Laboratory Testing Of Components Research Articles

Distribution of Dolichol in the Serum and Relationships between Serum Dolichol Levels and Various Laboratory Test Values

We examined the correlations between serum dolichol levels and laboratory test parameters in patients affected by disease, as well as the distribution of dolichol in sera from patients with hyperbetalipoproteinemia and hyperalphalipoproteinemia. Serum dolichol was evaluated by a reverse-phase HPLC method. After centrifugation, the serum dolichol found in healthy controls was mainly associated with medium-sized particles of the high-density lipoprotein (HDL) fraction. For patients with hyperbetalipoproteinemia, serum dolichol was also associated with the medium HDL fractions. However, for hyperalphalipoproteinemia patients the levels of large HDL and serum dolichol were increased, and serum dolichol was mainly associated with the large HDL fraction. On laboratory tests of components, the dolichol level was not correlated with the values for markers of the liver and biliary system, with the values of renal function markers, with creatine kinase activity, amylase activity or uric acid concentration, but was correlated with total cholesterol, HDL-cholesterol and apoA-I concentrations, and with lactate dehydrogenase (LDH) activity. These results suggest that serum dolichol exclusively localized in HDL, and in subpopulation, that in normocholesterolemia or hyperbeta-cholesterolemia is associated with HDL(3), which is small sized and high density HDL, however, that in hyperalphacholesterolemia is associated with HDL(2), which is large sized and lower density HDL.

The Testing of Airborne Inertial Navigation Systems

The limitations to the accuracy of an inertial navigator are first of all the inherent accuracy of the inertial components—gyros and accelerometers; secondly the accuracy with which these are controlled, i.e. by power supplies, and electronic circuitry; thirdly the accuracy of the associated navigation computer. All these three can be checked during manufacture and by laboratory testing of components and systems. However, there remains the effect of the aircraft environment on accuracy. It is possible to simulate some of the environment, for example vibration and temperature, in the laboratory, but it is not possible to simulate realistic accelerations, velocities and displacements, and so flight trials form an essential part of the evaluation of an inertial system. Flight trials may be preceded by trials in a land vehicle on grounds of economy, but such trials are of limited value because of the limited velocities and displacements available. In this paper we shall attempt to summarize our experience at R.A.E. and A. & A.E.E. of laboratory, van and flight testing of inertial navigators which has been acquired in joint trials over the past five or six years. During the next twelve months we shall be associated in trials of three further inertial navigators, the Elliott E5, the Sperry SGN 10 and the Ferranti FMP-B, and we shall also describe in this paper some of the techniques which will be used for the first time in these trials. This is not intended to be an exhaustive treatment of system testing, but will be mainly confined to the systems and tests of which we have practical experience.