Jump Start Research Articles

Morphometric features of the duodenal wall in piglets during different periods of postnatal and neonatal ontogenesis under the influence of the ‘Globigen Jump Start’ feed additive

The morphological parameters of the small intestinal mucosa, such as villi size and crypts, play a key role in the formation of the intestinal tube’s absorption surface. The number of goblet and enterochromaffin cells indicates the epithelium’s functional condition in terms of mucus secretion and production of catecholamines and hormones (serotonin, dopamine). That is why it is important to study and determine certain morphometric parameters of the duodenal wall in piglets during different periods of neonatal and postnatal development, especially during stress situations, namely weaning and transition to protein feeding. The article presents the resulting effect studies of ‘Globigen Jump Start’ feed additive on the histo-morphological parameters of the piglets’ duodenal mucosa on day 7, 14 and 28 of life. A positive effect on mitigating weaning stress was manifested by a decrease in the quantitative and linear indicators of histoarchitectonics of intestinal wall’s individual morphological components. A significant increase in goblet cells, especially in the experimental group, had a positive impact on the mucopolysaccharide synthesis. The piglets’ gastrointestinal tract physiology involves a complex interaction between the central nervous system, metasympathetic nervous system, APUD system, and endocrine system. Due to these systems, the information is transmitted according to the direct and reverse communication mechanisms in the regulation of the gastrointestinal tract function. An increase in the number of enterochromaffin cells and their nuclei diameter in the experimental group of piglets indicated an increased synthesis of catecholamines and hormones. It has an extremely positive effect on the immune and physiological status of piglets, thus emphasizing the crucial role of serotonin in neuronal metabolism and the formation of stress resistance. The increase in the thickness of the duodenal wall muscle layer, in our opinion, occured due to the active peristalsis, which was enhanced by the action of some catecholamines, which were synthesized in a slightly larger amount under the influence of nutrients making up the ‘Globigen Jump Start’ feed additive.

Immunobiological status of the organism of young pigs during their triphasic period cultivation and actions of corrective factors

The problem of the impact and consequences of technological stress is accompanied by several reactions that do not always have a positive effect on the animal's body. The work aimed to investigate the dynamics of indicators of the immunobiological status of piglets during their three-phase rearing and the use of immunostimulating agents Globigen® Pig Doser and Globigen® Jump Start. Parallel studies were conducted based on the private farm “Meat Resources” LLC of the Lviv region of the Starosambir district, which practices three-phase pig breeding. The experiment involved 36 analog piglets and hybrids of Landrace and Great White breeds, which were formed into 3 groups of 12 animals each. Piglets of the control group were fed the standard ration provided by the technology. During the first three days of life, newborn piglets of the first experimental group were given 2 ml/gal of liquid Globigen®Pig Doser. The piglets of the second experimental group were given a powdered dry product Globigen®Jump Start, which was added to the main diet at 0.2 % per ton of feed. It was established that the use of means with an immunostimulating effect was accompanied by a decrease in the content of Ig M in the blood samples of experimental groups of piglets. Thus, in the blood serum of 30-day-old piglets under the influence of Globigen® Pig Doser with a high level of probability (Р < 0.02), a decrease in the content of this class of antibodies was found to the level of 1.59 mg/ml, and under the influence of Globigen® Jump Start the content in the blood serum of 60-day-old piglets, having reached the lowest value, was 2.08 mg/ml. The positive effect of immunostimulating agents, which was characterized by an increase in the amount of Ig G, was found in experimental groups of pigs at the age of 60 days: 17.10 mg/ml for the effects of Globigen® Pig Doser and 17.08 mg/ml for the impact of Globigen® Jump Start. The highest content of Ig A with high probability (P < 0.001) was found in blood samples of animals that were given Globigen® Jump Start – 3.45 mg/ml and 3.86 mg/ml under the influence of Globigen® Pig Doser. The practicality and effectiveness of the use of means with immunostimulating properties, the main active ingredient of which is the immunoglobulin of a chicken egg, is explained by the ability to influence the pathogenesis of diseases of the gastrointestinal tract, which arise as a result of weakening the resistance of the animal body under the influence of a large number of technological stresses. Research data prove that the specificity of the action of Ig Y has a positive effect on the preservation of the integrity of the villi of the intestinal mucosa, which is reflected by the strengthening of its protective and barrier function, which in general contributes to the increase in the percentage of animal survival: using Globigen®Pig Doser 80.0 % and 86.7 % using Globigen®Jump Start. Based on such results, it can be asserted that the use of Globigen® Pig Doser and Globigen® Jump Start for three-phase pig farming is scientifically justified and economically feasible.

Olivine May Have Given Life a Jump Start

A mineral common throughout the solar system nudges a reaction that produces sugar molecules from formaldehyde.

The dynamics of the content of immunoglobulins in the blood serum of piglets according to the actions of immunostimulating agents

Inconsistency in housing and feeding conditions, production stress, a combination of environmental factors, and technological solutions reduce the protective properties of the animal body, which often leads to a decrease in their productive properties. The work aimed to investigate changes in indicators of the humoral protection factor, in particular, the quantitative composition of immunoglobulins M, G, and A in the body of young pigs under the influence of immunostimulating agents Globigen® Pig Doser and Globigen® Jump Start, which include specific Ig Y. To perform this task in the conditions of the private farm of FG PE "Glynyany Agro" of Lviv region, Zolochiv district, which uses a single-phase method of raising pigs, a study was conducted with the involvement of 36 piglets-analogues of crossbreeds of the Great White and Landrace breeds, which were formed into three groups of 12 animals each. Piglets of the control group were fed feed of a standard diet. The piglets of the first experimental group were orally administered 2 ml/g of Globigen®Pig Doser during the first three days after birth. Then, according to the technology, they consumed the feed prescribed in the diet. The piglets of the second experimental group were given Globigen®Jump Start, which was mixed with the feed of the basic ration in the amount of 2 kg per ton of feed and, starting from the age of 7 days, was fed to the piglets according to the technology. It was established that the use of immunostimulating agents was characterized by an increase in Ig G and Ig A in the blood serum of piglets in the most critical period of their lives. Thus, in the blood serum of 30-day-old piglets under the influence of Globigen® Pig Doser, with a high level of probability (Р < 0.01), an increase of this class of antibodies to the level of 13.47 mg/ml was detected, with the use of Globigen® Jump Start, this indicator reached the mark 12.51 mg/ml. Since this period, colostral immunity, represented by placental immunoglobulins of class G and colostrum immunoglobulins of class A, is already exhausted; we assume that the formation of the body's immune response of young pigs has begun. We believe that the increase in the content of class A immunoglobulins, most likely the secretory form of the piglets themselves, when using Globigen® Jump Start, which reached the mark of 1.48 mg/ml, indicates the formation of immune resistance mechanisms. The effectiveness, specificity, and mechanism of action of these agents is based on the ability of their components, particularly Ig Y, to bind to pathogens or their fragments, to neutralize and safely remove them from the body, which helps to increase the barrier function of the intestinal mucosa. The obtained research results confirm the practicality of using Globigen® Pig Doser and Globigen® Jump Start immunostimulants during single-phase rearing of piglets to increase the level of non-specific resistance and obtain healthy young animals with a high level of viability.

Application of Globigen Jump Start feed additive in feeding lactating sows and piglets

Modern methods of pig breeding increasingly use various immunotropic, probiotic agents and feed additives that affect the intestinal microbiota when used in feeding farrowing and lactating sows. The research was conducted in the conditions of a pig farm in the Kyiv region. The number of sows at the pig complex is 500 heads, PIC genetics. Clinically healthy sows with 2–3 farrowing and without rest with similar performance were selected for the study. Two groups of sows were formed by analogs, which were kept in one farrowing ward 5 days before farrowing, with 8 heads in each of the control and experimental groups. For the experiment on sows and piglets in the early rearing period, the Globigen Jump Start feed additive was used. We studied the effect of feeding Globigen Jump Start feed additive, which contains specific lgY immunoglobulins in rations for gilt sows and piglets in the early growing period in the amount of 1 kg and 2 kg per ton of compound feed, respectively. As a result of research, it was established that feeding the drug mentioned above to sows contributed to better preservation of the live weight of lactating sows by 20% compared to sows of the control group. Under the influence of the addition of a feed additive, the quality of sow milk improved. In particular, there was a tendency to increase certain amino acids (cystine, valine, isoleucine, arginine, lysine, and glutamic acid) and some macro- and microelements (magnesium, zinc, sodium, phosphorus, and slightly calcium). Adding the Globigen Jump Start feed additive to piglets' diet increased average daily gains by 18.52%, a decrease in diarrhea by 45.83%, and better feed conversion.

COVID-19 as a Jump Start for Industry 4.0? Motivations and Core Areas of Pandemic-Related Investments in Digital Technologies at German Firms

Academic studies prior to the pandemic rather emphasized that the progression towards Industry 4.0 happened in an incremental manner. However, the extraordinary circumstances of the pandemic have led to considerable investments that were widely interpreted as a (generalized) digitalization push. However, little is known about the character of such investments and their effects. The goal of this contribution is to provide an empirically based overview of recent investment in digital technologies in six economic sectors of the German economy: mechanical engineering, chemicals, automotives, logistics, healthcare, and financial services. Based on 36 case studies and a survey at 540 companies, we investigate the following questions: 1. How much did the COVID-19 pandemic reduce existing obstacles for investments in digitalization measures? 2. Is there a universal digitalization push due to the COVID-19 pandemic that differs from the trajectory before the pandemic? The results show that the pandemic affected investment in an unequal manner. It was driven by the immediate need to sustain business operations through the virtualization of communication among employees and with external partners. However, there was less dynamism in shop-floor-related digitalization, as it was less related to epidemiological concerns and is more long-term in nature.

Unit Warm-up: Jump start into tertiary studies

BackgroundA high level of preparedness for engagement is essential for a smooth transition into tertiary studies. Regardless, many first-year nursing students appear underprepared, a situation likely exacerbated by today's increasingly diverse student population. Students' preparedness to begin tertiary education can be hampered by factors such as environmental changes, technical issues and paid work demands. For first year students, this period is frequently marked by apprehension and a sense of unpreparedness. ObjectivesTo report the difference in first-year nursing students’ pre- and post-subject preparedness and understanding after participating in a Unit Warm-Up. DesignA quantitative survey. SettingsAn online pre- and post-survey prior to the commencement of a subject. ParticipantsFirst-year, first-semester nursing students. MethodsStudents could choose to participate in a “Unit Warm-Up” strategy before commencing a subject. Those who participated were invited to complete the pre- and post-survey created with the Qualtrics survey software. Survey questions focused on students' subject preparedness, level of anxiety about the subject's content, level of motivation and understanding of the subject's learning outcomes. Data was collected over a four-year period. ResultsThe findings revealed that participating in the Unit Warm-Up from 2019 to 2021 had a significant impact on students' preparedness and understanding of the subject's learning outcomes. In 2022, no significant changes were observed, which could have been influenced by extreme flooding in the regions. Anxiety levels among students decreased from 2019 to 2021, but not in 2022. Motivation remained consistent over time. When compared to overall pass rate and student satisfaction trends, such a Unit Warm-Up strategy may have a positive impact. ConclusionA Unit-Warm-Up strategy has merit as a jump start into tertiary studies. Nevertheless, external factors such as the Covid pandemic and environmental disasters can disrupt students’ anxiety and readiness for participating in a subject.

Designing a virtual mental health consultation program to support and strengthen childcare centers impacted by COVID-19: A randomized controlled trial protocol

BackgroundThe COVID-19 pandemic has had negative psychosocial impacts on young children; teachers in childcare centers continue to be overwhelmed by how to address the downstream psychological effects children are experiencing. This randomized controlled trial will study the role of a community-based, childcare center-support system in improving resilience and mitigating the long-term impacts of COVID-19 on children's development. MethodsThis study will be modeled on a successful Early Childhood Mental Health Consultation (ECMHC) intervention which utilizes mental health consultants to deliver a Jump Start+: COVID 19 Support (JS + CS) virtual toolkit to childcare centers in Miami-Dade County via a Kubi robot. The toolkit comprises four strength-based strategies likely to be effective in improving resiliency following disasters: Safety Planning, Effective Communication, Adult Self-Care, and Trauma-Informed Behavior Support. Our first aim will utilize a cluster randomized trial to examine the effectiveness of JS + CS on improving the psychosocial functioning of young children, as compared to an obesity prevention intervention control group. Children will be followed at 6, 12, 18, and 24 months. The second aim will examine the mechanisms that contribute to effective uptake by teachers of the JS + CS support strategies on child outcomes. The third aim will explore implementation barriers/facilitators as well as potential societal contextual factors (e.g., vaccine uptake) to help centers serving disproportionately affected minority communities recover from and prepare for future crises. ConclusionThis design will inform the refinement and scaling of JS + CS and generalize impacts to other childcare center interventions in the context of disasters.

Dynamics of morphological and biochemical indicators of blood of young pigs using Globigen® Pig Doser and Globigen ® Jump Start with different methods of their keeping

The article deals with the influence of Globigen® Pig Doser and Globigen® Jump Start products, which contain specific Ig Y, which is characterized by pronounced immunostimulating properties. A comprehensive analysis of the use and influence of these agents on the morphological and biochemical indicators of the blood of young pigs under conditions of intensive technologies under different methods of cultivation in different periods of their growth and development – 30, 60, and 120 days – was carried out. It was set that the use of the proposed means had a prolonged positive effect, which concerning hematological indicators, mainly appeared by an increase in the number of erythrocytes and the concentration of hemoglobin in the blood of experimental groups of animals of both farms of all age periods. It is worth noting that in the farm with single-phase breeding of pigs (FE PE “Glynyany Agro”) under the influence of Globigen®Pig Doser, the number of erythrocytes in the blood of animals was increased and, corresponding to the physiological norm, fluctuated between 7.09 and 7.43 T/l, and the concentration of hemoglobin, having reached the maximum value, in the blood of all experimental groups of animals was 108.62–112.77 g/l. In the farm, which practices three-phase pig breeding (“Meat Resources” Ltd.), under the influence of Globigen® Pig Doser, a pronounced effect has appeared in animals 60 and 120 days old; the number of erythrocytes in their blood was increased to 7.46–7.69 T/l, and under the influence of Globigen® Jump Start, a tendency to a gradual increase in hemoglobin concentration was observed, which stopped at 99.28 g/l in 120-day-old piglets. Evaluating the level of protein metabolism in animals under the influence of Globigen® Pig Doser and Globigen® Jump Start, a tendency to increase the total protein content, compared to the control, in the blood of animals in all age periods in both farms was set. It was noted that under the action of Globigen®Jump Start, the total protein content in the blood of 120-day-old piglets from a farm with single-phase farming (FE PE “Glynyany Agro”) was 76.38 g/l, and in a farm with three-phase farming (Ltd. “Meat resources”) 75.08 g/l. In addition, it was set that the normalization of the ratio of protein fractions, in particular, the use of Globigen® Pig Doser and Globigen® Jump Start, increased the synthesis of albumin and normalized gamma-globulin to the level of the physiological norm. The “Glynyany Agro” FE found a more pronounced effect with single-phase piglet rearing. It was concluded that Globigen® Pig Doser and Globigen® Jump Start positively influence maintaining body homeostasis.

Effects of Red Meat and Proton Pump Inhibitors on Rat Gut pH and Claudin-2

ObjectivesProlonged use of Proton Pump Inhibitors (PPIs) may alter the gut pH and integrity of the gut barrier which play significant roles in health and the aging process. High consumption of red meat may lead to inflammatory gastrointestinal (GI) conditions, including colorectal cancer; however, research results have been inconsistent. There is limited research evaluating the effects of red meat vs white meat and the interaction with PPI treatment, focusing on the integrity of the gut. Therefore, the purpose of this study was to examine the effects of white meat vs red meat on GI organ pH, and claudin-2 levels in rats treated with and without PPI. MethodsIn a 2 (diet) × 2 (treatment) factorial design, 28 nine-month-old Sprague Dawley male rats were arranged into four groups: white meat, white meat with PPI, red meat, red meat with PPI. Diets consisted of 70% rat chow and 30% meat powder with or without PPI administered at 0.05 g/kg in the feed. After an 8-week feeding intervention, blood samples were collected to examine claudin- 2 levels. Gut pH levels were taken in the stomach, duodenum, ileum, cecum, proximal colon, distal colon, and anus. ResultsPPI administration increased pH in the stomach (P = 0.026). Red meat diets exhibited a decreased pH in the cecum (P = 0.005) and the proximal colon (P = 0.013). Red meat with PPI increased pH in the proximal colon (P = 0.009). Red meat groups showed greater claudin-2 levels (P = 0.007), especially with PPI (P = 0.026). ConclusionsIncreased levels of claudin-2 are associated with leaky gut and inflammation in the digestive system. Our study demonstrated that red meat with PPI may disturb gut integrity as compared to non-PPI, or to white meat groups. Elevated pH by PPI may reduce symptoms in patients with acid reflux but also increase their chance of leaky guts, especially with red meat. Further studies are needed to investigate the association of lowering gut pH in red meat diets with the risk of inflammation. It is vital to investigate these relationships because PPIs are often used for gastric acid problems, and diet is a critical component of such treatment. Funding SourcesSan Diego State University College of Health and Human Services faculty Jump Start Grant (PI: Tianying Wu, Co-PI: Mee-Young Hong).

Effects of Red Meat Consumption With Proton Pump Inhibitors on Cardiovascular Disease Risk Factors in Rats

ObjectivesCardiovascular disease (CVD) is the leading cause of death in the United States. Many studies showed that high consumption of red meat contributes to the risk of CVDs due to its negative effects on cholesterol and blood pressure. In addition, long-term use of proton pump inhibitors (PPIs) has been reported to have an adverse impact on vascular functions. The purpose of this study was to examine the effects of red meat consumption with PPIs on cardiometabolic risk factors in rats. MethodsTwenty eight 9-month-old Sprague Dawley male rats were divided into four groups in a 2 diets (white meat powder or red meat powder) × 2 treatments (with or without PPI) factorial design. The diets consisted of 70% rat chow and 30% meat powder while PPI treatment was included in 0.05 g/kg diet. After 8 weeks of feeding, tissues were harvested and blood was collected for analysis of glucose, lipid profiles, total antioxidant capacity, and liver function enzymes. ResultsThere were no significant differences in initial weight and final body weight among groups. However, rats fed with red meat powder exhibited lower weight gain (P = 0.049) and lower epididymal fat (P = 0.046). PPI administration increased aspartate aminotransferase (AST, P = 0.003), creatine kinase (CK, P = 0.049), and resulted in an increasing trend in alkaline phosphatase (AP, P = 0.063) but no significant differences were found between red meat vs. white meat. There were no significant differences in glucose, HbA1C, lipid profiles, total antioxidant capacity, alanine aminotransferase (ALT), lactate dehydrogenase (LDH), and gamma glutamyl transferase (rGT) between meat types or PPI treatments. ConclusionsThe results suggest that red meat consumption might have some positive effects on body composition by lowering weight gain and epididymal fat compared to white meat consumption while not significantly impacting other cardiometabolic risk factors. Nevertheless, increasing trends in some liver function enzymes indicate that the use of PPIs may cause some hepatic damage. Further research is needed to determine the underlying mechanisms of the current findings. Funding SourcesSan Diego State University College of Health and Human Services faculty Jump Start Grant (PI: Tianying Wu, Co-PI: Mee-Young Hong).

Infant and early childhood mental health consultation in a diverse metropolitan area.

IECMHC can and should be a vehicle that promotes greater equity in access to high quality relationships within an early classroom environment. It is important to consider consultation through a racial equity lens to ensure that it is integrated in all levels of work. The goal of the study was to replicate the results from other IECMHC programs with a diverse, largely Latinx, population. The Jump Start program was given the unique opportunity to adapt the Georgetown Framework of Infant and Early Childhood Mental Health Consultation to a multicultural population in Miami. A total of 88 early learning programs and 244 teachers participated. Services were provided in English, Spanish, and Creole at the program- and classroom-level. Pre- and post-data were collected at both levels. Significant improvements at the program- and classroom-level were found post-consultation. Consultants demonstrated fidelity to core program practices while providing culturally and linguistically competent service. The current study replicated findings regarding the effectiveness of IECMHC while expanding results to a diverse metropolitan community. Key features of program success may be attributed to the use of highly trained consultants, action planning, fidelity monitoring, and enrollment of programs that were ready and have a champion for IECMHC.

RN to BSN Jump Start to Success

As part of the call to increase the number of registered nurses prepared with a Bachelor of Science in Nursing degree coupled with barriers faced in nursing education due to COVID-19, one for-profit university launched an registered nurses to Bachelor of Science in Nursing Jump Start to Success initiative. The purpose of this descriptive review of an educational innovation was to determine if outcomes between Jump Start students and matriculated students would be equal in the program. The Jump Start initiative enrolled non-matriculating students who were awaiting graduation and successful National Council of State Boards of Nursing completion by offering two courses tuition-free. During the analysis period, data revealed the first course mean final numeric grade for matriculated students was 94.5 compared to 95.0 for Jump Start students (x2 = 0.2064, p = 0.649588; t-test = -5.11, p = 1.84). Final numeric grades for both groups had a normal bell curve distribution. Additionally, 55% of Jump Start students matriculated into the registered nurses to Bachelor of Science in Nursing Online Degree Completion Option. The Jump Start initiative has provided a foundation on which future initiatives can be built that promote seamless academic progression. Educational institutions should continue to collaborate to develop creative and innovative enrollment strategies.

PAY, PICK, AND PRIDE: An FGDnography about the Student's Perception and Cultural Practices of Digital Payment Method on Jump Start Coffee Machine

This article focuses on the behavior of student consumers about their experiences of purchases through e-wallets based on the stage of exposure, attention, and interpretation. The qualitative research was conducted using the FGDnography method, that is, a focus group discussion on the nature of the topic. The FGDnography was conducted for eight Bakrie University student participants, Jump Start Coffee consumers. The results show that the experience of Jump Start Coffee digital wallet payment methods at Bakrie University was practical and amusing because Jump Start Coffee vending machines provide a lot of convenience for consumers. Although there are some deficiencies, Jump Start Coffee is still considered a practical vending machine, including cashless payments that have fulfilled the lifestyle needs of millennial young people. To cite this article (7TH apa STYLE)::Selvonia, F. & Kania, D. (2021). The Practice of Digital Payment Culture on Jump Start Coffee Machines: A Consumer FGDnography of Bakrie University Students. Journal Communication Spectrum: Capturing New Perspectives in Communication, 11(2), 139-149. http://dx.doi.org/10.36782/jcs.v11i2.2023

Unit Warm-Up: Jump Start into Tertiary Studies

Unit Warm-Up: Jump Start into Tertiary Studies

Immune status of young pigs different methods of their breeding using means Globigen® Pig Doser and Globigen® Jump Start

The article deals with the influence of the use of means for young pigs Globigen® Pig Doser та Globigen® Jump Start, which due to the content of specific Ig Y have immunostimulatory properties. Assessing the level of nonspecific resistance of piglets, which are based on determining the content of T- and B-lymphocytes and their populations in the blood of animals 30-, 60- and 120-day-old, the trend of increasing the number of T-helpers, T-natural killers and B-lymphocytes in the experimental groups of animals of both farms. It was found that the content of T-helpers during single-phase rearing of pigs became more important under the action of Globigen® Pig Doser and ranged from 30.16−35.15 %, and during three-phase rearing – under the action of Globigen® Jump Start 34.58−35.08 %. An increase in the content of B-lymphocytes to the level of physiological norm was noted: FE PE “Glynjany Agro” (single-phase cultivation) in the first experimental group 16.75–19.45 %, in the second 17.66–21.11 %. At Ltd. “Meat Resources” (three-phase cultivation) 17.7–21.02 % and 18.91–21.01 %, respectively, in the first and second experimental groups. Regarding the indicators of the content of T-natural killers, there is a tendency to increase their number in the blood of animals of experimental groups by an average of 4.90 % for single-phase rearing and 3.09 % for three-phase rearing of pigs. Such data give grounds to claim that there is a formation of the immune response to the action of pathogens, which plays an important role in maintaining the barrier function of the intestinal mucosa, which in turn reduces mortality and increases the average daily gain of young pigs. Under the action of immunostimulants, the safety of piglets in FE PE “Glynjany Agro” (single-phase rearing) at 30 days of age increased to 81.3−93.7 %, and in Ltd. “Meat Resources” (three-phase rearing) to 80.0−86.7 %. In piglets FE PE “Glynjany Agro”, up to 120 days of age, the average daily gain was 0.710 and 0.691 kg using Globigen® Pig Doser and Globigen® Jump Start, and in piglets from Ltd. “Meat Resources” these figures were 0.595 and 0.628 kg.

Globigen Jump Start usage as a replacer for blood plasma in prestarter feed for piglets

At the current stage of development of the feed industry a lot of feed additives are used for animal feeding. Everyone knows that period of piglet’s weaning from sows is always the most critical in the process of pigs’ raising. The further result of fattening depends on this period. Therefore, it is important that the diet is adapted to the age of the piglets and the development of their digestive tract. In recent years, either in the world or in Ukraine, the African swine fever (ASF) has become a widespread disease, leading to the decline and closure of a number of pig farms. This prompted the process of safe feed preparation review, and especially the use of a number of make up feed ingredient. The risk group includes porcine blood plasma and its products, which since 2018 have been temporarily banned for use in pig feed in China and a number of European countries. A positive factor in this is the reduction of new outbreaks of this disease. But the lack of blood plasma in prestarter feed for piglets can lead to reduced productivity of piglets due to the lack of animal protein, reduced feed intake, as blood plasma affects the taste of feed. The article presents the results of the feed additive Globigen Jump Start use instead of blood plasma in pre-starter feed for piglets from birth to 42 days of age and in the conditions of industrial inspection. It was found that the replacement of , blood plasma in pre-starter feed for suckling piglets and piglets after weaning for feed additive Globigen Jump Start contributed to an increase in daily intake by 6 g or by 2.6 %. At the same time, the cost of feed per weight gain 1 kg decreased in the experimental group by 7.89 %. As a result of industrial testing when replacing blood plasma with immunological feed additive in the ratio of 42 kg to 2 kg, respectively, has a significant economic impact on the cost of prestarter feed. This has a positive effect on the piglets' eating and digestibility of feed, which is reflected in better average daily gains, final weight and improved feed conversion and piglet safety.

GLOBIGEN JUMP START APPLICATION WITHIN THE PRE-STARTER FEED TO THE POST-WAENING PIGLETS

Balanced addition of essential amino acids, vitamins and minerals, easily digestible proteins, namely proteins of animal origin is an important factor for efficient feeding and pigs performance, that leads to a systematic search for new solutions when using feed additives. They provide digestibility, better absorbtion of protein, vitamins, minerals and other nutrients. Such supplements include blood plasma, meat and bone meal, fish meal and others.
 Besides fishmeal, other protein groups are dangerous in relation to African swine fever. Furthermore blood plasma additionally to the protein group contains immunoglobulins that can passively affect the immune system of piglets, An alternative to blood plasma is the animal nutrition supplement Globigen Jump Start, which is made from chicken eggs, containing essential and replaceable amino acids with a high percentage of absorption. Another important factor is the presence of specific IgY immuno-globulins, which being ingested have a negative effect on the pathogenic intestinal microflora, namely viruses, bacteria and cryptosporidium. Knowledge of the feed additive Globigen Jump Start effect gave impetus to the study of its effect on the piglets’ performance during the stressful period after weaning.
 The objective of the work was evaluation of the effect of the Globigen Jump Start fed within the pre-starter feed on the productive characteristics of post-weaning piglets. Based on the obtained research results, the best ones were shown in the experimental group, which was fed compound feed containing Globigen Jump Start in the amount of 2 kg / t of compound feed. It was found that at the end of the experiment, the weight of piglets in the control group was 19.2 kg, and in the experimental group - 21.0 kg, which is 1.8 kg or 9.4% more comparing to the control.

44499 Heterogeneity of treatment effect among patients with type 2 diabetes and body mass index >=27kg/m^2 in the Jump Start Study

ABSTRACT IMPACT: This is the first study to use QUINT analyses to examine heterogeneity of treatment effect for group medical visits among individuals with type 2 diabetes. QUINT is a data driven method that assumes no a priori assumptions regarding effect moderators - an important step in the path towards personalized medicine. OBJECTIVES/GOALS: To examine heterogeneity of treatment effect (HTE) in Jump Start, a trial that compared the effectiveness of group medical visits (GMVs) focused on medication management only versus the addition of intensive weight management (WM) on glycemic control for patients with type 2 diabetes and body mass index >=27kg/m^2. METHODS/STUDY POPULATION: Jump Start patients (n=263) were randomized to a GMV-based medication management plus low carbohydrate diet-focused WM program (WM/GMV; n = 127) or GMV-based medication management only (GMV; n = 136) for diabetes control. We used QUalitative INteraction Trees (QUINT), a tree-based clustering method, to determine if there were subgroups of patients who derived greater benefit from either WM/GMV or GMV. Subgroup predictors included 32 baseline demographic, clinical, and psychosocial factors. Outcome was hemoglobin A1c (HbA1c). We conducted internal validation via bootstrap resampling to estimate bias in the range of mean outcome differences among arms. RESULTS/ANTICIPATED RESULTS: QUINT analyses indicated that for patients who had not previously attempted weight loss, WM/GMV resulted in better glycemic control than GMV alone (mean difference in HbA1c improvement = 1.48%). For patients who had previously attempted weight loss and had lower cholesterol and blood urea nitrogen levels, GMV alone was better than WM/GMV (mean difference in HbA1c improvement = 1.51%). Internal validation resulted in moderate corrections in the mean HbA1c differences between arms; however, differences remained in the clinically significant range. DISCUSSION/SIGNIFICANCE OF FINDINGS: Among patients with diabetes and BMI>=27kg/m^2, a low-carbohydrate, weight loss focus may better improve HbA1c in those who have never attempted weight loss. A medication management focus may be better in those who have attempted weight loss and have lower cholesterol and blood urea nitrogen.

Off to a Jump Start: Using Immersive Activities to Integrate Continuity Clinic and Advocacy.

BACKGROUNDTraining in advocacy is an important component of graduate medical education. Several models have been implemented by residency programs to address this objective. Little has been published regarding application of immersive advocacy activities integrated into continuity clinic.OBJECTIVETo create an Integrated Community Health and Child Advocacy Curriculum (ICHCA) by integrating advocacy activities that were immersive and contextualized in a continuity clinic setting and to familiarize interns with continuity clinic immediately at the beginning of their training.METHODSWe utilized a socio-constructivist lens, Kern's Six-step curriculum development and a published curriculum mapping tool to create the curriculum. Twenty residents completed ICHCA in 2019. Evaluations from key stakeholders including participants, support staff and attendings were analyzed on four levels of Kirkpatrick's model. We compared results before intervention, immediately following intervention and ten months following intervention.RESULTSWe demonstrated improvement in learner satisfaction, knowledge and behaviors with respect to advocacy in the clinical environment. Response rate was 70% (7/10) for attendings, 75% for support staff (15/20) and 72.5% for residents (29/40). Our intervention was feasible, no cost, and required no additional materials or training as it relied on learning in real time.CONCLUSIONSAn integrated advocacy curriculum utilizing the mapping tool for curricular design and evaluation is feasible and has value demonstrated by improvements in reaction, knowledge, and behaviors. This model improves understanding of social responsibility and can be implemented similarly in other residency programs.