Journal Of Engineering Research Articles

The effect of early weight-bearing and later weight-bearing rehabilitation interventions on outcomes after ankle fracture surgery: A systematic review and meta-analysis of randomised controlled trials.

This systematic review aimed to analyse the effect of early weight bearing versus late weight bearing on rehabilitation outcomes after ankle fractures, which primarily include ankle function scores, time to return to work/daily life and complication rates. The China National Knowledge Infrastructure, Wanfang Data Knowledge Service Platform, China Science and Technology Journal, Web of Science, PubMed, Embase and Cochrane Library databases were searched. The focus was on identifying randomised controlled trials centred on early weight-bearing interventions for post-operative ankle fracture rehabilitation. All databases were searched for eligible studies published within the period from database inception to 20 June 2023. The eligible studies were screened according to the inclusion criteria. Study quality was evaluated using the methodology recommended by the Cochrane Handbook for the Systematic Evaluation of Interventions. Two authors independently performed the literature search and data extraction. Eligible studies were subjected to meta-analyses using Review Manager 5.3. Based on the time points at which post-operative ankle function was reported in the studies included in this paper, we decided to perform a meta-analysis of ankle function scores at 6weeks post-operatively, 12weeks post-operatively, 24-26weeks post-operatively and 1year post-operatively. A total of 11 papers, comprising 862 patients, were included. Meta-analysis indicated that patients receiving early weight-bearing interventions, which referred to weight-bearing for 6weeks post-operatively, experienced enhancements in ankle function scores (Olerud-Molander score, AOFAS score or Baird-Jackson score) at various post-operative milestones: 6weeks (SMD=0.69, 95% CI: 0.49-0.88 and p<0.01), 12weeks (SMD=0.57, 95% CI: 0.22-0.92 and p<0.01) and the 24-26weeks range (SMD=0.52, 95% CI: 0.20-0.85 and p<0.01). The results of subgroup analyses revealed that the effects of early weight-bearing interventions were influenced by ankle range-of-motion exercises. Additionally, early weight bearing allows patients to return to daily life and work earlier, which was evaluated by time when they resumed their preinjury activities (MD=-2.74, 95% CI: -3.46 to -2.02 and p<0.01), with no distinct elevation in the incidence of complications (RR=1.49, 95% CI: 0.85-2.61 and p>0.05). The results showed that early weight bearing is effective in improving ankle function among post-operative ankle fracture patients and allows patients to return to daily life earlier. Significantly, the safety profile of early weight bearing remains favourable, with no higher risk of complications than late weight bearing.

Efficacy of substances containing 3 types of active ingredients-saponins, flavones, and alkaloids in regulation of cytokines in autoimmune diseases a systematic review and Meta-analysis based on animal studies.

To investigate the efficacy of substances containing 3 types of active ingredients-saponins, flavones, and alkaloids on experimental animals with autoimmune diseases (AIDs). The protocol for this systematic review and Meta-analysis was prospectively registered with PROSPERO (CRD42023395741). Searches were conducted in the China National Knowledge Infrastructure, Wanfang, Chinese Science and Technology Journals, China Biomedical, PubMed, Cochrane Library, and Embase databases to screen for animal studies investigating the therapeutic effects of saponins, flavones, or alkaloids on autoimmune diseases; consequently, corresponding data extraction tables were prepared. Systematic Review Centre for Laboratory Animal Experimentation was used to assess the risk of methodological bias in the included literature. RevMan 5.4 was used for the Meta-analysis on the 8 serum cytokines. A total of 31 studies were included, all of which were randomized controlled studies. Meta-analysis indicated that substances rich in saponins, flavones, and alkaloids reduced serum levels of interleukin (IL)-1β [standardized mean difference (SMD) = -1.94, 95% confidence interval (CI) (-2.99, -0.90), P = 0.0003], IL-6 [SMD = -1.65, 95% CI (-2.33, -0.97,) P < 0.000 01], IL-17 [SMD = -2.41, 95% CI (-3.61, -1.20), P < 0.0001], tumor necrosis factor (TNF)-α [SMD = -1.84, 95% CI (-2.61, -1.06), P < 0.0001], and interferon (IFN)-γ [SMD = -1.54, 95% CI (-2.43, -0.65), P = 0.0007], but increased serum levels of IL-4 [SMD = 1.30, 95% CI (0.15, 2.44), P = 0.03) and IL-10 [SMD = 2.05, 95% CI (1.39, 2.70), P < 0.000 01) in animal models. However, no significant regulatory effect of these three active components was observed on serum levels of IL-2 [SMD = -0.63, 95% CI (-1.82, 0.57), P = 0.30]. Substances containing saponins, flavones, and alkaloids regulated the changes of immune-related cytokines, it may be a novel dietary substance to relieve and control autoimmune diseases in the future.

The 150th Anniversary of the Journal of Transportation Engineering : Our Distinguished History and the Future of Transportation Engineering

The 150th Anniversary of the <i>Journal of Transportation Engineering</i> : Our Distinguished History and the Future of Transportation Engineering

Numerical modeling of the fracturing mechanisms of unconsolidated sand reservoirs under water injection

Produced Water Re-Injection is a standard practice in oil and gas operations. When performed at sufficiently high pressures, it can trigger the fracturing of the reservoir, which should be controlled to stimulate the formation without compromising its safety. While the mechanisms of the hydraulic fracturing of brittle rocks are well-understood, this understanding is more challenging in the case of unconsolidated sand reservoirs. Recent experimental studies indicate that pseudofractures in such formations primarily result from shear banding and flow channelization. There is a need for further interpretation of the experimental findings through numerical models that account for the proper physical phenomena. For that, a coupled finite element model of water percolation, particle transport and strain localization is developed to replicate the experiments of radial injection of water in mixtures of sand and fines by Nguyen et al., 2022: An experimental setup with radial injection cell for investigation of fracturing in unconsolidated sand reservoirs under fluid injection. Journal of Petroleum Science and Engineering 213:11036. To simulate shear banding, the model accounts for strain-softening behavior and introduces material imperfections in a few weak elements. Particle mobilization starts once a critical fluid velocity is reached and permeability is assumed to be a function of particle concentration. The numerical models can replicate the geometry of the observed radial pseudofractures, as well as the measured fracturing pressures. They also qualitatively capture the effects of the initial stress state on the fracturing pressure, the fracture length and on the permeability increases during the fracturing regime as observed in the laboratory tests. Notably, the numerical results gave hints on the role of the coupling between strain localization and particle transport on the formation of the pseudofractures. These findings are used to propose an updated conceptual model for the hydraulic fracturing of sand packs.

Meta-analysis on clinical efficacy of ringheaded thumbtack needle in the treatment of allergic rhinitis.

To evaluate the efficacy and safety of ringheaded thrumbtack needle in the treatment of allergic rhinitis (AR). Clinical studies about treatment of AR with ringheaded thrumbtack needle were searched from databases of CNKI, Wanfang, China Science and Technology Journal, China Biology Medicine disc, PubMed, Embase and Web of Science from their inception to November 2022. Two researchers independently screened the literature and collected related information. The total effective rate, visual analogue scale (VAS) for AR, rhinoconjunctivitis quality of life questionnaire (RQLQ), and recurrence rate were the main outcome indicators. Secondary outcome indicators included quantitative scores of symptoms and signs, 'quartering' symptom evaluation scale, etc. All the included studies were subjected to Meta-analysis using Stata software. A total of 22 clinical studies involving 1 491 participants were included. The results of Meta-analysis indicated that the total effective rate of ringheaded thrumbtack needle in the treatment of AR was higher than that of traditional Chinese and Western medicine ［RR=1.20, 95%CI (1.14, 1.26), P<0.001］, and recurrence rate is lower than conventional therapy ［OR=0.35, 95%CI (0.14, 0.89), P=0.027］. Moreover, The VAS score ［WMD=-1.30, 95%CI (-1.85, -0.75), P<0.001］ and RQLQ score ［WMD=-6.75, 95%CI (-12.74, -0.76), P=0.027］ of AR treated by ringheaded thrumbtack needle were lower than those of traditional Chinese and Western medicine. Ringheaded thrumbtack needle can improve the total effective rate, reduce the disease recurrence, and improve the symptoms of discomfort when AR outbreaks, and has no significant adverse reactions. However, the reliability is limited. Thus, it is still necessary to improve the level of evidence quality by including researches with large samples, rigorous design and international standards.

Visionary figures in the field of electrochemistry who revolutionized voltammetry

Understanding energetics and electron behavior has been pivotal in elucidating numerous fundamental phenomena, including electricity, corrosion, respiration, energy generation in biological systems, intermolecular interactions within living organisms, organic synthesis, drug development, enzyme functions, and the design of biosensors, among others. As 2024 records the centennial anniversary of the completion of the first polarograph by Nobel laureate Jaroslav Heyrovský (awarded the Nobel Prize in Chemistry in 1959), it presents an opportune moment to pay tribute to several eminent electrochemists who have made significant contributions to the field of voltammetric techniques. Following our recent acknowledgment of the outstanding women who have made substantial contributions to voltammetry in a prior publication, this article aims to briefly highlight the major achievements of several distinguished male figures in the field (Jaroslav Heyrovský, Allen J. Bard, Christian Amatore, Richard Compton, Jean-Michel Savéant, Fraser Armstrong, Fritz Scholz, Joseph Wang, Milivoj Lovrić, Valentin Mirčeski, Alan M. Bond). Given that many of these remarkable personalities have contributed both as authors and referees for the Macedonian Journal of Chemistry and Chemical Engineering, this tribute serves as a fitting acknowledgment of their remarkable accomplishments on the occasion of the journal's 50th anniversary.

Trends in mathematics education and insights from a meta-review and bibliometric analysis of review studies

AbstractReview studies are vital for advancing knowledge in many scientific fields, including mathematics education, amid burgeoning publications. Based on an extensive consideration of existing review typologies, we conducted a meta-review and bibliometric analysis to provide a comprehensive overview of and deeper insights into review studies within mathematics education. After searching Web of Science, we identified 259 review studies, revealing a significant increase in such studies over the last five years. Systematic reviews were the most prevalent type, followed by meta-analyses, generic literature reviews, and scoping reviews. On average, the review studies had a sample size of 99, with the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines commonly employed. Despite certain studies offering nuanced distinctions among review types, ambiguity persisted. Only about a quarter of the studies explicitly reported employing specific theoretical frameworks (particularly, technology, knowledge, and competence models). Co-authored publications were most common within American institutions and the leading countries are the United States, Germany, China, Australia, and England in publishing most review studies. Educational review journals, educational psychology journals, special education journals, educational technology journals, and mathematics education journals provided platforms for review studies, and prominent research topics included digital technologies, teacher education, mathematics achievement, and learning disabilities. In this study, we synthesised a range of reviews to facilitate readers’ comprehension of conceptual congruities and disparities across various review types, as well as to track current research trends. The results suggest that there is a need for discipline-specific standards and guidelines for different types of mathematics education reviews, which may lead to more high-quality review studies to enhance progress in mathematics education.

Efficacy and safety of intrapleural perfusion with hyperthermic chemotherapy for malignant pleural effusion: a meta-analysis

ObjectiveTo evaluate the efficacy and safety of intrapleural perfusion with hyperthermic chemotherapy (IPHC) in treating malignant pleural effusion (MPE).MethodsPubMed, Embase, Cochrane Library, Chinese National Knowledge Infrastructure (CNKI), Chinese Biomedical Literature Database (CBM), VIP Chinese Science and Technology Journal Full-text Database (VP-CSJFD), and Wanfang database were searched by computer from database establishment to January 17, 2024. Relevant randomized controlled articles with IPHC as the observational group and intrapleural perfusion chemotherapy (IPC) as the control group for MPE were included. Then, the methodological quality of the included articles was evaluated and statistically analyzed using Stata 16.0.ResultsSixteen trials with 647 patients receiving IPHC and 661 patients receiving IPC were included. The meta-analysis found that MPE patients in the IPHC group had a more significant objective response rate [RR = 1.31, 95%CI (1.23, 1.38), P < 0.05] and life quality improvement rate [RR = 2.88, 95%CI (1.95, 4.24), P < 0.05] than those in the IPC group. IPHC and IPC for MPE patients had similar incidence rates of asthenia, thrombocytopenia, hepatic impairment, and leukopenia.ConclusionCompared with IPC, IPHC has a higher objective response rate without significantly increasing adverse reactions. Therefore, IPHC is effective and safe. However, this study is limited by the quality of the literature. Therefore, more high-quality, multi-center, large-sample, rigorously designed randomized controlled clinical studies are still needed for verification and evaluation.

Naval engineering and ship control special edition III

The third Naval Engineering and Ship Control special edition of the Journal of Marine Engineering and Technology aims to present cutting-edge research on naval engineering and ship control, as was presented during the International Naval Engineering Conference and Exhibition (INEC) and the International Ship Control Systems Symposium (iSCSS), held together in Delft in 2022.

Comparative efficacy and safety of ginkgo-based Chinese patent medicines in patients with hypertension: A systematic review and network meta-analysis of randomized clinical trials.

The efficacy and safety of different oral ginkgo-based Chinese patent medicines (CPMs) regimens for hypertension patients were analyzed based on the network meta-analysis of the frequency framework. We conducted a comprehensive search of PubMed, Cochrane Library, Embase, China National Knowledge Infrastructure, Wanfang, China Science and Technology Journal Database, and Chinese Biomedical Literature Database to gather data on randomized controlled trials (RCTs) evaluating the efficacy of 8 ginkgo biloba oral preparations for the treatment of hypertension. The trials included in the analysis were conducted from the inception of the databases up to September 2023. Methodological quality and risk of bias were assessed using the RoB 2.0 evaluation tool, and a reticulated meta-analysis was conducted using STATA MP 14 software. The RCTs included in this study were published studies and therefore did not require ethics committee review or patient consent. We ultimately included 46 RCTs covering 8 CPMs including ginkgo biloba tablet (GBT), GB capsule (GBC), ginkgo biloba drop (GBD), ginkgo biloba ketone ester drop, Fufangyinxing capsule, fufangyinxingtongmai oral liquid, Yinxingmihuan oral liquid, Yindanxinanotong softgel capsule (YDXNT). GBD + CT demonstrated the highest effectiveness in reducing systolic blood pressure (surface under the cumulative ranking [SUCRA] = 78.7%) and improving total effective rate (SUCRA = 86.7%). GBC + CT exhibited the greatest efficacy in reducing diastolic blood pressure (SUCRA = 92.6%). GBT + CT was identified as the most effective in lowering total cholesterol (TC) (SUCRA = 100%). Additionally, YDXNT + CT demonstrated notable improvements in triglyceride levels (SUCRA = 92.2%), Nitric oxide (NO) (SUCRA = 93.9%), and ET-1 (SUCRA = 67.5%). In terms of safety, 14 studies reported the occurrence of adverse reactions with a high degree of clinical heterogeneity, which was only qualitatively analyzed in this study. We found that a combination of 8 ginkgo-based CPMs + CT was effective in hypertension compared with CT. The evidence showed that GBD + CT were the best in improving systolic blood pressure and total effective rate, GBC + CT improved diastolic blood pressure, GBT + CT were the most effective in improving TC, and YDXNT + CT was the most effective in improving TG, NO, and ET-1. Adverse effects were only analyzed qualitatively, and the number of adverse effects of CPMs treatment was relatively low compared to CT. In addition, the quality of the literature included in the study was low, and further validation through RCTs with larger sample sizes, higher quality, and more rigorously designed is needed.

Circling the Square with Straightedge &amp; Compass in Euclidean Geometry

There are three classical problems remaining from ancient Greek mathematics which are extremely influential in the development of Geometry. They are Trisecting an Angle, Squaring the Circle, and Doubling the Cube problems. I solve the Squaring the Circle problem, of which paper is published in the International Journal of Mathematics Trends and Technology (Volume 69, June 2023). Upstream from this method of exact “Squaring the Circle”, we can deduce, conversely/inversely, to get a new Mathematical challenge "CIRCLING THE SQUARE" with a straightedge &amp; a compass in Euclidean Geometry. This study idea came from my exact solution “Squaring the Circle by Straightedge &amp; compass in Euclidean Geometry”, published by IJMTT in June 2023 at https://ijmttjournal.org/Volume-69/Issue-6/IJMTT-V69I6P506.pdf for this ancient Greek Geometry problem. In this research, I adopt the ANALYSIS method to prove the process of solving this new challenge problem, which has not existed in the Mathematics field till today. The process is an inverse/converse solution solving the ancient Greek Geometry challenge problem of “Squaring the Circle”, using a straightedge &amp; a compass. I hereby commit that this is my own personal research project.

Preface

2024 8th International Conference on Machine Vision and Information Technology (CMVIT 2024), was successfully held on February 24, 2024, which was organized by Asia Pacific Institute of Science and Engineering (APISE), media supported by Internet of Things Technologies, Modern Electronics Technique, Journal of Xidian University, Journal of Information and Intelligence, Telecommunication Engineering, Chinese Journal of Engineering, Journal of Computer Applications.The conference was held in Singapore during Feb. 23-25, 2024 as planned. Considering that some participants could not attend in person, the conference was adjusted as hybrid conference, as a combination of on-line and off-line conference.The proceedings of this year’s edition comprised three main categories: “1. Generation and Fusion”; “2. Data Analysis and Application”; “3. Detection-classification and Segmentation”. All these submissions were rigorously reviewed by the Program Committee. The conference attracted 43 submissions in total, and out of 13 papers were accepted, including countries like USA, Japan, China, India, Thailand, Pakistan, Australia, Sri Lanka, etc.On the conference day, 8 oral presentations and 15 posters presentation were arranged according to the participants’ choices. Each presenter was given 12 minutes to deliver their presentation, including 2 minutes Q&A. Two awards, one best oral presentation award and one best poster presentation award were selected by the end of conference. Prof. Shahram Latifi from University of Nevada, Las Vegas (USA), gave a wonderful opening remark. Two distinguished keynote speakers, including Prof. Yan Yang from T Southwest Jiaotong University, China and Prof. Jing Zhang from Sichuan University, China delivered excellent speeches, sharing their latest and insightful research ideas. The technical session and poster session were formally presided over by Dr. Haidong Shao, who delivered exemplary and thought-provoking remarks.CMVIT 2024 aims to present the latest research and results of scientists related to Machine Vision and Information Technology and other topics. By oral and poster presentation, this conference provides opportunities for the delegates to exchange new ideas, to establish business or research relations as well as to find global partners for future collaborations.We express our deepest gratitude to each and every participant for their valuable contributions, insightful discussions, and unwavering commitment to advancing global collaboration. Together, we have laid the foundation for a brighter and more interconnected future.List of Committees are available in this pdf.

RETRACTION: Novel computer‐aided lung cancer detection based on convolutional neural network‐based and feature‐based classifiers using metaheuristics

RETRACTION: Z. Guo, L. Xu, Y. Si, and N. Razmjooy, “Novel computer‐aided lung cancer detection based on convolutional neural network‐based and feature‐based classifiers using metaheuristics,” International Journal of Imaging Systems and Technology 31, no. 4 (2021): 1954–1969. https://doi.org/10.1002/ima.22608The above article, published online on 5 June 2021 in Wiley Online Library, has been retracted by agreement between the authors, the journal's Editor in Chief, Mohamed Seghier, and Wiley Periodicals, LLC. Following the article's publication, the journal was contacted by co‐author Yujuan Si, who stated that she had not participated in any way in the work presented in the article or its preparation, and that the email address used to correspond with the journal in her name had been fabricated. In the following investigation, the authors stated that Yujuan Si's inclusion in the author list was due to her supervisory role over co‐author Lina Xu as a mentor for her PhD studies, and that authorship attribution occurred without Yujuan Si's knowledge nor consent due to inadequate communication among the co‐authors. However, the ownership of the email address attributed to Yujuan Si for journal correspondence (bio_sp@163.com) remains uncertain. The retraction has been agreed due to concerns about the fabricated email address and author impersonation, which calls all aspects of the work presented into question. Following the investigation's findings, the corresponding author Navid Razmjooy has agreed on the decision to retract the article on behalf of all authors.

Risk factors of central catheter bloodstream infections in intensive care units: A systematic review and meta-analysis.

Central catheter bloodstream infections (CRBSI) is a major cause of healthcare-associated infections. However, few factors are generally accepted and some studies have conflicting finding about some factors, possibly caused by limitation associated with an individual study. This study was to identify risk factors for CRBSI in intensive care units. We searched the PubMed, Cochrane Library, Web of science and EMBASE databases and the 4 top Chinese-language databases, including WanFang data, China National Knowledge Infrastructure (CNKI), and Chinese Science and Technology Journal Database (VIP), China Biology Medicine disc (CBM) as of July 2023. Case control and cohort studies were included. Two authors independently screened the literature and evaluated the quality of the studies using the Newcastle-Ottawa scale (NOS). The pooled effect size was estimated using the odds ratio (OR), and the corresponding 95% confidence interval (CI) was calculated. The Cochrane Q (χ2) and I2 tests were used to assess heterogeneity among studies, and each risk factor was tested for its robustness using fixed- or random-effects models. A total of 32 studies enrolled, among which eleven factors were identified, they were divided into two categories: modifiable and unmodifiable factors. Modifiable factors: duration of catheterization (≥ 5d) (OR: 2.07, 95%CI: 1.41-3.03), duration of catheterization (≥ 7d) (OR: 3.62, 95%CI: 2.65-4.97), duration of catheterization (≥ 14d)(OR: 4.85, 95%CI: 3.35-7.01), total parenteral nutrition (OR: 2.27,95%CI: 1.56-3.29), use of multiple-lumen catheters(OR: 3.41, 95%CI: 2.27-5.11), times of tube indwelling (OR: 3.50, 95%CI: 2.93-4.17), length of ICU stay (OR: 4.05, 95%CI: 2.41-6.80), the position of indwelling(OR: 2.41, 95%CI: 2.03-2.85); Unmodifiable factors: APACHEII scores (OR: 1.84, 95%CI: 1.54-2.20), Age≥ 60 years old (OR: 2.19, 95%CI: 1.76-2.73), the extensive use of antibiotic (OR: 3.54, 95%CI: 1.65-7.61), Diabetes mellitus (OR: 3.06, 95%CI: 2.56-3.66), Immunosuppression (OR: 2.87, 95%CI: 2.08-3.95). Effective interventions targeting the above modifiable factors may reduce the risk of developing CRBSI in ICU and improve the clinical outcome of patients. Further prospective studies are needed to confirm these findings.

Statement of Retraction: Enhancing the quality and reputation of Critical Reviews in Environmental Science and Technology journal: 2023 updates

Statement of Retraction: Enhancing the quality and reputation of Critical Reviews in Environmental Science and Technology journal: 2023 updates

Effects of human milk odor stimulation on feeding in premature infants: a systematic review and meta-analysis

Previous studies suggested odor stimulation may influence feeding of premature neonates. Therefore, this systematic review and meta-analysis of randomized controlled trials was conducted to assess the effect of human milk odor stimulation on feeding of premature infants. All randomized controlled trials related to human milk odor stimulation on feeding in premature infants published in PubMed, Cochrane, Library, Medline, Embase, Web of science databases and Chinese biomedical literature databases, China National Knowledge Infrastructure, China Science and Technology Journal Database (VIP) and Wanfang Chinese databases were searched, and The Cochrane Handbook 5.1.0 was used to evaluate the quality and authenticity of the literature. Relevant information of the included studies was extracted and summarized, and the evaluation indexes were analyzed using ReviewManager5.3. The retrieval time was from the establishment of the database to July 28, 2022.12 articles were assessed for eligibility, and six randomized controlled studies were eventually included in the meta-analysis (PRISMA). A total of 6 randomized controlled studies with 763 patients were finally included in the study, and the quality evaluation of literatures were all grade B. Human milk odor stimulation reduced the transition time to oral feeding in premature infants [SMD = − 0.48, 95% CI (− 0.69, − 0.27), Z = 4.54, P < 0.00001] and shortened the duration of parenteral nutrition [MD = − 1.01, 95% CI (− 1.70, − 0.32), Z = 2.88, P = 0.004]. However, it did not change the length of hospitalization for premature infants [MD = − 0.03, 95% CI (− 0.41, 0.35), Z = 0.17, P = 0.86]. The implementation of human milk odor stimulation can reduce the transition time to oral feeding and the duration of parenteral nutrition in premature infants, but further studies are needed to determine whether it can reduce the length of hospital stay in premature infants. More high-quality, large-sample studies are needed to investigate the effect of human milk odor stimulation on the feeding process and other outcomes in premature infants.

Efficacy and safety of tetrandrine in treatment of rheumatoid arthritis: a meta analysis.

To explore the efficacy and safety of tetrandrine in the treatment of rheumatoid arthritis. Randomized controlled studies of tetrandrine in the treatment of rheumatoid arthritis were searched in China National Knowledge Infrastructure (CNKI), China Science and Technology Journal Database (VIP), World Wide Web Database, SinoMed, PubMed, Springer, Web of Science, the Cochrane Central Register of Controlled Trails database. A meta-analysis was conducted using R software version 3.5.3 to evaluate the clinical outcomes, including the total effective rate, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), rheumatoid factor (RF), visual analog scale (VAS) for pain, disease activity score (DAS), tender joint count (TJC), swollen joint count (SJC), and morning stiffness duration, as well as adverse events of RA patients. A total of 10 articles were included in the study. The meta-analysis indicated that tetrandrine significantly improved the total effective rate (OR=3.27, 95%CI: 2.01-5.37, P<0.01), ESR (SMD=1.12, 95%CI: 0.06-2.19, P<0.05), CRP (SMD=0.75, 95%CI: 0.28-1.22, P<0.01), VAS (SMD=0.55, 95%CI: 0.21-0.89, P<0.01), SJC (SMD=0.85, 95%CI: 0.40-1.31, P<0.01), TJC (SMD=1.16, 95%CI: 0.58-1.74, P<0.01), and morning stiffness (SMD=1.09, 95%CI: 0.68-1.50, P<0.01). However, no statistical significance was found in RF (SMD=1.70, 95%CI: －1.10-4.51, P>0.05) and DAS (SMD=0.26, 95%CI: －0.59-1.11, P>0.05). The overall incidence of adverse events associated with tetrandrine treatment for rheumatoid arthritis was 20% (95%CI: 12%-27%, I2=60%, P<0.05), with mild severity and favorable outcomes. Tetrandrine is effective in the treatment of RA patients with a mild degree of adverse events.

A step-by-step guide on how NOT to get published in a high impact educational technology journal

Many elements come together to make for a good, publishable manuscript in a high-impact educational technology journal. There are also some fatal errors and omissions that will doom a paper to be immediately declined. In this editorial, we focus on the latter. Checking the aims and scope of a journal is a simple step to ensure that the publication of an article is not delayed and time is not wasted. Unfortunately, it seems this step is neglected by many aspiring authors. Beyond a misalignment with the aims and scope of the journal, we will discuss some of the other main reasons why manuscripts have recently been declined by AJET. We hope that this editorial will assist authors to ensure that they do not make the same mistakes.

Kuntai capsule for the treatment of diminished ovarian reserve: A systematic review and meta-analysis of randomized controlled trials

Ethnopharmacological relevanceDiminished ovarian reserve (DOR) results in reduced fertility. Kuntai capsule, a Chinese patent medicine, which can nourish the heart and kidneys, has shown promising efficacy in its treatment. However, there is no enough clinical evidence to confirm the efficacy and safety of Kuntai capsule. Aim of the studyThis review aims to evaluate Kuntai capsule's potential benefits and detriments for diminished ovarian reserve. Materials and methodsDatabases namely China National Knowledge Infrastructure, WANFANG Database, Chinese Science and Technology Journal Database, Chinese Biomedical Literature Database, PubMed, Cochrane Library, and Embase were searched from their inception to July 2023. We included randomized controlled trials (RCTs) comparing Kuntai capsule to hormone therapy (HT) and Kuntai capsule in combination with HT to HT alone for DOR treatment. The risk of bias was evaluated using RoB 1.0. A Meta-analysis was performed using RevMan 5.4 software. The primary outcomes were antral follicle count (AFC) and serum anti-Müllerian hormone (AMH), secondary outcomes were follicle-stimulating hormone (FSH) and adverse reactions. ResultsA Meta-analysis of 12 randomized controlled trials (RCTs), encompassing a total of 905 DOR patients was conducted. The results indicated that the combination of Kuntai capsule with HT exhibited superior efficacy in enhancing AFC (MD = 1.34, 95% CI [0.96,1.72]) and AMH levels (MD = 1.09 (ng/mL) 95% CI[0.80,1.38]), Kuntai capsule demonstrated improvements in AFC (MD = 0.65, 95% CI [0.48,0.83]) in DOR patients compared to HT alone. ConclusionsBased on the available results, the combination of Kuntai capsule with HT appears to improve the AFC, AMH and FSH levels of DOR patients. Kuntai capsule alone appears to improve the AFC and FSH levels of DOR patients. However, included trials had methodological quality issues, further standardized research is required.

A systematic review and meta-analysis on sodium tanshinone IIA sulfonate injection for the adjunctive therapy of pulmonary heart disease

AimsSodium tanshinone IIA sulfonate (STS) injection has been widely used as adjunctive therapy for pulmonary heart disease (PHD) in China. Nevertheless, the efficacy of STS injection has not been systematically evaluated so far. Hence, the efficacy of STS injection as adjunctive therapy for PHD was explored in this study.MethodsRandomized controlled trials (RCTs) were screened from China Science and Technology Journal Database, China National Knowledge Infrastructure, Wanfang Database, PubMed, Sino-Med, Google Scholar, Medline, Chinese Biomedical Literature Database, Cochrane Library, Embase and Chinese Science Citation Database until 20 January 2024. Literature searching, data collection and quality assessment were independently performed by two investigators. The extracted data was analyzed with RevMan 5.4 and STATA 14.0. Basing on the methodological quality, dosage of STS injection, control group measures and intervention time, sensitivity analysis and subgroup analysis were performed.Results19 RCTs with 1739 patients were included in this study. Results showed that as adjunctive therapy, STS injection combined with Western medicine showed better therapeutic efficacy than Western medicine alone for PHD by increasing the clinical effective rate (RR = 1.22; 95% CI, 1.17 to 1.27; p < 0.001), partial pressure of oxygen (MD = 10.16; 95% CI, 5.07 to 15.24; p < 0.001), left ventricular ejection fraction (MD = 8.66; 95% CI, 6.14 to 11.18; p < 0.001) and stroke volume (MD = 13.10; 95% CI, 11.83 to 14.38; p < 0.001), meanwhile decreasing the low shear blood viscosity (MD = -1.16; 95% CI, -1.57 to -0.74; p < 0.001), high shear blood viscosity (MD = -0.64; 95% CI, -0.86 to -0.42; p < 0.001), plasma viscosity (MD = -0.23; 95% CI, -0.30 to -0.17; p < 0.001), hematokrit (MD = -8.52; 95% CI, -11.06 to -5.98; p < 0.001), fibrinogen (MD = -0.62; 95% CI, -0.87 to -0.37; p < 0.001) and partial pressure of carbon dioxide (MD = -8.56; 95% CI, -12.09 to -5.02; p < 0.001).ConclusionSTS injection as adjunctive therapy seemed to be more effective than Western medicine alone for PHD. However, due to low quality of the included RCTs, more well-designed RCTs were necessary to verify the efficacy of STS injection.