Worldwide experience in the exploration of oil-andgas (hereafter, petroleum) fields shows that drilling deep wells in thick saliferous caprock above the petroleum pools often becomes problematic, or even becomes impossible, due to high-pressure spouts generated by abnormally high formation pressure (AHFP) of fluids [1] that develops in virtually all large petroliferous basins (Fig. 1). At the Siberian Craton, the AHFP phenomenon has received too little attention, although considerable hydrocarbon and hydromineral resources of Russia are located in this region. For example, the giant Verkhnechonskoe (Upper Chona) oiland gascondensate field, the Kovykta gas condensate field, and the Znamensky economic brine field have been discovered and explored. Three main geological factors determine the prospects of further development of the Siberian rare-metal brines (in essence, liquid polycomponent ores): (1) very high concentration of useful elements (Br, Li, Mg, and others); (2) reservoir rocks with high (locally, abnormally high) conduction; and (3) abnormally high formation pressure. The study of interrelations between the aforementioned factors and localization of brines in the sedimentary cover are crucial in minerageny of economic brines at the Siberian Craton. Therefore, the models of the distribution of high-quality reservoir rocks in a geological section serve as a basis for forecasting, prospecting, and exploration of hydromineral resources. This communication is devoted to the possible role of nappe tectonics in the development of AHFP and in the formation of industrial pools of rare-metal brines on the Siberian Craton. The in-depth and system analysis of nappe–fold structural features of East Siberia is based on the morphokinematic model of zonal distribution of nappe belts at the southern margin of the Siberian Craton [2]. This model is permanently upgraded and replenished by new factual data [3–7]. It becomes clear that the nappe dislocations not only control spatial distribution of petroleum fields, but also govern the formation and localization of economic pools of rare-metal brines at the southern margin of the platform. This allows us to reappraise the resources of the Siberian brines from a principally new view.