Kind Of Therapy Research Articles

“A Kind of Therapy”: Wheelchair Sport Athletes and Health-Related Quality of Life

ABSTRACT The purpose of this study was to understand the meaning physically impaired1 wheelchair sport athletes attributed to wheelchair basketball participation as well as potential physical, psychological, and social health-related quality of life (HRQOL) benefits. Specifically, the experiences of wheelchair sport athletes from low- and middle-income countries (LMIC) affected by ongoing or recent conflict were examined. Focus group participants for this study included 108 wheelchair basketball athletes (77 men and 31 women) from seven men’s and three women’s national teams at an international wheelchair basketball tournament held in India. All teams were from LMICs in Africa and Asia that were served by the International Committee of the Red Cross due to recent or ongoing armed conflict. Data analysis produced three interrelated themes related to HRQOL: (1) improvements to physical health, (2) psychological impact of sport participation, and (3) social well-being. Physical benefits included improvements to physical functional capacity and decreases in medical complications. Psychological benefits included freedom and respite from inaccessibility and improved self-beliefs and feelings of capability on and off the court. Social well-being benefits included camaraderie in the team setting and positive interpersonal interactions with members of the broader community. Overall, the findings indicated that wheelchair sport is indicated as positively impacting numerous HRQOL indicators for disabled participants in LMIC and is a valuable rehabilitative option and meaningful endeavor for disabled persons.

Implementasi Hot Pack Untuk Peningkatan Suhu Tubuh Pada Pasien Hipotermi Pasca Operasi

Introduction: As a kind of therapy, surgery involves cutting into the patient in order to reach the targeted location of the body. The risk of hypothermia is a potential consequence of anesthesia. A dangerous drop in core temperature, below 36 degrees Celsius, causes hypothermia. One way to alleviate cold symptoms is using a warm compress. An alternative to using hot packs to raise core temperature is a warm compress. Hot packs have many advantages over buli-buli, the most notable of which is that they can be reused and never run out of steam. Objective: This community service activity is to implement hot packs on hypothermic patients. Method: As part of their community service, volunteers take patients' temperatures using electronic thermometers. Including thirty individuals who were found to have hypothermia. Result: Impact of Volunteer Work Hypothermia after administration of a hot pack, with a pre-package average temperature of 35.20 degrees Celsius Average core temperature before administration of the hot pack: 36.50 °C Body temperature values ranged from 34.10C before implementation to 36.70C thereafter, with a low value of 35.10C and a high value of 35.90C before and after, respectively. Conclusion: This proves that there is an increase in body temperature in hypothermic patients after implementing Hot packs.

Exploring Senolytic and Senomorphic Properties of Medicinal Plants for Anti-Aging Therapies.

Senolytic and senomorphic therapies have gained more and more attention in the last decade. This kind of therapy is based on the killing of cellular senescent cells without harming the "normal" cells. Aging is not a disease. Clinical studies on healthy people will be difficult to conduct. Therefore, one possibility is to draw on the large repertoire of medicinal plants and use their senolytic properties to provide mild anti-aging therapies. Chamomile, goldenrod, reishi, and green tea were tested for their ability to trigger senolysis. Quercetin was used as control substance. Cellular senescence was induced with 25 µM etoposide in human dermal fibroblasts and established for at least 14 days. The plant extracts were tested for their antioxidant potential (DPPH assay) and their polyphenol content. Senolysis was determined by presto blue assay of young and etoposide-induced senescent cells, and SA-β-Gal assays were also performed. The senomorphic properties of the plants were investigated using IL-6 ELISA and qPCR. It turned out that chamomile triggers a kind of cytokine storm and causes the cytokine values in the ELISA and in the qPCR to rise extremely, and other senescence-associated phenotype (SASP) markers were also elevated. Goldenrod and quercetin tend to have a senolytic and senomorphic effect, respectively. Regarding the senolytic and senomorphic properties of herbs, we found that all tested herbs can have a senolytic effect, and a senomorphic effect of quercetin has also been discovered. With regard to the effect of chamomile, however, we can say that seemingly harmless tea products may have harmful effects, especially in combination with chemotherapy, at least in cell culture experiments. Nevertheless, inflammation is a double-bladed mechanism with positive effects, for example, in healing, but also known negative effects.

20 years clinical application of the vacuum bell for conservative treatment of pectus excavatum-past, present, future.

For decades, open surgical repair was the only available method to treat pectus excavatum (PE). In 1998 Donald Nuss described first time a minimally invasive repair of pectus excavatum (MIRPE), and today MIRPE is performed with increasing frequency worldwide. However, despite its minimally invasive approach, with the widespread use of MIRPE the character and number of complications have increased. 20 years ago, non-surgical measures such as vacuum bell therapy (VBT) were introduced as a useful complement for specific treatment of PE patients. However, until today there are no existing validated guidelines concerning VBT. The study includes the results of an online survey submitted to the members of Chest Wall International Group (CWIG), a selective review of the English spoken current literature with focus on VBT and an analysis of our own previous studies concerning VBT. Seventy-two percent of the CWIG members practicing in 47 different institutions confirmed to use VBT for PE patients. Furthermore, within the last 10 to 15 years an increasing number of studies were identified reporting on successful use of VBT for PE. However, a recently published study stated that the effect of VBT is predominantly because of thickening of the chest wall by increasing pre-sternal adipose tissue. There was one study comparing VBT to MIRPE but no randomized and/or prospective studies comparing conservative treatment vs. surgical repair or conservative treatment vs. no specific therapy. Variables predictive of an excellent outcome could be identified. Especially in younger PE patients, VBT is reported with increasing frequency in the survey as well as in the literature. However, validated guidelines concerning VBT are still not available. Non-operative treatment of PE with VBT proved to be safe and a potential alternative to surgical repair in carefully selected PE patients. Patient's age at diagnosis and severity of the PE represents relevant variables to decide which kind of therapy might be successful to correct PE. Especially in PE patients under the age of 10 years, VBT seems to represent the first step of specific therapy.

Ericksonian Hypnosis as a Possible Form of Inquiry: A Peircean Phenomenological Approach.

The present article proposes a phenomenological analysis of Ericksonian hypnosis, highlighting it as a potential form of inquiry on human subjectivity. Ericksonian hypnosis is one of the most innovative therapeutic approaches created in the twentieth century. It is commonly understood as a kind of therapy and not a possible way of inquiry. Therapists usually associate hypnosis to private or institutional practice, and rarely to universities or research centers. Consequently, Ericksonian hypnosis is usually seen as a school of therapy and not a creative form of inquiry that may significantly contribute to understanding both the field of hypnosis as well as the human self. To achieve our objective, this work explains the three categories of Peircean Phenomenology and its relevance as a meta-theory to describe and promote the understanding of the different fields of experience in hypnosis. A case study of Erickson's hypnosis is then presented and discussed through the three clinical attitudes inspired by these phenomenological categories. Each attitude will also be linked to a specific knowledge pathology, such as pop theories, technicism, and doctrinarian thought. Some remarks will be made to approach Erickson's hypnosis to other schools of psychotherapy during the explanation on clinical attitudes. Therefore, the authors demonstrate that Erickson's approach of hypnosis is not just a school of therapy with its list of interventions, but that it affords relevant contributions to understanding human subjectivity while simultaneously being a form of inquiry.

Clinical, endoscopic, pathological characteristics and management of cap polyposis: experience from a Tertiary Hospital in China.

Cap polyposis (CP) is a rare kind of benign disease, and the majority of previously published relevant articles involve a small number of patients. Hence, we summarized our experience to contribute additional data, hoping to raise awareness of this disease. From 1 January 2017 to 1 November 2021, consecutive patients diagnosed with CP were retrospectively reviewed. Their medical histories, and laboratory, imaging, endoscopic, and pathology results were analyzed. We made telephone calls to the patients and searched for the information in our electronic medical records to obtain the follow-up results. Forty-one patients were chosen for analysis. The median age of the patients was 20years old, and 90.24% (37 patients) of the patients were male. The majority of the patients presented with hematochezia. The rectum was the most commonly affected site, and the Helicobacter pylori infection rate was high. There were multiple and combined treatments for these patients. These treatments can be divided into 3 main categories: medical therapy, endotherapy and surgery. Medical therapy helped to diminish the size of but the polyps were difficult to resolve; however, the patients' symptoms could be diminished. Twenty-three patients underwent surgical resection, and 12 patients received endotherapy. We further compared the two methods of polyp resection. Both endotherapy and surgery were safe, and the recurrence risk was not significantly different between the two kinds of therapy (p = 0.321). The clinical improvement of medical treatments was not satisfactory, and endotherapy or surgical resection could remove the polyposis and provide temporary relief, but the recurrence rates were high.

Multifunctional and stimuli-responsive liposomes in hepatocellular carcinoma diagnosis and therapy

Hepatocellular carcinoma (HCC) is the most prevalent type of liver cancer, mainly occurring in Asian countries with an increased incidence rate globally. Currently, several kinds of therapies have been deployed for HCC therapy including surgical resection, chemotherapy, radiotherapy and immunotherapy. However, this tumor is still incurable, requiring novel strategies for its treatment. The nanomedicine has provided the new insights regarding the treatment of cancer that liposomes as lipid-based nanoparticles, have been widely applied in cancer therapy due to their biocompaitiblity, high drug loading and ease of synthesis and modification. The current review evaluates the application of liposomes for the HCC therapy. The drugs and genes lack targeting ability into tumor tissues and cells. Therefore, loading drugs or genes on liposomes can increase their accumulation in tumor site for HCC suppression. Moreover, the stimuli-responsive liposomes including pH-, redox- and light-sensitive liposomes are able to deliver drug into tumor microenvironment to improve therapeutic index. Since a number of receptors upregulate on HCC cells, the functionalization of liposomes with lactoferrin and peptides can promote the targeting ability towards HCC cells. Moreover, phototherapy can be induced by liposomes through loading phtoosensitizers to stimulate photothermal- and photodynamic-driven ablation of HCC cells. Overall, the findings are in line with the fact that liposomes are promising nanocarriers for the treatment of HCC.

KarXT: Combination of Xanomeline and Trospium

KarXT is an oral, research-stage M1/M4-preferring muscarinic agonist that is being developed to treat psychiatric and neurological conditions, such as schizophrenia and Alzheimer’s disease-related psychosis. It is a combination of the muscarinic agonist xanomeline and the muscarinic antagonist trospium. Idea behind this psychopharmaceutical is to preferentially stimulate muscarinic receptors in the central nervous system and to unlock the therapeutic potential of xanomeline, while minimizing adverse effects observed in prior studies. All in all, KarXT is the first potential medication of its kind with a genuinely distinctive dual mechanism that treats symptoms of severe mental illness without relying on the dopaminergic or serotonergic pathway. If approved, this strategy could offer people with serious mental illnesses a different kind of therapy and positively influence their lives.

Proses Spiritual Emotional Freedom Technique (SEFT) Untuk Meningkatkan Kesejahteraan Psikologis Lanjut Usia

Entering old age will certainly have changes felt by the elderly such as changes in economic, psychological, and social aspects. People who are not ready to face these changes will be vulnerable to psychological problems. It is possible that this condition will actually have a negative impact on the health of the elderly, which can actually reduce their psychological well-being. In an effort to improve the psychological well-being of the elderly, one of them is by providing Spiritual Emotional Freedom Technique therapy. SEFT therapy is one method that can be used to improve their psychological well-being. This kind of therapy is useful in overcoming difficulties related to physical health, emotions, and cognitive function. In the context of improving the psychological well-being of the elderly, the purpose of this study is to be able to see how effective the therapy is for the elderly. Panti Sosial Tresna Werdha Budi Mulia 3 was used as a research location conducted with a qualitative case study methodology. Based on the results of the research after the provision of SEFT therapy, there are certainly changes that are felt, such as the ability of the elderly to get rid of their negative emotions, stress pressure, the sadness they feel is also slowly decreasing.

Polydopamine Nanosystems in Drug Delivery: Effect of Size, Morphology, and Surface Charge

Recently, drug delivery strategies based on nanomaterials have attracted a lot of interest in different kinds of therapies because of their superior properties. Polydopamine (PDA), one of the most interesting materials in nanomedicine because of its versatility and biocompatibility, has been widely investigated in the drug delivery field. It can be easily functionalized to favor processes like cellular uptake and blood circulation, and it can also induce drug release through two kinds of stimuli: NIR light irradiation and pH. In this review, we describe PDA nanomaterials’ performance on drug delivery, based on their size, morphology, and surface charge. Indeed, these characteristics strongly influence the main mechanisms involved in a drug delivery system: blood circulation, cellular uptake, drug loading, and drug release. The understanding of the connections between PDA nanosystems’ properties and these phenomena is pivotal to obtain a controlled design of new nanocarriers based on the specific drug delivery applications.

The Challenge of Single-Photon Emission Computed Tomography Image Segmentation in the Internal Dosimetry of 177Lu Molecular Therapies.

The aim of this article is to review the single photon emission computed tomography (SPECT) segmentation methods used in patient-specific dosimetry of 177Lu molecular therapy. Notably, 177Lu-labelled radiopharmaceuticals are currently used in molecular therapy of metastatic neuroendocrine tumours (ligands for somatostatin receptors) and metastatic prostate adenocarcinomas (PSMA ligands). The proper segmentation of the organs at risk and tumours in targeted radionuclide therapy is an important part of the optimisation process of internal patient dosimetry in this kind of therapy. Because this is the first step in dosimetry assessments, on which further dose calculations are based, it is important to know the level of uncertainty that is associated with this part of the analysis. However, the robust quantification of SPECT images, which would ensure accurate dosimetry assessments, is very hard to achieve due to the intrinsic features of this device. In this article, papers on this topic were collected and reviewed to weigh up the advantages and disadvantages of the segmentation methods used in clinical practice. Degrading factors of SPECT images were also studied to assess their impact on the quantification of 177Lu therapy images. Our review of the recent literature gives an insight into this important topic. However, based on the PubMed and IEEE databases, only a few papers investigating segmentation methods in 177Lumolecular therapy were found. Although segmentation is an important step in internal dose calculations, this subject has been relatively lightly investigated for SPECT systems. This is mostly due to the inner features of SPECT. What is more, even when studies are conducted, they usually utilise the diagnostic radionuclide 99mTc and not a therapeutic one like 177Lu, which could be of concern regarding SPECT camera performance and its overall outcome on dosimetry.

Comparison of neurodermatitis management based on effectiveness and safety

Neurodermatitis, also known as atopic dermatitis or atopic eczema is the long-term inflammation in the skin. There are many different kinds of therapies without clear conclusions and recommendations as to which therapy is the most effective and safest. This paper aims to compare the effectiveness and safety of four commonly used therapies: steroid therapy, traditional Chinese medicine (TCM), Phototherapy, and habit reversal. The methodology used was through gathering/searching papers with keywords such as, neurodermatitis management, atopic dermatitis, habit reversal, steroid therapy, and comparing the effectiveness and safety of the varying therapies. The results showed us that studies concerning the different therapies should be explored and more therapies need data for us to come to a clear recommendation.

Quality Assurance Investigations and Impurity Characterization during Upscaling of [177Lu]Lu-PSMAI&T

[177Lu]Lu-PSMAI&T is widely used for the radioligand therapy of metastatic castration-resistant prostate cancer (mCRPC). Since this kind of therapy has gained a large momentum in recent years, an upscaled production process yielding multiple patient doses in one batch has been developed. During upscaling, the established production method as well as the HPLC quality control were challenged. A major finding was a correlation between the specific activity and the formation of a pre-peak, presumably caused by radiolysis. Hence, nonradioactive reference standards were irradiated with an X-ray source and the formed pre-peak was subsequently identified as a deiodination product by UPLC-MS. To confirm the occurrence of the same deiodinated side product in the routine batch, a customized deiodinated precursor was radiolabeled and analyzed with the same HPLC setup, revealing an identical retention time to the pre-peak in the formerly synthesized routine batches. Additionally, further cyclization products of [177Lu]Lu-PSMAI&T were identified as major contributors to radiochemical impurities. The comparison of two HPLC methods showed the likelihood of the overestimation of the radiochemical purity during the synthesis of [177Lu]Lu-PSMAI&T. Finally, a prospective cost reduction through an optimization of the production process was shown.

The Effect of Chemical Treatments on the Tissues around the Tooth

This synthesis of research was carried out in order to assess the impact of chemical treatments on gum tissues. Chemical compounds are used in a variety of dental applications, including caries prevention, pulp treatment, and periodontal care. Understanding how these medications affect the surrounding tissues is critical for successful treatment results. We thoroughly reviewed the existing literature and relied on any relevant research published between 2000 and 2021. The results imply that, depending on the kind of therapy and the substance used, chemical therapies may have both helpful and negative effects on the tissues around a tooth. More study is needed to determine the most effective techniques for protecting the long-term health of the surrounding tissues.

Understanding the Background of Personality Disorders and the Influence of Early Experiences with Parents to their View of God

Early relationship is very significant in developing a healthy personality. What a child experience during first three years of life can have a lifelong impact. Early relationships not only act as a template of the brain, but also mold and shape the child’s ability for future relationships with others. Early relationship also becomes the determinant of normal or pathological splitting. Splitting is universal and not all splitting cause a pathology. Maternal-availability is essential during first three years of life. Normal splitting can happen when good-enough mother on some occasion is unavailable or unable to attend to the infant and meet his needs. The child can tolerate the good-enough mother’s unavailability at certain times because he or she is in ‘holding environment’ that makes the child feel secure, protected, and not excessively frustrated. Pathological splitting can happen when the infant receives excessively unsatisfying, frustrating and abusive experience. Severe splitting makes one to see everything in terms of black and white. He or she is not able to accept bad and good at the same time or cannot accept paradoxical qualities in others. A normal person can accept this paradoxical quality, but a personality disorder person cannot accept this paradoxical quality. Finally, early relationships influence one’s relationship to God, how he or she sees God and experience God. Three studies have found that early relationship with parents, whether secure or insecure relationships can influence how one sees God and relates to God (Gravitt, 2011; Pehr Granqvist, 2007; Rosalinda Cassibba, 2013). One who has a secure attachment with his or her parent, tend to trust God and has a secure relationship with God as well. As a therapist, it is essential that we provide a secure base for our patients or clients. Psychodynamic therapy is the kind of therapy that proved to help patients with Personality Disorders. Successful treatment should not only relieve symptoms but also make intrapsychic change by providing patients with a relationship that enables them to resolve the splitting of their ego.

A Narrative Review on CD44's Role in Glioblastoma Invasion, Proliferation, and Tumor Recurrence.

High invasiveness is a characteristic of glioblastoma (GBM), making radical resection almost impossible, and thus, resulting in a tumor with inevitable recurrence. GBM recurrence may be caused by glioma stem-like cells (GSCs) that survive many kinds of therapy. GSCs with high expression levels of CD44 are highly invasive and resistant to radio-chemotherapy. CD44 is a multifunctional molecule that promotes the invasion and proliferation of tumor cells via various signaling pathways. Among these, paired pathways reciprocally activate invasion and proliferation under different hypoxic conditions. Severe hypoxia (0.5-2.5% O2) upregulates hypoxia-inducible factor (HIF)-1α, which then activates target genes, including CD44, TGF-β, and cMET, all of which are related to tumor migration and invasion. In contrast, moderate hypoxia (2.5-5% O2) upregulates HIF-2α, which activates target genes, such as vascular endothelial growth factor (VEGF)/VEGFR2, cMYC, and cyclin D1. All these genes are related to tumor proliferation. Oxygen environments around GBM can change before and after tumor resection. Before resection, the oxygen concentration at the tumor periphery is severely hypoxic. In the reparative stage after resection, the resection cavity shows moderate hypoxia. These observations suggest that upregulated CD44 under severe hypoxia may promote the migration and invasion of tumor cells. Conversely, when tumor resection leads to moderate hypoxia, upregulated HIF-2α activates HIF-2α target genes. The phenotypic transition regulated by CD44, leading to a dichotomy between invasion and proliferation according to hypoxic conditions, may play a crucial role in GBM recurrence.

Art therapy as a primary and adjunct therapy in interventions for people living with serious illnesses - a review of the literature

Introduction and purpose Art-therapy is a therapeutic method which uses art as a tool to achieve benefits in physical and mental health. This kind of psychotherapy uses artistic media as a basic form of communication. As an additional form of treatment, combined with medication, it helps not only to explore a patient’s difficulties and problems but also to overcome them. Art-therapy is playing an increasing role in the context of health in individuals struggling with different diseases, especially with the mental ones. This is a growing field of research and the aim of this brief review is to provide an update on the positive effects of art-therapy and to list health problems in which it would be significant to use this kind of therapy. Materials and methods A search was conducted using PubMed and GoogleScholar data bases. Articles were searched in English using the following key words: “art therapy”, “psychodrama”, “dance movement therapy”, “music therapy”, “creative art therapy”. Description of the state of knowledge Art-therapy has a wide range of benefits in chronically ill patients. Most common are the awareness of the emotions and behaviors and helping to deal with them, helping to deal with the process of treatment. The literature also draws attention to other results such as increasing self- esteem and improving the quality of life. Summary Art-therapy is associated with health benefits in people struggling with different health problems. Art-therapy has great potential to participate in future basic and adjunctive therapy but further research is needed in this area.

Detection of Alzheimer’s disease using Magnetic Resonance Images Based on VGG19 & DenseNet169

Abstract: Alzheimer's disease is a fatal degenerative brain condition. It is a neurological condition that primarily impacts seniors. The disease of Alzheimer's is the main factor in mental illness. Early detection and the right kind of therapy can greatly aid in controlling the complaint because this is a progressing sickness. This design suggests a model that analyses brain MRI sample images to determine whether or not a person has Alzheimer's disease. For this type, we employ the VGG19 and DenseNet169 architectures, providing a comparative study of which frame exhibits promising outcomes.

The Girl Who Wants to Get Rid of Her Left Leg—Body Identity Dysphoria

Introduction: One of the strangest kinds of misperceptions of the body is “Body Integrity Dysphoria” (BID), formerly named as “Body Identity Integrity Disorder” (BIID). The affected people have the feeling that a limb is not part of their body. They can feel it, they can use it, they can move it, but they cannot get along with the fact that it is a part of their own body. Most feel the need for an amputation of a leg, others of both legs, some want a palsy and use a wheelchair. Still discussed is whether other disablements such as blindness, dumbness, deafness or a desire to have an incontinency can be included in this diagnosis. This review discusses parallels and differences to transgender/trans identity, body dysmorphic disorder, alien limb syndrome, hemineglect, and self-induced amputations in schizophrenic patients. The cause for the need to be disabled is still unknown; the review gives an overview about psychological and neurological theories of explanation and what kind of therapy may help. Methods: This is a narrative review of about 20 years of research about Body Integrity Dysphoria by the author. Results: Overall, no psychopathological deviations were found, none of the affected persons examined by us were actually delusional or schizophrenic, which underlines that there is a neurological malfunction in the brain that has existed since birth. However, psychological mechanisms intensify the symptoms. There are clear parallels to other forms of interference between the external body and mental body representation. Different types of therapies have been able to provide help to better deal with BID, but there has been little to bring about a real cure. In contrast, BID-affected persons who achieved amputation (or other desired forms of disability) were satisfied and able to return to work. Conclusions: BID remains an enigmatic disorder. We have learned a lot over the past 20 years that the mental and physical bodies do not have to match.

Spiritual Guidance for Patients According to Ibn- Qayyem Al-Jawziyyah: An Analytical Study of the Prophetic Medicine Book

Spiritual guidance has recently received much attention at the level of medical research and scientific studies and has been used much at the level of applied and realistic treatments in hospitals and medical centers. This kind of therapy was not strange to Islamic medicine, but it was a cornerstone and a prominent feature in medicine. Ibn Al-Qayem made significant contributions related to spiritual guidance as he shed light in his book The Prophetic Medicine on spiritual recovery and its elements, and he set rules and guidelines for spiritual therapy. His writings on spiritual guidance and its sources played a significant role in understanding spiritual guidance. This research paper aims to introduce an integrated formulation of spiritual guidance based on Ibn Al-Qayem’s book The Prophetic Medicine.