Kinetic Metrics Research Articles

Cross-Scale Decoupling Kinetic Processes in Lithium-Ion Batteries Using the Multi-Dimensional Distribution of Relaxation Time.

To non-destructively resolve and diagnose the degradation mechanisms of lithium-ion batteries (LIBs), it is necessary to cross-scale decouple complex kinetic processes through the distribution of relaxation times (DRT). However, LIBs with low interfacial impedance render DRT unreliable without data processing and closed-loop validation. This study proposes a hierarchical analytical framework to enhance timescale resolution and reduce uncertainty, including interfacial impedance reconstruction and multi-dimensional DRT analysis. Interfacial impedance is reconstructed by eliminating simulated inductive and diffusive impedance based on a high-fidelity frequency-domain model. Multi-dimensional DRT decouples solid electrolyte interphase (SEI) and charge transfer (CT) processes by the reversibility of electrochemical reactions with state of charge (SOC) to characterize electrode kinetic evolution driven by SOC and temperature through timescales and peak area. The findings reveal that reconstructed impedance improves the accuracy of identified time constants by ≈20%. Cross-scale DRT results reveal that SOCs below 10% at 25 °C effectively distinguish electrode kinetics due to the high correlation between cathodic CT and SOC. Kinetic metrics characterize that anodic SEI or CT are different control steps limiting the low-temperature performance of different cells. This work underscores the potential of the proposed framework for non-destructive diagnostics of kinetic evolution.

Interaction between multiple convertible child restraint systems and pediatric occupants in oblique impacts

Objectives To assess the interaction of multiple rearward-facing (RF) and forward-facing (FF) CRS restrained pediatric occupants on their kinetics in oblique impacts. Methods A Q3s and a Q1.5 ATD were restrained in 2 CRSs of varying widths—standard (503mm) and slim-fit (425mm)—in the 2 rear outboard seats of a 2023 compact sedan rigidized rear seat bench. A surrogate door structure was mounted at the left outboard location. The Q1.5 was seated in an RF configuration, and the Q3s was seated in RF or FF configurations across tests. The ATDs were restrained as follows: (1) both ATDs in standard CRSs and (2) both ATDs in slim-fit CRSs, switching between the outboard seats for a total of 8 conditions. The condition with the highest head kinetic metrics from these tests was reproduced in a ninth test with the rear seat’s center armrest lowered between CRSs. The entire environment was subjected to an oblique impact at 60° using the FMVSS 213 impact pulse. Results The Q3s’ head contacted the nearby CRS shell when seated farside. When seated nearside, the Q3s’ head contacted the surrogate door structure in 1 of 4 conditions. The Q1.5’s head contacted the nearby CRS in 2 of 4 conditions when seated farside. The Q3s when seated RF had higher HIC15 and head 3ms clip acceleration (H3ms), regardless of farside or nearside position. When seated farside, upper neck tensile force (Fz) for the Q3s in FF configuration (2,317.4 and 2,077.9 N) was higher than that in RF configuration (1,850.8 and 1,802.8 N). When seated nearside, the same in FF configuration (701.3 and 1,029.4 N) was lower than that in RF configuration (997.6 and 1,261.7 N). Repeating the condition with the highest head kinetic metrics (HIC15 = 1246; H3ms = 114.4 g) but lowering the center armrest between the CRSs resulted in lower head kinetic metrics (HIC15 = 916, H3ms = 93.5 g). Conclusions In most cases, the farside seated ATD’s head contacted the nearside CRS shell, resulting in elevated injury metric numbers and higher loading in both CRS types. The nearside ATD did not experience detrimental effects of the interaction with the farside occupant and CRS.

Should individuals with unilateral transtibial amputation carry a load on their intact or prosthetic side?

Carrying side loads often occurs during activities of daily living. As walking is most unstable mediolaterally, side load carriage may further compromise gait biomechanics, especially for transtibial amputees (TTAs). This study investigated the effects of side load carriage on gait kinetics during steady-state walking to determine which side, intact or prosthetic, TTAs should carry a load. Twelve unilateral TTAs wore a passive-elastic foot and carried a side load of 13.6 kg while walking at their self-selected speed. Kinetic metrics, including ground reaction force peaks and impulses, loading and unloading rates, and joint moments and powers, were analyzed. TTAs had smaller propulsive forces on their intact limb during the prosthetic side load condition. During the intact side load condition, they exhibited smaller hip flexor moment in late stance and smaller knee flexor moment at the end of swing on their intact limb. They had higher hip and knee abductor moments on their intact limb and prosthetic limb in early and late stance during the contralateral side load condition. TTAs generated higher hip extensor power at weight acceptance during the ipsilateral side load. Significant interactions were observed in hip extensor power and abductor moment, suggesting strong associations between hip extensor power generation and the ipsilateral side load and between hip abductor moment and the contralateral side load. These mixed results demonstrate some kinetic changes due to side load carriage and suggest that the side TTAs should carry a load depends on the desired effects, primarily on their intact limb.

Influence of virtual reality and task complexity on digital health metrics assessing upper limb function

BackgroundTechnology-based assessments using 2D virtual reality (VR) environments and goal-directed instrumented tasks can deliver digital health metrics describing upper limb sensorimotor function that are expected to provide sensitive endpoints for clinical studies. Open questions remain about the influence of the VR environment and task complexity on such metrics and their clinimetric properties.MethodsWe aim to investigate the influence of VR and task complexity on the clinimetric properties of digital health metrics describing upper limb function. We relied on the Virtual Peg Insertion Test (VPIT), a haptic VR-based assessment with a virtual manipulation task. To evaluate the influence of VR and task complexity, we designed two novel tasks derived from the VPIT, the VPIT-2H (VR environment with reduced task complexity) and the PPIT (physical task with reduced task complexity). These were administered in an observational longitudinal study with 27 able-bodied participants and 31 participants with multiple sclerosis (pwMS, VPIT and PPIT only) and the value of kinematic and kinetic metrics, their clinimetric properties, and the usability of the assessment tasks were compared.ResultsIntra-participant variability strongly increased with increasing task complexity (coefficient of variation + 56%) and was higher in the VR compared to the physical environment (+ 27%). Surprisingly, this did not translate into significant differences in the metrics’ measurement error and test–retest reliability across task conditions (p > 0.05). Responsiveness to longitudinal changes in pwMS was even significantly higher (effect size + 0.35, p < 0.05) for the VR task with high task complexity compared to the physical instrumented task with low task complexity. Increased inter-participant variability might have compensated for the increased intra-participant variability to maintain good clinimetric properties. No significant influence of task condition on concurrent validity was present in pwMS. Lastly, pwMS rated the PPIT with higher usability than the VPIT (System Usability Scale + 7.5, p < 0.05).ConclusionThe metrics of both the VR haptic- and physical task-based instrumented assessments showed adequate clinimetric properties. The VR haptic-based assessment may be superior when longitudinally assessing pwMS due to its increased responsiveness. The physical instrumented task may be advantageous for regular clinical use due to its higher usability. These findings highlight that both assessments should be further validated for their ideal use-cases.

Total-body dynamic PET/CT imaging reveals kinetic distribution of [13N]NH3 in normal organs.

To systematically investigate kinetic metrics and metabolic trapping of [13N]NH3 in organs. Eleven participants performed total-body [13N]NH3 dynamic positron emission tomography (PET). Regions of interest were drawn in organs to obtain time-to-activity curves (TACs), which were fitted with an irreversible two-tissue compartment model (2TC) to investigate constant rates K1, k2 and k3, and to calculate Ki. Additionally, one-tissue compartment model using full data (1TCfull) and the first four minutes of data (1TC4min) were fitted to TAC data. K1 and k2 were compared among different models to assess [13N]NH3 trapping in organs. Kinetic rates of [13N]NH3 varied significantly among organs. The mean K1 ranged from 0.049 mL/cm3/min in the muscle to 2.936 mL/cm3/min in the kidney. The k2 and k3 were lowest in the liver (0.001min- 1) and in the pituitary (0.009min- 1), while highest in the kidney (0.587min- 1) and in the liver (0.800min- 1), respectively. The Ki was largest in the myocardium (0.601 ± 0.259 mL/cm3/min) while smallest in the bone marrow (0.028 ± 0.022 mL/cm3/min). Three groups of organs with similar kinetic characteristics were revealed: (1) the thyroid, the lung, the spleen, the pancreas, and the kidney; (2) the liver and the muscle; and (3) the cortex, the white matter, the cerebellum, the pituitary, the parotid, the submandibular gland, the myocardium, the bone, and the bone marrow. Obvious k3 was identified in multiple organs, and significant changes of K1 in multiple organs and k2 in most organs were found between 2TC and 1TCfull, but both K1 and k2 were comparable between 2TC and 1TC4min. The kinetic rates of [13N]NH3 differed among organs with some have obvious 13N-anmmonia trapping. The normal distribution of kinetic metrics of 13N-anmmonia in organs can serve as a reference for its potential use in tumor imaging.

The dynamic strength index is a reliable and feasible tool to assess neuromuscular performance in male and female handball players

ABSTRACT The aim of this study was to explore the reliability and feasibility of the isometric mid-thigh pull (IMTP) and dynamic strength index (DSI) in semi-professional handball players (seventeen male and eighteen female). A cross-sectional design was used to determine the test-retest reliability of several kinetic metrics registered with a force plates. The peak force, peak relative force, rate of force development (RFD 0–250 ms), and impulse 0–250 ms were selected from the IMTP test, whereas the peak propulsive force was chosen from the countermovement jump test to obtain the DSI. The intraclass correlation coefficient (ICC), coefficient of variation (CV), standard error of the measurement (SEM) and smallest detectable difference (SDD) were calculated. A paired sample t-test was also performed. No significant differences were found between the testing sessions for all variables, except for peak propulsive force for all players (p = 0.036) and DSI for female players (p = 0.037). Reliability for all kinetic metrics was good to excellent (ICC = 0.78–0.97), with low variability (CV ≤ 8.64%), being the SEM scores lower than SDD. In conclusion, the IMTP test and DSI are highly reliable and feasible tools for assessing neuromuscular performance in semi-professional handball players.

Method—AMIDR: A Complete Pulse Method for Measuring Cathode Solid-State Diffusivity

The Atlung Method for Intercalant Diffusion and Resistance (AMIDR) is a novel, high accuracy method for measuring solid state diffusivity and interface resistance related to the Atlung Method for Intercalant Diffusion (AMID) with several key differences. Most notably, AMIDR is designed to analyze the voltage response over time of “complete” pulses, pulses that last until an impedance steady state is reached. These differences allow for AMIDR to return diffusivity results with a higher degree of confidence than Galvanostatic Intermittent Titration Technique (GITT) and at a faster rate with higher state of charge (SOC) resolution than Electrochemical Impedance Spectroscopy (EIS). In this study, three different lithium transition metal oxides were studied. These active materials showed very similar kinetic behaviour that varied with dependence on the fraction of Ni atoms filling sites in the Li layer. AMIDR comes with a user-friendly python program complete with a user interface that is intended to assist other researchers in measuring active material diffusivity in a controlled, repeatable manner. This program, along with instruction on its use, the results of this study from raw data to the final key kinetic metrics, and a video summary of AMIDR design are available for download at https://github.com/MitchBall/AMIDR.

Dynamic total-body PET/CT imaging with reduced acquisition time shows acceptable performance in quantification of [18F]FDG tumor kinetic metrics.

To investigate the feasibility of reducing the acquisition time for continuous dynamic positron emission tomography (PET) while retaining acceptable performance in quantifying kinetic metrics of 2-[18F]-fluoro-2-deoxy-D-glucose ([18F]FDG) in tumors. In total, 78 oncological patients underwent total-body dynamic PET imaging for ≥ 60min, with 8, 20, and 50 patients receiving full activity (3.7 MBq/kg), half activity (1.85 MBq/kg), and ultra-low activity (0.37 MBq/kg) of [18F]FDG, respectively. The dynamic data were divided into 21-, 30-, 45- and ≥ 60-min groups. The kinetic analysis involved model fitting to derive constant rates (VB, K1 to k3, and Ki) for both tumors and normal tissues, using both reversible and irreversible two-tissue-compartment models. One-way ANOVA with repeated measures or the Freidman test compared the kinetic metrics among groups, while the Deming regression assessed the correlation of kinetic metrics among groups. All kinetic metrics in the 30-min and 45-min groups were statistically comparable to those in the ≥ 60-min group. The relative differences between the 30-min and ≥ 60-min groups ranged from 12.3% ± 15.1% for K1 to 29.8% ± 30.0% for VB, and those between the 45-min and ≥ 60-min groups ranged from 7.5% ± 8.7% for Ki to 24.0% ± 24.3% for VB. However, this comparability was not observed between the 21-min and ≥ 60-min groups. The significance trend of these comparisons remained consistent across different models (reversible or irreversible), administrated activity levels, and partial volume corrections for lesions. Significant correlations in tumor kinetic metrics were identified between the 30-/45-min and ≥ 60-min groups, with Deming regression slopes > 0.813. In addition, the comparability of kinetic metrics between the 30-min and ≥ 60-min groups were established for normal tissues. The acquisition time for dynamic PET imaging can be reduced to 30min without compromising the ability to reveal tumor kinetic metrics of [18F]FDG, using the total-body PET/CT system.

Correlation between kinetic and kinematic measures, clinical tests and subjective self-evaluation questionnaires of the affected upper limb in people after stroke.

Assessment of stroke recovery should include multiple sources of information in order to obtain a complete understanding of the individual's rehabilitation progress. Self-evaluation questionnaires' scores do not always correspond to the scores of commonly used clinical evaluation tools. The purpose of this study was to assess the relationship between self-evaluation questionnaires, clinical tests, and kinematic and kinetic analyses of the affected upper limb after stroke, and to determine the correlation between these measures and self-reported general function 2-4 years after the stroke. Twenty-six subjects recovering from stroke were included in the study. Spearman's correlation coefficient was used to measure the correlation between Stroke Impact Scale (SIS), Motor activity Log (MAL), Fugl-Meyer Assessment (FMA) and Action Reach Arm Test (ARAT) scores, and kinematic and kinetic analyses. A logistic regression was used to assess the extent to which these measures may predict the participants' functional self-reported status 2-4 years post stroke. Sections regarding hand function, hand force and general ADL of the self-evaluation questionnaires correlated with kinematic variables. However, only questionnaires that focus on hand function correlated with clinical tests. Mean and maximal hand velocity had the strongest correlations with self-evaluation questionnaires and with the clinical tests, more than other kinematic variables. Self-evaluation questionnaires and clinical tests were found to be correlated with hand kinetic metrics force-to-time ratio and number of force peaks. SIS hand force domain, mean velocity and maximal velocity predicted self-reported general function 2-4 years after the stroke. Self-evaluation questionnaires should be considered for wider use in the clinical evaluation of a patient's stroke recovery, since they add important information on the individual's functional status, which is not reflected in the clinical tests.

One-tenth-activity total-body positron emission tomography versus full-activity imaging in patients with a complex of hepatic malignant tumors: a retrospective study.

The value of ultra-low-activity 2-[18F]-fluoro-2-deoxy-D-glucose (18F-FDG) positron emission tomography (PET) imaging in patients with hepatic malignancies remains unclear. A cross-sectional study was conducted from April 2019 to May 2021 in Zhongshan Hospital, Fudan University. A total of 49 patients with hepatic malignancies, including hepatocellular carcinoma (HCC) (n=13) or intrahepatic cholangiocarcinoma (ICC) (n=36), underwent 60-min dynamic PET imaging, with 15 undergoing full-activity 18F-FDG and 34 undergoing ultra-low-activity 18F-FDG. The kinetic metrics (K1-k3, and Ki) of tumors were calculated and compared between the activity groups. Another 54 patients (27 each group) with hepatic malignancies, including HCC (n=9), ICC (n=34), and metastases (n=11), underwent static imaging. Image qualities were compared between the groups in terms of 5-point Likert scores (with a score ≥3 fulfilling the clinical requirement), the mean standardized uptake value (SUVmean), the standard deviation of standardized uptake value (SUVSD), and the signal-to-noise ratio (SNR) of the liver; the SUVmean of blood pool and muscle; and the tumor-to-liver ratio (TLR), tumor-to-blood ratio (TBR), and tumor-to-muscle ratio (TMR) of lesions. Intergroup comparisons were performed using Chi-squared test for categorical variables and the Student's t-test or the Mann-Whitney test for continuous variables depending on the normality of variables. There was a nonsignificant difference in the kinetic metrics (K1-k3 and Ki) of tumors between the activity groups. In static imaging, 1-min full-activity (F1) and 8-min ultra-low-activity (L8) images obtained image-quality scores >3 and were thus selected for intergroup comparisons. Nonsignificant differences in SUVmean of liver, blood pool, and muscle were identified between F1 and L8 images (P=0.641, P=0.542, and P=0.073, respectively) although the liver SNR was slightly higher in F1 (13.10 vs. 11.31; P=0.003). Lesion detectability was 98.5% and 100% for F1 and L8 images, respectively, but there were no significant differences in TLR, TBR, or TMR between the groups. The results of this single-center study indicate that the performance of ultra-low-activity PET imaging is comparable to that of full-activity imaging in patients with hepatic malignancies.

Study on Microelectrochemical Inhomogeneity of an SA508-309L/308L Overlay Welded Joint.

The corrosion behavior of the dissimilar metal welded joint (DMWJ) is highly dependent on its heterogeneous microstructures. However, directly measuring the electrochemical properties of microstructures in different heat-affected zones (HAZs) is a formidable challenge, because traditional bulk electrochemistry can only offer an average signal. Herein, the microelectrochemical properties of an SA508-309L/308L DMWJ were measured in 3.5 wt % NaCl solution using lithography and capillary techniques. Specifically, high-throughput microelectrochemical tests, including open circuit potential (OCP), electrochemical impedance spectroscopy (EIS), and potentiodynamic polarization (PDP), were conducted on 168 spots (Φ 12 μm). Results revealed five typical EIS responses and seven varieties of PDP curves (different magnitudes of the current density). The maps of thermodynamic and kinetic metrics, such as polarization resistance derived from EIS, corrosion potentials, and corrosion currents extracted from potentiodynamic polarization curves, demonstrated good consistency. The uniform corrosion tendency of the SA508 HAZ subregions during the immersion tests is basically consistent with its Ecorr_avg order of subcritical HAZ (C5, -371 mV) < intercritical HAZ (C4, -546 mV) < fine-grained HAZ2 (C3, -579 mV) < fine-grained HAZ1 (C2, -593 mV). The random presence of inclusions leads to highly heterogeneous microelectrochemical properties of the DMWJ, thereby causing localized corrosion to occur preferentially. Moreover, the macroscopic corrosion behavior is affected by the corrosion products, which display a protective effect that modifies the local electrochemical activity of the SA508 HAZ. The combination of microelectrochemical properties allows for a more comprehensive understanding of the macroscopic corrosion behavior of metals and the galvanic effect between the heterogeneous microstructures.

Assessing dynamic metabolic heterogeneity in prostate cancer patients via total-body [68Ga]Ga-PSMA-11 PET/CT imaging: quantitative analysis of [68Ga]Ga-PSMA-11 uptake in pathological lesions and normal organs.

This study aimed to quantitatively assess [68Ga]Ga-PSMA-11 uptake in pathological lesions and normal organs in prostate cancer using the total-body [68Ga]Ga-PSMA-11 PET/CT and to characterize the dynamic metabolic heterogeneity of prostate cancer. Dynamic total-body [68Ga]Ga-PSMA-11 PET/CT scans were performed on ten prostate cancer patients. Manual delineation of volume-of-interests (VOIs) was performed on multiple normal organs displaying high [68Ga]Ga-PSMA-11 uptake, as well as pathological lesions. Time-to-activity curves (TACs) were generated, and the four compartment models including one-tissue compartmental model (1T1k), reversible one-tissue compartmental model (1T2k), irreversible two-tissue compartment model (2T3k) and reversible two-tissue compartmental model (2T4k) were fitted to each tissue TAC. Various rate constants, including K1 (forward transport rate from plasma to the reversible compartment), k2 (reverse transport rate from the reversible compartment to plasma), k3 (tracer binding on the PSMA-receptor and its internalization), k4 (the externalization rate of the tracer) and Ki (net influx rate), were obtained. The selection of the optimal model for describing the uptake of both lesions and normal organs was determined using the Akaike information criteria (AIC). Receiver operating characteristic (ROC) curve analysis was performed to determine the cut-off values for differentiating physiological and pathological [68Ga]Ga-PSMA-11 uptake. Both 1T1k and 1T2k models showed relatively high AIC values compared to the 2T3k and 2T4k models in both pathological lesions and normal organs. The kinetic behavior of pathological lesions was better described by the 2T3k model compared to the 2T4k model, while the normal organs were better described by the 2T4k model. Significant variations in kinetic metrics, such as K1, k2, and k3, and Ki, were observed among normal organs with high [68Ga]Ga-PSMA-11 uptake and pathological lesions. The high Ki value in normal organs was primarily determined by elevated K1 and low k3, rather than k2. Conversely, the high Ki value in pathological lesions, ranking second to the kidney and similar to salivary glands and spleen, was predominantly determined by the highest k3 value. Notably, k3 exhibited the highest performance in distinguishing between physiological and pathological [68Ga]Ga-PSMA-11 uptake, with an area under the curve (AUC) of 0.844 (95% CI, 0.773-0.915), sensitivity of 82.9%, and specificity of 74.1%. The k3 values showed better performance than SUVmean (AUC, 0.659), SUVmax (AUC, 0.637), and other kinetic parameter including K1 (AUC, 0.604), k2 (AUC, 0.634), and Ki (AUC, 0.651). Significant discrepancies in kinetic metrics were detected between pathological lesions and normal organs, despite their shared high uptake of [68Ga]Ga-PSMA-11. Notably, the k3 value exhibits a noteworthy capability to distinguish between pathological lesions and normal organs with elevated [68Ga]Ga-PSMA-11 uptake. This discovery implies that k3 holds promise as a prospective imaging biomarker for distinguishing between pathologic and non-specific [68Ga]Ga-PSMA-11 uptake in patients with prostate cancer.

Test–Retest Reliability of the Magnitude and Direction of Asymmetry in the Countermovement Jump, Drop Jump, and Countermovement Rebound Jump

This study aimed to investigate the test–retest reliability of three bilateral jump tests to assess asymmetry and determine the consistency of both the magnitude and direction of asymmetry between two testing sessions. Thirty-three participants performed the countermovement jump (CMJ), drop jump (DJ), and countermovement rebound jump (CMRJ—jump 1: CMRJ1; jump 2: CMRJ2) over two sessions. Inter-limb asymmetry was calculated for kinetic metrics, including the mean propulsive force, net braking impulse, and net propulsive impulse. Test reliability was computed using intraclass correlation coefficients (ICC), coefficients of variation (CV), and standard error of measurement. Furthermore, analysis of variance was used to determine the systematic bias between jump types and sessions. Kappa coefficients were utilised to assess the consistency of asymmetry favouring the same limb. Results showed poor to excellent reliability for all jump tests between sessions (ICC range = 0.19–0.99, CV range = 2.80–11.09%). A significantly higher magnitude of asymmetry was revealed for the net braking impulse during the DJ compared to the CMRJ2 (p ≥ 0.014, g ≤ 0.53). When computing the direction of asymmetry between test sessions, Kappa coefficients revealed that levels of agreement were substantial (Kappa = 0.63–0.70) for the CMJ, moderate to almost perfect (Kappa = 0.59–0.94) for the CMRJ1, moderate to almost perfect (Kappa = 0.58–0.81) for the DJ, and slight to moderate for the CMRJ2 (Kappa = 0.19–0.57). These results underscore the variable nature of both the magnitude and direction of asymmetry during jump testing. Thus, practitioners should carefully choose evaluation methods and metrics characterised by low variability to ensure robust asymmetry assessments.

Analysis of Kinetic Metrics in Submarining vs Non-Submarining Conditions for a 6YO Pediatric Human Body Model in Frontal Impacts

&lt;div&gt;Field data has shown that belt-positioning boosters help reduce the risk of injury to children in a crash. This study builds on prior submarining work (Slusher et al. 2022) and aims to analyze kinetic metrics (which can be easily recorded from anthropomorphic test devices in crash tests) in submarining and non-submarining conditions for a 6-year-old pediatric human occupant in frontal crashes.&lt;/div&gt;

Xylanase immobilized on β-cyclodextrin functionalized magnetic nanoparticles: Implications for antioxidant component extraction and fruit juice quality improvement

Amongst various materials employed for modifying magnetic nanoparticles (MNPs), β-cyclodextrins (β-CDs) possess outstanding features for surface engineering of MNPs to improve the enzyme attachment. Herein, β-CD was modified onto MNPs and fabricated as a unique nanocarrier for the immobilization of xylanase. A variety of analytical techniques were applied to characterize the structural, morphological and chemical features of the as-prepared nanobiocatalyst. Notably, the xylanase immobilized onto the synthesized nanocomplex exhibited efficient reactivity and remarkable stability against harsh environmental condition. Besides, the as-prepared nanobiocatalyst could maintain 50 % of its original catalytic activity even after 12 successive reuses. The storage stability results showed that the free and immobilized xylanases lost approximately 65 % and 35 % of their original activity, respectively, after 90 days. The evaluation of kinetic metrics confirmed the remarkable improvement of immobilized xylanase performance. The effect immobilized xylanase on the reduction of apple and pineapple juices turbidity indicated that the turbidity decrease rate of apple juice occurred quickly (about 32 % in 90 min, for free and immobilized xylanases) rather than pineapple juice (about 20 % in 90 min, for both kinds of enzymes). The nanobiocatalyst also exhibited good recycling as approved by retention of 60 % and 70 % of relative activity after eight reuses in clarification of apple and pineapple juices. Additionally, the ability of immobilized xylanase to the extraction of antioxidant components demonstrated that the nanobiocatalyst can extract antioxidant outstandingly much higher than free enzyme. The resultants of this research indicates the great potential of the immobilized xylanase for employing in a wide range of bio-applications.

Evaluation Methods and Measurement Challenges for Industrial Exoskeletons.

In recent years, exoskeleton test methods for industrial exoskeletons have evolved to include simulated laboratory and field environments. Physiological, kinematic, and kinetic metrics, as well as subjective surveys, are used to evaluate exoskeleton usability. In particular, exoskeleton fit and usability can also impact the safety of exoskeletons and their effectiveness at reducing musculoskeletal injuries. This paper surveys the state of the art in measurement methods applied to exoskeleton evaluation. A notional classification of the metrics based on exoskeleton fit, task efficiency, comfort, mobility, and balance is proposed. In addition, the paper describes the test and measurement methods used in supporting the development of exoskeleton and exosuit evaluation methods to assess their fit, usability, and effectiveness in industrial tasks such as peg in hole, load align, and applied force. Finally, the paper includes a discussion of how the metrics can be applied towards a systematic evaluation of industrial exoskeletons, current measurement challenges, and future research directions.

Performance and symmetry measures during vertical jump testing at return to sport after ACL reconstruction

ObjectiveVertical jump tests are more sensitive in revealing asymmetries in performance metrics at the time of return to sport after anterior cruciate ligament (ACL) reconstruction (ACLR) than horizontal hop tests....

Neuromuscular Performance Changes in Elite Futsal Players Over a Competitive Season.

Spyrou, K, Alcaraz, PE, Marín-Cascales, E, Herrero-Carrasco, R, Cohen, DD, and Freitas, TT. Neuromuscular performance changes in elite futsal players over a competitive season. J Strength Cond Res 37(5): 1111-1116, 2023-A professional futsal season imposes a great amount of physiological and mechanical stress on players. The main aim of this study was to examine the changes in neuromuscular performance qualities across the season. Ten professional male players performed a 10-m sprint, standing long jumps (SLJs), and countermovement jumps (CMJs) during the competitive season (i.e., every ∼5 weeks from September to January). A one-way repeated measures ANOVA with post hoc pairwise comparisons and effect sizes (ESs) were used to analyze potential differences among these assessments. A significant and large decline was found in concentric peak power ( p = 0.040; ES = 1.24). A nonsignificant and moderate decrease was observed in sprint ability ( p = 0.155; ES = 1.03), CMJ height ( p = 0.175; ES = 1.00), and SLJ distance ( p = 0.164; ES = 1.03). Regarding other CMJ kinetic variables, nonsignificant and moderate changes were found. In summary, considering the neuromuscular performance tests and variables assessed, only concentric peak power in CMJ decreased significantly across the season; however, nonsignificant decrements were observed in sprinting time, SLJ, CMJ height, and other kinetic metrics. CMJ variables during the jump-land cycle should be incorporated alongside more traditional measures (e.g., jump height) to monitor performance during the season.

Influence of Reduced-Gravity Treadmill Running on Sensor-Derived Biomechanics.

Reduced gravity treadmills have become increasingly prevalent in clinical settings. The purpose of this study was to assess the influence of manipulated levels of bodyweight during reduced gravity treadmill running on sensor-derived spatiotemporal, kinematic, and kinetic measures. Reduced gravity conditions would result in significantly altered biomechanical measures compared with 100% gravity conditions, with the most pronounced effects anticipated in the 20% condition. Cross-sectional clinic-based study. A total of 16 runners (8 male [M; age, 28.88 ± 5.69 years; body mass index [BMI], 25.08 ± 3.74 kg/m2], 8 female [F; age, 28.75 ± 5.23 years, BMI, 21.05 ± 3.46 kg/m2]) participated in this study. Participants wore commercially available sensors on their shoelaces and ran in a reduced gravity treadmill at a self-selected pace for 5 minutes each at 100%, 80%, 60%, 40%, and 20% bodyweight in a randomized order. The pace remained constant across all conditions, and rating of perceived exertion (RPE) was obtained following each condition. Step-by-step spatiotemporal, kinematic, and kinetic metrics were extracted to calculate mean outcome measures for each bodyweight condition. Repeated measures analyses of variance were conducted to assess the influence of the different bodyweight reduction levels on RPE and runners' biomechanics. Higher pressure creating lower bodyweight conditions resulted in significantly increased stride length and decreased cadence, contact time, impact g, and RPE, along with a shift toward forefoot strike types compared with higher body weight conditions (P < 0.01). All other outcomes were comparable across conditions. Reduced bodyweight running significantly altered spatiotemporal measures and reduced the vertical component of loading. Our findings offer objective information on expected biomechanical changes across pressure levels that clinicians should consider when incorporating reduced gravity treadmill running into rehabilitation plans.

Reliability and Effectiveness of a Lateral Countermovement Jump for Stratifying Shuffling Performance Amongst Elite Basketball Players.

Though research suggests that basketball players spend approximately 31% of game actions shuffling laterally, limited data are available on the kinetic factors that separate fast and slow shufflers. The purpose of this study was twofold: (1.) Examine the reliability of kinetic metrics from a single-leg Lateral Countermovement Jump (LCMJ) (2.) Determine if kinetic metrics from the LCMJ can stratify above (i.e., "fast") or below (i.e., "slow") median shuffling performance. Twenty professional basketball players participated in the reliability study (21.7 ± 3.5 years, 1.98 ± 0.1 m; 89.9 ± 10.9 kg). One hundred seven professional and thirty-three collegiate basketball players (N = 140) (22.7 ± 3.5 years, 2.0 ± 0.1 m; 98.4 ± 11.9 kg) participated in the experimental study examining the ability of LCMJ kinetics to stratify shuffling performance. Reliability was assessed using Bland-Altman plots, coefficients of variation (CVs), typical errors (TEs), and intraclass correlation coefficients (ICCs). Anthropometric and LCMJ kinetic differences between fast and slow shufflers were assessed with an independent t-test. Four kinetic metrics (peak vertical force, peak lateral force, relative lateral force, and lateral impulse) met within- and between-session reliability thresholds (CV &lt; 10% and ICC &gt; 0.70). Faster shufflers generated significantly more relative lateral force than their slower counterparts (9.51 ± 0.8 Nx/kg vs. 8.9 ± 0.9 Nx/kg, %Diff 6.3, p &lt; 0.00007, ES = 0.70). Basketball practitioners who have access to triaxial force plates may consider adding the LCMJ into their testing battery, as relative lateral force is a reliable metric that can stratify fast and slow shufflers.