The liver viability monitoring during its procurement is critical to guarantee the safe liver transportation. Traditionally, the viability is assessed by taking invasive biopsy on the liver surface. Recently, the noninvasive thermal images of liver surface have been used as an alternative assessment way. Researchers have proposed monitoring and classification approaches based on the thermal images. Existing works have demonstrated the importance of the temporal variation or the spatial variation of the thermal images to the viability monitoring. However, there is no prior work to leverage the graph structure of the spatio-temporal processes for the viability monitoring. In this paper, we propose a time-vertex signal processing framework for the irregular thermal data of the pure liver region monitoring. In particular, we extract features of irregular thermal data based on the joint Fourier transform (JFT), which is an integration of graph Fourier transform (GFT) and discrete Fourier transform (DFT). The extracted JFT features can accurately reconstruct the thermal images with a limited number of features. Then, we use a non-parametric online change-point estimation method, based on online scan B statistics, to monitor the JFT features without a parametric distribution. Our proposed framework is applied to both simulation and the liver procurement data, and achieves good monitoring performance.