Human activities can significantly influence the quality of water flowing from a watershed, either positively or negatively. As water moves through the system, these impacts accumulate, with all land-based activities having the potential to affect the water quality and quantity experienced by downstream stakeholders. Similarly, the actions of upstream landowners impact the water that flows across others' properties. Geospatial techniques like remote sensing and geographic information systems (GIS) are invaluable tools for analysing drainage patterns within a watershed and the associated changes in land use and cover. This study focuses on the Panzara river basin, a principal tributary of the larger Tapi river basin, situated in central India between the westward-flowing Godavari and Narmada river systems, which both ultimately discharge into the Arabian Sea. The study area spans latitudes from 20°42'0" N to 21°18'0" N and longitudes from 74°06'0" E to 75°00'0" E, covering a geographical area of 2,986.05 square kilometers with a perimeter of 570.51 kilometers. The watershed delineation was carried out using Shuttle Radar Terrain Mapper (SRTM) data with a 30-meter resolution. For land use and land cover (LULC) analysis, Landsat 5 TM C2L1 and Landsat 8 OLI/TIRS C2L1 datasets, both with 30-meter resolution, were utilized. The present study conducts a morphometric analysis and assesses LULC changes within the Panzara river basin between 2000 and 2021. Morphometric parameters such as linear parameters [Drainage density (Dd), Stream frequency (Fs), Mean bifurcation ratio (Rbm), Drainage texture ratio (Dt), Length of overland flow (Lo)] and areal parameters [Elongation ratio (Re), Circulatory ratio (Cr), Form factor (Rf), Compactness coefficient (Cc)] were used to prioritize sub-watersheds. Furthermore, the study classifies the observed LULC changes between satellite imagery datasets from 2000 and 2021, quantifying the percentage changes in the respective LULC classes across the sub-watersheds over the two decades. The overall accuracy of the LULC classification was 81.82% for 2000 and 88.88% for 2021, with Kappa coefficients of 0.772 and 0.85, respectively. In terms of prioritizing sub-watersheds, common sub- watersheds such as SW-1, SW-10, and SW-15 were classified under moderate priority, while SW-5, SW-8, and SW-14 were classified under the lowest priority. The results of this study, particularly the prioritization of sub-watersheds, can be instrumental for hydraulic engineers in planning and managing water resources in the Panzara river basin.