Research objectives: Describe the knowledge of monkeypox among students ofHanoi Medical University in 2022; Analysis of some factors related to knowledge ofmonkeypox among students of Hanoi Medical University in 2022.Subjects and research methods: A cross-sectional descriptive study on students in9 majors from the first to the sixth year of Hanoi Medical University.Results: Out of 440 students, 26,4% passed, and 73,6% failed the monkeypoxknowledge test. Students mainly get information about Monkey Smallpox throughsocial networks and online information channels. Students answered “Do not know”about the monkeypox knowledge test questions with an average of 44%. There is astrong correlation between gender and field of study to medical student’s knowledgeabout monkeypox. Regarding gender, the knowledge rate achieved in men was4,725 times higher (95% CI: 3,01 - 7,41; p<0,001). Regarding subjects, students ofTraditional Medicine, Preventive Medicine, and Nursing have knowledge rates of3,64 times (95% CI: 1,59 - 8,35) and 5,89 times, respectively. 95% CI: 2,25 - 15,45),5,16 times (95% CI: 2,138 - 12,450) compared to general students (p<0,05).Conclusion: Knowledge about monkeypox among students of Hanoi MedicalUniversity participating in the survey is still deficient. Gender and discipline showedsignificant associations with student’s knowledge levels. The above results raise theurgency of improving knowledge about monkeypox in aluminum subjects.