The object of this study is to analyze kinetics and kinematics of knee prosthesis. We have developed a new type of prosthesis which is capable of deep knee flexion. We created a 3D mathematical model incorporating the above prosthesis. Using this model simulation was performed under the simple knee flexion. As for simple knee flexion motion, a cadaver experiment was also performed.We performed the simulation for simple knee flexion to verify the validity of the model by comparing the results with those of the experiment. Our model can calculate the knee motion precisely because in our model not only a femorotibial component but also a patellofemoral component are included, and major muscles, ligaments and tendons are taken into account. From our model, we could calculate contact trajectories and contact forces on the articulating surfaces, ligaments' strains as well as valus-valgus and rotation angles of the knee. When we compared the resultant forces during simple knee flexion, the variation pattern from simulation was in good agreement with that of experiment. And we confirmed the feasibility and usefulness of our model.