Introduction: By directly affecting the environment and creating employee satisfaction, ergonomics creates quality products or services, organizational productivity, and customer satisfaction. Participation is a kind of participation and involvement in decision-making, planning, and implementation. The present research was conducted to evaluate and measure the impact of collaborative management with macro ergonomics on organizational productivity through the mediating variable of employee empowerment and participation in the General Directorate of Technical and Vocational Training of Fars province. Materials and Methods: This research is a descriptive survey type. To carry out this research, 208 employees of the General Directorate of Technical and Vocational Training of Fars province were selected in 1402 by a simple sampling method based on the Karjesi and Morgan formula. Four standard questionnaires of participatory management, employee empowerment, organizational productivity, and employee participation were used to collect data. The reliability of the questionnaires was investigated using Cronbach's alpha, and the content validity ratio (CVR) was used for the validity of the questionnaires. The effect of participatory management with macro ergonomics on organizational productivity was evaluated using the paired t-test. Also, SPSS and AMOS statistical software were used for data analysis. Results: Cronbach's alpha coefficient of the standard questionnaire of participatory management, employee empowerment, organizational productivity, and employee participation was 0.803, 0.755, 0.790, and 0.946, respectively, and the CVR value of the questionnaires was calculated 1, 0.99, 1 and 1 respectively. And therefore the validity and reliability of the questionnaires were confirmed. This research showed that participatory management has a positive and significant effect on the empowerment of employees from the perspective of macro ergonomics and productivity (p=0.034). The positive impact of empowering employees on the organization's productivity was confirmed with the perspective of macro ergonomics and employee participation (p=0.041) Finally, the mediating role of employee empowerment and employee participation on organizational productivity was confirmed (p=0.031). Conclusion: According to the obtained results, the application of macro ergonomics leads to an increase in the acceptance power of employees and commitment to changes, and provides the most suitable help to improve their safety, satisfaction, and productivity.