Key Location Research Articles

From Controversy to Consensus: Neurogenesis and Neuroplasticity

More and more research in recent years has focused on neurogenesis and neuroplasticity. The hippocampus is a key location of adult neurogenesis. Because this part of the brain is regulated by environmental variables, it must be mentioned the therapeutic potential for neurodegenerative illnesses and brain injuries. Furthermore, this information challenges the historical concept of a static brain and tries to demonstrate its flexibility, adaptability, and possibility for regeneration. Those mechanisms which are found in a variety of mammalian species, including humans, are important when it comes to adaptive learning and memory, thus providing insights into cognitive well-being and mental health. The discovery of the brain's dynamic nature represented by new neurons, marks a shift in the field of neurology with far-reaching potentials. This paper highlights the significant potential of adult neurogenesis when it comes to clinical applications such as Alz-heimer’s disease.

Insights Into Antimicrobial Resistance From Dental Students in the Asia–Pacific Region

BackgroundDentists, as prominent prescribers, are key stakeholders in addressing the antimicrobial resistance (AMR) crisis. Dental students’ perceptions about the topic have been underexplored in the Asia–Pacific region, a key location for the development and spread of AMR. Thus, the aim of this study was to evaluate the awareness and confidence to prescribe antimicrobials amongst dental students studying in the region. MethodsStudents from 15 dental schools in 4 countries were invited to participate in a cross-sectional online survey during 2022–2023. A previously validated and standardised 14-item instrument was utilised. ResultsIn all, 1413 responses were collected from Australia (n = 165), Sri Lanka (n = 112), Japan (n = 173), and Vietnam (n = 963). Of those, 201 were from final-year students (14.2%). On a scale from 1 to 10, awareness on AMR was placed at a mean (SEM) priority of 8.09 (0.05). With regards to target areas to address for mitigation of the AMR crisis, participants placed general public awareness at the top (mean [SEM] 8.53 [0.05]). Final-year students presented a mean (SEM) level of confidence to prescribe antibiotics of 6.01 (0.14) on a scale from 1 to 10, whilst 59.7% and 56.8% indicated feeling pressured to prescribe by patients or when lacking time, respectively. Final-year students participating in research activities assigned a higher priority to AMR compared to their peers not involved in research (mean [SEM] 8.6 [0.19] vs 7.81 [0.16]; P = .01). ConclusionsThis study highlights a need for increased awareness and confidence to prescribe amongst dental students in the Asia–Pacific region, an understudied population thus far. To mitigate this issue, the implementation (followed by assessment) of local educational and antibiotic stewardship initiatives is warranted.

The geodynamics of plume-influenced mid-ocean ridges: insights from the Foundation Segment of the Pacific-Antarctic Ridge

The intersection of the Foundation Plume with the Pacific-Antarctic Ridge is a key location in global geodynamics where a mantle plume is approached by and interacting with a fast-spreading mid-ocean ridge. Here, we discuss a comprehensive major and trace element and Sr-Nd-Pb isotope dataset of new and existing samples from the young Foundation Seamount Chain (<5 Ma) and adjacent section of the Pacific-Antarctic Ridge. We use the geochemistry of axial, off-axis and intraplate lavas to map the spatial extent of plume dispersal underneath the ridge as well as the internal zonation of the upwelling plume. We show that the unusual length, increased crustal thickness and occurrence of silicic rocks on the axis of the Foundation Segment are the direct result of plume being tapped by the axial melting zone. We demonstrate that the plume is not homogeneous but shows a HIMU-like (high time-integrated 238U/204Pb) OIB (Ocean Island Basalt) component characterized by 206Pb/204Pb of up to 20.5 in its center and a more EM1-like (Enriched Mantle one) OIB component characterized by low U/Pb and 206Pb/204Pb but high Rb/Nb and 87Sr/86Sr towards its edges. Plume entrainment leads to a high magma supply rate that fosters the formation of silicic rocks and triggers the lengthening of the segment over time. However, plume dispersal is not symmetric as the geochemical tracers for the OIB component are extending <100 km northwards but >300 km southwards. We relate this to the current plate tectonic framework in which the obliquity between the migrating ridge and the absolute plate motions induces a sub-axial asthenospheric flow that preferentially channels plume material southwards.

Re-Orientations: Spain and Jerusalem in the Longue Durée

ABSTRACT This article provides a brief overview of Spain’s historical ties to Jerusalem, arguing that a Mediterranean approach to Spanish Jerusalem encourages us to resituate the Holy City in both space and time as a key location in the articulation of Spanish imperial and national identity. By recovering the fundamental Mediterraneanness of Spanish entanglements with Jerusalem, scholars are also obliged to recognize at once the complex, interdependent, porous borders through which the categories of empire and nation are regularly negotiated, and the profoundly transtemporal resonance of those configurations, which continue to matter today.

Evaluation of the Water Mass Composition in the Sea of Okhotsk and Its Long‐Term Change Using an Advanced Mapping Technique

AbstractThe Sea of Okhotsk is a marginal sea that plays a major role in the ventilation of the North Pacific, being the key location where Dense Shelf Water (DSW) forms at the surface and sinks to the intermediate layer. The Okhotsk Sea Intermediate Water (OSIW) is a key water mass because it includes large amounts of DSW, outflows to the North Pacific, and supplies the ocean with the micronutrient iron. OSIW has been warming over the past few decades, which is attributed to a decreasing trend in DSW production. The acquisition of numerous hydrographic data after 2000 in the Kuril Basin, especially dissolved oxygen from profiling floats, offers an opportunity to better quantify the water mass composition of OSIW, and the changes in OSIW properties and DSW volume. Here, we used all available hydrographic records and a mapping technique specially adapted to polar and sub‐polar regions to revisit the Sea of Okhotsk water properties and document their long‐term changes. Our analysis revealed that the volume of heavier DSW (potential density above 26.9 kg.m−3) has decreased over the past three decades by 3,600 km3, or 15% of the volume present before 1990. This decline is nearly entirely compensated for by an increase in lighter DSW. This shift toward lighter DSW is possibly a sign of the weakening of the intermediate overturning circulation starting in the Okhotsk Sea. Additionally, we found that dense Soya Current Water only accounts for about 1% of OSIW, against the 5% previously estimated.

Late Quaternary hydroclimate variability in Madagascar and its connection to atmospheric circulation patterns

Large uncertainties still exist about the long-term mechanisms influencing the hydroclimate variability of southeast Africa where proxy data and model simulations indicate rainfall dipoles between subtropical and tropical areas. The topography of Madagascar, located off the southeastern coast of Africa, modulates these dipoles while its climate is influenced by the position of the Intertropical Convergence Zone (ITCZ) and the Subtropical High as well as the sea surface temperature (SST) of SW Indian Ocean. The island can thus be considered a key location for the understanding of the tropical SE African climatic variability and the interplay between atmospheric patterns. However, the scarcity of continuous records from Madagascar has made the evolution of regional late Quaternary climate and its driving mechanisms difficult to assess. Here, we present a 26-kyr record of the deuterium/hydrogen isotope ratio (δD) of biomarkers (n-alkanes) from the central eastern part of the island at Antananarivo at around 1250 m a.s.l. Preliminary summary pollen data are also presented as a comparison. The δD profiles of aquatic plant and terrestrial plant-derived n-alkanes generally exhibit similar trends implying that they all record changes in the isotope composition of source water, namely meteoric water that recharges soil and lake waters. In this tropical region, the δD variability of precipitation is mainly influenced by the amount effect reflecting the intensity of precipitation associated with the monsoon. We observe: (i) stable and wet conditions during the Last Glacial Maximum, (ii) drier conditions from 18.5 to 15 ka (ka before present) during the Heinrich Stadial 1 (iii) high humidity after 15 ka culminating at the Younger Dryas (YD), (iv) drier conditions from 11.7 ka to 8.2 ka, (v) a return to humid climate until 2.8 ka, and (vi) an arid phase followed by increased wetness after 0.9 ka, although the record is likely influenced by human-induced vegetation changes the last 1.2 ka. This climate signal is similar to other records from the Mozambique Channel but opposite to records from the East African mainland and the subtropical southern Africa, especially between 20 and 25°S. Although there is a good correspondence of our record with insolation- driven migrations of ITCZ during the LGM and the early Holocene, the dipoles are largely consistent with the modern rainfall anomaly and are best explained by the interlinked effects of the SST changes and the variability of the Mozambique Channel Trough.

Stable isotopic composition of tissues and shells in the Mediterranean mussel, Mytilus galloprovincialis, in estuarine and aquaculture settings

The Mediterranean mussel, Mytilus galloprovincialis Lamarck, 1819 is a widely distributed commercially important bivalve species, and is one of two cultivated bivalve species in the Adriatic Sea, with the Krka River estuary being a key aquaculture location. Understating the feeding ecology of M. galloprovincialis could help aquaculture be more efficient. The aim of this study is to use stable isotopes to advance our understanding of M. galloprovincialis feeding ecology, as well as explore the potential of their shell as proxies for environmental change. We analyzed stable isotope composition (hereafter, δ13C and δ15N), of M. galloprovincialis soft tissue, as well as the δ15N signature of its shell, over one year at multiple sites in the Krka River estuary. Mussels showed differences in the isotopic niche depending on the site, indicating that feeding varies according to geographic location, likely due to specific conditions in the Krka River estuary and differences in food availability. During our entire survey period, marine organic carbon was the dominant source in the mussels cultivated in the Krka estuary. However, in the period from late summer to late autumn, the contribution of freshwater carbon sources increased for both sites situated in the middle estuary. The distinct feeding patterns observed at each sampling site could be attributed to a combination of factors such as local hydrographic conditions, food availability, and the presence of other competing species. Overall, the stable isotope results present valuable information on the feeding ecology of Mytilus galloprovincialis, highlighting the complex interactions between environmental factors and feeding habits. The results of our study contribute to the isotope data archive for M. galloprovincialis. Furthermore, this work shows the potential of M. galloprovincialis shell δ15N values as an indicator for nitrogen loading in aquaculture settings and coastal marine environments.

Pollution Havens in South-East Asia: Examining Japanese Multinational Enterprises in the Philippines

Pollution Havens in South-East Asia: Examining Japanese Multinational Enterprises in the Philippines

Provenance signature and tectono–sedimentary setting of the Permian Shihezi formation (Ordos basin, China): Insights from geochemistry and detrital zircon U–Pb dating

During the depositional period of the Permian Shihezi Formation, the southern margin of the Ordos Basin was a key location for studying the tectonic movement of the North China Craton (NCC) and South China Blocks. The sedimentary environment was the first period of complete transition from marine to continental. However, the distribution of sediments controlled by a multi–provenance supply and the response of deposition to tectonics remain ambiguous, and the restoration of paleogeography remains in the qualitative stage, restricting the study of larger-scale tectono–sedimentary patterns. Based on field profiles and core observations, the paleocurrent direction, lithic fragments, heavy mineral assemblages, rare earth element distribution patterns, 11 detrital zircon U–Pb age datasets, and discrimination diagram of major and trace elements, the provenance signature and tectono–sedimentary setting were revealed. The results indicated that there are three main provenances in the southern margin of the Ordos Basin: North Qilian and western and eastern sections of the North Qinling Orogenic Belt. The tectonic setting of the North Qilian was a continental island arc, and the North Qinling was transformed from a passive to an active continental margin. Owing to the continued intense tectonic activities of the North Qilian, a braided river delta with a large sedimentary range developed in the west, and it was mixed with detrital sediments from the western section of the North Qinling with weak tectonic activity in the central. Affected by the uplift of the southern North China Craton, the sedimentary environment in the eastern range was unstable, and the thickness distribution of sandy sediments in the braided river delta was uneven. Refinement of provenance and deposition has important implications for the study of basin–mountain coupling relationships and paleogeographic reconstruction in the southern Ordos Basin and provides a basis for the study of collision evolution of the North and South China Blocks in the Permian.

Automatic height measurement of central serous chorioretinopathy lesion using a deep learning and adaptive gradient threshold based cascading strategy

Accurately quantifying the height of central serous chorioretinopathy (CSCR) lesion is of great significance for assisting ophthalmologists in diagnosing CSCR and evaluating treatment efficacy. The manual measurement results dominated by single optical coherence tomography (OCT) B-scan image in clinical practice face the dilemma of weak reference, poor reproducibility, and experience dependence. In this context, this paper constructs two schemes: Scheme Ⅰ draws on the idea of ensemble learning, namely, integrating multiple models for locating starting key point in the height direction of lesion in the inference stage, which appropriately improves the performance of a single model. Scheme Ⅱ designs an adaptive gradient threshold (AGT) technique, followed by the construction of cascading strategy, which involves preliminary location of starting key point through deep learning, and then employs AGT for precise adjustment. This strategy not only achieves effective location for starting key point, but also significantly reduces the large appetite of deep learning model for training samples. Subsequently, AGT continues to play a crucial role in locating the terminal key point in the height direction of lesion, further demonstrating its feasibility and effectiveness. Quantitative and qualitative key point location experiments in the height direction of lesion on 1152 samples, as well as the final height measurement display, consistently conveys the superiority of the constructed schemes, especially the cascading strategy, expanding another potential tool for the comprehensive analysis of CSCR.

Kidney-targeted antioxidant salvianolic acid B nanoparticles restoring lysosome homeostasis for acute kidney injury therapy

Acute kidney injury (AKI) is highly correlated with oxidative stress, and the application of antioxidants is one of the promising treatments. Salvianolic acid B (SAB) is a natural polyphenol with powerful antioxidant effects. Due to its inherent characteristic of inferior bioavailability, its clinical application is impeded. In this study, small SAB-incorporated nanoparticles (SFA) were synthesized via the self-assembly of SAB, ferric ions, and bovine serum albumin (BSA). Apart from antioxidant activity, the SFA nanoparticles were found to efficiently restore lysosome dysfunction induced by reactive oxygen species (ROS) in human kidney proximal tubular epithelial HK-2 cells. The small size and BSA incorporation make the SFA nanoparticles to be promising AKI-targeting nanoparticles. They are rapidly accumulated and long-term retained in injured kidneys of glycerol-induced AKI mice, especially in the proximal tubules which are the key lesion location during AKI. In vivo studies indicate that SFA nanoparticles show a superior protective effect compared with the free drug by suppressing oxidative stress and maintaining lysosome homeostasis indicated by enhanced heme oxygenase-1 (HO-1) expression and restored cathepsin B (CTSB) activity, respectively. In summary, this study develops a delivery system for the antioxidant SAB enhancing local delivery and offering an additional lysosome restoring mechanism for AKI therapy.

Semantic segmentation for multisource remote sensing images incorporating feature slice reconstruction and attention upsampling

ABSTRACT Multisource remote sensing images have rich features and high interpretability and are widely employed in many applications. However, highly unbalanced category distributions and complex backgrounds have created some difficulties in the application of remote sensing image semantic segmentation tasks, such as low accuracy of small target segmentation and inaccurate edge extraction. To solve these problems, in this paper, a feature map segmentation reconstruction module and an attention upsampling module are proposed. In the encoder part, the input feature map is equally segmented, and the segmented feature map is enlarged to effectively improve the small target feature information expression ability in the model. In the decoder part, the key segmentation and location information of shallow features are obtained using the global view. The deep semantic information and shallow spatial location information are fully combined to achieve a more refined upsampling operation. In addition, the attention mechanism of the spatial and channel squeeze and excitation block (scSE) is applied to pay more attention to important features and to suppress irrelevant background and redundant information. To verify the effectiveness of the proposed method, the WHU-OPT-SAR dataset and six state-of-the-art algorithms are utilized in comparative experiments. The experimental results show that our model has demonstrated the best performance and low computational complexity. With only approximately half the floating-point operation count and the number of model parameters of the MCANet model, which is specially designed for the dataset, our model surpasses MCANet by 1.52% and 1.53% in terms of mean intersection over union (mIoU) and F1 score, respectively. In particular, for small object regions such as roads and other categories, compared to the baseline model, the IoU and F1 score of our model are improved by 5.27% and 3.99% and by 5.68% and 5.65%, respectively. These results demonstrate the superior performance of our model in terms of accuracy and efficiency.

Research on the high temperature calibration of the electromagnetic damping generator applied to the rotary steerable system

The Electromagnetic Damping Generator (EDG) used for petroleum exploration is faced with the problem of high local temperature during its downhole work. To avoid the damage to its internal circuit caused by high temperature, the key EDG circuit is required to be heat-resistant based on the electromagnetic induction principle and the current heating effect. First of all, the working condition with the maximum heating power was figured out after studying the heating power characteristics of EDG. Then the multi-field coupling model of the temperature field, electromagnetic field and structure of the damper, as well as its iterative analytic model were established to identify the relationship between the temperature rise of the key location of the damper part and its working time in the downhole environment and the room-temperature experimental environment, which provided data support for EDG optimization design. Finally, a EDG prototype was developed, and the test bench was set up by replacing the load with resistors to verify the accuracy of the iterative analytical model. The results showed that the temperature value calculated by the model well fit the experimental value. Therefore, the downhole operation reliability of the EDG and the safety of corresponding bench tests are guaranteed, which has certain guiding significance for EDG optimization design and its experimental study.

Machine learning approaches to evaluate infants’ general movements in the writhing stage—a pilot study

The goals of this study are to describe machine learning techniques employing computer-vision movement algorithms to automatically evaluate infants’ general movements (GMs) in the writhing stage. This is a retrospective study of infants admitted 07/2019 to 11/2021 to a level IV neonatal intensive care unit (NICU). Infant GMs, classified by certified expert, were analyzed in two-steps (1) determination of anatomic key point location using a NICU-trained pose estimation model [accuracy determined using object key point similarity (OKS)]; (2) development of a preliminary movement model to distinguish normal versus cramped-synchronized (CS) GMs using cosine similarity and autocorrelation of major joints. GMs were analyzed using 85 videos from 74 infants; gestational age at birth 28.9 ± 4.1 weeks and postmenstrual age (PMA) at time of video 35.9 ± 4.6 weeks The NICU-trained pose estimation model was more accurate (0.91 ± 0.008 OKS) than a generic model (0.83 ± 0.032 OKS, p < 0.001). Autocorrelation values in the lower limbs were significantly different between normal (5 videos) and CS GMs (5 videos, p < 0.05). These data indicate that automated pose estimation of anatomical key points is feasible in NICU patients and that a NICU-trained model can distinguish between normal and CS GMs. These preliminary data indicate that machine learning techniques may represent a promising tool for earlier CP risk assessment in the writhing stage and prior to hospital discharge.

Speleothems uncover Late Holocene environmental changes across the Nuragic period in Sardinia (Italy): A possible human influence on land use during bronze to post-Iron Age cultural shifts

During the Bronze and Iron Age, Sardinia was home of one of the most technologically advanced Mediterranean societies (the Nuragic culture). Given its key geographical location, the island was also the fulcrum of deep cultural exchanges. Toward the end of the Iron Age, Phoenicians, and especially Carthaginians and Romans, massively frequented Sardinia for different purposes. This marks an important cultural transition for the region, as the ancient Nuragic-related society terminated. At the same time, this impacted the subsistence and land use practices. Together with middle to late Holocene climate changes, the novel anthropic activities had a pivotal role in shaping the landscape around the island. However, high resolution climate and environmental records for these culturally important phases are still lacking in Sardinia. Thus, this paper explores palaeoenvironmental changes from the Bronze Age to post Iron Ages times by using carbonate speleothems from Suttaterra de Sarpis Cave (Urzulei, central east Sardinia), strategically located nearby the Or Murales Nuragic Village. U–Th ages (n = 20) indicate that five stalagmites comprehensively span the last ∼7000 years. Peculiarly, they all show an evident stratigraphic discontinuity. Age models attest that hiatuses can be at times associated with the discontinuities, spanning periods of ∼1200 to ∼200 years. Importantly, the discontinuities occurred from the Late Iron Age to the Roman period. Based on fabric observations, trace elements and δ13C- δ18O analyses, the discontinuities are primarily attributed to a progressive change of land use above the cave. We suppose that deforestation aimed to clearance for agriculture and livestock practices probably was the most impacting factor for infiltration dynamics and soil state, thus affecting the studied speleothems, although archaeological and historical data are absent for the specific study area. Instead, this is in line with the cultural transition occurring in Sardinia toward the end of the Iron Age, with novel agricultural practices imported by the overseas populations. The anthropic disturbance to the millennial-long karst equilibrium possibly overprinted the response of speleothem proxies to climate oscillations, although future higher resolution analyses are necessary to better investigate the evolution of climate during the Holocene as well as its role in the development of ancient civilizations. Indeed, this is the first speleothem-based Holocene palaeoenvironmental reconstruction accomplished in Sardinia. Considering the paucity of natural lakes in this key location, speleothems here demonstrate their potential in exploring human-driven palaeoenvironmental changes during times of cultural transitions within the Mediterranean context.

Automatic zoning for retinopathy of prematurity with a key area location system.

Retinopathy of prematurity (ROP) usually occurs in premature or low birth weight infants and has been an important cause of childhood blindness worldwide. Diagnosis and treatment of ROP are mainly based on stage, zone and disease, where the zone is more important than the stage for serious ROP. However, due to the great subjectivity and difference of ophthalmologists in the diagnosis of ROP zoning, it is challenging to achieve accurate and objective ROP zoning diagnosis. To address it, we propose a new key area location (KAL) system to achieve automatic and objective ROP zoning based on its definition, which consists of a key point location network and an object detection network. Firstly, to achieve the balance between real-time and high-accuracy, a lightweight residual heatmap network (LRH-Net) is designed to achieve the location of the optic disc (OD) and macular center, which transforms the location problem into a pixel-level regression problem based on the heatmap regression method and maximum likelihood estimation theory. In addition, to meet the needs of clinical accuracy and real-time detection, we use the one-stage object detection framework Yolov3 to achieve ROP lesion location. Finally, the experimental results have demonstrated that the proposed KAL system has achieved better performance on key point location (6.13 and 17.03 pixels error for OD and macular center location) and ROP lesion location (93.05% for AP50), and the ROP zoning results based on it have good consistency with the results manually labeled by clinicians, which can support clinical decision-making and help ophthalmologists correctly interpret ROP zoning, reducing subjective differences of diagnosis and increasing the interpretability of zoning results.

KSLD-TNet: Key Sample Location and Distillation Transformer Network for Multistep Ahead Prediction in Industrial Processes

KSLD-TNet: Key Sample Location and Distillation Transformer Network for Multistep Ahead Prediction in Industrial Processes

Taguatagua 3: A new late Pleistocene settlement in a highly suitable lacustrine habitat in central Chile (34°S).

We present the results of the excavations and analyses of the diverse and exceptional archaeological assemblage of Taguatagua 3, a new late Pleistocene site located in the ancient Tagua Tagua lake in Central Chile (34°S). The anthropogenic context is constrained in a coherently dated stratigraphic deposit which adds new information about the mobility, subsistence strategies, and settlement of the early hunter-gatherers of southern South America. The age model constructed, as well as radiocarbon dates obtained directly from a combustion structure, indicate that the human occupation occurred over a brief time span around 12,440-12,550 cal yr BP. Considering taphonomic, geoarchaeological, lithic, archaeobotanical, and zooarchaeological evidence, as well as the spatial distribution combined with ethnographic data, we interpret Taguatagua 3 as a logistic and temporary camp associated mainly with gomphothere hunting and butchering. Nevertheless, several other activities were carried out here as well, such as hide and/or bone preparation, small vertebrate and plant processing and consumption, and red ochre grinding. Botanical and eggshell remains suggest that the anthropic occupation occurred during the dry season. Considering the contemporaneous sites recorded in the basin, we conclude that the ancient Tagua Tagua lake was a key location along the region's early hunter-gatherer mobility circuits. In this context, it acted as a recurrent hunting/scavenging place during the Late Pleistocene due to its abundant, diverse, and predictable resources.

Knowledge of Noncommunicable Diseases and Social Media among Secondary School Teachers in Akinyele Local Government Area Oyo State Nigeria

Abstract Background: Social media (SM) are now widely available and can potentially play an important role in the prevention of noncommunicable diseases (NCDs). The school environment is a key location for educating children about NCDs and the teachers’ level of knowledge may have an impact on them. This study investigated the knowledge of NCDs and SM among secondary school teachers. Materials and Methods: Using a self-administered questionnaire, data were collected from 423 randomly selected male and female secondary school teachers teaching in both public and private secondary schools located in Akinyele Local Government Area, Oyo State, in May 2018. Knowledge of SM was measured on a 10-point scale (scores 0–3, 4–6, and 7–10 were rated as poor, fair, and good, respectively), while knowledge of NCDs was measured on a 28-point scale (scores 0–8, 9–18, and 19–28 were rated as poor, fair, and good, respectively). Data were analyzed using descriptive statistics and multiple regression tests at a 5% level of significance. Results: Findings showed that the mean age of respondents was 33.5 ± 0.5 and 52.5% were female. About half (51.5%) of the respondents had good knowledge of SM. Less than half (28.1%) had good knowledge of NCDs. Knowledge of SM was significantly associated with age (P &lt; 0.001), while knowledge of NCDs had no significant association. Conclusion: Based on these results, a gap exists regarding teachers’ knowledge of NCDs. Health professionals may contribute to teacher training curriculum development to include health education targeted toward NCD prevention.

Strategic ambiguity: Turkey, Russia and the War in Ukraine

As a NATO member, Turkey is formally an adversary of Russia. Moreover, Turkey’s interests in the Middle East and the southern Caucasus frequently conflict with Russia’s. Yet Turkey has forged a productive working relationship with Russia over the years of Erdogan’s rule, with ties between the two ranging across defence, foreign policy and energy. In particular Turkey has finessed its reaction to the war in Ukraine: it has opposed Russia’s invasion at the United Nations, provided lethal aid to Ukraine and limited Russian naval access to the Black Sea; at the same time Turkey has refused to implement Western sanctions, continued to buy Russian gas, and allowed Russian tourism and trade to continue. Neither Russia nor the West can force Turkey to become more accommodating to their interests: Turkey’s key geostrategic location means it effectively has both sides over a barrel.