Koch's Treatment Research Articles

Haematological profiles after Intensive phase of Anti Koch Treatment with special emphasis on bone marrow changes

BackgroundTuberculosis remains a major public health problem in various parts of the world. It leads to various haematological changes. Study of these haematological changes will help better patient management. Objective & methodsIt is to evaluate haematological changes in tuberculosis patients and compare the result with special emphasis to bone marrow changes as active case search is sharply decreasing the miliary tuberculosis. It is also to evaluate the patients with before and after the Intensive Phase of Anti Koch Treatment. Sputum positive and sputum negative tuberculosis patients confirmed by other ancillary techniques were included into this study. It is conducted at a tertiary level hospital in rural area. ResultIn this study bone marrow hypercellularity was of erythroid series with only 1.92% patients showed granuloma in bone marrow aspiration. In addition to bone marrow changes, significant changes were evident in haemoglobin level, Erythrocyte Sedimentation Rate (ESR) Total White Blood Cell count and RBC count. DiscussionIn majority cases this study showed Erythroid Hyperplasia. It is sharp contrast with other study where myeloid hyperplasia was evident. This study also differs from other study where high number of bone marrow granuloma was reported. In this study only 1.92% cases showed bone marrow granuloma. This study also documented higher number of anaemic cases mostly because of the institute serves poor and tribal population. ConclusionIn our study the cases showing granuloma and hyperplasia of myeloid series were limited. With introduction of Directly Observed Treatment and house to house active case search helped to sharply decrease bone marrow granuloma by limiting multi-organ spread. This study showed, ESR level may be considered as prognostic parameters of tuberculosis.

English

Tuberculous otitis media is a rare disease that is clinically variable and nonspecific. Tuberculous otitis media can be difficult to diagnose because it can easily be confused with other acute or chronic middle ear conditions. The signs and symptoms are variable and nonspecific and often differ from classic descriptions. Furthermore, no two cases may not necessarily present itself clinically in the same manner. Cases of chronic otitis media that are unresponsive to the usual therapy or show unexpected postoperative evolution should be investigated for tuberculosis. Tuberculous otitis media should be suspected after failure of current antibiotics or persistent effusion after tympanoplasty or mastoidectomy. Because of these factors, the diagnosis is often made during surgery or postoperatively. Late diagnosis delays the start of treatment, thereby increasing the risk of complications. KEY-WORDS: Tuberculous otitis media, chronic otitis media, mastoidectomy Key Messages: Tuberculous otitis media is a rare disease, which still persists in clinical practice despite effective antitubercular treatment. It may have varied modes of presentation making early diagnosis difficult. If left undiagnosed can cause significant damage to middle ear and other surrounding structures INTRODUCTION: Tuberculosis remains the leading cause of death secondary to infectious diseases worldwide in persons older than 5 years. Tuberculosis of middle ear is a comparatively rare entity usually seen in association with or secondary to pulmonary tuberculosis. Tuberculosis is one the major infectious disease with predominant involvement of lung and lymph nodes but tuberculosis of the middle ear is uncommon. Tuberculous otitis media is generally considered a disease of children and young adults, as patients <15 years of age account for 84% of all cases. Case report 1: A 19 year old female came to our institution with a history of right ear discharge since 4 yrs which was yellowish, scanty, continuous, foul smelling and non blood stained. She was treated with local and systemic antibiotics but her discharge did not reduce with medications. She also complained of decreased hearing on the right side. She had a history of abdominal Kochs 3yrs back for which she took AKT (anti Koch treatment) for 6 months. One year back she had a tubercular gluteal abscess which was drained under spinal anaesthesia. She took medications (AKT) for 9 months for the latter. Examination revealed a central perforation with granulations in middle ear. Ear swab for culture and sensitivity showed no bacterial growth. Her pure tone audiogram showed right sided severe mixed hearing loss. Schuler’s view X-ray mastoid showed loss of pneumatization of right mastoid region. CBC, blood urea and electrolytes were insignificant. Chest x-ray was unremarkable.

Subcutaneous filariasis: An unusual case report

<i>Wuchereria bancrofti </i> presented in subcutaneous nodule is a very rare presentation. <i> Wuchereria bancrofti </i> first reported by Bancrofti in Brisbane in 1876 and the name filaria Bancrofti was given in 1877 and the generic name was given in 1878. A 15-year-old male patient's known case of pulmonary Koch's with incidentally detected subcutaneous nodule on right arm pit, cytology from the nodule shows many sheathed microfilaria along with segment of an adult female worm. Wet mount peripheral blood smear shows nocturnal motile microfilaria. The <i> Wuchereria bancrofti </i> is known to be associated with pulmonary Koch's. Nocturnal motility and cytomorphological features differentiate <i> Wuchereria bancrofti </i> from <i> Wuchereria loa loa</i> . After giving diethyl carbamazine (DEC 6 mg/kg) for 21 days without disturbing anti Koch's treatment schedule and microfilaria disappeared from peripheral blood.

CANADIAN COMMISSION DENIES AUTHORIZATION FOR CIRCULAR ON KOCH TREATMENT FOR CANCER

To the Editor:— Apparently a circular letter has been widely distributed among members of the medical profession in the United States, indicating that this commission has compiled a series of proofs of the efficacy of the Koch treatment of cancer. A sponsor of the Koch treatment appeared before this commission and submitted some evidence, in the main consisting of case histories. To correct any erroneous inference that might be drawn from the circular mentioned, it should be noted that this commission has made no report expressing any opinion whatever of the efficacy or otherwise of the treatment as a remedy or cure for cancer.

Advertising the Koch Treatment

Advertising the Koch Treatment

The W. F. Koch Treatment of Cancer

The W. F. Koch Treatment of Cancer

Koch's Lymph as a cause of Mental Disorder

In a special number of the “Berliner Klin. Wochenschrift” is the report of a contribution to the discussion on Koch's treatment by Prof. Jolly, the well-known alienist, who has succeeded Prof. Westphal at the Charité. Prof. Jolly's contribution is on the development of certain psychoses as an after-effect of the injections by Koch's method. We feel inclined to exclaim “Et tu Jolly!” for of all recent impeachments of the “cure” surely this was the least to be expected. Prof. Jolly must, however, be read, for we shall then find that what he says is, in all respects, most reasonable, and that his statement may be said to amount to an impeachment of some degree of seriousness. He first points out the well-established fact that pyrexia does not affect the mind, during its presence only, in the form of the delirium of fever, but that any and every kind of fever is liable to be followed by certain psychoses. He then states that it was most reasonable to expect that the fever artificially excited by Koch's method would not prove an exception to this rule, and proceeds to detail three cases in which as a sequel to the injections a definite insanity arose.

Koch's Treatment of Tuberculosis: Official Prussian Report — Experimental Therapeutics of Diphtheria — The Annual Report of the Board of Health of the City of New York — Medical Notes

Editorial from The New England Journal of Medicine — Koch's Treatment of Tuberculosis: Official Prussian Report — Experimental Therapeutics of Diphtheria — The Annual Report of the Board of Health of the City of New York — Medical Notes

The Koch Treatment in Munich

The Koch Treatment in Munich

THE KOCH TREATMENT COMBINED WITH SURGICAL PROCEDURES.From the Surgical Department of the Moabit City Hospital, Berlin.

ARTICLE II.—THE SURGICAL PROCEDURES AS APPLIED TO TUBERCULOSIS OF THE GLANDS, BONES AND JOINTS. Surgeons naturally seem to be of different opinions as to the procedures which are indicated in surgery of tuberculous bones, joints and glands, when they have been subjected to the Koch treatment. I will attempt in the following, with the help of a few specially selected cases, to outline our principles in the treatment of such patients. First of all, it is absolutely necessary to have a perfect understanding of the action of the remedy, for numerous complications often arise during the course of the treatment which have the greatest influence upon the temperature curve as well as upon the wound conditions. The fever curve indicates exactly whether or not the action of the Koch remedy is free from contemporaneous influence. When the temperature rises rapidly after the injection and on the following day the fever

The Present Status of the Koch Treatment in Germany.

<h3>To the Editor:</h3> —I have just received a letter from Berlin, some quotations from which I think will be of special interest to your readers as indicating the present status of the Koch treatment in Germany. He says: "Dr. Koch's remedy is still with us, but becoming less popular daily, if I may judge from students and others who have an opportunity of witnessing the treatment. Beside the French and not a few German opponents who are animated by feelings of rivalry or the like, some there are of late who, closely observing the matter, do not hesitate to condemn the treatment as both fruitless, dangerous and unscientific, since it seems to diminish the patient's strength and physical resistance by its local and general powerful action, and hence a condition favorable to the extension of tuberculosis. Koch's announcement of January 15, besides the disclosure concerning the composition of the substance,

Koch's Treatment of Tuberculosis

Koch's Treatment of Tuberculosis

Koch's Treatment of Tuberculosis

Koch's Treatment of Tuberculosis

Koch's Treatment of Tuberculosis

Koch's Treatment of Tuberculosis

Official Report on the Results of Koch's Treatment in Prussia

Official Report on the Results of Koch's Treatment in Prussia

Professor Koch's Treatment of Tuberculosis

Professor Koch's Treatment of Tuberculosis

Etiology and Treatment of Pleurisy — Koch's Treatment of Tuberculosis — Reports on Recent Progress in Medicine — Medical Notes

Etiology and Treatment of Pleurisy — Koch's Treatment of Tuberculosis — Reports on Recent Progress in Medicine — Medical Notes

Personal Impressions of Koch's Treatment at Berlin, with Early Notes of Cases Treated in the Royal Infirmary of Edinburgh

Personal Impressions of Koch's Treatment at Berlin, with Early Notes of Cases Treated in the Royal Infirmary of Edinburgh

Lecture on Koch's Treatment of Tuberculosis

Lecture on Koch's Treatment of Tuberculosis

Some Aspects of Professor Koch's Treatment of Tuberculosis

Some Aspects of Professor Koch's Treatment of Tuberculosis