Covid-19 became a global challenge even though the African Region's people were less affected as per reported statistics. The pandemic hit all economies resulting in the deterioration of critical economic indicators. It is evidenced by the abnormal fall of the prices in different sectors, such as energy, mining, agriculture, aviation, and travel industry, and in the financial markets, followed by abnormal unemployment across many sectors. This paper reviewed the impact of COVID-19 on the key economic processes in the African Region. Specifically, it looked at examining the role of leading global institutions in mitigating the economic impact of the pandemic to the countries of the African Region and the role of global institutions in uplifting the African economy. Due to a limited number of researches on the impact of Covid-19, data collection methods are the same as those applied in other systematic reviews. Reporting standards established by other social science journals; the evaluation, statistical and meta-analytic literature; and expert opinions. Two independent reviewers abstracted the study, reconciled it with the development team, and provided feedback. The covid-19 pandemic hit several economic areas such as agriculture, mining, aviation industry, and financial markets. African countries took several initiatives to fight against the Covid-19 pandemic in collaboration with global institutions such as WHO and IMF. African countries took initiatives in areas such as business innovation and financial support for financial institutions, improving health infrastructure and researches activities on Covid-19 as well improving people's livelihood. Also, African countries are recommended to follow global institutions' advice and guidelines for economic recovery.
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