As the main means of resolving labor disputes, labor dispute arbitration has played an important role in resolving labor disputes in China, protecting the legitimate rights and interests of the parties, and promoting harmonious and stable labor relations. The governments and social organizations of Guangdong, Hong Kong and Macao are building a social governance pattern of co-construction and co-governance and a multi-dispute handling mechanism of labor disputes. In this context, the existing labor dispute arbitration institutions in China are no longer sufficient to solve the problems of cross-border labor disputes. It is feasible and necessary to build a specialized institution for cross-border labor arbitration in the Guangdong-Hong Kong-Macao Greater Bay Area. Based on this, the article puts forward feasible suggestions on the positioning, construction mode, personnel composition and supporting mechanism setting of specialized agencies, to make up for the deficiencies of the current labor dispute resolution mechanism, and to promote the construction of Guangdong-Hong Kong-Macao labor relations and the legalization process in the Greater Bay.