IntroductionPain is almost the main problem after surgery, effective pain management is crucial for recovery, since poorly managed pain can have detrimental effects on a patient's physical functioning, mental health, interpersonal connections, and productivity. ObjectiveOur study compares LA and OA to evaluate post-operative pain in 42 h using the Visual Analouge Scale (VAS) with the goal decreasing the requirement for opioids to address postoperative pain. MethodsA retrospective analysis of patients with an appendicitis diagnosis who were admitted to the Department of General Surgery at General Hospital University of Muhammadiyah Malang between January 2018 and June 2019. 258 individuals with acute appendicitis, with 137 undergoing open appendectomy (OA) and 121 undergoing laparoscopic appendectomy (LA). ResultWe reported patients who obtained OA surgery experienced significant pain on first day, compared with patients who underwent LA operation, who reported light pain (P = 0.000). On second day Thirteen patients who underwent OA surgery reported a reduction in pain levels from moderate to mild (P = 0.000). Patients who underwent LA procedure, 59 participants had a significant reduction of pain level, 54 patients reduced from mild to no pain. and moderate pain to light pain reported in 5 patients, whereas the remaining 62 had no change level of pain (P = 0.000). ConclusionIn terms of post-operative pain, the LA operation is a reliable surgical technique and is preferable to an OA appendectomy.