Kimura's Disease Presenting Research Articles

Kimura Disease Presenting as Unilateral Proptosis

Purpose: Kimura disease is a rare chronic inflammatory disease that usually presents with painless subcutaneous nodules at the head and neck area, but rarely occurs around the eyes. We report unique case of Kimura disease involving the orbit and arm, which has not been reported in Korea.Case summary: A 16-year-old boy presented with exophthalmos and eyelid swelling of right eye over the last 2 years. Orbital magnetic resonance imaging (MRI) showed hypertrophy of extraocular muscles of right eye. He also complained of multiple painless masses of the left forearm that persisted during the same period. The MRI showed hypertrophy of extraocular muscles of right eye and multiple lymphadenopathy along the brachial artery of the left elbow. Excisional biopsy of the left arm mass and lymph nodes was performed and the lesions were diagnosed as Kimura disease involving the dermal nodule and lymph nodes. The patient was managed with oral corticosteroid and cyclosporine and showed remarkable improvement of proptosis and hypertrophy of extraocular muscles.Conclusions: We report a rare case of Kimura disease causing hypertrophy of extraocular muscles which was successfully treated with immunosuppressive agents.

Kimura Disease Presenting With New Raynaud Phenomenon: A Common Symptom Caused by an Uncommon Disease.

Kimura Disease Presenting With New Raynaud Phenomenon: A Common Symptom Caused by an Uncommon Disease.

Kimura's Disease: A Rare Cause of Parotid Swelling.

Kimura's disease also known as subcutaneous angioblastic lymphoid hyperplasia with peripheral eosinophilia is a rare clinicopathological entity. It is a chronic granulomatous disease of unknown etiology. The clinical presentation varies from subcutaneous swellings of the head and neck region with regional lymphadenopathy with salivary gland involvement to systemic manifestations like nephrotic syndrome. The clinical features are mild, rarely life threatening. The present article is a case report of Kimura's disease presenting as multiple swellings at the left temporal region, left parotid and bilateral post auricular region. Though the lesion is benign, the cosmetic disfigurement caused by the swellings was of significant concern to our patient. MRI Scan was suggestive of a parotid swelling extending into the temporal and post auricular region of the left side. Surgical modality of treatment was adopted- Superficial Parotidectomy with excision of subcutaneous swellings. Histopathological examination confirmed the diagnosis of Kimura's disease. The mode of presentation as multiple large swellings with the involvement of the parotid gland created a diagnostic dilemma, hence this article intends to consider Kimura's disease as a rare but possible cause of a parotid swelling.

Kimura's Disease Presenting as Proliferative Glomerulonephritis with Complete Heart Block.

Kimura's Disease Presenting as Proliferative Glomerulonephritis with Complete Heart Block.

Kimura's Disease Presenting as a Post Cricoid Mass - A Diagnostic Challenge

Kimura’s disease (KD) is a rare immune mediated chronic inflammatory disorder of unknown etiology which involves subcutaneous plane and is usually seen in parotid region. It is also known to affect cervical lymph nodes and pharynx. There has been no report of this disease isolated to post cricoid region. We report a case of hoarseness of voice in an elderly lady who was found to have a smooth mass in post cricoid region with forward displacement and fixity of right arytenoid. She had eosinophilia and biopsy revealed lymphoid hyperplasia with infiltration of eosinophils and vascular proliferation, suggestive of Kimura’s disease. Diagnosis was confirmed by immunohistochemistry. She was treated with prednisolone at a dose of 1 mg per kg body weight per day for 3 weeks. Patient is symptomatically better and mass has not recurred after a period of 3 months.

Kimura Disease Presenting as Forehead Soft Mass.

Kimura Disease Presenting as Forehead Soft Mass.

Ultrasonographic findings of Kimura's disease presenting in the upper extremities.

To describe ultrasound findings of Kimura's disease arising in the upper extremities. Five patients with Kimura's disease confirmed by surgical resection were retrospectively reviewed by two musculoskeletal radiologists and a pathologist. All six lesions involved the epitrochlear area and appeared as partially (n=5) or poorly (n=1) marginated subcutaneous masses with the presence of curvilinear hyperechoic bands intermingled within the hypoechoic components by US. Moderate (n=4) to severe (n=2) vascular signals were observed in some proportion of the hyperechoic bands by color Doppler US. The associated findings were the increased echogenicity of surrounding subcutaneous fat (n=6) and adjacent lymphadenopathy (n=4). Microscopic examination showed proliferation of lymphoid follicles with prominent germinal centers and intervening fibrosis. In this study, Kimura's disease arising in the upper extremities showed a partially defined hypoechoic subcutaneous mass with internal hyperechoic bands and moderate-to-severe vascularities, increased echogenicity of the surrounding subcutaneous fat and adjacent lymphadenopathy on US. Thus, when these US features are observed in the typical epitrochlear region of an Asian individual, especially if accompanied by peripheral eosinophilia, Kimura's disease should be considered as a possible diagnosis.

Unusual presentation of kimura′s disease

Kimura's disease is a rare form of chronic eosinophilic inflammatory disorder with associated lymphadenopathy in head and neck region and serous cavity effusions and marked predilection for the head and neck with a tendency to present as a discrete, enlarging mass. Although many cases of Kimura's disease with head and neck lymphadenopathy and nephrotic syndrome have been described in the literature, only two cases of Kimura's disease presenting with pleural effusion have been reported recently. There are no reports of Kimura's disease with ascites. We report the case of a 38-year-old nondiabetic, normotensive man who had undergone inguinal node biopsy consistent with Kimura's disease, 8 months before he presented to us. On admission, he had right moderate pleural effusion, but no ascites or any lymph nodal involvement. He developed recurrent pleural effusion and ascites in the ward. Initially he showed good remission with systemic steroids, but later on was refractory to further necessary treatment. He also rapidly developed signs of nephrotic syndrome. In spite of vigorous treatment, patient died of severe hypovolemia, hypoproteinemia, and nephropathy.

Kimura's Disease Presenting as the Middle Mediastinal Mass

Kimura's disease usually located in the periauricular area most frequently; however, we believe that there have been no reports about kimura's disease presenting as middle mediastinal mass. we describe the diagnosis and treatment of kimura's disease in the middle mediastinum.

Kimura's Disease

A 13-year-old Indian boy with Kimura's disease presenting as a tumour-like swelling of the cheek and submandibular regions is reported and the literature reviewed. A distinction between Kimura's disease and angiolymphoid hyperplasia with eosinophilia is made in the differential diagnosis of eosinophilia-associated diseases and reactive lymphadenopathy.

A Case of Kimura's Disease Presenting as a Rhinophyma-like Configuration

A Case of Kimura's Disease Presenting as a Rhinophyma-like Configuration

Two cases of Kimura's disease in the hand—Case report

Two cases of patients with Kimura's disease presenting as tenosynovitis of the hand and wrist are reported. Two cases of patients with Kimura's disease presenting as tenosynovitis of the hand and wrist are reported.