Laboratory Profile Of Dengue Fever Research Articles

Clinical and Laboratory Profile of Dengue Syndrome in Pediatric patients: Study in a Tertiary Care Hospital, Dhaka, Bangladesh

Introduction: Dengue fever is a mosquito-borne arboviral (arthropod-borne virus) disease which is of global concern. This fever is a benign syndrome caused by an arthropod-borne virus and is characterized by Biphasic fever, myalgia, arthralgia, rash, leukopenia, and lymphadenopathy. Aim of the study: This study aimed to evaluate the clinical and laboratory profile of dengue fever in children less than 15 years old admitted to an urban hospital. Methods: This retrospective study was conducted in the Department of Paediatrics of Anwer Khan Modern Medical College Hospital (AKMMCH), Dhaka, Bangladesh during the period from 4 April 2019 to 9 September 2019. They have followed up on the symptoms, platelet count and management of the patients. Data were analysed by using MS-Excel-2016. Result: In total 98 patients from both groups completed the study. In our study, we found a maximum of 54.08% were male, more than half 53(54.08%) patients were below five years of age, about 95(96.94%) of the patients had a fever. Maximum patients, 81(82.65%), were managed by I/V fluid, more than 72(73.47%) of the patients were managed by paracetamol. Others by antibiotics 16(16.33%), platelet transfusion 14(14.29%) and blood transfusion 12(12.24%). Other management also includes plasma, & dopamine. Conclusion: These study children about 0-15 years of age more commonly suffer from dengue fever. As the vaccine is not available in Bangladesh, these patients need a timely diagnosis and critical monitoring during the disease course to prevent severity and mortality.

Clinical Profile and outcome of Dengue Fever in Under 5 Children Admitted at a Tertiary Care Hospital, Dhaka

Background: Dengue has become a major public health problem in Bangladesh with gradually increasing infectivity and severity. Most vulnerable population are children especially children below 5 years of age. However, data regarding dengue among this age group is limited. The objectives of this study were to see the clinical and laboratory profile of dengue fever (DF) in children below 5 years of age and their outcome. Methods: This cross – sectional observational study was carried out in the department of Paediatrics, BIRDEM General Hospital from May 2023 to September 2023. One hundred eighty nine confirmed dengue cases were enrolled in the study. Their clinical profile and laboratory findings including haemoglobin (Hb%), haematocrit (Hct), total count of white blood cells (TC), platelet count (PC), serum alanine aminotransferase (S. ALT), serum aspartate aminotransaminase (S. AST), prothrombin time (PT), international normalized ratio (INR), activated partial thromboplastin time (aPTT), serum calcium and serum sodium level were documented and analyzed. Results: Among 189 children 57(30.1%) were infants and 132(69.8%) patients were aged 1 to 5 years. Depending upon the severity of dengue 98(51.8%) were classical dengue fever, 65(34.3%) and 14(7.4%) presented with dengue shock syndrome (DSS) and dengue heamorrhagic fever (DHF) respectively. Fever was present in all children, other common features were vomiting (34.9%), cough (25.9%), dehydration (26.9%), pleural effusion (34.3%), ascites (23.2%) and skin rash (18.5%). Shock were present in 41.1% cases. Warning signs like restlessness, lethargy, altered level of consciousness, convulsion was present in 16.4%, 9.5%, 2.6% and 11.6% respectively. All the children were improved and discharged. Conclusion: In this study dengue presented classically in most of the children. Dengue shock syndrome and dengue haemorrhagic fever were below 10%. The outcome was excellent with no modality. Early reporting to hospital appeared important. J Bangladesh Coll Phys Surg 2023; 41: 25-28

Pattern of Presentation and Outcome in Dengue Fever in Hospitalized Children in A Hospital in Dhaka

Background : A large number of people are becoming infected with dengue fever, which is a mosquito borne viral disease. It is mostly self-limiting, but complications can result with significant morbidity and mortality. In recent years, there has been a significant increase in the number of cases, with the majority of the population being children. There is scarcity of data regarding dengue in children in our country. Hence, to evaluate, the clinical and laboratory profile of Dengue Fever (DF) among the children and their outcome was aim of this research work.
 Materials and methods: This is a retrospective observational study, performed among the serologically confirmed dengue virus infected 200 children, admitted in Department of Paediatrics, Kurmitola General Hospital (KGH) Dhaka from April 2019 to December 2021. Clinical and laboratory indicators were documented daily in the study cases, and the data were analyzed by SPSS version 25.
 Result: Out of the 200 cases, 100 patients (50 percent) had classical DF, 61 patients (30.5 percent) had Dengue Hemorrhagic Fever (DHF) while 39 patients (19.5 percent) had Dengue Shock Syndrome(DSS). Mean age of patients were 5.8±3.6 years, male predominance. Most patients belong to urban area and middle socioeconomic background. Gastrointestinal symptoms were more prevalent in DHF patients. Most of the patients had thrombocytopenia and raised hematocrit. Thrombocytopenia, an elevated Hematocrit (hct) an elevated hypertransaminesemia were all found to be statistically significant in DHF. 85% patients were treated with crystalloid and 14% with colloid, found excellent outcome with no death.
 Conclusion: Dengue fever is a major health problem, with a wide range of symptoms, from mild and self-limiting to severe and fatal. Unrecognized manifestations include a wide range of symptoms spanning multiple organ systems. Doctors should be on the lookout for atypical signs and symptoms.
 IAHS Medical Journal Vol 4(2), December 2021; 41-45

Clinical and Laboratory Profile of Dengue Fever in Elderly Patients Admitted in a Tertiary Hospital from 2013 to 2018

Philippines is among the top southeast Asian country that is endemic to Dengue Fever based on DOH reported cases - from a reported 152,224 in 2017 to an increase in 216,190 in 2018. Most studies in the country are derived from the pediatric and/or young adult population hence, there is a dearth of data describing our elderly patient with dengue. This is a retrospective observational study of elderly individuals diagnosed with Dengue Fever admitted at St. Luke's Medical Center, E. Rodriguez, Quezon City from January 1, 2013 to December 31, 2018. A total of 142 elderly were recorded; 65% are females.

Clinical and laboratory profile of dengue fever in children from a tertiary care centre of Gandaki Province, Nepal

Introduction: Dengue, the arthropod borne viral disease is serious public health problem in Nepal. The clinical diagnosis of dengue has become challenging in children as it is presented with nonspecific symptoms. The objective of present study was to assess different clinical presentations and outcomes of dengue fever in tertiary care centre.
 Methods: A record based observational cross-sectional study was carried out on all dengue positive patients of aged 11 months to 15 years presented in Gandaki Medical College from July to November 2019. Total 74 patients with history of fever with dengue seropositive were included in the study. All the clinical and haematological findings were recorded in semi-structured questionnaire form.
 Results: Of 74 patients 40 (54.1%) males and 34 (45.9%) were females. Fiftyone (68.9%) were cases of dengue without warning sign, 18 (24.3%) were dengue with warning signs and 5(6.8%) cases had severe dengue symptoms. Most of the patients (78.38%) were from Kaski district. Fever (100%) was the most common clinical presentation followed by headache (36.5%), vomiting (25.7%), and retro orbital pain (20.3%). Common laboratory findings included thrombocytopenia (59.4%) and leukopenia (35.1%). Among 74 cases, 68 were in stable condition and treated in OPD or in ward, and 6 were admitted in ICU of which one developed warning signs and other 5 had severe dengue. All the enrolled children recovered well and there was no mortality during this period.
 Conclusions: Fever, headache, vomiting, thrombocytopenia and leukopenia were most common presentation of dengue fever among children. Appropriate clinico-laboratory diagnosis and management is relatively simple, inexpensive and very effective in saving lives as long as correct and timely interventions are instituted.

A Retrospective Study of Clinical and Laboratory Profile of Dengue Fever in Tertiary Care Hospital, Wardha, Maharashtra, India

Dengue disease is caused by dengue virus which is a vector born viral infection. The prevalence of dengue has increased dramatically from past few decades. The clinical symptoms vary from asymptomatic to severe hemorrhagic fever leads to high morbidity and mortality. Method- This retrospective study was carried out during January 2019 to December 2019. The laboratory test was done by using J Mitra & Co on Day 1 of their visit to the hospital which shows NS1, IgM and IgG reactivity towards dengue fever. The clinical profile information data was collected from patient records. Out of 640 samples 62.18% (398) was positive. The percentage of positive males and females were 60.78%, 64.23% respectively. The highest prevalence of dengue infection was observed more in age group between 31-40 years (81.69%) and least prevalence in age group 71-80 years (36.36%). Most of the patients were positive for NS1Ag121 (30.4%) followed by IgM positive 87 (21.9%) & 59 (14.8%) positive for both IgM and NS1 Ag The highest number of infections was seen during October (75.8%) post monsoon season. All patients had a fever, followed by head ache (82%) and body pains (66.4%), 64.84% stayed in the hospital less than 5 days. In tropical and sub-tropical regions dengue is still a leading public health problem especially during rainy and post monsoon seasons. Both NS1 Ag and IgM detection in early acute phase has potential diagnostic value. So, to reduce mortality there need to initiate community-based cohort studies to predict the pace of dengue spread based on clinical presentation and laboratory findings during epidemics in India. Aedesaegypti is a common vector for transmission of DENV, CHIKV and ZIKV, so there is a need to screen for these infections in endemic areas.

Clinical and laboratory profile of dengue fever in hospitalized children in a tertiary care hospital in Bangladesh

Background: Dengue is a major health problem affecting Bangladesh. The number of cases have increased over the last few years with a large number of population being children. However data regarding dengue among children is limited. The objectives of this study were to see the clinical and laboratory profile of dengue fever (DF) in children and their outcome.
 Methods: This cross - sectional study was carried out in the department of Paediatrics, BIRDEM General Hospital 2 from June 2018 to August 2019. Three hundred and ten confirmed dengue cases were enrolled in the study. Their clinical profile and laboratory findings including haemoglobin (Hb%), haematocrit (Hct), total count of white blood cells (TC), differential count of white blood cells ( DC), platelet count (PC), serum alanine aminotransferase ( S. ALT), serum aspartate aminotransaminase (S. AST), prothrombin time (PT), international normalized ratio (INR), activated partial thromboplastin time (APTT) were documented. Comparison was made between the clinical and laboratory profile with severity of dengue.
 Results: One hundred and ninety eight (63.9%) had dengue fever, 58(18.7%) had dengue haemorrhagic fever (DHF I, II) and 54 ( 17.4 %) had dengue shock syndrome ( DHF III and IV). All the patients had fever, vomiting was present in 40%, ascites and skin rash in 21 %, pleural effusion 20%, abdominal pain 14% and 12.2% came with shock.Thrombocytopenia, raised hct, raised liver enzymes and abnormal coagulation profile were more common in dengue haemorrhagic fever when compared to patients with dengue fever.
 Conclusion: Gastrointestinal features like vomiting, ascites ,abdonminal pain were common presentations. Thrombocytopenia, raised hct, raised liver enzymes, abnormal coagulation profile were more common in dengue haemorrhagic fever.
 Birdem Med J 2020; 10(3): 200-203

Clinical and laboratory profile of dengue fever in children in a tertiary care hospital of Navi Mumbai, India

Background: Dengue fever is a mosquito born arboviral illness endemic in tropical countries and causes significant mortality and morbidity due to lack of definitive treatment. The objective of this study was to assess the clinical and laboratory profile of confirmed cases of dengue in children up to 12 years of age and also to charactrise the risk factors for severe dengue.Methods: This is a descriptive, observational, retrospective study done in the Department of Pediatrics, Terna Medical College, Nerul, Navi Mumbai, India. Medical records of all children up to 12 years of age diagnosed to have dengue were reviewed. Their clinical and laboratory profile were recorded in a pro forma and analyzed. All cases were classified as per WHO guidelines into non severe and severe dengue cases.Results: Among the 117 confirmed dengue cases, (84.6%) had non severe dengue and (15.4%) had severe dengue. The most common age group affected was 9-12 years (45.3%) with a male to female ratio of 2.4:1. Fever was the most common clinical feature seen in all cases followed by headache (83%), myalgia (81%), ascites (24.7%), vomiting (17.9%). Clinical signs of ascitis, hepatomegally, gastrointestinal bleeding, pleural effusion and shock were predominantly associated with severe dengue cases. Laboratory parameters showed leukopenia in 58.1% and thrombocytopenia (platelet counts <20,000/cumm3) in16.2% cases. Elevated liver enzymes, raised hematocrit (36.3%) and coagulation abnormalities were seen in over 50% dengue cases and were significantly associated with severe dengue dengue.Conclusions: Knowledge of clinical and laboratory profile of dengue cases of a particular area will help in early prediction of risk factors for severe dengue resulting in favourable outcome of such cases.

English

English

Study of clinical and laboratory profile of dengue fever in a tertiary care hospital

Background: Dengue fever is one of the most common arboviral mediated outbreaks reported with increased prevalence over the last few years with considerable morbidity and mortality. This study was designed to study the clinical and biochemical parameters in dengue fever patients.Methods: Prospective observational study was undertaken among adult patients in a tertiary care hospital. fifty patients were studied and analysed. All patients who were NS1 (Non-Structural Protein 1) antigen or IgM dengue positive were included in the study. Clinical features, haematological and biochemical parameters were noted.Results: Of the 50 patients studied, majority were males (68%). Fever was the major symptom (100%) followed by Body ache (84%), Headache (64%), Retro-orbital pain (52%), Myalgia (48%), conjunctival injection (40%), Itching (40%), abdominal pain (36%), Bradycardia (34%), Rash (30%), pleural effusion and ascites both seen in (28%). Significant derangements in platelet (76%), leucocyte counts (84%) and serum transaminases (58%) were noted.Conclusions: Fever associated with headache, retroorbital pain, erythematous morbilliform rash, conjunctival injection and itching over palms and soles along with thrombocytopenia, leukopenia, elevated liver transaminases should prompt a clinician on the possibility of dengue infection. Platelet transfusions have little role in management of dengue patients unless patients having active bleeding secondary to thrombocytopenia due to dengue fever.

The clinical and laboratory profile of dengue fever in a tertiary care hospital

Background: Dengue fever is one of the most common acute viral illness associated with considerable morbidity and mortality. Recently, there is an alarming rise of dengue in India. This study was undertaken to know the clinical profile and laboratory findings during the evolution of dengue fever.Methods: A total of 120 patients of dengue fever who were NS1 antigen or IgM dengue positive, admitted to medical wards of Narayana Medical College, Nellore included in the study. Thorough clinical examination and relevant laboratory investigations performed in all patientsResults: Males were commonly affected (72.4%). Fever was the most common presentation (100%), followed by headache (96%) myalgia (94%), abdominal pain (24.46%), and retro-orbital pain (12.45%). Malena was the most common hemorrhagic manifestation. Laboratory findings include varying degree of thrombocytopenia in all patients, leukocytopenia (30.52%), increased hematocrit (>45%) (67.59%) and deranged liver function test (58.33%)Conclusions: Early diagnosis, monitoring, and prompt supportive management can reduce mortality in dengue. Atypical presentations of dengue should be kept in mind, which may cause a delay in the diagnosis. Increased community awareness and vector control measures need to be strengthened during the peri-monsoon period to reduce the burden of dengue cases.

A Study of Clinical and Laboratory Profile of Dengue Fever in a Tertiary Care Teaching Hospital

A Study of Clinical and Laboratory Profile of Dengue Fever in a Tertiary Care Teaching Hospital

Clinical and laboratory profile of dengue fever: a retrospective study

Background: The global incidence of dengue has grown dramatically in recent decade. Half of world’s population is now at risk. India represents significantly a larger burden, accounting for nearly 34% of the global burden of dengue infection. Dengue infection needs to be addressed as a single disease with different clinical presentations ranging from asymptomatic conditions to severe clinical courses that may lead to high morbidity and mortality.Method: This was retrospective observational study carried out during period of July 2017 to April 2018, to study clinical profile and laboratory parameters in dengue fever patients. Confirmed dengue cases having NS1 positive or IgM positive or having both NS1 and IgM positive or dengue ELISA reactive, having minimum one CBC reports done and not having other confounding factor such as co-infection, bone marrow diseases etc. that may altered clinical and laboratory results are included in study. Statistical analysis was done by SPSS software version 18.0.Results: Out of 48 confirmed dengue cases maximum patients 58.33% was from young age group (21 to 40 years) with M:F ratio was 2.43:1. Fever was found in 100% patients, in order of frequency followed by headache, bodyache, abdominal pain, weakness, retro-orbital pain, anorexia, dry cough, back pain, nausea, diarrhoea, vomiting, rash, joint pain, itching and malena.NS1was positive in 41.67% cases, dengue ELISA in 31.25%, IgM was positive in 20.83% cases, and both NS1 and IgM positive were in 4.17% cases. TLC count was low 35.42%, high in 12.50% of cases and remaining had normal TLC count. Platelet count was ranged between normal platelet counts to thrombocytopenia. One case had platelet count less than 20000. Out of 48 patients, 2 (4.17%) had malena.Conclusion: In this study, fever was found in all patients, and headache, body ache and weakness were common symptoms, but significant number of patients also had gastroentstinal and respiratory symptoms like abdominal pain, nausea, diarrhea, vomiting and dry cough. TLC count ranging from normal TLC, leukopenia to leucocytosis. Large number of patients had low platelet count that shows dengue fever had varied clinical presentation.

A Study of Clinical and Laboratory Profile of Dengue Fever in Tertiary Centre

A Study of Clinical and Laboratory Profile of Dengue Fever in Tertiary Centre

Clinical and laboratory profile of dengue fever in hospitalized children among South Indian population

Background: Dengue fever is currently regarded globally as one of the most important mosquito-borne viral diseases. Children suffering from dengue fever shows a large variation in clinical features and laboratory parameters. This study was focused to evaluate the clinical presentation, associated laboratory and radiological profiles that may be useful to diagnose dengue fever.Methods: Prospective observational study including 500 children with serological positive dengue fever admitted in a tertiary care hospital in South India.Results: In this study mean age of presentation of children with dengue fever was 8.4±1.2 years with male predominance. The incidence of children presenting with DF, DHF and DSS was 61%, 23% and 16% respectively. The most common symptom was fever in 100% patients followed by vomiting in 69%, abdominal pain in 64.2%, bleeding manifestations in 43% and periorbital pain in 28.8% of patients. The NS1 was positive in 39.2% cases, dengue IgM in 29% of cases and IgG positive in 30.4% cases. By ultrasonography it was observed that 34% of patients had ascites, 28% with pericholecystic edema, 12% with bilateral pleural effusion, 10% with right sided Pleural effusion and hepatomegaly and 5% with splenomegaly. The most common cause of death was cardiorespiratory arrest secondary to DIC.Conclusions: Detection of Ns1 antigen to diagnose dengue is proposed to be superior when compared to antibodies detection. It is also concluded that diagnosis of dengue should be made comprehensively by clinical examination with supporting laboratory and radiological investigations.

Clinical and laboratory profile of dengue fever in children during an outbreak - one year study at tertiary care hospital, Chennai, Tamilnadu, India

Background: Dengue fever is a mosquito borne arboviral disease which is of global concern. It is endemic in tropical countries with annual incidence of 7.5 to 32.5 million cases. It commonly affects the young adults and paediatric cases of Dengue haemorrhagic fever has high mortality. The objective of this study was to assess the clinical and laboratory profile and outcomes of dengue fever in children of less than 18 years of age. The study was conducted for a period of one year during an outbreak, in a tertiary care hospital of Chennai, Tamilnadu, India.Methods: This was a prospective cross sectional study and 200 cases of dengue fever were enrolled and classified as per WHO guidelines. The clinical profile and demographic profile was recorded in a structured questionnaire form. Haematological parameters were recorded and followed till the day of discharge. The duration of stay was recorded and outcomes were noted.Results: A total of 200 cases with 113 males and 87 females, 177 non severe dengue cases and 23 severe cases of dengue fever were classified. The mean age of admission was 9 years and mean duration of stay in hospital was 4.61 days. Fever was most common presenting symptom (100%) and hepatomegaly (58.5%) was common clinical finding. Bleeding manifestations were seen in severe dengue cases. Statistical significance was seen in rise in SGOT levels, rise in haematocrit and pleural effusion with severe dengue cases and non-severe dengue cases. The case fatality rate was zero.Conclusions: Understanding the knowledge of presentations and associated features would help to predict the severity of the disease. In children, if symptoms like fever, pain, rashes, and vomiting are associated with Hepatomegaly and elevated SGOT in context of low total platelet count, a strong possibility of dengue fever is present, especially in an epidemic setting. Early suspicion and effective management can reduce the severity.