Objective: Although the association between foot posture and altered mechanics of the knee joint in osteoarthritis (OA) has been investigated by several authors, the actual toe kinematics and function in individuals with knee OA has received little attention. Hence, the objective of this study is to determine the association between toe grip strength and knee function in individuals with knee OA. Patients and Methods: In this cross-sectional study, 145 participants will be recruited using purposive sampling. The toe grip strength will be measured using a pinch dynamometer and the Timed Up and Go test will be used assess knee function. The measurements will be recorded in a single session. Results: The data will be tabulated and subjected to statistical analysis using the Karl Pearson correlation coefficient. Conclusion: The findings of this study may assist in modifying treatment approaches to include strengthening of the toe grip musculature in the management of knee OA.