Disparities In Knowledge Research Articles

Viral hepatitis knowledge and vaccination awareness among men who have sex with men (MSM) in 43 countries of the WHO European Region: results from the European MSM Internet Survey, EMIS-2017

Background Recent hepatitis A virus outbreaks in Europe affecting men who have sex with men (MSM) and ongoing hepatitis B virus transmission among MSM underscore the ongoing need for viral hepatitis prevention in this population. Aim To describe viral hepatitis knowledge and associated factors among MSM in the WHO European Region to inform targeted prevention. Methods In the European MSM Internet Survey (EMIS-2017), basic knowledge was defined as correctly identifying at least 4 of 5 statements about viral hepatitis and vaccination. We described basic knowledge by country. In a multilevel logistic regression model, we estimated adjusted odds ratios (aOR) with 95% confidence intervals (CI) for having basic knowledge and explanatory variables: sociodemographic characteristics, history of hepatitis C and/or HIV diagnosis, sexual orientation disclosure at last sexually transmitted infections (STI) test and outness. Results Of 113,884 participants across 43 WHO European Region countries, 68% demonstrated basic knowledge, ranging from 50% in Israel to 80% in the Netherlands. Basic knowledge was significantly associated with older age (≥ 40 years vs < 25 years, aOR: 2.9, 95% CI: 2.7–3.0), a history of hepatitis C and/or HIV diagnosis (aOR: 1.8, 95% CI: 1.7–1.9) and sexual orientation disclosure at last STI test (aOR: 1.3, 95% CI: 1.2–1.3), among other factors. Conclusions We found a knowledge disparity regarding viral hepatitis and hepatitis vaccination awareness among MSM across Europe, highlighting a need to address these gaps. A non-judgemental, accepting climate that allows individuals attending medical services to safely disclose their sexual orientation is fundamental to enable healthcare professionals to target information and preventative measures more effectively.

Disparities in Cervical Cancer Knowledge and Trust in Information Sources Among Diverse American Women.

Cervical cancer rates have declined due to prevention and screening, but disparities remain. This study examines how trust and preference in information sources affect knowledge and behaviors, alongside demographic differences to identify health disparities. This study used Health Information National Trends Survey data and employed weighted chi-square tests and multivariate logistic regression to analyze associations between knowledge, behaviors, and demographic differences. The results revealed significant disparities in HPV awareness, with lower awareness among Black (OR, 0.521), Hispanic (OR, 0.398), and Asian (OR, 0.138) women compared to Whites. Age and education also played roles, as older and less-educated women were less informed. Trust in doctors was crucial; women with low trust in doctors (aOR, 0.499; 95% CI, 0.252-0.989) had lower odds of having heard of HPV. Preference for written materials as a primary information source (aOR, 0.312; 95% CI, 0.122-0.793) also correlated with lower HPV awareness compared to preferring information from doctors. Furthermore, women with low trust in charity organizations (aOR, 0.647; 95% CI, 0.461-0.909) were less likely to believe HPV causes cervical cancer, while those who preferred the internet as an information source (aOR, 1.544; 95% CI, 1.026-2.324) had higher odds of having heard of HPV compared to those preferring doctors. Minority populations, older women, and those with lower education levels had significantly lower HPV knowledge. These findings highlight the need for tailored communication, community outreach, policy initiatives, culturally sensitive approaches, digital health interventions, and strategies promoting patient-provider trust to address these disparities.

Deepfakes in the context of AI inequalities: analysing disparities in knowledge and attitudes

Deepfakes in the context of AI inequalities: analysing disparities in knowledge and attitudes

Wealth-related disparities of comprehensive knowledge of HIV among reproductive-aged women in Ethiopia: a decomposition analysis

IntroductionHuman Immunodeficiency Virus and Acquired Immune Deficiency Syndrome (HIV/AIDS) remains a major global public health concern, especially in low-income countries like Ethiopia. Insufficient awareness about HIV/AIDS makes women vulnerable to infection. Notably, there is a disparity in the comprehensive HIV knowledge among reproductive-aged women in poorer and wealthier households. However, the contributing factors for wealth-related disparities in comprehensive knowledge of HIV among reproductive-aged women in Ethiopia have not been explored.MethodsWe used the women's record (IR) of the 2016 Ethiopian demographic health survey. Erreygers normalized concentration index and curve were used to analyze the percentage contribution of factors in the comprehensive knowledge of HIV difference across wealth index. The concentration index was decomposed into contributing factors for poor comprehensive knowledge among poorer households.ResultsA total of 14,599 reproductive-aged women were included in the analysis. The comprehensive knowledge of HIV was 14.75% and 29.33% in the poorest and wealthiest households, respectively. The weighted Erreygers normalized concentration index (ECI) was 0.11 with Standard error = 0.015 (P value < 0.05). Age (− 0.17%), residence (1.4%), education (26.2%), occupation (1.38%), region (0.61%), wealth index (30.8%), media exposure (13.4%), and internet access (0.67%) significantly contributed to the wealth-related inequalities.ConclusionThere was a pro-rich distribution of comprehensive knowledge of HIV among reproductive-age women in Ethiopia. Wealth, education, and media exposure were the major contributing factors to the wealth-related inequalities. Policymakers should prioritize media exposure and education, and work to improve the comprehensive knowledge of women in poorer households.

Education is necessary but not sufficient for addressing disparities in concussion knowledge, attitudes, and perceptions

ABSTRACT Introduction Concussion leads to immediate cognitive, physiological, psychological, and emotional consequences that, if left untreated, may persist resulting in longer-term effects. Concussion education programs provide students with the knowledge necessary for them to make an informed decision to seek care should an injury occur. Methods In this observational cohort study, youth participating in public middle or high school athletics in a suburban county in Pennsylvania were asked to complete a survey to assess their concussion knowledge, attitudes, and perceptions before and after concussion education. Results All students increased scores from pre- to posteducation (mean difference, 0.08 to 0.67). Students from noncontact sports, higher grades, and higher Child Opportunity Index (COI) schools tended to have higher scores both before and after concussion education compared to students from contact sports, lower grades, or lower COI schools. Discussion Disparities were identified before and after the educational intervention between sport participation, grade level, and schools with different COI. Although concussion education was successful, with students showing improvement in all questions related to concussion knowledge, attitudes, and perceptions, this study identifies a need for the development of more equitable educational support systems. Understanding these differences may provide opportunities for targeted educational strategies, which might result in improved outcomes for younger athletes, those participating in contact sports, and those from lower COI schools.

National survey on Congenital Cytomegalovirus Awareness and Screening Practices among Healthcare Professionals

ObjectivesCongenital cytomegalovirus (CMV) infection, resulting from maternal-fetal transmission of CMV, poses a substantial risk to maternal and child health. It is the most prevalent congenital viral infection, and the prevention and management of this condition rely heavily on the knowledge and awareness of healthcare professionals. MethodsThis cross-sectional survey was conducted between March 1, 2023, and August 31, 2023, across multiple tertiary centers in various Saudi Arabian cities. It assessed the understanding and awareness of congenital CMV infection among 400 healthcare professionals from diverse specialties. The study utilized a structured questionnaire to evaluate knowledge levels, obtain demographic data, and identify factors influencing awareness. ResultsThe study revealed significant disparities in knowledge levels, with around 84 % of participants categorized as having “low" knowledge. Obstetricians and gynecologists exhibited better knowledge. Factors like specialization, age, and professional experience significantly affected knowledge levels. Additionally, many healthcare professionals perceived a lack of information and awareness regarding CMV among their peers. ConclusionCongenital CMV infection is a major public health concern with potential severe consequences. The study identified knowledge disparities, particularly among non-specialist healthcare practitioners, emphasizing the need for targeted educational programs and focused awareness initiatives. Key factors, such as expertise, age, and experience, underscore the importance of addressing ongoing knowledge gaps, highlighting the need for continuous efforts to mitigate challenges associated with CMV infection.

Empowering youths through citizen science to address health inequalities in adolescence

Abstract Citizen Science (CS) stands as a beacon of hope in the fight against inequalities in adolescent health, revolutionizing scientific research by involving individuals from diverse backgrounds. Unlike traditional methods, CS transcends academic boundaries, fostering inclusivity and collaboration irrespective of age, nationality, or social status. This approach has gained momentum in adolescent health research, empowering young people as co-researchers from project inception, thereby reducing disparities in health knowledge and access. Studies demonstrate its efficacy in enhancing empowerment and health literacy among participants. YouthChronic is an example of how CS can mitigate health inequalities among adolescents. The project ensures active participation in every research stage by engaging adolescents with chronic conditions as citizen scientists. Open-ended questions facilitate detailed responses, while participation in analysis and dissemination enhances their research involvement and sense of ownership. Through initiatives like YouthChronic, CS is reshaping the research landscape, making it more relevant and impactful to bridge the inequality gap. Young Citizen Scientists’ views on their participation: “As part of YouthChronic, we felt like our experiences with chronic conditions were finally being heard. The researchers were cool-they listened to us, let us be flexible with our participation, and even taught us some research skills. Learning from other peers’ experiences made us feel less alone and gave us new insights. But it’s frustrating that we’re limited by resources. We have big ideas, like running an advocacy campaign, but we need funding to make them happen”. In conclusion, by actively involving adolescents in the scientific process through CS initiatives like YouthChronic, we can reduce inequalities in adolescent health, empower marginalized voices, and pave the way for a brighter, more inclusive future in scientific exploration and discovery.

Measuring undergraduate evolution learning using the CANS: psychometric strengths and limitations

BackgroundEvolution continues to be one of the most difficult biological topics to teach, warranting innovative pedagogical tools and assessment strategies for enhancing evolutionary instruction. A major advance in measuring the evolution knowledge of undergraduate students came with the development of the Conceptual Assessment of Natural Selections (CANS). In this study, we use the CANS to measure knowledge and learning of natural selection in a large (N > 6000) sample of undergraduate students to expand upon prior validity testing of this instrument and advance knowledge of student evolutionary reasoning. We apply the Rasch measurement framework to examine if the CANS productively measures the intended construct and investigate the patterns of knowledge and learning about evolution among students with different backgrounds and demographic characteristics.ResultsWhile a unidimensional Rasch model demonstrated acceptable reliabilities and fit for most of the CANS items, some items showed problematic fit statistics and were resistant to instruction. The instrument items also did not span the full range of student abilities, which suggests relatively low measurement precision. Our large sample also allowed rigorous tests of multidimensionality, revealing the presence of multiple dimensions or constructs, some of which may not be intentional. These results generated specific item-level recommendations for improving this instrument. Using Rasch measures to examine learning patterns, we found that pre-test evolution knowledge was low but that there were high learning gains by the end of the course. However, some concept categories were found to be more difficult than others, suggesting the need for more attention to these areas by instructors. We also identified pre-test disparities in evolutionary knowledge by socially defined race and biological sex, yet students from all groups achieved comparable learning gains at the end of the course.ConclusionThe CANS holds great potential to generate critical insights about student evolutionary reasoning and provide information about which instructional approaches most effectively mitigate the notable knowledge disparities among students. We leverage the findings of this study to propose tangible ways in which this instrument may be improved in order to better achieve both of these goals.

The relationship between gender and cultural beliefs of malaria into typhoid progression among rural rice farmers in Central Kenya

Background: Women have an increased risk of contracting malaria in Kenya and the developing world because of gender roles and the cultural belief systems about disease progression and treatment. Cultural belief systems about illness progression have important implications for gender-based health intervention. Objectives: The main objective of this research is to explore how rice farming Kikuyu ethnic group in the Mwea division of central Kenya cultural beliefs about malaria into typhoid progression. It also aims to examine the association between gender and malaria into typhoid progression cultural belief system. Design: The study employs cross-sectional study design (N=250). Variables related to demographic and cultural beliefs on malaria into typhoid progression were collected using a structured questionnaire. Results: More than 62% of women and 47% of men interviewed adhere to malaria into typhoid progression belief system. Multivariable logistic analysis shows women are more than twice as likely than men to believe in malaria into typhoid progression (aOR 2.15; 95% CI 1.21, 3.79, p &lt; 0.009). Conclusion: The study demonstrates the underlying cultural factors related to the gender disparity in the appropriate knowledge on cultural belief system of malaria into typhoid progression which could influence the overall women’s health outcomes in developing countries. Keywords: Malaria; Typhoid; illness progression; cultural beliefs; gender disparity in Health.

Inadequate Sunlight Exposure as A Risk Factor for Nutritional Rickets: A Systematic Review

Insufficient sunlight exposure significantly contributes to the development of nutritional rickets, highlighting the critical importance of sunlight in maintaining optimal bone health and preventing this debilitating condition. Nutritional rickets, a preventable skeletal disorder, has significant implications for child health and development, particularly where there is limited sunlight exposure. Adequate sunlight exposure, especially in the form of ultraviolet B (UVB) radiation, is essential for synthesizing and maintaining optimal vitamin D levels, which are key in preventing nutritional rickets. This systematic review aims to comprehensively analyze the relationship between inadequate sunlight exposure and the development of nutritional rickets among children. The review could inform effective preventive strategies by identifying the precise levels of sunlight exposure needed for healthy development and the factors contributing to inadequate exposure. Literature was searched through Google scholar, PubMed (Medline), Cochrane, and Elsevier using the following key terms; Nutritional rickets, Sunlight exposure, and vitamin D deficiency. Only peer-reviewed articles and research theses were included. Additionally, only literature reporting on nutritional rickets as a result of inadequate sunlight exposure practices were included. A total of 9 papers were included in the review. Findings such as Limited Sunlight Exposure with factors such as closed housing environments, urbanization, and cultural practices contributing to this phenomenon, Misconceptions and Fear regarding potential harms associated with sunlight exposure, such as skin cancer, sterility, and blindness, Disparities in Knowledge and Practices about sunlight exposure, Environmental Influences such as housing conditions and access to outdoor spaces significantly influence sunlight exposure opportunities for children. Interventions aimed at enhancing sunlight accessibility and creating sun-safe environments are crucial for optimizing exposure and preventing rickets. Comprehensive strategies are necessary to address sunlight exposure practices' complexities, including education, cultural sensitivity, policy reforms, and environmental modifications. Integrating these interventions is essential for promoting optimal sunlight exposure and improving child health outcomes.

Cross-sectional study of assessment of lung cancer (LC) screening awareness in an underserved community in the Bronx, New York.

155 Background: LC remains the second most diagnosed cancer but is the leading cause of cancer death in the USA, accounting for 21% of all cancer deaths. Despite advances in screening and treatment, it remains the principal cause of cancer mortality worldwide. Notably, survival rates have improved from 21% to 25% over the past 5 years. However, LC screening with low-dose computed tomography (LDCT) is underutilized, with only 5.8% of eligible individuals screened in 2021. Methods: A prospective 29-question survey was conducted at St. Barnabas Health Care System in the Bronx, NY, from February to April 2024. The survey included patients aged 50-80, both former and active smokers. Data on demographics, social determinants, and knowledge of LC and LDCT screening were collected and processed using JASP Version 0.18.3. The study aimed to assess the community's knowledge of lung cancer screening, with demographic characteristics as secondary outcomes. Results: From all the surveys collected, 115 met the inclusion criteria, 53% male (61) and 47% female (54), with no significant difference between proportions (p=0.576). The median age was 63 years. Race: 73% were Hispanic, 22% Black, and 5% White, with significant differences from an equal distribution (p&lt; 0.001). Legal Status, citizens (74%), followed by green card holders (17%). Most of the patients lived in the USA for over 20 years (90%), with very few having lived for less than five years (1%), indicating a long-term residency trend (p &lt; 0.001). Education Level: high school education was the most common (58%), followed by middle school (17%) and elementary school (15%). Doctorate and graduate degrees were less common (7%). 91% of patients were aware of the relationship between cigarette smoking and LC, while 9% did not (p&lt;0.001). On the other hand, 66% believed there was a relationship between e-cigarette use and LC, while 44% believed there was not. Patients with an income greater than $50,000 have significantly more knowledge of the screening tool for LC (STLC), as indicated by a Chi-square value of 50.87 (p &lt; 0.05, with a critical value of 5.99). Patients with low education levels have less knowledge of the existing STLC, with a Chi-square of 143.587 (p&lt;0.05 and a critical value of 9.488). Conclusions: Our study highlights critical disparities in LC awareness and knowledge of screening tools among different demographic groups. There is a clear need for targeted educational initiatives, especially for lower-income and less-educated populations, to improve understanding of LC risks associated with both traditional and electronic cigarette use. The significant presence of long-term Hispanic residents suggests that culturally tailored interventions could be particularly effective. Addressing these gaps is essential for enhancing lung cancer prevention and early detection efforts across diverse communities.

Integrating traditional knowledge of non-Western humanities and social sciences: a research agenda through the Chinese lens

ABSTRACT The global knowledge asymmetries, dominated by academic centers in Western societies, have marginalized traditional non-Western knowledge. In line with the call for intellectual pluriversality, non-Western scholars in the humanities and social sciences (HSS) have witnessed a revitalization of traditional knowledge in research. Nonetheless, how they integrate their traditional knowledge into research lacks theoretical grounding and empirical substantiation. This study specifically examines the research agenda of contemporary Chinese HSS academics who are attempting to integrate traditional Chinese and modern Western knowledge. Through interviews, it seeks to understand their reasons, goals, principles, and strategies related to such knowledge integration. It first underscores the rationales stemming from global knowledge disparities and Chinese individuals’ limited exposure to their traditional knowledge. It then reveals guiding principles for understanding traditional Chinese knowledge. Last, it provides strategies for knowledge integration, including comparative analysis and the transformation of traditional Chinese knowledge into modern theories and methodologies. Such a research agenda transcends critical reflection on the hegemonic and inequitable global knowledge system, promoting tangible actions to facilitate HSS research in China and beyond.

Artificial intelligence and the dawn of an algorithmic divide

Emerging technologies like artificial intelligence (AI) and algorithms reshape news curation and consumption. Against this background, previous research has been focused on divides between groups regarding access to such digital technologies. Disparities in awareness and knowledge of AI across socio-demographic groups seem to persist, potentially leading to an algorithmic divide. Despite this situation, there is still limited research into such an emerging inequality. Building on the framework of algorithmic literacy, this study aims to contribute to this gap with findings from a national representative study in Germany (N = 1,090) in January 2022, considering socio-demographic factors such as age, gender, and education. Findings shed important light on the extent to which news audiences are knowledgeable about the use of AI and algorithms in news selection and recommendation, as well as in society. The results of our analysis imply that newsrooms should increase their knowledge about the potential divides created by applying AI across sectors to various socio-demographic groups and stay vigilant about the level of transparency of their AI use.

Abstract B092: ‘We’ve got to go to the doctor and we’re scared to death’: Community members perspectives on sexual orientation and gender identity data collection in healthcare settings

Abstract Purpose: Much research is needed to advance our knowledge of LGBTQ cancer disparities, but research is hindered by inconsistency in collection of data on sexual orientation and gender identity (SOGI) across clinical and research settings. Nationally, there have been increased efforts to standardize SOGI data collection. The purpose of this study was to identify potential patient-level barriers and facilitators to SOGI data collection within the catchment area of a midwestern cancer center. Methods: Investigators conducted 4 focus groups in partnership with community-based organizations and stakeholder groups that reflected the catchment area’s diverse populations. Using a semi-structured approach, participants were asked about their experiences with SOGI data collection, barriers and facilitators to this collection, and how they viewed the practice of collecting SOGI data. Focus groups were audio recorded and transcribed. Data was coded and interpreted using applied thematic analysis. Results: Four focus groups were conducted with 32 participants in total. There were 2 LGBTQ groups (one mixed race/ethnicity, one African American), and 2 predominantly non-LGBTQ groups (one African American and one Middle Eastern/North African or MENA). Across all participants, 53% were African American (n=17), 25% identified as MENA (n=8), 28% were White (n=9), 44% of the participants identified as women (n=19), one individual identified as a transgender woman &amp; 2 individuals as non-binary, and 53% reported their sexual orientation as gay/lesbian/same-loving. In all groups, participants emphasized a need to educate both patients and providers about the importance of SOGI data collection, why it is collected, and its relevance to improving medical care. Participants further discussed the quality and depth of the patient-provider relationship as a critical factor in a patient’s comfort and willingness to share SOGI data. Participants also underscored the importance of privacy ownership (i.e., the ownership of one’s own private information) and control in relation to SOGI status, and the desire to minimize potential privacy turbulence of an unexpected and unwelcome disclosure breach. All groups discussed how the potential for harm resulting from SOGI disclosure could deter patients from sharing SOGI information. Those who identified as LGBTQ, recounted both personal experiences and the experiences of others in which disclosure of SOGI information directly led to poor treatment by a healthcare professional. It is this potential for harm and discrimination that led many participants to stress the need for privacy control until a safe environment is established. Conclusions: Findings highlight a number of potential patient barriers to SOGI data collection from community members’ perspectives, including the need for widespread education on this topic and clinical environments in which patients are safe disclosing SOGI status. Future research and practice should consider specific methods to normalize the practice of SOGI data collection in the cancer care context. Citation Format: Ariel Washington, Ali Fakih, Lindsey Toman, Riham Ayoub, Emma Noble, Susan Musto, Brittany Dowe, Scott Ellis, Andrea Sakleh, Hayley S. Thompson, Latonya Riddle-Jones. ‘We’ve got to go to the doctor and we’re scared to death’: Community members perspectives on sexual orientation and gender identity data collection in healthcare settings [abstract]. In: Proceedings of the 17th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2024 Sep 21-24; Los Angeles, CA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2024;33(9 Suppl):Abstract nr B092.

Parental Knowledge, Attitudes, and Practices Regarding Early Childhood Caries in Bihor, Romania: A Cross-Sectional Study.

Early childhood caries (ECC) is a significant global health issue, particularly affecting deciduous teeth in young children. ECC is prevalent in Romania, where nearly half of children experience dental caries. This study aimed to assess the influence of gender, age, and living environment on parents' knowledge, attitudes, and practices (KAP) regarding ECC in Bihor County, Romania, using a KAP-type questionnaire. A cross-sectional study was conducted between March and September 2024, utilizing an online KAP questionnaire distributed via social networks. The sample comprised 419 parents of children under six years old. Respondents provided socio-demographic data and answered questions regarding their knowledge, attitudes, and practices concerning ECC prevention, treatment, and oral health. Statistical analysis was conducted using Chi-square tests to assess associations between demographic factors and parental KAP. A p-value of less than 0.05 was considered statistically significant. Of the 419 respondents, 83.1% were female, and 62.5% were between the ages of 31 and 40. Significant gender-based differences were found in knowledge about pain from caries (93.7% of female participants vs. 81.7% of male participants, p = 0.004) and the importance of brushing twice daily (93.7% of female respondents vs. 80.3% of male respondents, p = 0.010). Younger parents (aged 18-30) were more likely to affirm the effectiveness of fluoride (65.4%) compared to those aged 31-40 (53.1%, p = 0.02). Urban parents were more likely to correctly identify the timing of tooth eruption (59.1% vs. 52.6% of rural parents, p = 0.021). The study highlights gender, age, and urban-rural disparities in parental knowledge and attitudes towards ECC. These findings underscore the need for targeted educational interventions to improve oral health outcomes and reduce ECC prevalence in the Bihor region. Tailored public health strategies addressing demographic factors could enhance preventive oral health behaviors and reduce the healthcare burden associated with untreated dental caries.

Comparative Perceptions of Fluoride Toxicity in Oral Hygiene Products: Insights from the General Population and Healthcare Professionals.

The safety of oral hygiene products is a growing concern, particularly regarding the toxicity of specific ingredients used in their formulations. The purpose of this study was to evaluate the knowledge and attitudes of dentists, physicians, pharmacists, and the general public regarding ingredients in oral hygiene products, especially fluoride. Additionally, this study aimed to identify which ingredients may exhibit potential toxicity based on historical records of any adverse effects being induced by a material/component. A self-administered questionnaire was used in an online cross-sectional observational study to collect data on sociodemographic characteristics, knowledge of fluoride in dental medicine, fluoride usage practices in oral hygiene products, opinions on ingredient toxicity in oral hygiene products, and personal experiences of adverse reactions to products and their components. The collected data underwent descriptive and regression analyses to reveal patterns and relationships within the dataset. The study found a moderate overall knowledge level regarding fluoride usage in dentistry among participants (Md = 5.00, IQR 2.50-7.00). Healthcare professionals exhibited significantly higher knowledge scores compared to the general population (p ≤ 0.001), with dental professionals displaying the highest scores. Regarding concerns about the usage of fluoride, the majority of respondents (77.0%) did not express any concerns. Minor concerns included the risk of ingestion (6.0%) and dental fluorosis (4.6%). Among the other ingredients in oral hygiene products, respondents named alcohol as the most toxic ingredient (70.3%), followed by artificial colors (53.1%), artificial sweeteners (50.4%), and parabens (50.1%). It is noteworthy that the majority of participants (61.6%) stated that they had never experienced any side effects associated with the use of oral hygiene products. This study underscores disparities in fluoride knowledge between healthcare professionals and the general population in Croatia, with dental experts exhibiting a superior understanding. Despite lingering misconceptions about fluoride content and potential toxicity, the majority of participants acknowledge its oral health benefits and use fluoride products regularly.

Artificial intelligence in respiratory care: knowledge, perceptions, and practices-a cross-sectional study.

Artificial intelligence (AI) is reforming healthcare, particularly in respiratory medicine and critical care, by utilizing big and synthetic data to improve diagnostic accuracy and therapeutic benefits. This survey aimed to evaluate the knowledge, perceptions, and practices of respiratory therapists (RTs) regarding AI to effectively incorporate these technologies into the clinical practice. The study approved by the institutional review board, aimed at the RTs working in the Kingdom of Saudi Arabia. The validated questionnaire collected reflective insights from 448 RTs in Saudi Arabia. Descriptive statistics, thematic analysis, Fisher's exact test, and chi-square test were used to evaluate the significance of the data. The survey revealed a nearly equal distribution of genders (51% female, 49% male). Most respondents were in the 20-25 age group (54%), held bachelor's degrees (69%), and had 0-5 years of experience (73%). While 28% had some knowledge of AI, only 8.5% had practical experience. Significant gender disparities in AI knowledge were noted (p < 0.001). Key findings included 59% advocating for basics of AI in the curriculum, 51% believing AI would play a vital role in respiratory care, and 41% calling for specialized AI personnel. Major challenges identified included knowledge deficiencies (23%), skill enhancement (23%), and limited access to training (17%). In conclusion, this study highlights differences in the levels of knowledge and perceptions regarding AI among respiratory care professionals, underlining its recognized significance and futuristic awareness in the field. Tailored education and strategic planning are crucial for enhancing the quality of respiratory care, with the integration of AI. Addressing these gaps is essential for utilizing the full potential of AI in advancing respiratory care practices.

Human Settlement Pressure Drives Slow‐Moving Landslide Exposure

AbstractA rapidly growing population across mountain regions is pressuring expansion onto steeper slopes, leading to increased exposure of people and their assets to slow‐moving landslides. These moving hillslopes can inflict damage to buildings and infrastructure, accelerate with urban alterations, and catastrophically fail with climatic and weather extremes. Yet, systematic estimates of slow‐moving landslide exposure and their drivers have been elusive. Here, we present a new global database of 7,764 large (A ≥ 0.1 km2) slow‐moving landslides across nine IPCC regions. Using high‐resolution human settlement footprint data, we identify 563 inhabited landslides. We estimate that 9% of reported slow‐moving landslides are inhabited, in a given basin, and have 12% of their areas occupied by human settlements, on average. We find the density of settlements on unstable slopes decreases in basins more affected by slow‐moving landslides, but varies across regions with greater flood exposure. Across most regions, urbanization can be a relevant driver of slow‐moving landslide exposure, while steepness and flood exposure have regionally varying influences. In East Asia, slow‐moving landslide exposure increases with urbanization, gentler slopes, and less flood exposure. Our findings quantify how disparate knowledge creates uncertainty that undermines an assessment of the drivers of slow‐moving landslide exposure in mountain regions, facing a future of rising risk, such as Central Asia, Northeast Africa, and the Tibetan Plateau.

Effects of 5α-reductase inhibition by dutasteride on reproductive gene expression and hormonal responses in zebrafish embryos

Steroid 5α-reductase (SRD5A) is a crucial enzyme involved in steroid metabolism, primarily converting testosterone to dihydrotestosterone (DHT). Dutasteride, an inhibitor of SRD5A types 1 and 2, is widely used for treating benign prostatic hyperplasia. An adverse outcome pathway (AOP) has been documented wherein SRD5A inhibition decreases DHT synthesis, leading to reduced levels of 17β-estradiol (E2) and vitellogenin (VTG), subsequently impairing fecundity in fish (AOP 289). However, the molecular and cellular mechanisms underlying these effects remain poorly understood. In this study, we assessed the impact of SRD5A inhibition on zebrafish embryos (Danio rerio). Exposure to dutasteride resulted in decreased DHT, E2, and VTG levels, showing a positive correlation. Dutasteride also downregulated the expression of reproduction-related genes (srd5a2, cyp19a1, esr1, esr2a, esr2b, and vtg), with interrelated reductions observed across these levels. Docking studies suggested that dutasteride's effects may operate independently of androgen receptor (AR) and estrogen receptor (ER) interactions. Furthermore, co-exposure of dutasteride (0.5 or 2 μM) with 0.5 μM DHT revealed gene expression levels comparable to the control group. These findings underscore DHT's pivotal role in modulating estrogenic function and the interplay between estrogenic and androgenic responses in vertebrates. Our proposed AOP model offers insights into mechanistic gaps, thereby enhancing current understanding and bridging knowledge disparities.

Transparency in Central Bank and Credit Expansion: Empirical Evidence from Asian Countries

Abstract This research investigated the influence of central bank transparency on credit expansion in 15 Asian nations (both advanced and emerging) during the period from 2000 to 2019. Panel OLS and Dynamic GMM estimation are used to identify the impact of central bank transparency on the credit spread. The findings indicate that central bank transparency plays a crucial role in lowering credit spreads and facilitating credit expansion. In addition, the influence of central bank transparency on credit spreads has a greater effect in emerging economies than in developed economies, highlighting the significance of transparency for tackling information asymmetry within the credit system. Overall, the research highlights the significance of central bank independence in reducing knowledge disparities and promoting a more transparent credit environment.