium-steam reaction. To avoid explosion consequences, they started to install hydrogen passive autocatalytic recombiners (PARs) at NPPs. Calculating simulation based on PAR models is used to predict and justify the needed quantity of PARs and the chosen place of their location inside the NPP. To validate PAR computational models, experimental data are need. Within the scope of this work, the integrated tests of the RVK-500 type recombiner, which included 20 experiments, were conducted to obtain large body of data on PAR operation in different modes and conditions that can be realized in case of hypothetical accident at NPP. For this purpose, a facility equipped with a measuring set able to work at high pressures, temperatures, and humidity was constructed. The tests were conducted in accord with thepredevopled PAR testing procedure and program to describe PAR characteristics, such as its start-up, H2 recombination rate, efficiency, and ignition limit. In addition, a small-scale facility was used to study the potential of particles separated from the catalytic elements to induce combustion.

Temporal Fairness in Multiwinner Voting

Multiwinner voting captures a wide variety of settings, from parliamentary elections in democratic systems to product placement in online shopping platforms. There is a large body of work dealing with axiomatic characterizations, computational complexity, and algorithmic analysis of multiwinner voting rules. Although many challenges remain, significant progress has been made in showing existence of fair and representative outcomes as well as efficient algorithmic solutions for many commonly studied settings. However, much of this work focuses on single-shot elections, even though in numerous real-world settings elections are held periodically and repeatedly. Hence, it is imperative to extend the study of multiwinner voting to temporal settings. Recently, there have been several efforts to address this challenge. However, these works are difficult to compare, as they model multi-period voting in very different ways. We propose a unified framework for studying temporal fairness in this domain, drawing connections with various existing bodies of work, and consolidating them within a general framework. We also identify gaps in existing literature, outline multiple opportunities for future work, and put forward a vision for the future of multiwinner voting in temporal settings.

The Esquinzo Ultra-Alkaline Rock Suite of Fuerteventura Basal Complex (Canary Islands): Evidence for Origin of Carbonatites by Fractional Crystallization

The origin of the carbonatites that appear on Earth is one of the most controversial current topics in the petrogenesis of igneous rocks. Situated in the northern sector of the Basal Complex of Fuerteventura (Canary Islands), the Miocene Esquinzo ultra-alkaline plutonic rock complex is composed of pyroxenites, melteigites-ijolites-urtites, malignites-nepheline syenites, carbonatites, silicocarbonatites, nephelinites and nepheline phonolites. This work tries to establish the genesis of this massif of ultra-alkaline rocks with associated carbonatites from Fuerteventura (which are very rare in the oceans). The geochemical characteristics of these rocks and the minerals that are included in them have allowed us to establish their origin. This complex was generated by three successive magmatic events associated with differentiation of melanephelinite magmas emplaced in the oceanic crust. Silicocarbonatite and calciocarbonatite (sövites) dykes are related to the first magmatic event and were formed by fractional crystallization of H2O- and CO2-rich ijolite magmas. The melanephelinite magmas that formed these plutonic ultra-alkaline rocks were apparently generated as partial melts of asthenospheric mantle, which assimilated enriched lithospheric mantle material as they ascended. The upwelling of this large body of anomalous asthenospheric Miocene material exceeded the deformation associated with plate motions and led to an oceanic rifting event in Fuerteventura.

Augmentative and alternative communication: the experience of Malaysian speech-language pathologists and caregivers of individuals with aphasia

ABSTRACT Background Augmentative and Alternative Communication (AAC) serves as a compensatory intervention approach for individuals with aphasia and is often introduced by speech-language pathologists (SLPs) after outcomes from restorative approaches plateau. Communication partners (i.e., caregivers) have a pivotal role in ensuring the successful use of AAC by adults with aphasia. Despite there being a large body of research on the use of AAC by adults with aphasia little is known about the experience of caregivers of individuals with aphasia who use AAC in supporting its use. Aims This study conducted in Malaysia was aimed to (a) explore the practices of Malaysian SLPs when introducing AAC to adults with acquired communication disorders (ACD) including aphasia and (b) describe the experience of caregivers regarding the use of AAC by adults with aphasia under their care. Method & Procedures This mixed-methods study had two phases. In Phase 1, a survey was distributed to 200 SLPs throughout Malaysia. Thirty-seven SLPs who met the inclusion criteria of having a caseload of more than 80% adults and at least 20% adults with aphasia responded to the survey and provided information about their use of AAC. For Phase 2, eight caregivers of adults with aphasia who had been introduced to AAC were interviewed to obtain information about their experience using AAC. Outcomes & Results Findings from Phase 1 indicated that Malaysian SLPs most often introduced unaided and low-tech AAC to adults with ACD (including aphasia). Most of them felt that they lacked knowledge and skills in the provision of AAC services to adults and hoped for more training. Three themes emerged from the qualitative content analysis conducted on interview transcripts from Phase 2: (a) the positive impact of the use of AAC, (b) challenges faced when using AAC, and (c) hopes for the future. The findings of this study suggest that both SLPs and caregivers recognize the importance of AAC for adults with ACD including aphasia and need to work together closely to promote inclusion of adults with aphasia who use AAC and acceptance of AAC as a form of aphasia rehabilitation.

Multiphoton imaging of hippocampal neural circuits: techniques and biological insights into region-, cell-type-, and pathway-specific functions.

The function of the hippocampus in behavior and cognition has long been studied primarily through electrophysiological recordings from freely moving rodents. However, the application of optical recording methods, particularly multiphoton fluorescence microscopy, in the last decade or two has dramatically advanced our understanding of hippocampal function. This article provides a comprehensive overview of techniques and biological findings obtained from multiphoton imaging of hippocampal neural circuits. This review aims to summarize and discuss the recent technical advances in multiphoton imaging of hippocampal neural circuits and the accumulated biological knowledge gained through this technology. First, we provide a brief overview of various techniques of multiphoton imaging of the hippocampus and discuss its advantages, drawbacks, and associated key innovations and practices. Then, we review a large body of findings obtained through multiphoton imaging by region (CA1 and dentate gyrus), cell type (pyramidal neurons, inhibitory interneurons, and glial cells), and cellular compartment (dendrite and axon). Multiphoton imaging of the hippocampus is primarily performed under head-fixed conditions and can reveal detailed mechanisms of circuit operation owing to its high spatial resolution and specificity. As the hippocampus lies deep below the cortex, its imaging requires elaborate methods. These include imaging cannula implantation, microendoscopy, and the use of long-wavelength light sources. Although many studies have focused on the dorsal CA1 pyramidal cells, studies of other local and inter-areal circuitry elements have also helped provide a more comprehensive picture of the information processing performed by the hippocampal circuits. Imaging of circuit function in mouse models of Alzheimer's disease and other brain disorders such as autism spectrum disorder has also contributed greatly to our understanding of their pathophysiology. Multiphoton imaging has revealed much regarding region-, cell-type-, and pathway-specific mechanisms in hippocampal function and dysfunction in health and disease. Future technological advances will allow further illustration of the operating principle of the hippocampal circuits via the large-scale, high-resolution, multimodal, and minimally invasive imaging.

Animal Enjoinments and the Social Control of Animal Offenders: Geographic Hot–Cold Spot Evidence of Racial and Income Bias in the Enforcement of Animal Protection Regulations

A large body of research examining crimes against animals exists. An overlooked question in that literature is whether animal social control responses contain race, class and ethnicity processing biases against offenders similar to those found in criminal justice outcomes. Addressing that possibility, the current study examined the geographic distribution of civil animal enjoinments employed to suspend an individual's pet ownership rights. SaTScan© was employed to identify census-tract level hot/cold spots for animal enjoinments. The analysis indicated that hot/cold spots were statistically associated with census-tract race, ethnicity and income characteristics. Thus, while enjoinments may protect some animals from harm, the enjoinment process itself contains evidence of discrimination, suggesting that enjoinments may reflect perceptions of social disorganization rather than the actual distribution of animal crimes.

Quantitative evaluation of the global impacts of human land modification on raptors.

Raptors are threatened by anthropogenic land modifications, but targeted quantitative assessment of these impacts is lacking. We conducted the first global quantitative evaluation of the impacts of human-modified land on raptors. We used eBird data from 2001 to 2020 on 425 raptor species and occupancy models to assess the impacts of human-modified land on raptor distribution. The mean spatiotemporal correlations of human settlement, cropland, and pasture with raptor occupancy probability were -0.048 (SE 0.031), -0.134 (0.032), and -0.145 (0.032), respectively. The mean sensitivity of raptor occupancy probability to settlement, cropland, and pasture was -5.760 (2.266), -3.128 (1.540), and -2.402 (1.551), respectively. The occupancy probability of raptors with a large body mass was more negatively correlated with cropland (phylogenetic generalized least squares regressions: slope = -0.052 [SE 0.022], t=-2.335, df=1,407, p=0.020, λ=0.006) and more positively correlated with pasture (slope=0.047 [0.022], t=2.118, df=1,407, p=0.035, λ=0.013). The occupancy probability of raptors with a more extensive range size was more positively correlated with cropland (slope=0.002 [0.004], t=0.399, df=1,407, p < 0.001, λ=0.000). Raptors that prefer open habitats were more positively correlated with cropland (analysis of variance: F=3.424, df=2, p=0.034, λ=0.000) and pasture (F=6.577, df=2, p=0.002, λ=0.000). In Africa and South America, where raptor species are most abundant, raptor occupancy probability decreased over 20years, most likely due to habitat fragmentation associated with human land modification. Although raptors with different ecological characteristics had different responses to human land modification, the impacts of settlement, cropland, and pasture on mean raptor occupancy probability were negative, regardless of space and time.

The use of injectable orthobiologics for knee osteoarthritis: A European ESSKA-ORBIT consensus. Part 1-Blood-derived products (platelet-rich plasma).

The aim of this European Society of Sports Traumatology, Knee Surgery and Arthroscopy (ESSKA) consensus is to provide recommendations based on evidence and expert opinion to improve indications, decision-makingand administration-related aspects when using blood-derived orthobiologics (for simplicity indicated as PRP-platelet-rich plasma-with PRP being the most common product) for the management of knee osteoarthritis (OA). Leading European expert clinicians and scientists were divided into a steering group, a rating group and a peer review group. The steering group prepared 28 question-statement sets divided into three sections: PRP rationale and indications, PRP preparation and characterisationand PRP protocol. The quality of the statements received grades of recommendation ranging from A (high-level scientific support)to B (scientific presumption), C (low-level scientific support) or D (expert opinion). The question-statement sets were then evaluated by the rating group, and the statements scored from 1 to 9 based on their degree of agreement with the statements produced by the steering group. Once a general consensus was reached between the steering and rating groups, the document was submitted to the peer review group who evaluated the geographic adaptability and approved the document. A final combined meeting of all the members of the consensus was held to produce the official document. The literature review on the use of blood-derived products for knee OA revealed that 9 of 28 questions/statements had the support of high-level scientific literature, while the other 19 were supported by a medium-low scientific quality. Three of the 28 recommendations were grade A recommendations: (1) There is enough preclinical and clinical evidence to support the use of PRP in knee OA. This recommendation was considered appropriate with a strong agreement (mean: 8). (2) Clinical evidence has shown the effectiveness of PRP in patients for mild to moderate degrees of knee OA (KL ≤ 3). This recommendation was considered appropriate with a strong agreement (mean: 8.1). (3) PRP injections have been shown to provide a longer effect in comparison to the short-term effect of CS injections. They also seem to provide a safer use profile with less potential related complications. This recommendation was considered appropriate with a very strong agreement (mean: 8.7). Six statements were grade B recommendations, 7 were grade C and 12 were grade D. The mean rating score was 8.2 ± 0.3. The consensus group reached a high level of agreement on all the questions/statements despite the lack of clear evidence for some questions. According to the results from this consensus group, given the large body of existing literature and expert opinions, PRP was regarded as a valid treatment option for knee OAand as a possible first-line injectable treatment option for nonoperative management of knee OA, mainly for KL grades 1-3. Level II.

Study of myopia progression and risk factors in Hubei children aged 7–10 years using machine learning: a longitudinal cohort

BackgroundTo investigate the trend of refractive error among elementary school students in grades 1 to 3 in Hubei Province, analyze the relevant factors affecting myopia progression, and develop a model to predict myopia progression and the risk of developing high myopia in children.MethodsLongitudinal study. Using a cluster-stratified sampling method, elementary school students in grades 1 to 3 (15,512 in total) from 17 cities in Hubei Province were included as study subjects. Visual acuity, cycloplegic autorefraction, and height and weight measurements were performed for three consecutive years from 2019 to 2021. Basic information about the students, parental myopia and education level, and the students’ behavioral habits of using the eyes were collected through questionnaires.ResultsThe baseline refractive errors of children in grades 1 ~ 3 in Hubei Province in 2019 were 0.20 (0.11, 0.27)D, −0.14 (−0.21, 0.06)D, and − 0.29 (−0.37, −0.22)D, respectively, and the annual myopia progression was − 0.65 (−0.74, −0.63)D, −0.61 (−0.73, −0.59)D and − 0.59 (−0.64, −0.51)D, with the prevalence of myopia increasing from 17.56%, 20.9%, and 34.08% in 2019 to 24.16%, 32.24%, and 40.37% in 2021 (Χ2 = 63.29, P < 0.001). With growth, children’s refractive error moved toward myopia, and the quantity of myopic progression gradually diminished. (F = 291.04, P = 0.027). The myopia progression in boys was less than that in girls in the same grade (P < 0.001). The change in spherical equivalent refraction in myopic children was smaller than that in hyperopic and emmetropic children (F = 59.28, P < 0.001), in which the refractive change in mild myopia, moderate myopia, and high myopia children gradually increased (F = 73.12, P < 0.001). Large baseline refractive error, large body mass index, and high frequency of eating sweets were risk factors for myopia progression, while parental intervention and strong eye-care awareness were protective factors for delaying myopia progression. The nomogram graph predicted the probability of developing high myopia in children and found that baseline refraction had the greatest predictive value.ConclusionMyopia progression varies by age, sex, and myopia severity. Baseline refraction is the most important factor in predicting high myopia in childhood. we should focus on children with large baseline refraction or young age of onset of myopia in clinical myopia prevention and control.

Machine learning review of hand surgery literature

Background: Latent Dirichlet Allocation is an artificial intelligence model which processes text into topics, and has had broad application in medicine, political science, and engineering. As the orthopedic hand literature continues to grow, such technology may have value in efficiently conducting identifying trends and conducting systematic reviews. The purpose of this study is to demonstrate the use of Latent Dirichlet Allocation and machine learning to review literature and summarize the past 21 yr of hand surgery research. Methods: All original research articles published in the Journal of Hand Surgery (American), Journal of Hand Surgery (European), Hand, Journal of Bone and Joint Surgery (JBJS), Clinical Orthopaedics and Related Research (CORR), Journal of the American Academy of Orthopaedic Surgeons (JAAOS) and Plastic and Reconstructive Surgery (PRS) from 2000-2021 were analyzed using Latent Dirichlet Allocation, generating 50 topics which were then ranked by popularity and trended over the previous 21 yr. Results: Research article abstracts totaling 11,501 from 2000-2020 were extracted and analyzed to create 50 topics. Conclusion: This is the first study of its kind to utilize machine learning models for reviewing the hand surgery literature. Machine learning possesses the ability to rapidly process a large body of test and assess the current state of research and trends or research topics, which can aid clinicians and researchers in time-intensive tasks to provide clues that will promote areas of further study.

An evidential linguistic ELECTRE method for selection of emergency shelter sites

In many circumstances, decisions are based on subjective experience. However, some views can be vague, meaning that policymakers do not know exactly how they should express their opinions. Therefore, it is necessary for researchers to provide scientific decision frameworks, among which the multi-criteria decision making (MCDM) method in the linguistic environment is gradually favored by scholars. A large body of literature reports relevant approaches with regard to linguistic term sets, but existing approaches are insufficient to express the subjective thoughts of policymakers in a complex and uncertain environment. In this paper, we address this problem by introducing the concept of evidential linguistic term set (ELTS). ELTS generalizes many other uncertainty representations under linguistic context, such as fuzzy sets, probabilities, or possibility distributions. Measures on ELTS, such as uncertainty measure, dissimilarity measure and expectation function, provide general frameworks to handle uncertain information. Modeling and reasoning of information expressed by ELTSs are realized by the proposed aggregation operators. Subsequently, this paper presents a novel MCDM approach called evidential linguistic ELECTRE method, and applies it to the case of selection of emergency shelter sites. The findings demonstrate the effectiveness of the proposed method for MCDM problems under linguistic context and highlight the significance of the developed ELTS.

Abstract IA008: Racial disparities in guideline-concordant endometrial cancer treatment

Abstract Mortality associated with endometrial cancer is 98% higher among Black as compared with White women. A large body of literature has evaluated differential treatment patterns as a potential determinant of increased mortality among Black women. In most studies, receipt of individual endometrial cancer treatment components (i.e., surgery, radiation, chemotherapy) is compared between Black and White women. Moreover, individual treatment components are typically considered binary variables (received vs. not received) with the received category reflecting a wide spectrum of treatments received. For example, women who receive one vs. six cycles of chemotherapy would be similarly labeled as receiving chemotherapy, despite a clear difference in treatment intensity. In contrast, recent studies have begun to evaluate racial and ethnic differences in the complete course of treatment as a unit, within the context of established guidelines. The National Comprehensive Cancer Network guidelines provide evidence-based endometrial cancer treatment recommendations based on clinical trials and observational research. Surgery is the first step of guideline-concordant treatment and pathology factors captured from surgery inform adjuvant treatment recommendations. Since the distribution of tumor characteristics that guide treatment recommendations varies between Black and White women, we should expect racial differences in use of adjuvant radiation and chemotherapy. However, when conceptualizing treatment as guideline-concordant vs. discordant, racial and ethnic differences clearly signal disparate quality of care. In this presentation, we will discuss the need for research on endometrial cancer treatment disparities to shift from a paradigm of exploring individual treatment components to one in which receipt of guideline-concordant treatment is the focus. Moreover, through the lens of a recently funded grant, we will discuss the value of using an explicit disparities definition in analyses of guideline-concordant treatment, which allows for decomposition of the sources of racial and ethnic disparities. Differences in healthcare related to clinical need or preference are not considered sources of disparities, reflecting the normative view that these differences are acceptable, and therefore, just. On the other hand, unjust sources of disparities include the operation of healthcare systems, the legal and regulatory climate, and discrimination, among other factors. In addition to the selection of a rigorous and nuanced disparities definition, future research on guideline-concordant treatment disparities should investigate the role of multilevel factors that reflect the social determinants of health. Cancer health disparities are entrenched in the social determinants of health, which cannot be effectively addressed at the individual-level alone. Citation Format: Ashley S. Felix. Racial disparities in guideline-concordant endometrial cancer treatment [abstract]. In: Proceedings of the AACR Special Conference on Endometrial Cancer: Transforming Care through Science; 2023 Nov 16-18; Boston, Massachusetts. Philadelphia (PA): AACR; Clin Cancer Res 2024;30(5_Suppl):Abstract nr IA008.

Childhood interpersonal trauma and postpartum parenting alliance: The role of mindfulness in couples.

A large body of evidence demonstrates that childhood interpersonal trauma is associated with poorer parental and couple outcomes following the birth of a new child. As a unique component of couple functioning, parenting alliance is key during this transition period and is associated with long-term parental and child well-being. However, parenting alliance remains understudied in relation to childhood trauma, and little is known regarding the underlying mechanisms of this relationship among couples. Given its documented role in the intimate relationships of childhood interpersonal trauma-exposed individuals, dispositional mindfulness could be considered as a potential explanatory mechanism. Using a dyadic approach, this study examined the role of dispositional mindfulness, and its different facets, in the association between cumulative childhood interpersonal trauma (CCIT) and parenting alliance. A randomly selected community sample of 421 parental couples with infants completed online questionnaires. For both mothers and fathers, CCIT was associated with a more negative perception of parenting alliance through lower dispositional mindfulness, specifically through lower scores on the nonjudgment and describing facets. Moreover, results revealed dyadic indirect effects between parents' CCIT and their partner's parenting alliance through both partners' dispositional mindfulness. This study provides insight on how parents of an infant may influence each other's perceived parenting alliance through their dispositional mindfulness. Results also highlight mindfulness as a relevant mechanism for CCIT survivors who struggle to establish or maintain a positive parenting alliance, as well as the need to involve both parents in research and intervention. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

Comparison of Short-term Results: Robotic-assisted vs. Conventional Bilateral Total Knee Arthroplasty

Introduction: Robotic-assisted total knee arthroplasty is becoming widely accepted as a method to improve intra-operative measures and post-operative functional outcomes. While there is a large body of evidence supporting robotic-assisted unilateral total knee arthroplasty (TKA), few studies have examined the outcomes of this technology in simultaneous bilateral TKA procedures. Thus, the purpose of the study is to compare the clinical outcomes between patients undergoing simultaneous robot-assisted bilateral total knee arthroplasty (raTKA) versus conventional bilateral total knee arthroplasty (convTKA). Methods: We retrospectively reviewed 140 simultaneous bilateral TKA cases (61 conventional, 79 robot-assisted) performed by a single surgeon in a single institution from January 1, 2015 to December 11, 2020. The institution’s electronic medical records were reviewed for patient demographic information, operative data, and post-operative complications. Outcomes Based Electronic Research Database (OBERD) records were reviewed for patient-reported outcomes (Oxford Knee Score and SF-12 Version 1) preoperatively and postoperatively at 6 months, 1 year, and 2 years. Results: Both raTKA and convTKA groups exhibited clinically relevant improvements beyond the minimally clinically important difference (MCID) in SF-12 physical and Oxford Knee Scores at 6 months, 1 year, and 2 years post-surgery. There were no statistically significant differences found between the two groups in terms of postoperative SF-12 scores, Oxford Knee Scores, complications, or revision rates. The raTKA group had a longer length of stay (2.6 versus 2.2 days, P=0.001) and a significantly different discharge disposition with more patients entering acute rehab compared to the convTKA group (20 versus 7 patients respectively, P=0.031). Conclusion: Robotic-assisted total knee arthroplasty has a non-inferior impact on short-term patient outcomes compared to conventional methods in patients undergoing simultaneous bilateral total knee arthroplasty. Level of evidence: III

The feminist perspective as a counterpoint in the architecture of Anna Bofill (1977–1996)

The vast and plural production of the woman architect, musician, activist, occasional educator and tireless researcher Anna Bofill Levi (Barcelona, 1944) is characterized by certain features that make its author a unique personality, although one hardly known and recognized in the Spanish and international circles that are the custodians of prestige in architecture. She has achieved most public recognition as a composer, the field in which she has been most productive over time and developed the furthest. Her music is characterized by the number of references, especially contemporary, she includes, the wide diversity of countries where it has been performed, and the range of people to whom she has dedicated her works, all these aspects testifying to her cosmopolitan and libertarian spirit and her commitment to equality. Her incessant writing, with all the reading it entails, has also left us with a large body of written work, extending over a number of fields, including most notably her reflections on the influence of the gender-based perspective on urban planning. A factor also reflected in her architecture, for example, in the implementation of participatory processes in her project designs. She joined the Taller de Arquitectura from the time she began her studies at the School of Architecture in Barcelona in 1964—she graduated in 1972—, and then commenced her independent career in 1981, although her first solo works date from 1977. Her work at the head of her office for almost 20 years is evidence of a tireless capacity for work and an unwavering commitment to people's welfare. This paper analyses Anna Bofill's contributions to feminist thinking through her work as an architect. Also, it addresses the study of a cultured person, a woman with great sensitivity and a strong political and personal commitment who has suffered discrimination and who has made rigor and determination the means to achieve her non-negotiable freedom.