La Rosa Research Articles

RETRACTION: Bach2 overexpression represses Th9 cell differentiation by suppressing IRF4 expression in systemic lupus erythematosus.

Y. Sheng, J. Zhang, K. Li, H. Wang, W. Wang, L. Wen, J. Gao, X. Tang, H. Tang, H. Huang, M. Cai, T. Yuan, L. Liu, X. Zheng, Z. Zhu and Y. Cui, "Bach2 Overexpression Represses Th9 Cell Differentiation by Suppressing IRF4 Expression in Systemic Lupus Erythematosus," FEBS Open Bio 11, no. 2 (2021): 395-403, https://doi.org/10.1002/2211-5463.13050. The above article, published online on 28 November 2020 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the authors; the journal Editor-in-Chief, Miguel A. De la Rosa; FEBS Press; and John Wiley and Sons Ltd. The retraction has been agreed following diagnostic errors identified by the authors in the patient samples used in this study. Based on the issues identified, the editors and authors consider the conclusions substantially compromised.

8359 Increased hepatic SGK1 activity promotes metabolic dysfunction-associated fatty liver disease in a sex-dependent manner

Abstract Disclosure: A. Vastola-Mascolo: None. G. Hernández: None. D. Alvarez de la Rosa: None. The serum and glucocorticoid-induced kinase 1 (SGK1) is a Ser/Thr kinase with key roles in fluid and electrolyte homeostasis, blood pressure regulation and energy metabolism. Its expression is controlled by steroid hormones such as glucocorticoids, mineralocorticoids and estrogen, in addition to other stimuli such as glucose. SGK1 activation mainly depends on the PI3 kinase pathway, implicating it in insulin signaling. Previous work from our laboratory demonstrated that a systemic increase in SGK1 activity exacerbates diet-induced development of metabolic syndrome in mouse, characterized by obesity, glucose intolerance, insulin resistance, dyslipidemia and hypertension. In addition, a high-fat diet rapidly led to the development of hepatic steatosis. We now test the hypothesis that at least part of the effects of increased systemic SGK1 activity promoting the development of metabolic syndrome are due to alterations in liver glucose or lipid handling. To that end we developed a mouse strain with hepatocyte-specific transgenic SKG1 expression and challenged it with high-fat or high-fat/high-sucrose diets. Our results show sex differences in the development of obesity, with a marked increase in body weight in female, but not male transgenic animals. Glucose homeostasis was normal in both sexes. Increased obesity in females correlated with increased lipid accumulation in the liver. However, liver fibrosis, inflammation and dyslipidemia were more marked in male animals, further suggesting an interaction between SGK1 and sex steroid hormone signaling. Our results demonstrate a key role of SGK1 in liver lipid metabolism and suggest a crosstalk between this signaling pathway and sex hormones, which determine a more negative outcome in male animals. Presentation: 6/1/2024

TRICHINELLA MURRELLI POZIO AND LA ROSA, 2000 IN A GRAY FOX (UROCYON CINEREOARGENTEUS) FROM PENNSYLVANIA: A NEW HOST RECORD FOR THIS ZOONOTIC NEMATODE.

Trichinella murrelli Pozio and La Rosa, 2000, is the primary sylvatic trichinellid encountered in temperate North America. During a survey for Sarcocystis in wild canids, a single worm matching the morphology of encapsulated Trichinella was observed in a muscle tissue squash from a gray fox male originating from Pennsylvania. The worm was photographed and then separated from the host tissue by artificial digestion, and genomic DNA was extracted from the worm. This DNA was subjected to species-specific multiplex PCR and short-read genomic sequencing. The banding pattern of the multiplex PCR indicated that the worm was T. murrelli, and the sequence of the mitochondrial Cytochrome c oxidase 1 gene and the ribosomal 18S ribosomal RNA, Internal Transcribed Spacer 1, 5.8S ribosomal RNA, Internal Transcribed Spacer 2, and 28S ribosomal RNA confirmed the diagnosis. This is the first report of T. murrelli in gray foxes that includes assays for assigning parasite species. This report confirms suspected data from surveys conducted over 30 yr ago and establishes a new host record for T. murrelli.

Concha Méndez y los dibujos animados: las Silly Symphonies de Walt Disney en El Carbón y la Rosa (1935)

In the 1920s and 1930s in Spain, several authors expressed their admiration for cartoons in their literary texts. Among the works that were inspired by these films, the children’s theatre piece El Carbón y la Rosa (1935), which Concha Méndez published in Madrid, stands out. Besides that, the writer made explicit the link of this text with Walt Disney’s animated films and the influence of the short films that belong to the Silly Symphonies can be seen in it. For this reason, this work aims to analyze how Méndez was inspired by them to create a theatrical play full of color, music and an anthropomorphic nature with the aim to wonder children.

Iterations and unions of star selection properties on topological spaces

In this paper, we investigate what selection principles properties are possessed by small (with respect to the bounding and dominating numbers) unions of spaces with certain (star) selection principles.. Furthermore, we give several results about iterations of these properties and weaker properties than paracompactness. In addition, we study the behaviour of these iterated properties on $\Psi$-spaces. Finally, we show that, consistently, there is a normal star-Menger space that is not strongly star-Menger; this example answers a couple of questions posed in [J. Casas-de la Rosa, S. A. Garcia-Balan, P. J. Szeptycki, \emph{Some star and strongly star selection principles}, Topology Appl. 258 (2019) 572-587]

Abstract 6684: Impact of fecal microbiome on the efficacy of neoadjuvant chemo-immunotherapy and colitis adverse events: Findings from the NADIM II Trial

Abstract Introduction: The balance and composition of the gut microbiome play a pivotal role in modulating the host immune system, and they have been associated with survival outcomes in patients undergoing immunotherapy-based treatments and immune-related adverse events. In this study, our objective was to analyze the fecal microbiota of non-small-cell lung cancer (NSCLC) patients with locally advanced disease undergoing neoadjuvant chemo-immunotherapy (IO-CT). Methods and patients: Baseline stool samples were collected from 86 resectable stage IIIA/B NSCLC patients enrolled in the NADIM II clinical trial (NCT03838159). The patients were randomly assigned to receive either neoadjuvant nivolumab plus chemotherapy (CT) or CT alone. DNA extraction was performed using the QIAamp PowerFecal DNA Kit (Qiagen), and the samples were analyzed using the Ion AmpliSeq Microbiome Health Research assay (ThermoFisher). The NGS analysis utilized the AmpliSeq Microbiome Health w1.3 workflow. Alpha diversity was assessed using the Simpson and Chao1 Index. Results: Among the 86 collected stool samples, 77 were deemed valid for analysis. Bacteroides were the most common genus with a relative percentage (RP) of 18.9% ± 14.8 followed by Faecalibacterium (13.4% ± 7.8). The presence of bacteria from the genera Bifidobacterium, and Faecalibacterium was associated with improved progression-free survival (PFS) [HR = 0.4 (0.16-0.98), and HR = 0.08 (0.01-0.72), respectively] and overall survival (OS) [HR = 0.19 (0.06-0.62)], and HR = 0.04 [0.01-0.43], respectively), in the experimental arm. The detection of Faecalibacterium prausnitzii (validated by qPCR) was associated with improved PFS [HR = 0.17 (0.04-0.76)] and OS [HR = 0.05 (0.01-0.29)] in the experimental. On the other hand, detection of bacteria from the genera Synergistes, Lactobacillus, and Anaerotruncus was associated to higher risk of disease progression [HR = 9.9 (1.2-85), HR = 3.7 (1.5-9.1), and HR = 12 (1.4-110)] and death [HR = 51 (3.2-820), HR = 6.7 (2-23), and HR = 25 (2.3-280)] in this set of patients.In the entire cohort, patients whose samples were in the highest tertile of alpha diversity, had significantly prolonged PFS compared to those with intermediate or low diversity [HR = 0.39 (0.16-0.94)]. Finally, 25 colitis adverse events (CAE) occurred in 18 patients, including two Grade 3 (2.3%) and four Grade 2 (4.6%) events. A higher RP of Bacteroides were found in patients who did not suffer colitis events (P = 0.016), whereas higher RP of Coriobacterium were detected in patients who suffered CAE (P = 0.023). Conclusions: Our findings suggest that composition of the gut microbiome may play a crucial role in the effectiveness of neoadjuvant IO-CT in NSCLC patients. Specifically, the presence of F. prausnitzii may enhance the antitumor activity of these treatments. Citation Format: Roberto Serna-Blasco, Alejandro Rodriguez Festa, Sandra Sanz-Moreno, Lucía Robado de Lope, Pilar Mediavilla Medel, Ernest Nadal, Jose Luis González Larriba, Alex Martínez-Martí, Reyes Bernabé, Joaquim Bosch-Barrera, Joaquín Casal-Rubio, Virginia Calvo, Amelia Insa, Santiago Ponce, Noemí Reguart, Javier de Castro, Joaquín Mosquera, Manuel Cobo, Andrés Aguilar, Carlos Camps, Rafael López de Castro, Teresa Morán, Isidoro Barneto, Delvys Rodríguez-Abreu, Carlos Aguado de la Rosa, Ramón Palmero, Florentino Hernando-Trancho, Javier Martín-López, Alberto Cruz-Bermúdez, Bartomeu Massuti, Miguel Ángel Molina Vila, Atocha Romero, Mariano Provencio. Impact of fecal microbiome on the efficacy of neoadjuvant chemo-immunotherapy and colitis adverse events: Findings from the NADIM II Trial [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 6684.

Withdrawal: Urinary exosomal tRNA-derived small RNA signatures as a predictive biomarker in lung cancer.

Withdrawal: Urinary exosomal tRNA-derived small RNA signatures as a predictive biomarker in lung cancer, published in FEBS OPEN BIO, 10.1002/2211-5463.13716. The above article, published online on 9th October 2023 in Wiley Online Library (wileyonlinelibrary.com), has been withdrawn by agreement between the journal Editor in Chief, Miguel De la Rosa, and Wiley Periodicals LLC. The withdrawal has been agreed following no response from the author to requests to sign the Journal's publishing license/to requests to approve their article proof for publication. https://doi.org/10.1002/2211-5463.13716.

Enzymatically acylated naringin with gut modulation potential

BackgroundNaringin is one of the main flavonoids in citrus fruits and byproducts. This flavanone has been shown to be a good antioxidant nutraceutical component, and it also has potential as a gut microbiome modulator, although its applications in final formulations represent a challenge due to its low solubility, both in water and in organic solvents. This work addresses this problem by functionalizing naringin through enzymatic acylation. ResultsThe enzymatic acylation catalyzed by the lipase Novozym® 435 and using acyl donors of different chain lengths, acetate (C2), propionate (C3), and laurate (C12), yielded in conversions of 95% at 24 h and 100% at 48 h, generating a monoacylated product. Both the aqueous and solvent solubility of acylated naringin products were improved while maintaining or even increasing their antioxidant activity. ConclusionsThis acylation process significantly enhanced both the water and solvent solubility of the acylated naringin products while preserving or even enhancing their antioxidant activity. In addition to the gut-modulating properties of flavonoids, acylating them with short- and medium-chain fatty acids could enhance their potential applications in the emerging field of research dedicated to understanding and modulating gut health.How to cite: Gutiérrez-Navarro E, Padilla-de la Rosa JD, Macías A, et al. Enzymatically acylated naringin with gut modulation potential. Electron J Biotechnol 2024; 68. https://doi.org/10.1016/j.ejbt.2023.12.003.

Marriage and the culture of peace (communication skills for families, therapists, dan society) Marriage and the culture of peace (communication skills for families, therapists, dan society) , by Cecilia Sarahi De La Rosa Vazquez and Paris A. Cabello-Tijerina, New York, NY, Routledge, 2023, 211 pp., £23.99 (paperback), ISBN: 9781032074542

Marriage and the culture of peace (communication skills for families, therapists, dan society) <b>Marriage and the culture of peace (communication skills for families, therapists, dan society)</b> , by Cecilia Sarahi De La Rosa Vazquez and Paris A. Cabello-Tijerina, New York, NY, Routledge, 2023, 211 pp., £23.99 (paperback), ISBN: 9781032074542

Retraction: IFITM3 promotes hepatocellular carcinoma invasion and metastasis by regulating MMP9 through p38/MAPK signaling.

IFITM3 promotes hepatocellular carcinoma invasion and metastasis by regulating MMP9 through p38/MAPK signaling. Jiaqi Min, Qian Feng, Wenjun Liao, Yiming Liang, Chengwu Gong, Enliang Li, Wenfeng He, Rongfa Yuan, Linquan Wu, FEBS Open Bio, 8: 1299-1311. https://doi.org/10.1002/2211-5463.12479 The above article, published online on 14 June 2018 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor-in-Chief Miguel De la Rosa, the corresponding author, FEBS Press, and John Wiley and Sons Ltd. The retraction has been agreed due to the identification of duplication and repositioning of images in Figs 2C-E and 3C,D and excessive editing (high contrast) of Western blot images throughout the article. The authors were unable to provide the original raw Western blot data upon request. Given the extent of the identified issues, the editors have lost confidence in the data presented and have therefore decided to retract it.

Retraction: Kinesin family member 3A stimulates cell proliferation, migration, and invasion of bladder cancer cells in vitro and in vivo.

Kinesin family member 3A stimulates cell proliferation, migration, and invasion of bladder cancer cells in vitro and in vivo. Q. Zhou, J. Yu, Q. Zheng, T. Wu, Z. Ji, Y. Zhuo. FEBS Open Bio 11, 1487-1496. https://doi.org/10.1002/2211-5463.12768. The above article, published online on November 27, 2019, in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the Editor-in-Chief Miguel A. De la Rosa, FEBS Press, and John Wiley and Sons Ltd. The retraction has been agreed following an investigation into concerns raised by a third party, which revealed inappropriate image duplications between this article and a previously published article [1]. Thus, the editors consider the conclusions of this manuscript substantially compromised. [1] Kun Zuo, Youhong Zhao, Yukun Zheng, De Chen, Xiaoli Liu, Song Du & Qing Liu (2019) Long non-coding RNA XIST promotes malignant behavior of epithelial ovarian cancer. OncoTargets and Therapy, 12: 7261-7267. DOI: 10.2147/OTT.S204369.

Ritual use of rosa de borracho (Clinopodium macrostemum (Moc. &amp; Sessé ex Benth.) Kuntze, Lamiaceae) in Oaxaca

Abstract. Calvo-Díaz DY, Aguilar-Hernández L, Jiménez-Noriega MS, Torres-Montúfar A. 2023. Ritual use of rosa de borracho (Clinopodium macrostemum (Moc. &amp; Sessé ex Benth.) Kuntze, Lamiaceae) in Oaxaca. Biodiversitas 24: 5105-5112. Plants play a vital role in the rich tapestry of Mexican culture, serving as medicine, food, clothing, rituals, and construction. Oaxaca is known for its abundance of bio- and cultural diversity, and as such, is home to numerous versatile and beneficial plant species alongside many traditional cultural festivals, including the famous Guelaguetza at the end of every July. Many plants have deep cultural and spiritual significance, and their traditional uses in ceremonies, rituals, and medicine have been passed down through generations. Here, we have studied the ceremonial use of rosa de borracho, or poleo (Clinopodium macrostemum (Moc. &amp; Sessé ex Benth.) Kuntze), in two communities of Oaxaca: Ocotlán de Morelos and Villa Sola de Vega. Semi-structured interviews were conducted with 40 community members to acquire valuable and relevant information about this plant and its importance in these communities. In Villa Sola de Vega, where residents are known as soltecos, the rosa de borracho is an essential element of Soltecan wedding ceremonies, which includes dancing Chilenas (traditional folk music) such as the Jarabe de la Rosa (a dance called syrup of the rose). In this particular dance, the Rosa de Borracho is the show's star, and important guests such as the godparents and cooks are gifted handwoven crowns to wear and bundles of the plant to carry. In Ocotlán, the rosa de borracho is used to adorn baskets and other artifacts for a ceremony called La Llevada del Guajolote, and is also gifted to everyone during the festivities. The same plant is also used on a procession before Christmas and New Year's Eve, wherein pilgrims known as roseros journey to the mountain searching for the plant for use in the day’s celebration. In this study, we have documented and described the ritual use of this plant and its cultural significance to these communities. In conclusion, rosa de borracho carries various symbolic meanings and is often included in sacred offerings to deities or spirits or in ceremonies to adorn altars, decorate ritual spaces, and create intricate floral arrangements, all of which lend it cultural significance in Oaxaca stemming from these ritual practices.

FRI162 Ligand-dependent Photocrosslinking of Mineralocorticoid Receptors Using Site-directed Incorporation of Unnatural Amino Acids

Abstract Disclosure: B. Almeida-Prieto: None. A.J. Gonzalez-Hernandez: None. T. Giraldez: None. D. Alvarez de la Rosa: None. Steroid receptors dimerize prior DNA binding as a key step for translational activation of target genes. It appears that several domains of the receptors play a role in the process. In addition, current evidence suggests that the active conformation of steroid receptors may not always be a dimer, but involves different quaternary structures, characteristic for each receptor. Recent data obtained by our group suggests that agonist-bound mineralocorticoid receptors (MR) adopt a tetrameric form in the nucleoplasm, forming higher order oligomers when bound to hormone response elements in the chromatin. The formation of such complexes would likely requires more than one oligomerization interface. To generate a tool for investigating inter-subunit contacts, we incorporated photoactivatable crosslinkers into specific sites in MR using a genetically-encoded unnatural amino acid (p-Benzoyl-L-phenylalanine, BzF). We created a library of 26 amber stop codon mutants substituting conserved A, F, W and Y residues distributed along the N-terminal domain (NTD), DNA-binding domain (DBD) and ligand-binding domain (LBD) of the mouse MR coding sequence. Site-directed incorporation of BzF into MR was performed by co-expressing an orthogonal pair of BzF-specific aminoacyl-tRNA synthetase and an amber-suppressor tRNA with the mutant receptors. Characterization of the library showed that 18 mutants produced functional receptors after BzF incorporation. Using an in silico approach we identified position W914 in helix 10 of the LBD as a potential candidate for photocrosslinking. Treatment of cells expressing W914BzF with UV light selectively increased aldosterone-bound, but not cortisol-bound, MR transcriptional activity by approximately 50%. Increased activity was still apparent after hormone washout, suggesting that BzF-induced photocrosslinking at position 914 contributes to stabilizing an active conformation and identifying H10 as a putative region for ligand-specific oligomerization interface. Our results support the strong potential of this methodology for studying this new organization model proposed for MR and other steroid receptors, along with the characterization of functional protein-protein interactions. Presentation Date: Friday, June 16, 2023

FRI164 The Glucocorticoid Receptor is Required for Efficient Aldosterone-induced Transcription by the Mineralocorticoid Receptor

Abstract Disclosure: T.A. Johnson: None. G. Fettweis: None. K. Wagh: None. B. Almeida-Prieto: None. G.L. Hager: None. D. Alvarez de la Rosa: None. The glucocorticoid and mineralocorticoid receptors (GR and MR, respectively) have distinct, yet overlapping physiological and pathophysiological functions. There is evidence in the literature that the two receptors interact both functionally and physically, but the global role of this interdependence is poorly understood (1,2). Here, we analyze the impact of GR co-expression on MR genome-wide chromatin binding and transcriptional responses to aldosterone and glucocorticoids. Our data show that GR co-expression alters MR genome-wide binding in locus- and ligand-specific ways. MR binding to consensus hormone response elements is affected by GR. Additionally, gene responses by MR in the absence of GR are weak and show poor correlation with chromatin binding. In contrast, co-expression of GR greatly potentiates genome-wide MR-mediated transcription, particularly in response to aldosterone. These aldosterone-mediated transcriptional responses do not occur with GR alone. Finally, single molecule tracking of MR in live cells indicates that the presence of GR contributes to productive chromatin binding events. Together, our data indicate that co-expression of GR enables optimal aldosterone-mediated MR transcriptional activity, even in the absence of glucocorticoids. REFERENCES: (1) Mayumi Nishi et al., J Neuroscience. 2004 May 26; 24(21):4918 - 4927. (2) Liu et al., PNAS. Dec 1995; 92: 12480-12484. Presentation Date: Friday, June 16, 2023

Retraction statement: Long noncoding RNA MALAT1 promotes the stemness of esophageal squamous cell carcinoma by enhancing YAP transcriptional activity. FEBS Open Bio, 9: 1392-1402.

https://doi.org/10.1002/2211-5463.12676 The above article, published online on 22 May 2019 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the Editor-in-Chief Miguel A. De la Rosa, FEBS Press, and John Wiley and Sons Ltd. The retraction has been agreed following an investigation into concerns raised by a third party, which revealed inappropriate duplications between this and previously published articles [1-3]. Thus, the editors consider the conclusions of this manuscript substantially compromised. [1] RETRACTED: Wu, H., He, Y., Chen, H., Liu, Y., Wei, B., Chen, G., Lin, H. and Lin, H. (2019), Retracted: LncRNA THOR increases osteosarcoma cell stemness and migration by enhancing SOX9 mRNA stability. FEBS Open Bio, 9: 781-790. https://doi.org/10.1002/2211-5463.12620 [2] Xiao, Y., Pan, J., Geng, Q. and Wang, G. (2019), LncRNA MALAT1 increases the stemness of gastric cancer cells via enhancing SOX2 mRNA stability. FEBS Open Bio, 9: 1212-1222. https://doi.org/10.1002/2211-5463.12649 [3] Hou, H, Yu, X, Cong, P, Zhou, Y, Xu, Y, Jiang, Y. (2019). Six2 promotes non-small cell lung cancer cell stemness via transcriptionally and epigenetically regulating E-cadherin. Cell Prolif.; 52:e12617. https://doi.org/10.1111/cpr.12617.

The Community Museum of Sierra Hermosa (Zacatecas): Rethinking the Museology, Landscapes, and Archives from the Desert

This article presents the methodology and collective work strategies that constitute the Club de Lectura y Museo Comunitario de Sierra Hermosa (Sierra Hermosa Community Museum and Reading Club) in Zacatecas, Mexico, a space founded by visual artist Juan Manuel de la Rosa, a native of this place. The museum emerged as a small library in 2000; and a short time after its founding, the museological program incorporated textile workshops and an exhibition gallery for a collection organized with local and external donations. It also operates with a system of rotation within the town. This article reviews the historical, theoretical, and critical implications around the conception and action of the museum, with a focus on the colonial and the migration status that sustains the reality and history of this rural locality, situated on the Tropic of Cancer in the north of Mexico. In the context of extreme violence, extractive politics, and migratory crisis in Zacatecas, this article analyzes two artistic productions by the local painter Luis Lara and artist Cristóbal Gracia, developed in the context of this experimental and rural museum curatorial program. Moreover, this article redefines concepts such as the border, mobility, and cultural contact in an artistic, museological, and pedagogical context, and proposes alternatives to study Sierra Hermosa’s memory, history, and landscape.

Retraction statement: Yiwen Xiao, Jingjing Pan, Qian Geng, Ge Wang (2019), LncRNA MALAT1 increases the stemness of gastric cancer cells via enhancing SOX2 mRNA stability. FEBS Open Bio, 9: 1212-1222.

https://doi.org/10.1002/2211-5463.12649 The above article, published online on 29 April 2019 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the authors, the Editor-in-Chief Miguel A. De la Rosa, FEBS Press, and John Wiley and Sons Ltd. The retraction has been agreed following an investigation into concerns raised by a third party, which revealed inappropriate duplications between this and articles that were either previously published or published later in the same year [1-3]. Thus, the editors consider the conclusions of this manuscript substantially compromised. [1] RETRACTED: Wu, H., He, Y., Chen, H., Liu, Y., Wei, B., Chen, G., Lin, H. and Lin, H. (2019), Retracted: LncRNA THOR increases osteosarcoma cell stemness and migration by enhancing SOX9 mRNA stability. FEBS Open Bio, 9: 781-790. https://doi.org/10.1002/2211-5463.12620 [2] Yao, Q., Yang, J., Liu, T., Zhang, J. and Zheng, Y. (2019), Long noncoding RNA MALAT1 promotes the stemness of esophageal squamous cell carcinoma by enhancing YAP transcriptional activity. FEBS Open Bio, 9: 1392-1402. https://doi.org/10.1002/2211-5463.12676 [3] Hou, H, Yu, X, Cong, P, Zhou, Y, Xu, Y, Jiang, Y. (2019), Six2 promotes non-small cell lung cancer cell stemness via transcriptionally and epigenetically regulating E-cadherin. Cell Prolif. 52:e12617. https://doi.org/10.1111/cpr.12617.

Melanie J. La Rosa. Communities and the clean energy revolution: public health, economics, design, and transformation

Melanie J. La Rosa. Communities and the clean energy revolution: public health, economics, design, and transformation

Withdrawal statement: [Liu, X., Qiao, L., Zhang, H., Zhang,C., Ding, R., Kang, J., Liu, Y., Lin, J. and Yan, X. (2023), Argonaute 2 regulates LPS-induced inflammation in microglial BV2 cells by targeting Cadm1. FEBS Open Bio. Accepted Author Manuscript

The above article, published online on 4 April 2023 in Wiley Online Library (wileyonlinelibrary.com) as an Accepted Article (https://doi.org/10.1002/2211-5463.13606) has been withdrawn by agreement between the authors, the journal Editor-in-Chief Miguel A. De la Rosa, and John Wiley and Sons. The withdrawal has been agreed due to a dispute over authorship and the conceptualization of some of the data.

¿Vecindad amenazante o integración binacional? Concepciones comparadas de senadores argentinos en torno al litigio por los Hielos Continentales en la década de 1990

This article analyzes the positions of Argentine senators Alfredo Avelín and Carlos Leonardo de la Rosa regarding the Continental Ice litigation in the 1990s. The arguments that both senators developed for and against the Treaty and its background. The sources consulted include the Diary of Sessions of the Senate of the Nation on June 2 and 3, 1999, as well as the works Hielos Continentales Patagonicos and Acuerdo sobre los Hielos Continentales. It is hypothesized that Avelín uses arguments based on confrontational geopolitical conceptions that support the idea of ​​a “threatening neighborhood”. On the other hand, it is argued that de la Rosa justifies his conciliatory position through the concept of regional integration. In addition, it is argued that the current context favors de la Rosa more than Avelín, due to the progress towards the formation of an ascending security community between Argentina and Chile.