This research investigates a computational method, which can assist the development of occupants’ passive safety in future autonomous vehicles, more particularly in the definition of head kinematics in rotated seat arrangement during emergency braking. To capture these head motions, the methodology utilised an Active Human Model, whose head kinematics were validated in a previous work in three-point and lap-belt restraint configuration scenarios. A sled model was then built where the seat backrest angle (SBA) and the seat orientation, modelled by rotating the acceleration angle (AA), could be adjusted to represent various ‘living room’ seating conditions. A Design of Experiments study was then performed by varying AA from 0° to 360° in steps of 22.5° and SBA from 20° to 60° in steps of 8°. The responses were subsequently converted into a Reduced Order Model (ROM), which was then successfully validated through a comparison with the kinematic responses predicted with simulations. In terms of simulation time, it was found that the ROM was able to calculate the head kinematics in 3 s instead of the 1.5 h taken using Simcenter Madymo, without compromising predicted responses accuracy. This research has provided a unique method to define head kinematics corridors for seated occupants in autonomous vehicle interiors, including maximum head excursion, head kinematics as a function of time and define for the first time (a) the safe “or’ but not both head envelope within the cabin interior, and (b) capture the seated scenarios where head proximity to airbag systems could be of concern, following emergency braking.