Joint Replacement In Rheumatoid Arthritis Research Articles

Reverse shoulder joint replacement in rheumatoid arthritis: medium-term results in 37 patients

Objective:to assess functional results and quality of life in patients with rheumatoid arthritis (RA) after reverse shoulder joint replacement.Patients and methods.Examinations were made in 37 patients with RA involving the shoulder joint, who underwent shoulder joint replacement using a reverse DeltaX-tend DePuy prosthesis in 2006–2017. The investigators studied the volume of movements, the level of pain using the visual analogue scale, the function of the shoulder joint using the American Shoulder and Elbow Surgeons (ASES) Shoulder Score and the upper limb as a whole by the Disability of the Arm, Shoulder and Hand (DASH) questionnaire, a patient's functional status by the Health Assessment Questionnaire (HAQ), quality of life (QL) by EQ-5D (Euro Quolish instrument) and analyzed shoulder X-ray films before and in the late periods after surgery.Results.The volume of shoulder joint movements was found to increase. At 28.7 months postsurgery, the mean volume of flexion, abduction, and external rotation was 107.4Ѓ}15.2, 128.3Ѓ}8.5, and 46.4Ѓ}5.5°; respectively (p≤0.05). The patients experienced no pain in the late periods following surgery. Prior to surgery and at control examination, the mean ASES scores were 25.0Ѓ}4.7 and 79.4Ѓ}6.4, respectively (p≤0.05). Before surgery, the mean DASH score was 63.8Ѓ}4.2; in the late periods it decreased to 18.2Ѓ}8.6 (p ≤ 0.05). The mean preoperative HAQ score was 2.81; following surgery, it also decreased to 1.39 (p≤0.05). The postoperative EQ-5D QOL index score increased from 0.41 to 0.72. The rate of complications reached 10.8%.Conclusion.Reverse endoprosthetic replacement for end-stage shoulder joint damage (Larsen 4–5) with rotator cuff defect makes it possible to increase the volume of movements, to reduce pain, and to improve upper limb function, functional status, and quality of life in patients with RA.

AB0162 Expression of interleukin-20 and its receptor chains IL-20R1, IL-20R2 and IL-22R in synovium from patients with rheumatoid arthritis

BackgroundInterleukin-20 (IL-20) signals via the IL-20R1/IL-20R2 and IL-20R2/IL-22R1 heterodimeric receptor complexes. Elevated expression of IL-20 has been demonstrated in synovial tissue from patients with rheumatoid arthritis (RA). In the rat...

Lower limb joint replacement in rheumatoid arthritis

IntroductionThere is limited literature regarding the peri-operative and surgical management of patients with rheumatoid disease undergoing lower limb arthroplasty. This review article summarises factors involved in the peri-operative management of major lower limb arthroplasty surgery for patients with rheumatoid arthritis.MethodsWe performed a search of the medical literature, using the PubMed search engine (http://www.pubmed.gov). We used the following terms: ‘rheumatoid’ ‘replacement’ ‘arthroplasty’ and ‘outcome’.FindingsThe patient should be optimised pre-operatively using a multidisciplinary approach. The continued use of methotrexate does not increase infection risk, and aids recovery. Biologic agents should be stopped pre-operatively due the increased infection rate. Patients should be made aware of the increased risk of infection and periprosthetic fracture rates associated with their disease. The surgical sequence is commonly hip, knee and then ankle. Cemented total hip replacement (THR) and total knee replacement (TKR) have superior survival rates over uncemented components. The evidence is not clear regarding a cruciate sacrificing versus retaining in TKR, but a cruciate sacrificing component limits the risk early instability and potential revision. Patella resurfacing as part of a TKR is associated with improved outcomes. The results of total ankle replacement remain inferior to THR and TKR. RA patients achieve equivalent pain relief, but their rehabilitation is slower and their functional outcome is not as good. However, the key to managing these complicated patients is to work as part of a multidisciplinary team to optimise their outcome.

The Results of Multiple Total Joint Replacement in Rheumatoid Arthritis

The Results of Multiple Total Joint Replacement in Rheumatoid Arthritis

Costs and outcomes of total hip and knee joint replacement for rheumatoid arthritis

The objective of the study was to ascertain costs and outcomes of total joint replacement surgery for rheumatoid arthritis (RA) in Australia from the patients' perspective and to explore whether costs were affected by health status pre- or postsurgery. RA patients, scheduled for primary unilateral total knee replacement (TKR) or total hip replacement (THR) surgery at five Sydney hospitals, were approached. Preoperatively, patients retrospectively recorded expenses incurred over the previous 3 months and the health assessment questionnaire (HAQ). Postoperatively, patients completed detailed prospective cost diaries, short form (SF) 36, and HAQ every 3 months during the first postoperative year. In addition, patients were asked to complete a visual analogue measure for pain at 12 months postsurgery. Arthritis-specific cost information included prescription and nonprescription medication, visits to health professionals, tests, special equipment, alterations to the house, and use of private or community services. Thirty-one TKR and 11 THR patients provided cost data for the first postoperative year. Out-of-pocket costs and service utilization decreased over the first postoperative year for both TKR and THR patients. In addition, there was an improvement in the health status as measured by SF-36 but not the HAQ at 3 and 12 months postoperatively. The small sample size of this analysis is reflective of the current national trends of RA joint replacement surgery. Despite the low incidence of RA joint replacement surgery, it was substantiated that patients consider the positive impact on health outcomes and costs important. The generic SF-36 detected improvements in the health status of these RA patients, while total HAQ scores failed to do so. HAQ was found to be insensitive in reflecting improvements following lower limb replacement surgery. Patient out-of-pocket costs significantly decreased postoperatively; however, these costs remain substantial compared to osteoarthritis total joint replacement patients.

The impact of total joint replacement in rheumatoid arthritis.

Management of the patient with rheumatoid arthritis (RA) requires a multidisciplinary approach, the role of the surgeon being to improve functional ability for the patient by reconstructing a deteriorated joint by total joint arthroplasty (TJA). An advantage of prosthetic evaluation over pharmacological medication evaluations is that the 'compliance' of the patient with the treatment (i.e. the TJA) is 100%, even at long-term follow-up. However, long-term follow-up of prosthesis evaluation is as difficult as the evaluation of any other intervention. Although the goal of any intervention on an RA patient is to improve functional ability, and thus self-support, of the patient, objective evaluation of the surgical procedure, and of its impact on the patient, can be difficult. The potential chronic course of RA makes evaluation of a specific surgical procedure and its effect on the patient difficult to interpret. The success of the TJA is generally judged on a survivorship analysis at 10 or 15 years in national registries (i.e. >40000 implants); revision surgery is used as an end-point for survival of the TJA. With a mean 90% survival at 10-year follow-up, total hip arthroplasty and total knee arthroplasty may be considered gold-standard TJA procedures for the patient. While revision is the end-point, the course to this end-point starts with progressive micromotion of the prosthesis. The effect of prosthetic changes, and of medication on prosthesis migration, can be measured very accurately by radiostereometry. The latter measures the actual performance of the TJA in the bone. Next to these more procedure-oriented evaluations, patient-oriented evaluations (e.g. quality of life, patient expectations) are of importance in judging the impact of the TJA on the RA patient. These evaluations provide evidence that the pre-operative status of the joint/extremity determines the extent of post-operative functional gain. Thus, postponing TJA for too long will give less functional benefit.

Benefits of Multiple Joint Replacement in Rheumatoid Arthritis

Thebenefitsofmultiplejointreplacements were assessed in 21 patients withrheumatoidarthritiswho had bilateral hip and knee replacements. The mainbenefitwas relief of pain with 40 hips and 25 knees becoming completely pain-free. There was an improved range of movement in 38 hips but in only 11 knees and 8 knees were stiffer after surgery. Hipreplacementwas the preferred initial surgery but there was a mean delay of 50 months between hip and knee surgery suggesting a "domino effect" with increasing mobility as a consequence of hipreplacementeventually causing knees to deteriorate. All patients who completed a postal questionnaire found their ability to walk had improved but many noted an increase in ankle and foot pain which limited their walking. After their surgery patients were better able to perform certain activities of daily life, especially housework and dressing. It is concluded thatmultiplejointreplacementcontributes to improving the quality of life in disabled arthritic patients.

Devenir a long terme des alloprothèses métacarpophalangiennes dans la chirurgie de la main rhumatoïde

The authors have been using Swanson's prostheses for MP joint replacement in rheumatoid arthritis since 1968. After thirteen years of experience, they present an analysis of these prostheses from a clinical and radiological point of view. 88 joints replacements in 20 patients are reviewed. These operations were performed between 1968 and 1976. The average follow-up is nine years. The authors compare their results with those obtained in a previous study made in 1975. They show that a replacement arthroplasty with a Swanson type prosthesis, imparts considerable benefits to the patient in the form of complete disappearance of pain, improvement in function, and a more normal looking hand, in spite of radiologic deterioration.