John Lane Research Articles

Entomological Reference Collection: 85 years of contributions to public health.

The Department of Hygiene of the Faculty of Medicine of São Paulo (FMUSP), organized with the support of the Rockefeller Foundation, became the Institute of Hygiene, with the inaugural class taught by Samuel Darling in 1918. The history of Public Health Entomology is mixed with that of the Institute itself, which became the Faculty of Hygiene and Public Health in 1945. Still in the 1930s, Paulo César de Azevedo Antunes and John Lane organized Public Health Entomology within the Medical Parasitology area of the then Institute of Hygiene. During this period, the entomology laboratory came to be recognized for its research in the systematics of hematophagous insects, as well as in the ecology, biology and behavior of vectors. The Entomological Reference Collection (CER) originated naturally from the research of Paulo César Antunes and John Lane and is a national and international heritage covering primary and secondary types of insect species that are of interest to public health. Over the years, it has been consolidated with the efforts of Augusto Ayroza Galvão, Renato Corrêa, José Coutinho, Nelson Cerqueira, Ernesto Rabello, Oswaldo Forattini and others. In its over eighty years of activities, CER has enabled the training of several scientists able to act in programs of surveillance and control of endemic diseases associated with insect vectors throughout Latin America, in addition to training taxonomists focused on insects of interest in Public Health. Researchers from other Brazilian institutes and abroad joined the entomology laboratory because of its importance and the research developed in it. The growing scientific production made it possible for entomological studies developed at the Faculty of Public Health (FSP) to gain international visibility, contributing to the development of disease prevention and epidemic control actions in the country.

Furnishing Nature: Textile Materiality and the Victorian Home in Alfred Hayes’s The Vale of Arden and Other Poems (1895)

This article examines the conjunction of environmental aesthetics, textile materiality, and notions of the home in the work of the British poet and translator Alfred Hayes (1857–1936). Hayes, who authored six collections of poems, has been largely neglected in studies of Victorian poetry, yet his pastoral and religious verse was popular among Victorian and Edwardian readers. Hayes was also closely affiliated with the fin-de-siècle literary scene. He contributed to The Yellow Book, collaborated with Richard Le Gallienne and Norman Gale, and was reviewed by Oscar Wilde. The essay investigates the forms and functions of Hayes’s textile references and allusions to Victorian interiors in the collection The Vale of Arden and Other Poems, which was first published by John Lane at The Bodley Head in 1895. Its lyrics weave together depictions of rural England as a home with imagery inspired by the textures of luxurious fabrics and furnishing objects, thus testing the boundaries of exteriority and interiority. The article first surveys the contents, potential influences, and material design of Hayes’s little-researched book. It links Hayes’s use of poetic form and imagery to late Victorian understandings of organicism in Arts and Crafts design and home decoration. At the centre of the article will be a close reading of Hayes’s poem ‘My Study’. The poem portrays an idyllic landscape as the speaker’s study. It alludes to conceptions of the ‘house beautiful’ and the ‘book beautiful’ as it combines ecopoetic and religious notions of nature as a domestic space and as a site of learning. The article argues that textile ecologies are central to Hayes’s negotiation of relationships between nature and artifice, enabling a distinctive fusion of traditional English pastoral and fin-de-siècle aestheticism. The eco-aesthetic meditations of Hayes’s poetry highlight conceptual links between nature and notions of the dwelling space (‘oikos’), and, at the same time, suggest that material culture, specifically the fin-de-siècle craze for beautiful objects and textures, furnished Victorian nature poetry.

White Magic, Black Humour: Ella D’Arcy’s Narrative Strategies

Of the New Woman writers who wrote humour, Ella D’Arcy is one of the more elusive. Her humorous writing takes the form of satire which depends on a double reading. A straightforward reading of her stories sympathizes with her male protagonists engaging in unsuitable romances and bad marriages. A resisting reading, however, shows these men as egotistical fools whose efforts to set the terms of their romances backfire. D’Arcy’s double reading is dependent on her audience and therefore was rarely appreciated by her mostly male reviewers. Through her letters to her publisher John Lane, we also see how this doubleness informed her relationships with him and Henry Harland, the editor of The Yellow Book and D’Arcy’s employer and friend. Humour was not just a mode in D’Arcy’s writing, but a strategy in her job and particularly in her relationships with editor Henry Harland and publisher John Lane. Her letters to Lane, housed at the Clark Library at the University of California, Los Angeles, reveal an Austenian humour that was D’Arcy’s protection against these men’s capricious behaviours. We see D’Arcy adopting this ironic pose as she tries to keep The Yellow Book on schedule in the aftermath of Oscar Wilde’s arrest, and as she copes with Harland’s regular tantrums and Lane’s indifference. This paper explores the double readings of her stories and their connection to D’Arcy’s work at The Yellow Book.

Politicizing Anthropocene Poetry: Reading Provincialization of Anthropocene and Planetary Shift in Climate through a Comparative Analysis of Anthropocene Blues by John Lane and Anthropocene by Sudeep Sen

ABSTRACT Dipesh Chakraborty and Kathleen D Morrison engage in provincializing the Anthropocene to decenter the grasp of the idea that Anthropocene is an outcome of European industrial phase that enhanced socio-economic growth worldwide, thereby revealing the other causes for the culmination of the era of Anthropocene, offering a space to other cultural histories and Anthropogenic pursuits by non-European societies responsible for climate change. Local episodes of altered weather patterns and adversities when compared, they assist in conceiving the shift in the climate of Earth because of inclusivity of experiences across boundaries, giving importance to the planet that constitutes life. This paper is a comparative study of two poetry collections, Anthropocene Blues (2017) by John Lane and Anthropocene (2021) by Sudeep Sen to ascertain how these poets, belonging to two different continents represent the Anthropocene and deal with its provincialization through their poems. Through an analogical framework, this paper deliberates that how provincialization of Anthropocene facilitates a link to gain a panoramic view of the planet towards the realization of a planetary climate change.

Appalachia North: A Memoir

Appalachia North: A Memoir

President's Page

This marks the 10th year since the SEG Executive Committee, realizing the growing importance of near-surface geophysics in addressing humanitarian needs, approved the formation of a Near Surface Task Force. After four years of dedicated efforts by that task force to advance and promote the science, technology, and professional practice of geophysics as applied to near-surface problems, the SEG Near-Surface Geophysics Technical Section (NSTS) was established by the SEG Board of Directors during its October 2014 meeting following submission of applications by 50 Active SEG near-surface geophysics members. The first chair of the NSTS was John Lane Jr. The membership of the technical section has grown since its inception and includes individuals from a global and diverse community.

The Late-Victorian Little Magazine, by Koenraad Claes

Reviewed by: The Late-Victorian Little Magazine by Koenraad Claes David Finkelstein (bio) The Late-Victorian Little Magazine, by Koenraad Claes; pp. x + 278. Edinburgh: Edinburgh University Press, 2018, £89.50, $110.00. The nineteenth century saw explosive growth in the number of journals and literary periodicals issued for sale and subscription to an ever-expanding British reading public. The number of newspapers and periodicals produced in Britain over this period was staggering: John North, the general editor of The Waterloo Directory series on English, Irish, and Scottish nineteenth-century newspapers and periodicals, has published evidence of over 3,900 Irish titles, 7,300 Scottish titles, and over 100,000 English titles appearing over the course of the century. Many of these were short lived, with small readership numbers who failed to repay editorial energies with good money for variable periodical contents. Some journals were more successful in carving out spaces for enlightening and entertaining general readers, with heavyweight monthly literary periodicals such as early-century Blackwood’s Magazine (1817–1980), or mid-century-founded The Cornhill Magazine (1860–1975), sailing alongside nimble successors that sprang up in the wake of the demotic, pacy style of new journalism from the 1880s onward, championed by newspapers and journals such as Tit-Bits (1881–84). Comically dismissed by Matthew Arnold in 1887, the appeal of miscellanies such as George Newnes’s Tit-Bits lay in being light and wholesome but also serious enough to offer readers an appreciation of what its editor saw as higher forms of literature. Aspirational readers also found great pleasure in the fare offered in journals such as Newnes’s Strand Magazine (1891–1950), whose mix of interviews, articles, illustrations, and light fiction could be seen to sail along better than heavily laden, essay-based periodicals such as the Edinburgh Review (1802–1929) and the Quarterly Review (1809–1967). The fin de siècle saw a number of little magazines spring up espousing a fusion of visual culture, artisanal craftsmanship, and radical aesthetic considerations. Koenraad Claes’s The Late-Victorian Little Magazine takes up the story of a number of these little magazine productions and their earlier inspirations, focusing on a range of better-known English periodicals (such as the 1850 Pre-Raphaelite-inspired The Germ, the 1856 William Morris-initiated journal Oxford and Cambridge Magazine, and the 1890s Yellow Book [1894–97] and The Savoy [1896]). Claes’s study also takes in a survey of short-lived, lesser-known regional examples such as the Birmingham Guild-produced journal Quest (1894–96), and the polymathic Patrick Geddes’s Scottish-issued The Evergreen (1895–96). Claes’s focus is on little magazines that featured as part of the arts and crafts movement in the second half of the nineteenth century, and in particular those that strove to revive fine printing traditions and artisanal-based approaches to cultural production. Several chapters offer studies of journals emanating from the artisan guilds that drew inspiration from William Morris’s espousal of uncommercial, visually and aesthetically rich material production. Examples of journals that picked up on such themes were the Century Guild Hobby Horse (1884–92), its successor Hobby Horse (1893–94), and Quest. Claes offers sound insights into the material conditions of their production, and in some of the stronger sections of the volume, looks closely at the contradictions underpinning such journals’ championing of art as aesthetic pursuit against their need to ensure viability and survival through commercial sales, subscriptions, and advertising of mundane goods and services. Such arguments work well in the sections exploring the history and development [End Page 145] of the best-known and most controversial aesthetic little magazines of the century’s end, the Yellow Book and The Savoy. The publisher of the former, John Lane, proved a canny operator, turning the Aubrey Beardsley-illustrated Yellow Book into a scandalous success. Its distinct, yellow hardcover volumes became much sought after by well-heeled society members as a means of acquiring and demonstrating access to a decadent literary world represented by the likes of Oscar Wilde, John Buchan, Henry James, Kenneth Grahame, and George Moore. Following the infamous trial of Oscar Wilde in 1895 and his fall from grace...

Physiological Differences to the Brain Resulting from Anoxia & Early Childhood Trauma

The report focuses on the case of John Lane, who was convicted of murdering his girlfriend's daughter Angela Palmer by cooking her alive inside an oven. Three previously published research studies, two books, and an interview with the author were utilyzed in providing information significant to the consideration of the nature of John Lane's particular form of mental illness. Anoxia and childhood trauma are explored as causal factors leading to a higher risk of persons developing psychological problems.

Meeting Lydgate’s Ghost: Building Medieval History in Seventeenth-Century England

Abstract This article examines a manuscript poem composed by the seventeenth-century author John Lane. Writing in what is now London, British Library, Harley MS 5243, Lane revives the medieval poet John Lydgate in order to re-tell the story of Guy of Warwick, famous from medieval romance. In Lane’s poem, Lydgate returns from beyond the grave to proclaim the historicity of Guy’s legend and simultaneously preserve his own reputation as a chronicler of English history. While some scholars suggest that Lydgate’s popularity declined in the post-Reformation period due to his reputation as the ‘Monk of Bury’, and while it is true that significantly fewer editions of Lydgate’s poems were published in the decades after the Reformation, Lane’s poem offers another window into Lydgate’s early modern reputation. I argue that Lane’s historiographic technique in his Guy of Warwick narrative mirrors Lydgate’s own poetic histories. Both Lane and Lydgate grapple with existing historical resources and compose their narratives by compiling the accreted traditions of the past, supplementing these traditions with documentary sources and artefacts. This article, thus, complicates existing scholarly narratives that align Lydgate with medieval or monastic traditions, traditions perceived to be irrecoverably transformed by the events of the Reformation in England.

Anthropocene Blues: Poems. By John Lane

<i>Anthropocene Blues</i>: Poems. By John Lane

“She who would refine the fabric:” Contexts for Reading the Embroidering and Writing of Florence Farr and Una Taylor

Both Florence Farr and Una Taylor were Arts and Crafts embroiderers and writers whose work was published in John Lane’s avant-garde “Keynotes” series in the eighteen nineties. This essay identifies the contexts within which their work can be most helpfully examined, beginning with representations of embroidering in another of John Lane’s publications from the mid-eighteen nineties, The Yellow Book. Themes established through a consideration of this magazine’s visual and literary content are then related to the preoccupations of the Aesthetic movement as it emerged alongside the growing popularity of embroidery from the eighteen seventies onwards. Texts by Lucy Crane, Rhoda and Agnes Garrett and Janey Campbell are discussed as representative of the ongoing significance of “art embroidery” for the Arts and Crafts movement and a developing aestheticism. Against this background, Florence Farr and Una Taylor are considered as female embroiderers associated with the Morris family business whose literary works suggest both the questioning of established mores and a continued adherence to ritualism and medievalism. These apparently contradictory emphases can be seen as presaging early 20th century debates about the function of literature and embroidery.

Abstract A25: Prevalence of Klinefelter syndrome among males aged 0-19 years diagnosed with germ cell tumors: A report from the Children’s Oncology Group

Abstract Previous studies have suggested that males with Klinefelter syndrome (KS; 47, XXY) may be more likely to develop germ cell tumors (GCTs), particularly mediastinal GCTs. Due to the rarity of pediatric GCTs, there are no reports characterizing the prevalence of KS among males diagnosed with GCTs. We used data from a Children’s Oncology Group epidemiology study (2008-2015) to evaluate the prevalence of KS in males (n=433) diagnosed with GCTs (aged 0-19 years). These 433 cases provided saliva samples and had one parent who was willing to participate in the study and complete a questionnaire including questions about health history, demographics, and environmental exposures. Tumor characteristics (location and histology) were abstracted from pathology reports provided by the treating institution. GCT cases were classified as having KS if they had evidence of an extra copy of the X chromosome based on evaluation of array data from Illumina HumanCoreExome-12 genotyping chips. Genvisis was used to identify samples with sex aneuploidy and to determine the parent-of-origin for the nondisjunction. Using chi-square tests, we examined differences in age at diagnosis, race/ethnicity, tumor location and histology, and a number of birth characteristics between KS-GCT cases and GCT cases without chromosomal abnormalities (n=415). Using publically available data, we estimated the 1-year risk and corresponding Risk Ratio (RR) and 95% Confidence Interval (95% CI) of a male with KS developing a GCT. Based on analysis of array genotyping data, 3% (n=13) of male GCT cases had KS. Among these 13 cases, the extra X chromosome was of maternal origin in 7 cases and of paternal origin in 6 cases. Of the 13 KS cases with genotyping data, 5/9 (56%) KS-GCT cases with parental questionnaire data reported receiving a diagnosis of KS. The average age at GCT diagnosis for cases with genotyping-detected KS (n=13) was 13.8 years (standard deviation [SD], 4.4 years) compared with 12.5 years (SD, 6.2 years) for GCT cases without chromosomal abnormalities (n=415; p=0.45). We did not observe significant differences in patient or birth characteristics including race, birth weight and length, maternal age, paternal age, and the use of fertility drugs between the two groups. We confirmed that KS-GCT cases were significantly more likely to be diagnosed with extragonadal tumors (GCT [n=69/411; 17%]; KS-GCT [n=11/13; 85%]; p&amp;lt;0.01), particularly mediastinal tumors (GCT [n=20/406; 5%]; KS-GCT [9/13; 69%]; p&amp;lt;0.01), than GCT cases without chromosomal abnormalities. Mixed/other histology was the most common histologic subtype for KS-GCT (46%) and GCTs among patients without chromosomal abnormalities (41%; p=0.60). Based on data from the CDC WONDER database and the US Census Bureau, in 2013, the risk of developing a GCT among males aged 0-19 years without KS was estimated to be 0.000014 or approximately 1 in 70,000. Using our estimate that 3% of GCTs in males aged 0-19 years are diagnosed among patients who also have KS, we estimated the risk of a GCT among males with KS to be 0.00025, or approximately 1 in 4,000 (RR: 18.8; 95% CI: 11.7, 30.0). In our large case series of males diagnosed with GCTs, we observed that 3% of GCT cases (n=13/433) were also carriers of an extra X chromosome based on array genotyping data and were thus classified as having KS. Males aged 0-19 years with KS experience a large increase in risk of developing a GCT compared with males from the general population. Collectively, these findings suggest that young males with KS should be monitored for the development of a GCT. Similarly, the possibility of KS should be considered in males diagnosed with a mediastinal GCT during childhood or adolescence and these patients should be tested for the presence of KS. Citation Format: Lindsay A. Williams, Nathan Pankratz, John Lane, Michelle Roesler, Michaela Richardson, A. Lindsay Frazier, James Amatruda, Jenny N. Poynter. Prevalence of Klinefelter syndrome among males aged 0-19 years diagnosed with germ cell tumors: A report from the Children’s Oncology Group [abstract]. In: Proceedings of the AACR Special Conference: Pediatric Cancer Research: From Basic Science to the Clinic; 2017 Dec 3-6; Atlanta, Georgia. Philadelphia (PA): AACR; Cancer Res 2018;78(19 Suppl):Abstract nr A25.

Abstract 1219: Association between MICA polymorphisms, s-MICA levels, and pancreatic cancer risk in a population-based case-control study

Abstract Objectives: The immune system has been shown to play an important role in pancreatic cancer. Abnormal cells express the transmembrane major histocompatibility complex class I chain-related gene A (MICA) protein, which is recognized by receptors present on NK and cytotoxic T cells. However, pancreatic tumor cells release MICA protein in soluble form (called s-MICA) from the tumor surface and thus avoid immune surveillance. In our previous study, we showed that a higher serum concentration of the s-MICA protein was associated with increased pancreatic cancer risk. In the current study, we hypothesized that functional variants in the MICA gene are associated with higher circulating s-MICA levels and increased pancreatic cancer risk. We focused on the A5.1 MICA allele, as this allele encodes a MICA protein that is shorter than its normal counterpart and is more easily cleaved from the cell surface. Methods: MICA alleles and s-MICA levels were measured in 116 cases and 492 controls (n=608) in a population-based case-control study in Minnesota. Allele assignments were based on the number of repeat units in the amplified regions of the MICA gene, and s-MICA levels were measured by enzyme-linked immunoabsorbent assay. To address the non-normal distribution of s-MICA levels, general linear regression with a log link was used to assess mean s-MICA levels across MICA alleles. Unconditional logistic regression was used to calculate the odds ratio (OR) and 95% confidence intervals (CI) for pancreatic cancer after adjustment for age, sex, education, smoking status, alcohol consumption, and diabetes status. The analysis was restricted to Caucasians, who represented 96% of all study participants. Results: 452 participants (74%) possessed at least one copy of the A5.1 allele. After adjustment for confounders, participants with at least one copy of the MICA A5.1 allele were at an increased risk of pancreatic cancer (multivariable OR=2.00, 95% CI: 1.06-3.79), compared to participants who did not possess any A5.1 allele. Participants who had at least one copy of the A5.1 allele had 2.46 (95%CI: 2.36-2.56) times greater mean s-MICA levels than those without the A5.1 allele. These associations were consistent among pancreatic cancer cases and controls. Conclusions: Our study supports the role of the MICA A5.1 allele in impaired immune response, which may increase the risk of pancreatic cancer. Citation Format: Guillaume C. Onyeaghala, John Lane, Nathan Pankratz, Heather H. Nelson, Bharat Thyagarajan, Kristin E. Anderson, Anna E. Prizment. Association between MICA polymorphisms, s-MICA levels, and pancreatic cancer risk in a population-based case-control study [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr 1219.

Meeting Harry Crews

Meeting Harry Crews Dennis M. Wiseman (bio) In September 2016, Harry Crews reentered my life for the third time through Ted Geltner's fine biography Blood, Bone, and Marrow, a Biography of Harry Crews (2016). I am grateful for and moved by this third encounter that reveals Harry with the empathy, appreciation, and admiration that he deserves. Reading his life slowly, ten or fifteen pages at a time, a day or two intervening between sittings and, after forty years, I have finally given him the time he deserved thanks to this personally rewarding biography. When thinking my life with Harry Crews, I remind myself that I "met" Proust as a Master's candidate at Arizona, I met him again in Chapel Hill, and I met him most recently when I finally taught him to undergraduates. The third time is the charm. I will tell you about Harry and me (Harry didn't know there was a "Harry and Dennis" but bear with me) and how he dropped into and out of my life over the years. I had no idea that his story would resonate so much for me at this stage of my life, which is as a 66-year-old cyclist, former French professor, dean, provost (retired from all three of the preceding, still an old cyclist), baker of bread, and lover of words that communicate. From the biography, I will also tease out some episodes in his life that opened doors for me into Harry, his writing and into myself as well. Someone else's biography can be a fine teacher. In the spring of 1975 my friend Joe introduced me to Harry for the first time through Karate Is a Thing of the Spirit and Car. Joe was then and remains a son of the South, possessed of a keen sense of place and history. He knew that I was a far-traveling Army brat from Arizona and he may have given me these books to provide some unusual insights into the region but at that time I was submerged in the importance of courses in Literary Criticism, Old French, and Bibliography. For me at the time, Harry's paperbacks were easy, fast, entertaining reads telling stories of the soft, dark underbelly of a kind of life in the South. Who could not be intrigued by the Florida beach-town beauty contest circuit or a guy who eats a car in the lobby of a hotel? I liked the stories and left them behind, I thought, having failed to meet Harry or feel his place. At Wofford College in the spring of 1983 I met poet, naturalist, and novelist John Lane, another son of the South who is firmly grounded in [End Page 133] the Piedmont of South Carolina. John knew that I had read some Crews and he filed that away until the early spring of 1992 when Harry, all blood, bone, and marrow of him dropped into my life for the second time. Harry had been invited to speak in our college's visiting writers series and I asked to deliver the introduction for Harry's talk. To facilitate the introduction, John invited me to join him and Harry for dinner before the reading. Things went badly from the start. It was a cold, wet, dark evening in early February. In leaving Gainesville, Harry had locked his travel bag in the trunk of his car and so was in Spartanburg for two days with no change of clothes and only his shaving kit. John recalls that Harry wore hospital scrubs, a sleeveless sweatshirt and sported his "do and too" look—a Mohawk hairdo and showing off his tattoo that read: "What do you think of your blue-eyed boy now, Mr. Death?" on his bicep. His shaving kit must have contained a huge bottle of Aqua Velva because he reeked of it when John picked him up at the motel for dinner. John said that he smelled like his farmer uncles from North Carolina on Saturday night. I was in a coat and tie. Full of myself as a very young department chair, I had prepared a long, erudite academic introduction. At...

What's for dinner?

What's for dinner?

Walter v. Lane (1900)

Originality is a cornerstone of contemporary copyright law; in order to receive protection, works must be ‘original’. One of the persistent challenges for the courts has been identifying when a copy of a work can itself be an original work. This question of protecting copies of other works arose before originality was even a statutory requirement. In the seminal case of Walter v. Lane (1900), the House of Lords decided that verbatim reports in The Times of speeches given by the politician Lord Rosebery were protected under the existing copyright legislation. Walter v. Lane is a seminal copyright case still cited in 21st-century judgments. But it was also a principled personal conflict, with the Bodley Head publisher John Lane (1854-1925) and Liberal editor Charles Geake (1867-1919) on one side and Charles Frederic Moberly Bell (1847-1911), the Managing Director of The Times, on the other. This feud caused embarrassment and upset to Lord Rosebery himself, a friend to both Moberly Bell and Geake, who found himself caught in the middle. This chapter examines the legal and personal context of Walter v. Lane and challenges other interpretations of its holding. It argues that the primary legacy of the case comes from the principle that the law should protect works that are products of editing, re-creation, preservation, conservation, or reconstruction where they are the result of intellectual skill and labour and there exists a public interest in the relevant acts of copying.

Grand Dragon, and: Locker Room

Grand Dragon, and: Locker Room John Lane (bio) Grand Dragon In the first photo Scoggin wearsa formal shiny crimson robe,no iconic hood, black Gregory Peckhair swept back, his chin sharpenough to gig mill pond frogs.He tosses an album towarda smoky burning cross.The summer of '66 John Lennonsoaked the South in kerosene,saying the Beatles were more popularthan Jesus. Militant djs struck the matchto start the spreading fire, burningpiles of records flared everywhere,the touring Fab Four's vinylmelted to black sapin the radio station parking lots. I was twelve that summerof the Beatle fires. I rememberScoggin's face from our church,Saxon Methodist, as in Anglo-Saxon,on the outskirts of the mill village,home of this man in the scarlet robe. We were all clannish back then,pews around us held uncles, [End Page 61] aunts, and cousins. My mother, sister,and I shared a Sunday service oncewith Scoggin, visiting our churchfrom Grace Baptist with his son Bobby,my youth group buddy. Fifty years laterI can't get enough of the Grand Dragon,maybe the closest I've ever satto evil, only one pew removed. I Google a second photo, South Carolina'sshadow realm, this time Scogginsits at a hearing of the Un-AmericanActivities Committee investigatingthe Klan's resurgence—he pleadsthe Fifth and walks away. Handsomeand stark in his heavy black glassesand his Sunday meeting clothes,Scoggin looked more like AtticusFinch than Adolph Hitler, but the sharpchin was a dead giveaway. In the third photo the albums burningbecome another bonfire in a mowed fieldoutside an upstate town where boys myand Bobby's age stand in short pantsand watch from the klavern's edge.Scoggin's hand gestures toward a new flame,and the fiery cross burns in black and white. Saxon Methodist was staid brick,like other '60s churches—built to servethe will, dispensing gospel to keepwarm-blooded boys like us on a narrow way.The summer of '66 Bobby and I had a crushon the preacher's daughter, pressedbetween us on hay rides. I flirtedin her family's brick parsonage [End Page 62] living room, watching It's About Timeor Lost in Space on the rabbit earsSunday nights, after the churchhad emptied. That fall, beforethe Beatles furor broke, we listenedto Revolver, "I'm only Sleeping"spinning in back bedrooms to sit usup before we woke to fires. What didI know then of hate's scarletmelody and living flame? Now a cardinal in royal redpilfers the feeder. Its feathered maskmissing, a pink beak on a raw,naked skull. One Sunday the preacherstoked a puny fire in the church'sgravel parking lot and everyone,I think, pitched in. That is, everyonemaybe but me. My only clues to truthare that in a family photoI stand playing a tennis racketlike George Harrison in my raggedBeatles wig, so it must not have burned.I still have Revolver, so maybe I said"No" when the preacher asked us to spurnthe devil's rock and roll. I need to thinkof this as my first defiant acta way of living with the dragons who flewamong us then, their scales mirrors blindingthose who looked to see them beating past. [End Page 63] Locker Room after Elizabeth Bishop Home from schoolin the afternoon to restbefore basketball practice.It's still hot. The leaveson the water oak have notbegun to turn. It's quietI feel very alone.I pick up the mail fromthe box and there it is:Sports Illustrated's collegebasketball issue with PeteMaravich on the cover.I sit down in the front room(a place no one ever sits)and flip through the pages,past "The short takes" and"They said it," the ads forChevys, starched Arrow shirts.From my mother's bedroomthe cry, my name. At firstI'm not sure, but then again.Not alone, but...

The Titan by Theodore Dreiser

Reviewed by: The Titan by Theodore Dreiser James M. Hutchisson (bio) The Titan, by Theodore Dreiser. Edited by Roark Mulligan. Winchester: Winchester University Press, 2016. xvii + 628 pp. Paper, 40.00. "Sister Carrie all over again . . .": so wrote Theodore Dreiser to his friend the critic Albert Mordell on 6 March 1914 upon learning that, despite having signed a contract for his new novel, The Titan, with Harper and Brothers, the venerable firm was pulling the plug on its publication after printing 10,000 copies (Pizer 57). As is well known, Dreiser had suffered a similar embarrassment in 1900 when Frank Doubleday, of Doubleday, Page, and Company, blanching at the bold realism and frank treatment of then-taboo matters, such as sex and religion, effectively suppressed the publication of Dreiser's first novel and sent the author into a tailspin of depression from which it took him some time to recover and start writing again. Fourteen years did, however, make a difference. In 1900 Dreiser was a mostly unknown author with no literary leverage; in 1914, he was a respected writer, critic, editor, and observer of the American scene who had just had a creditable success with The Financier, also brought out by Harpers. And Dreiser had money in the bank; so, as he told Mordell, "my position happens to be by no means . . . insecure" (Pizer 57). Yet Dreiser was still stunned by the turn of events and not immediately sure what caused it. Why Harpers took such dramatic and unexpected action is investigated in full detail by Roark Mulligan in the historical commentary accompanying Winchester University Press's new edition of The Titan, the second volume of Dreiser's "Trilogy of Desire" featuring Frank Algernon Cowperwood, a fictional turn-of-the-century financier who was based in part on the Chicago magnate Charles T. Yerkes. As with most things Dreiserian, the Harpers debacle makes for an interesting story. Although Dreiser at first supposed that the novel's realism was too "hard and uncompromising" (Riggio 1: 132), such a surmise did not make complete sense. After all, Harpers had earlier published the story of Cowperwood's origins and rise to power, a tale replete with all the trademarks of Dreiser's bleakly mechanistic view of man's desires and ambitions. In truth, it was fear of libel that made Harpers play it safe, even as it made the printed copies and plates of the book available at cost to another publisher (it would turn out to be the British firm of John Lane, who was looking to expand its American offerings) and assured Dreiser that it remained interested in any future work. In his usual painstaking fashion, [End Page 251] Dreiser had done extensive research on his subject's public and private life (in the process compiling a staggering 435 pages of handwritten notes from holdings in Chicago's Newberry Library), which included Yerkes's affair with his ward and paramour Emilie Grigsby. By 1914, having inherited part of Yerkes's fortune, Grigsby had moved permanently to England and ingratiated herself into the royal household, where she was an intimate of George V's only daughter. She became well known as a society hostess and an intimate of the rich and famous. Grigsby appeared in Dreiser's novel as Berenice Fleming, Cowperwood's lover, and it was not a flattering portrait. One publisher in particular, and a close friend of Grigsby, Mitchell Kennerly, objected vehemently to the image of Grigsby in the book ("cheap, slanderous, and sensational" [Riggio 1: 136]) and mounted a oneman crusade to keep any firm from publishing The Titan, although he later relented partly, allowing that he admired Dreiser as a writer but that he still thought that the novel should never be published in Grigsby's adopted country of England. (Lane did issue it in England the following year, 1915.) The story behind Mulligan's editing of the text of the novel is no less interesting. We learn much about Dreiser's painstaking compositional process in the back matter to the volume. He composed the book rapidly and acceded to Harpers' editor Ripley Hitchcock's requests for deletion of cumbersome and sometimes irrelevant detail. Further cuts...

Cultural Diversity

Contemporary African-American classical composers Cedric Adderley, John Lane, and Trevor Weston intertwine strands of culture and individual experience to produce musical works whose distinct designs offer cultural resources that music educators can use to integrate diversity into instructional settings. Of special interest is their ability to combine traditional European styles and other musical styles, including jazz, gospel, and blues, in their music. The authors include recommendations for incorporating elements of these contemporary African-American–composed works into the curriculum.

Abstract A37: De novo and transmitted germline TP53 variation in pediatric osteosarcoma: A report from the Children's Oncology Group

Abstract Pathogenic germline variation in TP53, usually accompanied by familial Li-Fraumeni syndrome (LFS), is known to underly a small proportion of pediatric osteosarcoma (OS). However, the extent to which de novo mutations and rare but mildly deleterious variation in TP53 are found in the genomes of OS patients is only now coming into focus with next-generation sequencing. We recruited 285 patients with OS diagnosed at &amp;lt;20 years of age from North American Children's Oncology Group institutions between December, 2007 and March, 2010. Oragene saliva collection kits (DNA Genotek, Ottawa, Canada) or buccal swabs for DNA extraction were collected from patients and their parents, resulting in 229 complete triads and 59 dyads. From these, 95 triads were selected for whole exome sequencing (WES) based on the availability of both patient and parent samples and sufficient DNA mass. Libraries were created using the Agilent SureSelect All Exon V5+UTRs kit and were sequenced using a HiSeq 2000 that generated 100bp paired end reads with an average insert size of 188.8bp. We implemented the best practices as delineated in the GATK pipeline, including using BWA-MEM for alignment, GATK for quality recalibration and indel realignment, and GATK HaplotypeCaller for genotyping. On average, 35.0 million reads were delivered per sample, and the average read depth was 36.4x coverage. The average proportion of TP53 exons covered at 20x coverage was 76.2% (compared to 78.7% for all genes). Exons 1 and 9 were the only exons with poor coverage (mean coverage &amp;lt;20x). All putative TP53 variants were verified via Sanger sequencing; only verified variants are reported hereafter. Sequence variants were annotated using SNPEFF and ANNOVAR. Five patients exhibited rare, synonymous variation in exons 4 (Pro36Pro, 2 patients) and 6 (Arg213Arg, 3 patients). One patient exhibited rare, non-synonymous variation in exon 4 (Pro47Ser); this variant has a frequency of 0.005 across all populations in 1000 Genomes data and was predicted to be deleterious in 2 of 8 functional prediction algorithms. An additional two patients exhibited rare, non-synonymous variation in exons 7 (Cys238Tyr) and 8 (Gly279Glu). Neither variant was detected in parents or reported in 1000 Genomes data, and both were predicted to be deleterious by all functional prediction algorithms. The prevalence of pathogenic TP53 variation in our data (3/95 or 3.2%) is roughly similar to that reported previously, but importantly 2 of the 3 rare, non-synonymous variants were de novo. These results underscore the contribution of new mutations to OS risk and suggest that genetic counseling and TP53 mutation testing should be offered to patients even in the absence of a family history suggestive of LFS. This research was funded by NIH R01CA122371 and grants from the Hyundai Hope on Wheels foundation and the Zach Sobiech Osteosarcoma Fund of the Children's Cancer Research Fund, Minneapolis, MN. Citation Format: Logan Spector, Ian Lock, John Lane, Aaron Sarver, Mark Krailo, Rajaram Nagarajan, Nathan Pankratz. De novo and transmitted germline TP53 variation in pediatric osteosarcoma: A report from the Children's Oncology Group. [abstract]. In: Proceedings of the AACR Special Conference on Advances in Pediatric Cancer Research: From Mechanisms and Models to Treatment and Survivorship; 2015 Nov 9-12; Fort Lauderdale, FL. Philadelphia (PA): AACR; Cancer Res 2016;76(5 Suppl):Abstract nr A37.