King's College Hospital Medical Research Articles

Plasma-salicylate concentrations after small doses of acetylsalicylic acid.

Journal Article PLASMA-SALICYLATE CONCENTRATIONS AFTER SMALL DOSES OF ACETYLSALICYLIC ACID Get access M J H Smith M J H Smith Department of Chemical Pathology, King's College Hospital Medical School, Denmark Hill, London, S.E.5 Search for other works by this author on: Oxford Academic Google Scholar Journal of Pharmacy and Pharmacology, Volume 3, Issue 1, September 1951, Pages 409–414, https://doi.org/10.1111/j.2042-7158.1951.tb13082.x Published: 12 April 2011 Article history Received: 05 April 1951 Published: 12 April 2011

Vocational preferences in medicine and dentistry at King's College Hospital Medical School.

Vocational preferences in medicine and dentistry at King's College Hospital Medical School.

Progesterone and the Risk of Preterm Birth Among Women With a Short Cervix

Fetal Medicine Foundation Second Trimester Screening Group, Harris Birthright Research Centre for Fetal Medicine, King's College Hospital Medical School, Denmark Hill, London, UK

A Short Textbook of Surgery. By Selwyn Taylor, D.M., M.Ch., F.R.C.S., Dean, Royal Postgraduate Medical School; L. T. Cotton, M.Ch., F.R.C.S., Surgeon, King's College Hospital; and J. G. Murray, Ch.M., F.R.C.S. (E.), Professor of Surgery, King's College Hospital Medical School. 8½ × 5½ in. Pp. 628+x, with 87 illustrations. 1967. London: The English Universities Press Ltd. Paperback, 30s.; Library edition,

A Short Textbook of Surgery. By Selwyn Taylor, D.M., M.Ch., F.R.C.S., Dean, Royal Postgraduate Medical School; L. T. Cotton, M.Ch., F.R.C.S., Surgeon, King's College Hospital; and J. G. Murray, Ch.M., F.R.C.S. (E.), Professor of Surgery, King's College Hospital Medical School. 8½ × 5½ in. Pp. 628+x, with 87 illustrations. 1967. London: The English Universities Press Ltd. Paperback, 30s.; Library edition, 42s Get access A Short Textbook of Surgery. By Taylor Selwyn, D.M., M.Ch., F.R.C.S., Dean, Royal Postgraduate Medical School; Cotton L T, M.Ch., F.R.C.S., Surgeon, King's College Hospital; and Murray J G, Ch.M., F.R.C.S. (E.), Professor of Surgery, King's College Hospital Medical School. 8½ × 5½ in. Pp. 628+x, with 87 illustrations. 1967. London: The English Universities Press Ltd. Paperback, 30s.; Library edition, 42s. British Journal of Surgery, Volume 54, Issue 9, September 1967, Page 814, https://doi.org/10.1002/bjs.1800540923 Published: 08 December 2005

Thromboembolism: Diagnosis and treatment. Edited by V. V. Kakkar, F.R.C.S.E., F.R.C.S., King's College Hospital Medical School, London, and A. J. Jouhar, M.B., M.R.C.S., Kabi Pharmaceuticals Ltd., Ealing, London. 8½ × 5¼ in. Pp. 241 + xii. Illustrated. 1972. Edinburgh: Churchill Livingstone. £3.50

Thromboembolism: Diagnosis and treatment. Edited by V. V. Kakkar, F.R.C.S.E., F.R.C.S., King's College Hospital Medical School, London, and A. J. Jouhar, M.B., M.R.C.S., Kabi Pharmaceuticals Ltd., Ealing, London. 8½ × 5¼ in. Pp. 241 + xii. Illustrated. 1972. Edinburgh: Churchill Livingstone. £3.50

Blood flow measurement. Edited by Colin Roberts, King's College Hospital Medical School, London. Pp. 184. Illustrated. 1972. London: Sector Publishing Ltd. £ 4.20

Blood flow measurement. Edited by Colin Roberts, King's College Hospital Medical School, London. Pp. 184. Illustrated. 1972. London: Sector Publishing Ltd. £ 4.20

King's and some king's men. Being a Record of the Medical Department of King's College, London, from 1830 to 1909, and of King's College Hospital Medical School from 1909 to 1934. By H. Willoughby Lyle, M.D., F.R.C.S., Fellow of King's College, London; Dean Emeritus of King's College Hospital Medical School, etc. Royal 8vo. Pp. 613 + x. Illustrated. 1935. London:

King's and some king's men. Being a Record of the Medical Department of King's College, London, from 1830 to 1909, and of King's College Hospital Medical School from 1909 to 1934. By H. Willoughby Lyle, M.D., F.R.C.S., Fellow of King's College, London; Dean Emeritus of King's College Hospital Medical School, etc. Royal 8vo. Pp. 613 + x. Illustrated. 1935. London:

Vascular diseases. By Professor Ag. M. J. Tsapogas, M.D., M.Ch., New York; V. V. Kakkar, F.R.C.S., F.R.C.S. (Edin.), Research Fellow, Department of Surgery, King's College Hospital Medical School, London; and E.N. Gleave, F.R.C.S.,F.R.C.S. Tenovus Lecturer in the Department of Surgery, Welsh National School of Medicine. 9½ × 6½ in. Pp. 178, with 69 illustrations. 1968. London: H. K. Lewis &

Vascular diseases. By Professor Ag. M. J. Tsapogas, M.D., M.Ch., New York; V. V. Kakkar, F.R.C.S., F.R.C.S. (Edin.), Research Fellow, Department of Surgery, King's College Hospital Medical School, London; and E.N. Gleave, F.R.C.S.,F.R.C.S. Tenovus Lecturer in the Department of Surgery, Welsh National School of Medicine. 9½ × 6½ in. Pp. 178, with 69 illustrations. 1968. London: H. K. Lewis &

The student's handbook of surgical operations. By Sir Frederick Treves, Bart., G.C.V.O., C.B., LL.D., F.R.C.S. Sixth edition, revised by Cecil P. G. Wakeley, D.Sc., F.R.C.S. Eng., F.R.S. Edin., F.A.C.S., F.R.A.C.S., Senior Surgeon to King's College Hospital; Director of Surgical Studies and Teacher of Operative Surgery, King's College Hospital Medical School; etc. 7¼ × 4⅝ in. Pp. 563 + xii, with

The student's handbook of surgical operations. By Sir Frederick Treves, Bart., G.C.V.O., C.B., LL.D., F.R.C.S. Sixth edition, revised by Cecil P. G. Wakeley, D.Sc., F.R.C.S. Eng., F.R.S. Edin., F.A.C.S., F.R.A.C.S., Senior Surgeon to King's College Hospital; Director of Surgical Studies and Teacher of Operative Surgery, King's College Hospital Medical School; etc. 7¼ × 4⅝ in. Pp. 563 + xii, with

An experimental study of the recanalization of arterial and venous thrombi.

Journal Article An experimental study of the recanalization of arterial and venous thrombi Get access Charles Flanc Charles Flanc Department of Surgery, University of Melbourne, Royal Melbourne Hospital Present address: Department of Surgery, King's College Hospital Medical School, London, S.E.5 Search for other works by this author on: Oxford Academic Google Scholar British Journal of Surgery, Volume 55, Issue 7, July 1968, Pages 519–524, https://doi.org/10.1002/bjs.1800550707 Published: 06 December 2005

Radium, X rays, and the living cells: With physical introduction. By Hector A. Colwell, M. B. (Lond.), D.P.H. (Oxford), Assistant Radiologist, King's College Hospital Medical School, Revisedand enlarged edition, 1924, London:G. Bell & Sons Ltd. 21s. net

Journal Article Radium, X rays, and the living cells: With physical introduction. By Hector A. Colwell, M. B. (Lond.), D.P.H. (Oxford), Assistant Radiologist, King's College Hospital Medical School, Revisedand enlarged edition, 1924, London:G. Bell & Sons Ltd. 21s. net Get access Radium, X rays, and the living cells: With physical introduction. By Hector A Colwell, M. B. (Lond.), D.P.H. (Oxford), Assistant Radiologist, King's College Hospital Medical School, Revisedand enlarged edition, 1924, London: G. Bell & Sons Ltd. 21s. net. British Journal of Surgery, Volume 12, Issue 45, July 1924, Page 205, https://doi.org/10.1002/bjs.1800124528 Published: 05 December 2005

Investigation of the cause of miscarriage and its influence on women's psychological distress.

To determine whether knowledge of the possible cause of miscarriage reduces women's long term psychological distress. Prospective longitudinal study. Harris Birthright Research Centre for Fetal Medicine, King's College Hospital Medical School, London. In 143 women where a routine ultrasound scan at 10-14 weeks of gestation showed an anembryonic pregnancy or fetal death, investigations were carried out to help ascertain the cause of the pregnancy loss. The participants were divided into two groups according to whether the cause was identified or not, and the psychological conditions of the two groups were compared at four weeks and four months after the diagnosis of fetal loss. Anxiety, depression, grief, self-blame, worry. The scores for all outcome variables were significantly lower at the four-month compared with the four-week post-miscarriage assessment. A fetal chromosomal abnormality was the most commonly identified cause of miscarriage, and this group reported significantly less self-blame than women in whom no cause was identified. There were no significant differences between the groups on any other outcome variables. In women with a missed miscarriage, identification of the cause of fetal loss reduces the feelings of self-blame.

Letter. Correct estimation of parameters for ultrasound nuchal translucency screening

Prenatal DiagnosisVolume 18, Issue 5 p. 519-521 Correspondence Letter. Correct estimation of parameters for ultrasound nuchal translucency screening K. H. Nicolaides, K. H. Nicolaides Harris Birthright Centre for Fetal Medicine, King's College Hospital Medical School, London, U. K.Search for more papers by this authorR. J. M. Snijders, R. J. M. Snijders Harris Birthright Centre for Fetal Medicine, King's College Hospital Medical School, London, U. K.Search for more papers by this authorH. S. Cuckle, Corresponding Author H. S. Cuckle h.s.cuckle@leeds.ac.uk Centre for Reproduction, Growth and Development, Research School of Medicine, University of Leeds, 26 Clarendon Road, Leeds, LS2 9NZ, U.K.Reproductive Epidemiology, University of Leeds, 26 Clarendon Road, Leeds, LS2 9NZ, U.K.Search for more papers by this author K. H. Nicolaides, K. H. Nicolaides Harris Birthright Centre for Fetal Medicine, King's College Hospital Medical School, London, U. K.Search for more papers by this authorR. J. M. Snijders, R. J. M. Snijders Harris Birthright Centre for Fetal Medicine, King's College Hospital Medical School, London, U. K.Search for more papers by this authorH. S. Cuckle, Corresponding Author H. S. Cuckle h.s.cuckle@leeds.ac.uk Centre for Reproduction, Growth and Development, Research School of Medicine, University of Leeds, 26 Clarendon Road, Leeds, LS2 9NZ, U.K.Reproductive Epidemiology, University of Leeds, 26 Clarendon Road, Leeds, LS2 9NZ, U.K.Search for more papers by this author First published: 04 December 1998 https://doi.org/10.1002/(SICI)1097-0223(199805)18:5<519::AID-PD398>3.0.CO;2-UCitations: 131AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat No abstract is available for this article.Citing Literature Volume18, Issue5May 1998Pages 519-521 RelatedInformation

First trimester maternal serum alpha-fetoprotein in fetal trisomies.

To evaluate the potential value of maternal serum alpha-fetoprotein concentration in the detection of fetal trisomy at 10 to 13 weeks gestation and to examine the possible association between maternal serum alpha-fetoprotein and fetal nuchal translucency thickness. Cross-sectional study. Harris Birthright Research Centre for Fetal Medicine, King's College Hospital Medical School, London. Maternal serum alpha-fetoprotein concentration was measured at 10 to 13 weeks gestation in samples from 57 pregnancies with fetal trisomies (trisomy 21 (n = 35), trisomy 18 (n = 16), and trisomy 13 (n = 6)) in 228 matched controls in whom the fetal nuchal translucency was < 3 mm and in 114 chromosomally normal fetuses with translucency > or = 3 mm. In the control group maternal serum alpha-fetoprotein increased significantly with fetal crown-rump length (r = 0.451). In this group, the median maternal serum alpha-fetoprotein was not significantly different from that in the groups with trisomy 21 (median = 0.84 MoM), trisomy 18 (median = 0.86 MoM), or trisomy 13 (median = 0.94 MoM), respectively. Neither in the control group nor in the group with trisomic fetuses was maternal serum alpha-fetoprotein significantly associated with fetal nuchal translucency thickness (r = 0.01 and r = 0.03). Measurement of maternal serum alpha-fetoprotein concentration in the first trimester of pregnancy is not likely to be useful in the prediction of fetal trisomies.

First trimester maternal serum pregnancy-associated plasma protein A and pregnancy-specific beta 1-glycoprotein in fetal trisomies.

To examine the potential value of maternal serum levels of pregnancy-associated plasma protein A (PAPP-A) and pregnancy-specific beta 1-glycoprotein (SP1) in the detection of fetal trisomy. Cross-sectional study. The Harris Birthright Research Centre For Fetal Medicine, King's College Hospital Medical School, London, UK and Division of Maternal-Fetal Medicine, Jefferson Medical College, Philadelphia, USA. Maternal serum PAPP-A and SP1 concentrations were measured at 10 to 13 weeks gestation in samples from 42 pregnancies with fetal trisomy (trisomy 21, n = 29; trisomy 18, n = 9; trisomy 13, n = 4) and in samples from 210 matched controls. In controls, both maternal serum PAPP-A and SP1 increased significantly with gestation and in trisomic fetuses levels of both hormones were reduced. However, discriminant analysis demonstrated that SP1 did not contribute significantly in the distinction between trisomic and control pregnancies. Although levels of PAPP-A were reduced throughout the gestational range examined (10 to 13 weeks), especially in cases with fetal trisomy 21, the deviation was more pronounced at 10 to 11 weeks than at 12 to 13 weeks gestation. In 45% of pregnancies with fetal trisomy 21 and 70% of pregnancies with trisomies 18 or 13 maternal serum PAPP-A levels at 10 to 11 weeks gestation were below the 5th centile of the normal range. Maternal serum PAPP-A concentration in the first trimester of pregnancy may prove to be useful in the prediction of risk for fetal trisomies.

Platelet size and glycoprotein Ib and IIIa expression in normal fetal and maternal blood

Our purpose was to study platelet size and surface glycoprotein expression in normal fetal and maternal blood throughout pregnancy. A cross-sectional study was performed at the Harris Birthright Research Centre for Fetal Medicine, King's College Hospital Medical School, London. Fetal and maternal blood samples were obtained from uncomplicated pregnancies at 8 to 42 weeks' gestation (n = 101 and n = 117, respectively) and from 30 nonpregnant controls. Flow cytometry was used to determine platelet size and glycoprotein Ib and IIIa expression both before and after stimulation with adenosine diphosphate. Mean platelet size in both fetal and maternal blood was significantly lower than that of nonpregnant controls and decreased with advancing gestation. The surface density of glycoprotein Ib in maternal and fetal platelets was significantly lower than in nonpregnant controls but did not change with gestation. Adenosine diphosphate stimulation of maternal platelets resulted in increased percentage expression and surface density of all glycoproteins, whereas stimulation of control platelets resulted in increased surface density of glycoprotein Ib and percentage expression of glycoprotein IIIa. Adenosine diphosphate stimulation of fetal platelets resulted in increased surface density of glycoprotein Ib and IIIa. Pregnancy is associated with increased thrombocytopoiesis in both the mother and fetus. Maternal platelet glycoprotein expression and responsiveness to adenosine diphosphate stimulation is increased. Fetal platelets are phenotypically mature from at least 12 weeks' gestation and respond in an adultlike fashion to stimulation with adenosine diphosphate.

Fetal lymphocyte subpopulations in red blood cell iso-immunised pregnancies.

To study the association between fetal anaemia and alterations in lymphocyte subpopulations. Cross-sectional study. The Harris Birthright Research Centre for Fetal Medicine, King's College Hospital Medical School, London. Forty-three red blood cell iso-immunised pregnancies undergoing cordocentesis at 19 to 38 weeks gestation. Fetal blood haemoglobin concentration, erythroblast count and lymphocyte subpopulations. The mean T (CD3+), B (CD19+), T-helper (CD4+), T-suppressor/cytotoxic (CD8+) and natural killer (NK: CD16+/CD56+) cell counts in the anaemic fetuses were significantly lower than the appropriate normal mean for gestation (CD3+: t = -3.25, P < 0.01; CD19+: t = -2.14, P < 0.05; CD4+: t -4.03, P < 0.001; CD8+: t = -3.39, P < 0.01 and CD16+/CD56+: t = -3.49, P < 0.01). Furthermore, there was a significant association between the decrease in T lymphocyte number and the degree of fetal anaemia (r = 0.342, P < 0.05). Fetuses from red blood cell iso-immunised pregnancies exhibit nonselective lymphopenia that is proportional to the degree of anaemia.

Serum ferritin and cobalamin in growth retarded fetuses

To examine fetal and maternal serum cobalamin and ferritin concentrations in pregnancies complicated by fetal growth retardation. Harris Birthright Research Centre for Fetal Medicine, King's College Hospital Medical School, London. Cross sectional study. Fetal blood samples obtained by cordocentesis from 20 growth retarded fetuses at 26 to 36 weeks of gestation. Maternal venous blood was also collected and serum ferritin and cobalamin concentrations were measured by radio-immunoassay in the fetal and maternal samples. In the growth retarded group, the mean fetal serum concentration of cobalamin was higher than the normal mean for gestation (t = 3.27, P < 0.01), and this increase was significantly associated with fetal acidaemia (r = -0.686, P < 0.001) and erythroblastosis (r = 0.731, P < 0.001). In contrast, the fetal to maternal ferritin ratio was significantly reduced; there was a nonsignificant decrease in fetal serum and an increase in maternal serum ferritin concentration. There was an association between fetal serum ferritin concentration and erythrocyte count (r = -0.612, P < 0.01). In placental insufficiency, as in postnatal starvation and Kwashiorkor syndrome, uptake and storage of cobalamin by the fetal liver may be impaired. The decrease in fetal to maternal ratio of ferritin could be the consequence of impaired placental perfusion.

Pharmacology Researchers Receive 1988 Nobel Prize

DRUG RESEARCH clearly has the attention of the Nobel Prize committee. This year's Nobel Prize for Physiology or Medicine goes to three pioneering pharmacology researchers: George Hitchings, MD, and Gertrude Elion, DSc, Burroughs Wellcome Co, Research Triangle Park, NC, and Sir James Black, King's College Hospital Medical School, London. The committee noted: "While drug development had earlier mainly been built on chemical modification of natural products, they introduced a more rational approach based on the understanding of basic biochemical and physiological processes." From the prizewinners' work have come a whole string of drugs useful for treating leukemia, manipulating the immune response, controlling herpes infections, and managing gout, hypertension, heart disease, and gastric ulcers. Hitchings, a biochemist, arrived at Burroughs Wellcome in 1942 when the company was in Tuckahoe, NY. "When I started," he recalls, "it was to study antimetabolites of nucleic acid biosynthesis using analogues of the bases purine and

CABGs and KINGS: relevance and realism in the teaching of clinical ethics in Camberwell.

The author describes and evaluates two methods developed and used over a ten-year period at London's King's College Hospital Medical School to teach clinical ethics to medical students. One method included an eight-part course as part of the regular "Topic Teaching" lecture series; the other approach enlarged the scope of small discussion groups conducted by general practice physicians on the teaching wards. Higgs, Director of General Practice at the School, concludes that small group teaching appears to be the better method to encourage ethical questioning, to provoke debate, to allow students to see teacher uncertainty, and to help students assume the professional role without losing sight of the patient's viewpoint.